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Protein

Fibroleukin

Gene

FGL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in physiologic lymphocyte functions at mucosal sites.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroleukin
Alternative name(s):
Fibrinogen-like protein 2
pT49
Gene namesi
Name:FGL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:3696. FGL2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. fibrinogen complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28134.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 439416FibroleukinPRO_0000009106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi179 – 1791N-linked (GlcNAc...)2 Publications
Disulfide bondi213 ↔ 242PROSITE-ProRule annotation
Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence Analysis
Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi336 – 3361N-linked (GlcNAc...)2 Publications
Disulfide bondi371 ↔ 384PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ14314.
PRIDEiQ14314.

2D gel databases

REPRODUCTION-2DPAGEQ14314.

Expressioni

Tissue specificityi

Constitutively expressed in cytotoxic T-cells.

Gene expression databases

BgeeiQ14314.
CleanExiHS_FGL2.
ExpressionAtlasiQ14314. baseline and differential.
GenevestigatoriQ14314.

Organism-specific databases

HPAiHPA021011.
HPA026682.

Interactioni

Subunit structurei

Homotetramer; disulfide-linked.

Protein-protein interaction databases

BioGridi116083. 11 interactions.
STRINGi9606.ENSP00000248598.

Structurei

3D structure databases

ProteinModelPortaliQ14314.
SMRiQ14314. Positions 22-434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 436233Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili73 – 16593Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG297117.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000252953.
HOVERGENiHBG105002.
InParanoidiQ14314.
OMAiFYVANEF.
OrthoDBiEOG7X9G60.
PhylomeDBiQ14314.
TreeFamiTF336658.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14314-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLANWYWLS SAVLATYGFL VVANNETEEI KDERAKDVCP VRLESRGKCE
60 70 80 90 100
EAGECPYQVS LPPLTIQLPK QFSRIEEVFK EVQNLKEIVN SLKKSCQDCK
110 120 130 140 150
LQADDNGDPG RNGLLLPSTG APGEVGDNRV RELESEVNKL SSELKNAKEE
160 170 180 190 200
INVLHGRLEK LNLVNMNNIE NYVDSKVANL TFVVNSLDGK CSKCPSQEQI
210 220 230 240 250
QSRPVQHLIY KDCSDYYAIG KRSSETYRVT PDPKNSSFEV YCDMETMGGG
260 270 280 290 300
WTVLQARLDG STNFTRTWQD YKAGFGNLRR EFWLGNDKIH LLTKSKEMIL
310 320 330 340 350
RIDLEDFNGV ELYALYDQFY VANEFLKYRL HVGNYNGTAG DALRFNKHYN
360 370 380 390 400
HDLKFFTTPD KDNDRYPSGN CGLYYSSGWW FDACLSANLN GKYYHQKYRG
410 420 430
VRNGIFWGTW PGVSEAHPGG YKSSFKEAKM MIRPKHFKP
Length:439
Mass (Da):50,229
Last modified:November 1, 1996 - v1
Checksum:iDF34656288E49E68
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531G → E.1 Publication
Corresponds to variant rs2075761 [ dbSNP | Ensembl ].
VAR_013066

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36531 mRNA. Translation: CAA85298.1.
AF104015, AF104014 Genomic DNA. Translation: AAD10825.1.
AF468959 Genomic DNA. Translation: AAL68855.1.
BC033820 mRNA. Translation: AAH33820.1.
BC073986 mRNA. Translation: AAH73986.1.
CCDSiCCDS5591.1.
PIRiI37391.
RefSeqiNP_006673.1. NM_006682.2.
UniGeneiHs.520989.

Genome annotation databases

EnsembliENST00000248598; ENSP00000248598; ENSG00000127951.
GeneIDi10875.
KEGGihsa:10875.
UCSCiuc003ugb.3. human.

Polymorphism databases

DMDMi12230074.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z36531 mRNA. Translation: CAA85298.1.
AF104015, AF104014 Genomic DNA. Translation: AAD10825.1.
AF468959 Genomic DNA. Translation: AAL68855.1.
BC033820 mRNA. Translation: AAH33820.1.
BC073986 mRNA. Translation: AAH73986.1.
CCDSiCCDS5591.1.
PIRiI37391.
RefSeqiNP_006673.1. NM_006682.2.
UniGeneiHs.520989.

3D structure databases

ProteinModelPortaliQ14314.
SMRiQ14314. Positions 22-434.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116083. 11 interactions.
STRINGi9606.ENSP00000248598.

Polymorphism databases

DMDMi12230074.

2D gel databases

REPRODUCTION-2DPAGEQ14314.

Proteomic databases

PaxDbiQ14314.
PRIDEiQ14314.

Protocols and materials databases

DNASUi10875.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248598; ENSP00000248598; ENSG00000127951.
GeneIDi10875.
KEGGihsa:10875.
UCSCiuc003ugb.3. human.

Organism-specific databases

CTDi10875.
GeneCardsiGC07M076822.
HGNCiHGNC:3696. FGL2.
HPAiHPA021011.
HPA026682.
MIMi605351. gene.
neXtProtiNX_Q14314.
PharmGKBiPA28134.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG297117.
GeneTreeiENSGT00760000118809.
HOGENOMiHOG000252953.
HOVERGENiHBG105002.
InParanoidiQ14314.
OMAiFYVANEF.
OrthoDBiEOG7X9G60.
PhylomeDBiQ14314.
TreeFamiTF336658.

Miscellaneous databases

GeneWikiiFGL2.
GenomeRNAii10875.
NextBioi41295.
PROiQ14314.
SOURCEiSearch...

Gene expression databases

BgeeiQ14314.
CleanExiHS_FGL2.
ExpressionAtlasiQ14314. baseline and differential.
GenevestigatoriQ14314.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein."
    Ruegg C., Pytela R.
    Gene 160:257-262(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Small intestine.
  2. "Cloning and characterization of Hfgl2: the human counterpart to the mouse gene Fgl2."
    Yuwaraj S., Liu M., Marsden P., Levy G.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. SeattleSNPs variation discovery resource
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-53.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood and Pancreas.
  5. "Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes."
    Marazzi S., Blum S., Hartmann R., Gundersen D., Schreyer M., Argraves S., von Fliedner V., Pytela R., Ruegg C.
    J. Immunol. 161:138-147(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-179 AND ASN-336.
    Tissue: Plasma.
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-179 AND ASN-336.
    Tissue: Liver.

Entry informationi

Entry nameiFGL2_HUMAN
AccessioniPrimary (citable) accession number: Q14314
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1996
Last modified: March 4, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.