Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Reticulocalbin-2

Gene

RCN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Not known. Binds calcium.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi74 – 851PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi110 – 1212PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi162 – 1733; possibly ancestralPROSITE-ProRule annotationAdd BLAST12
Calcium bindingi199 – 2104PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi240 – 2515PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi276 – 2876PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117906-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-2
Alternative name(s):
Calcium-binding protein ERC-55
E6-binding protein
Short name:
E6BP
Gene namesi
Name:RCN2
Synonyms:ERC55
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:9935. RCN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi5955.
OpenTargetsiENSG00000117906.
PharmGKBiPA34304.

Polymorphism and mutation databases

BioMutaiRCN2.
DMDMi2493460.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000000414823 – 317Reticulocalbin-2Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei137PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14257.
MaxQBiQ14257.
PaxDbiQ14257.
PeptideAtlasiQ14257.
PRIDEiQ14257.

PTM databases

iPTMnetiQ14257.
PhosphoSitePlusiQ14257.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000117906.
CleanExiHS_RCN2.
ExpressionAtlasiQ14257. baseline and differential.
GenevisibleiQ14257. HS.

Organism-specific databases

HPAiHPA030694.
HPA030695.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
E6P031262EBI-356710,EBI-1177242From a different organism.
GABARAPL1Q9H0R83EBI-356710,EBI-746969
GABARAPL2P605203EBI-356710,EBI-720116

Protein-protein interaction databases

BioGridi111888. 50 interactors.
IntActiQ14257. 50 interactors.
MINTiMINT-1146851.
STRINGi9606.ENSP00000378349.

Structurei

3D structure databases

ProteinModelPortaliQ14257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 96EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini97 – 132EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini150 – 185EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini186 – 221EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini227 – 262EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini263 – 298EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi314 – 317Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the CREC family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ14257.
OMAiRKEFAIC.
OrthoDBiEOG091G0GUL.
PhylomeDBiQ14257.
TreeFamiTF314849.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 2 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14257-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLGPRTAAL GLLLLCAAAA GAGKAEELHY PLGERRSDYD REALLGVQED
60 70 80 90 100
VDEYVKLGHE EQQKRLQAII KKIDLDSDGF LTESELSSWI QMSFKHYAMQ
110 120 130 140 150
EAKQQFVEYD KNSDDTVTWD EYNIQMYDRV IDFDENTALD DAEEESFRKL
160 170 180 190 200
HLKDKKRFEK ANQDSGPGLS LEEFIAFEHP EEVDYMTEFV IQEALEEHDK
210 220 230 240 250
NGDGFVSLEE FLGDYRWDPT ANEDPEWILV EKDRFVNDYD KDNDGRLDPQ
260 270 280 290 300
ELLPWVVPNN QGIAQEEALH LIDEMDLNGD KKLSEEEILE NPDLFLTSEA
310
TDYGRQLHDD YFYHDEL
Length:317
Mass (Da):36,876
Last modified:November 1, 1997 - v1
Checksum:iE7C0A4211DBF04AB
GO
Isoform 2 (identifier: Q14257-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-149: K → KEFAICKKQSFCFWLLRFN

Note: Gene prediction based on EST data.
Show »
Length:335
Mass (Da):39,139
Checksum:i78B9EE873599B45C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055139149K → KEFAICKKQSFCFWLLRFN in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78669 mRNA. Translation: CAA55343.1.
BT009790 mRNA. Translation: AAP88792.1.
AK313833 mRNA. Translation: BAG36566.1.
AC051643 Genomic DNA. No translation available.
BC004892 mRNA. Translation: AAH04892.1.
CCDSiCCDS10291.1. [Q14257-1]
CCDS61719.1. [Q14257-2]
PIRiI37371.
RefSeqiNP_001258766.1. NM_001271837.1. [Q14257-2]
NP_002893.1. NM_002902.2. [Q14257-1]
UniGeneiHs.79088.

Genome annotation databases

EnsembliENST00000320963; ENSP00000319739; ENSG00000117906. [Q14257-2]
ENST00000394885; ENSP00000378349; ENSG00000117906. [Q14257-1]
GeneIDi5955.
KEGGihsa:5955.
UCSCiuc002bcd.4. human. [Q14257-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78669 mRNA. Translation: CAA55343.1.
BT009790 mRNA. Translation: AAP88792.1.
AK313833 mRNA. Translation: BAG36566.1.
AC051643 Genomic DNA. No translation available.
BC004892 mRNA. Translation: AAH04892.1.
CCDSiCCDS10291.1. [Q14257-1]
CCDS61719.1. [Q14257-2]
PIRiI37371.
RefSeqiNP_001258766.1. NM_001271837.1. [Q14257-2]
NP_002893.1. NM_002902.2. [Q14257-1]
UniGeneiHs.79088.

3D structure databases

ProteinModelPortaliQ14257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111888. 50 interactors.
IntActiQ14257. 50 interactors.
MINTiMINT-1146851.
STRINGi9606.ENSP00000378349.

PTM databases

iPTMnetiQ14257.
PhosphoSitePlusiQ14257.

Polymorphism and mutation databases

BioMutaiRCN2.
DMDMi2493460.

Proteomic databases

EPDiQ14257.
MaxQBiQ14257.
PaxDbiQ14257.
PeptideAtlasiQ14257.
PRIDEiQ14257.

Protocols and materials databases

DNASUi5955.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320963; ENSP00000319739; ENSG00000117906. [Q14257-2]
ENST00000394885; ENSP00000378349; ENSG00000117906. [Q14257-1]
GeneIDi5955.
KEGGihsa:5955.
UCSCiuc002bcd.4. human. [Q14257-1]

Organism-specific databases

CTDi5955.
DisGeNETi5955.
GeneCardsiRCN2.
HGNCiHGNC:9935. RCN2.
HPAiHPA030694.
HPA030695.
MIMi602584. gene.
neXtProtiNX_Q14257.
OpenTargetsiENSG00000117906.
PharmGKBiPA34304.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ14257.
OMAiRKEFAIC.
OrthoDBiEOG091G0GUL.
PhylomeDBiQ14257.
TreeFamiTF314849.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000117906-MONOMER.

Miscellaneous databases

ChiTaRSiRCN2. human.
GeneWikiiRCN2.
GenomeRNAii5955.
PROiQ14257.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000117906.
CleanExiHS_RCN2.
ExpressionAtlasiQ14257. baseline and differential.
GenevisibleiQ14257. HS.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 2 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRCN2_HUMAN
AccessioniPrimary (citable) accession number: Q14257
Secondary accession number(s): A8MTG6, F8WCY5, Q53XN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.