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Q14314

- FGL2_HUMAN

UniProt

Q14314 - FGL2_HUMAN

Protein

Fibroleukin

Gene

FGL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May play a role in physiologic lymphocyte functions at mucosal sites.

    Protein family/group databases

    MEROPSiS67.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroleukin
    Alternative name(s):
    Fibrinogen-like protein 2
    pT49
    Gene namesi
    Name:FGL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:3696. FGL2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. fibrinogen complex Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28134.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 439416FibroleukinPRO_0000009106Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi25 – 251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi179 – 1791N-linked (GlcNAc...)2 Publications
    Disulfide bondi213 ↔ 242PROSITE-ProRule annotation
    Glycosylationi235 – 2351N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi263 – 2631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi336 – 3361N-linked (GlcNAc...)2 Publications
    Disulfide bondi371 ↔ 384PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ14314.
    PRIDEiQ14314.

    2D gel databases

    REPRODUCTION-2DPAGEQ14314.

    Expressioni

    Tissue specificityi

    Constitutively expressed in cytotoxic T-cells.

    Gene expression databases

    ArrayExpressiQ14314.
    BgeeiQ14314.
    CleanExiHS_FGL2.
    GenevestigatoriQ14314.

    Organism-specific databases

    HPAiHPA021011.
    HPA026682.

    Interactioni

    Subunit structurei

    Homotetramer; disulfide-linked.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000248598.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14314.
    SMRiQ14314. Positions 22-434.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini204 – 436233Fibrinogen C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili73 – 16593Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiNOG297117.
    HOGENOMiHOG000252953.
    HOVERGENiHBG105002.
    InParanoidiQ14314.
    OMAiYVANEFL.
    OrthoDBiEOG7X9G60.
    PhylomeDBiQ14314.
    TreeFamiTF336658.

    Family and domain databases

    Gene3Di3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProiIPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view]
    PfamiPF00147. Fibrinogen_C. 1 hit.
    [Graphical view]
    SMARTiSM00186. FBG. 1 hit.
    [Graphical view]
    SUPFAMiSSF56496. SSF56496. 1 hit.
    PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q14314-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLANWYWLS SAVLATYGFL VVANNETEEI KDERAKDVCP VRLESRGKCE    50
    EAGECPYQVS LPPLTIQLPK QFSRIEEVFK EVQNLKEIVN SLKKSCQDCK 100
    LQADDNGDPG RNGLLLPSTG APGEVGDNRV RELESEVNKL SSELKNAKEE 150
    INVLHGRLEK LNLVNMNNIE NYVDSKVANL TFVVNSLDGK CSKCPSQEQI 200
    QSRPVQHLIY KDCSDYYAIG KRSSETYRVT PDPKNSSFEV YCDMETMGGG 250
    WTVLQARLDG STNFTRTWQD YKAGFGNLRR EFWLGNDKIH LLTKSKEMIL 300
    RIDLEDFNGV ELYALYDQFY VANEFLKYRL HVGNYNGTAG DALRFNKHYN 350
    HDLKFFTTPD KDNDRYPSGN CGLYYSSGWW FDACLSANLN GKYYHQKYRG 400
    VRNGIFWGTW PGVSEAHPGG YKSSFKEAKM MIRPKHFKP 439
    Length:439
    Mass (Da):50,229
    Last modified:November 1, 1996 - v1
    Checksum:iDF34656288E49E68
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti53 – 531G → E.1 Publication
    Corresponds to variant rs2075761 [ dbSNP | Ensembl ].
    VAR_013066

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36531 mRNA. Translation: CAA85298.1.
    AF104015, AF104014 Genomic DNA. Translation: AAD10825.1.
    AF468959 Genomic DNA. Translation: AAL68855.1.
    BC033820 mRNA. Translation: AAH33820.1.
    BC073986 mRNA. Translation: AAH73986.1.
    CCDSiCCDS5591.1.
    PIRiI37391.
    RefSeqiNP_006673.1. NM_006682.2.
    UniGeneiHs.520989.

    Genome annotation databases

    EnsembliENST00000248598; ENSP00000248598; ENSG00000127951.
    GeneIDi10875.
    KEGGihsa:10875.
    UCSCiuc003ugb.3. human.

    Polymorphism databases

    DMDMi12230074.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36531 mRNA. Translation: CAA85298.1 .
    AF104015 , AF104014 Genomic DNA. Translation: AAD10825.1 .
    AF468959 Genomic DNA. Translation: AAL68855.1 .
    BC033820 mRNA. Translation: AAH33820.1 .
    BC073986 mRNA. Translation: AAH73986.1 .
    CCDSi CCDS5591.1.
    PIRi I37391.
    RefSeqi NP_006673.1. NM_006682.2.
    UniGenei Hs.520989.

    3D structure databases

    ProteinModelPortali Q14314.
    SMRi Q14314. Positions 22-434.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000248598.

    Protein family/group databases

    MEROPSi S67.001.

    Polymorphism databases

    DMDMi 12230074.

    2D gel databases

    REPRODUCTION-2DPAGE Q14314.

    Proteomic databases

    PaxDbi Q14314.
    PRIDEi Q14314.

    Protocols and materials databases

    DNASUi 10875.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000248598 ; ENSP00000248598 ; ENSG00000127951 .
    GeneIDi 10875.
    KEGGi hsa:10875.
    UCSCi uc003ugb.3. human.

    Organism-specific databases

    CTDi 10875.
    GeneCardsi GC07M076822.
    HGNCi HGNC:3696. FGL2.
    HPAi HPA021011.
    HPA026682.
    MIMi 605351. gene.
    neXtProti NX_Q14314.
    PharmGKBi PA28134.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297117.
    HOGENOMi HOG000252953.
    HOVERGENi HBG105002.
    InParanoidi Q14314.
    OMAi YVANEFL.
    OrthoDBi EOG7X9G60.
    PhylomeDBi Q14314.
    TreeFami TF336658.

    Miscellaneous databases

    GeneWikii FGL2.
    GenomeRNAii 10875.
    NextBioi 41295.
    PROi Q14314.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14314.
    Bgeei Q14314.
    CleanExi HS_FGL2.
    Genevestigatori Q14314.

    Family and domain databases

    Gene3Di 3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProi IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view ]
    Pfami PF00147. Fibrinogen_C. 1 hit.
    [Graphical view ]
    SMARTi SM00186. FBG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56496. SSF56496. 1 hit.
    PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein."
      Ruegg C., Pytela R.
      Gene 160:257-262(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Small intestine.
    2. "Cloning and characterization of Hfgl2: the human counterpart to the mouse gene Fgl2."
      Yuwaraj S., Liu M., Marsden P., Levy G.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. SeattleSNPs variation discovery resource
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-53.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Blood and Pancreas.
    5. "Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes."
      Marazzi S., Blum S., Hartmann R., Gundersen D., Schreyer M., Argraves S., von Fliedner V., Pytela R., Ruegg C.
      J. Immunol. 161:138-147(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-179 AND ASN-336.
      Tissue: Plasma.
    7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-179 AND ASN-336.
      Tissue: Liver.

    Entry informationi

    Entry nameiFGL2_HUMAN
    AccessioniPrimary (citable) accession number: Q14314
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3