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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Paraburkholderia xenovorans (strain LB400)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi390 – 397ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:Bxeno_A1155
ORF Names:Bxe_A3290
OrganismiParaburkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeParaburkholderia
Proteomesi
  • UP000001817 Componenti: Chromosome 1

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei76 – 96HelicalUniRule annotationAdd BLAST21
Transmembranei138 – 158HelicalUniRule annotationAdd BLAST21
Transmembranei164 – 184HelicalUniRule annotationAdd BLAST21
Transmembranei263 – 283HelicalUniRule annotationAdd BLAST21
Transmembranei292 – 312HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716201 – 597Lipid A export ATP-binding/permease protein MsbAAdd BLAST597

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi266265.Bxe_A3290.

Structurei

3D structure databases

ProteinModelPortaliQ142P6.
SMRiQ142P6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 321ABC transmembrane type-1UniRule annotationAdd BLAST285
Domaini353 – 590ABC transporterUniRule annotationAdd BLAST238

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiFNQFFVG.
OrthoDBiPOG091H00DB.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q142P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKPTLSKP IGSGEASSPA VVFRRLWPYI KPLIWVLIGA IVAMAVSAAT
60 70 80 90 100
DAAIPALLKP LLDKGFGAHA NDRAKWFVPA AVIGLALIRS LSQYASGYLL
110 120 130 140 150
AYVTNKILLD LRLKMFDRMI HTSVAFFQRE TASTVINAIV FEVNQILNVL
160 170 180 190 200
LSVLVTLVRD SLTVVFLLGY LFYLNWRLTL IVAVLLPAIG WLVGKINRRL
210 220 230 240 250
RRLNREHQLL TNELSYIVEE SVGGYKVVKV HNGEQYEMDR FESMSKRLRG
260 270 280 290 300
YAMRMTVSGG LAQPLTQFLA SIALAVVITI AVVQSSSDQT TVGGFVAFVT
310 320 330 340 350
SMLLIISPLK HLMDVNQPLQ RGMTACEMIF GLIDEPSEPE GGGKPLERAH
360 370 380 390 400
GAVEFRDVSF VYSGNATHNR HTLDQISFRV APGEMIALAG PSGSGKTTLV
410 420 430 440 450
NLLPRFFDPT GGQILVDGVA IPEYDLHALR SQIAMVSQDV VLFNDTVANN
460 470 480 490 500
VAYGQTADAG KVKAALRAAN LWDTVEAMPK GIETLVGDNG MMLSGGQRQR
510 520 530 540 550
LAIARAIYKD APILILDEAT SALDSESERH VQAALETLMK GRTTLVIAHR
560 570 580 590
LSTIERADRI LVMEAGRIVE SGSHRELLAQ DGLYAHLHRI QFQQSAA
Length:597
Mass (Da):65,220
Last modified:August 22, 2006 - v1
Checksum:iE76FBE4A673640A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000270 Genomic DNA. Translation: ABE29693.1.
RefSeqiWP_011487426.1. NZ_CP008760.1.

Genome annotation databases

EnsemblBacteriaiABE29693; ABE29693; Bxe_A3290.
GeneIDi4002092.
KEGGibxb:DR64_991.
bxe:Bxe_A3290.
PATRICifig|266265.5.peg.1188.

Similar proteinsi

Entry informationi

Entry nameiMSBA_PARXL
AccessioniPrimary (citable) accession number: Q142P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: August 22, 2006
Last modified: June 7, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families