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Protein
Submitted name:

Estrogen receptor-related protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi182 – 257Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • estrogen receptor activity Source: InterPro
  • sequence-specific DNA binding Source: InterPro
  • steroid binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorImported
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Estrogen receptor-related proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ14267.
PeptideAtlasiQ14267.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000206249.

Structurei

3D structure databases

ProteinModelPortaliQ14267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini182 – 257Nuclear receptor DNA-bindingInterPro annotationAdd BLAST76
Domaini271 – 336RFX-type winged-helix DNA-bindingInterPro annotationAdd BLAST66

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.SAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOVERGENiHBG108344.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR003150. DNA-bd_RFX.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001292. Oestr_rcpt.
IPR011991. WHTH_DNA-bd_dom.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF02159. Oest_recep. 1 hit.
PF02257. RFX_DNA_binding. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR00543. OESTROGENR.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
PS51526. RFX_DBD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKIPLERPLG EVYLDSSKPA
60 70 80 90 100
VYNYPEGAAY EFNAAAAANA QVYGQTGLPY GPGSEAAAFG SNGLGGFPPL
110 120 130 140 150
NSVSPSPLML LHPPPQLSPF LQPHGQQVPY YLENEPSGYT VREAGPPAFY
160 170 180 190 200
RPNSDNRRQG GRERLASTND KGSMAMESAK ETRYCAVCND YASGYHYGVW
210 220 230 240 250
SCEGCKAFFK RSIQGHNDYM CPATNQCTID KNRRKSCQAC RLRKCYEVGM
260 270 280 290 300
MKGDEEKENN RASKPHSTPA TLQWLEENYE IAEGVCIPRS ALYMHYLDFC
310 320 330
EKNDTQPVNA ASFGKIIRQQ FPQLTTRRLG TRGQSK
Length:336
Mass (Da):37,309
Last modified:November 1, 1996 - v1
Checksum:i812D2E6D35589604
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69296 mRNA. Translation: AAA58461.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69296 mRNA. Translation: AAA58461.1.

3D structure databases

ProteinModelPortaliQ14267.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000206249.

Proteomic databases

PaxDbiQ14267.
PeptideAtlasiQ14267.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOVERGENiHBG108344.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiView protein in InterPro
IPR003150. DNA-bd_RFX.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001292. Oestr_rcpt.
IPR011991. WHTH_DNA-bd_dom.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
PfamiView protein in Pfam
PF02159. Oest_recep. 1 hit.
PF02257. RFX_DNA_binding. 1 hit.
PF00105. zf-C4. 1 hit.
PRINTSiPR00543. OESTROGENR.
PR00047. STROIDFINGER.
SMARTiView protein in SMART
SM00399. ZnF_C4. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
PS51526. RFX_DBD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ14267_HUMAN
AccessioniPrimary (citable) accession number: Q14267
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: February 15, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.