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Q14314 (FGL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroleukin
Alternative name(s):
Fibrinogen-like protein 2
pT49
Gene names
Name:FGL2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in physiologic lymphocyte functions at mucosal sites.

Subunit structure

Homotetramer; disulfide-linked.

Subcellular location

Secreted.

Tissue specificity

Constitutively expressed in cytotoxic T-cells.

Sequence similarities

Contains 1 fibrinogen C-terminal domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainCoiled coil
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular vesicular exosome

Inferred from direct assay PubMed 19056867. Source: UniProt

fibrinogen complex

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 439416Fibroleukin
PRO_0000009106

Regions

Domain204 – 436233Fibrinogen C-terminal
Coiled coil73 – 16593 Potential

Amino acid modifications

Glycosylation251N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Ref.6 Ref.7
Glycosylation2351N-linked (GlcNAc...) Potential
Glycosylation2631N-linked (GlcNAc...) Potential
Glycosylation3361N-linked (GlcNAc...) Ref.6 Ref.7
Disulfide bond213 ↔ 242 By similarity
Disulfide bond371 ↔ 384 By similarity

Natural variations

Natural variant531G → E. Ref.3
Corresponds to variant rs2075761 [ dbSNP | Ensembl ].
VAR_013066

Sequences

Sequence LengthMass (Da)Tools
Q14314 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: DF34656288E49E68

FASTA43950,229
        10         20         30         40         50         60 
MKLANWYWLS SAVLATYGFL VVANNETEEI KDERAKDVCP VRLESRGKCE EAGECPYQVS 

        70         80         90        100        110        120 
LPPLTIQLPK QFSRIEEVFK EVQNLKEIVN SLKKSCQDCK LQADDNGDPG RNGLLLPSTG 

       130        140        150        160        170        180 
APGEVGDNRV RELESEVNKL SSELKNAKEE INVLHGRLEK LNLVNMNNIE NYVDSKVANL 

       190        200        210        220        230        240 
TFVVNSLDGK CSKCPSQEQI QSRPVQHLIY KDCSDYYAIG KRSSETYRVT PDPKNSSFEV 

       250        260        270        280        290        300 
YCDMETMGGG WTVLQARLDG STNFTRTWQD YKAGFGNLRR EFWLGNDKIH LLTKSKEMIL 

       310        320        330        340        350        360 
RIDLEDFNGV ELYALYDQFY VANEFLKYRL HVGNYNGTAG DALRFNKHYN HDLKFFTTPD 

       370        380        390        400        410        420 
KDNDRYPSGN CGLYYSSGWW FDACLSANLN GKYYHQKYRG VRNGIFWGTW PGVSEAHPGG 

       430 
YKSSFKEAKM MIRPKHFKP 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein."
Ruegg C., Pytela R.
Gene 160:257-262(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Small intestine.
[2]"Cloning and characterization of Hfgl2: the human counterpart to the mouse gene Fgl2."
Yuwaraj S., Liu M., Marsden P., Levy G.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]SeattleSNPs variation discovery resource
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-53.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Blood and Pancreas.
[5]"Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes."
Marazzi S., Blum S., Hartmann R., Gundersen D., Schreyer M., Argraves S., von Fliedner V., Pytela R., Ruegg C.
J. Immunol. 161:138-147(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[6]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-179 AND ASN-336.
Tissue: Plasma.
[7]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-179 AND ASN-336.
Tissue: Liver.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z36531 mRNA. Translation: CAA85298.1.
AF104015, AF104014 Genomic DNA. Translation: AAD10825.1.
AF468959 Genomic DNA. Translation: AAL68855.1.
BC033820 mRNA. Translation: AAH33820.1.
BC073986 mRNA. Translation: AAH73986.1.
PIRI37391.
RefSeqNP_006673.1. NM_006682.2.
UniGeneHs.520989.

3D structure databases

ProteinModelPortalQ14314.
SMRQ14314. Positions 22-435.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000248598.

Protein family/group databases

MEROPSS67.001.

Polymorphism databases

DMDM12230074.

2D gel databases

REPRODUCTION-2DPAGEQ14314.

Proteomic databases

PaxDbQ14314.
PRIDEQ14314.

Protocols and materials databases

DNASU10875.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000248598; ENSP00000248598; ENSG00000127951.
GeneID10875.
KEGGhsa:10875.
UCSCuc003ugb.3. human.

Organism-specific databases

CTD10875.
GeneCardsGC07M076822.
HGNCHGNC:3696. FGL2.
HPAHPA021011.
HPA026682.
MIM605351. gene.
neXtProtNX_Q14314.
PharmGKBPA28134.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG297117.
HOGENOMHOG000252953.
HOVERGENHBG105002.
InParanoidQ14314.
OMAYVANEFL.
OrthoDBEOG7X9G60.
PhylomeDBQ14314.
TreeFamTF336658.

Gene expression databases

ArrayExpressQ14314.
BgeeQ14314.
CleanExHS_FGL2.
GenevestigatorQ14314.

Family and domain databases

Gene3D3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMSSF56496. SSF56496. 1 hit.
PROSITEPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiFGL2.
GenomeRNAi10875.
NextBio41295.
PROQ14314.
SOURCESearch...

Entry information

Entry nameFGL2_HUMAN
AccessionPrimary (citable) accession number: Q14314
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM