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Q14314

- FGL2_HUMAN

UniProt

Q14314 - FGL2_HUMAN

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Protein
Fibroleukin
Gene
FGL2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in physiologic lymphocyte functions at mucosal sites.

Protein family/group databases

MEROPSiS67.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroleukin
Alternative name(s):
Fibrinogen-like protein 2
pT49
Gene namesi
Name:FGL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:3696. FGL2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. fibrinogen complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28134.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 439416Fibroleukin
PRO_0000009106Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi25 – 251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi179 – 1791N-linked (GlcNAc...)2 Publications
Disulfide bondi213 ↔ 242 By similarity
Glycosylationi235 – 2351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi263 – 2631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi336 – 3361N-linked (GlcNAc...)2 Publications
Disulfide bondi371 ↔ 384 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ14314.
PRIDEiQ14314.

2D gel databases

REPRODUCTION-2DPAGEQ14314.

Expressioni

Tissue specificityi

Constitutively expressed in cytotoxic T-cells.

Gene expression databases

ArrayExpressiQ14314.
BgeeiQ14314.
CleanExiHS_FGL2.
GenevestigatoriQ14314.

Organism-specific databases

HPAiHPA021011.
HPA026682.

Interactioni

Subunit structurei

Homotetramer; disulfide-linked.

Protein-protein interaction databases

STRINGi9606.ENSP00000248598.

Structurei

3D structure databases

ProteinModelPortaliQ14314.
SMRiQ14314. Positions 22-434.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 436233Fibrinogen C-terminal
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili73 – 16593 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiNOG297117.
HOGENOMiHOG000252953.
HOVERGENiHBG105002.
InParanoidiQ14314.
OMAiYVANEFL.
OrthoDBiEOG7X9G60.
PhylomeDBiQ14314.
TreeFamiTF336658.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14314-1 [UniParc]FASTAAdd to Basket

« Hide

MKLANWYWLS SAVLATYGFL VVANNETEEI KDERAKDVCP VRLESRGKCE    50
EAGECPYQVS LPPLTIQLPK QFSRIEEVFK EVQNLKEIVN SLKKSCQDCK 100
LQADDNGDPG RNGLLLPSTG APGEVGDNRV RELESEVNKL SSELKNAKEE 150
INVLHGRLEK LNLVNMNNIE NYVDSKVANL TFVVNSLDGK CSKCPSQEQI 200
QSRPVQHLIY KDCSDYYAIG KRSSETYRVT PDPKNSSFEV YCDMETMGGG 250
WTVLQARLDG STNFTRTWQD YKAGFGNLRR EFWLGNDKIH LLTKSKEMIL 300
RIDLEDFNGV ELYALYDQFY VANEFLKYRL HVGNYNGTAG DALRFNKHYN 350
HDLKFFTTPD KDNDRYPSGN CGLYYSSGWW FDACLSANLN GKYYHQKYRG 400
VRNGIFWGTW PGVSEAHPGG YKSSFKEAKM MIRPKHFKP 439
Length:439
Mass (Da):50,229
Last modified:November 1, 1996 - v1
Checksum:iDF34656288E49E68
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531G → E.1 Publication
Corresponds to variant rs2075761 [ dbSNP | Ensembl ].
VAR_013066

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36531 mRNA. Translation: CAA85298.1.
AF104015, AF104014 Genomic DNA. Translation: AAD10825.1.
AF468959 Genomic DNA. Translation: AAL68855.1.
BC033820 mRNA. Translation: AAH33820.1.
BC073986 mRNA. Translation: AAH73986.1.
CCDSiCCDS5591.1.
PIRiI37391.
RefSeqiNP_006673.1. NM_006682.2.
UniGeneiHs.520989.

Genome annotation databases

EnsembliENST00000248598; ENSP00000248598; ENSG00000127951.
GeneIDi10875.
KEGGihsa:10875.
UCSCiuc003ugb.3. human.

Polymorphism databases

DMDMi12230074.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z36531 mRNA. Translation: CAA85298.1 .
AF104015 , AF104014 Genomic DNA. Translation: AAD10825.1 .
AF468959 Genomic DNA. Translation: AAL68855.1 .
BC033820 mRNA. Translation: AAH33820.1 .
BC073986 mRNA. Translation: AAH73986.1 .
CCDSi CCDS5591.1.
PIRi I37391.
RefSeqi NP_006673.1. NM_006682.2.
UniGenei Hs.520989.

3D structure databases

ProteinModelPortali Q14314.
SMRi Q14314. Positions 22-434.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000248598.

Protein family/group databases

MEROPSi S67.001.

Polymorphism databases

DMDMi 12230074.

2D gel databases

REPRODUCTION-2DPAGE Q14314.

Proteomic databases

PaxDbi Q14314.
PRIDEi Q14314.

Protocols and materials databases

DNASUi 10875.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000248598 ; ENSP00000248598 ; ENSG00000127951 .
GeneIDi 10875.
KEGGi hsa:10875.
UCSCi uc003ugb.3. human.

Organism-specific databases

CTDi 10875.
GeneCardsi GC07M076822.
HGNCi HGNC:3696. FGL2.
HPAi HPA021011.
HPA026682.
MIMi 605351. gene.
neXtProti NX_Q14314.
PharmGKBi PA28134.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG297117.
HOGENOMi HOG000252953.
HOVERGENi HBG105002.
InParanoidi Q14314.
OMAi YVANEFL.
OrthoDBi EOG7X9G60.
PhylomeDBi Q14314.
TreeFami TF336658.

Miscellaneous databases

GeneWikii FGL2.
GenomeRNAii 10875.
NextBioi 41295.
PROi Q14314.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q14314.
Bgeei Q14314.
CleanExi HS_FGL2.
Genevestigatori Q14314.

Family and domain databases

Gene3Di 3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProi IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR020837. Fibrinogen_CS.
[Graphical view ]
Pfami PF00147. Fibrinogen_C. 1 hit.
[Graphical view ]
SMARTi SM00186. FBG. 1 hit.
[Graphical view ]
SUPFAMi SSF56496. SSF56496. 1 hit.
PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein."
    Ruegg C., Pytela R.
    Gene 160:257-262(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Small intestine.
  2. "Cloning and characterization of Hfgl2: the human counterpart to the mouse gene Fgl2."
    Yuwaraj S., Liu M., Marsden P., Levy G.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. SeattleSNPs variation discovery resource
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLU-53.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Blood and Pancreas.
  5. "Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes."
    Marazzi S., Blum S., Hartmann R., Gundersen D., Schreyer M., Argraves S., von Fliedner V., Pytela R., Ruegg C.
    J. Immunol. 161:138-147(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-179 AND ASN-336.
    Tissue: Plasma.
  7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-179 AND ASN-336.
    Tissue: Liver.

Entry informationi

Entry nameiFGL2_HUMAN
AccessioniPrimary (citable) accession number: Q14314
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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