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Q14257

- RCN2_HUMAN

UniProt

Q14257 - RCN2_HUMAN

Protein

Reticulocalbin-2

Gene

RCN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Not known. Binds calcium.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi74 – 85121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi110 – 121122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi162 – 173123; possibly ancestralPROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi199 – 210124PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi240 – 251125PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi276 – 287126PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: ProtInc
    2. protein binding Source: IntAct

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Reticulocalbin-2
    Alternative name(s):
    Calcium-binding protein ERC-55
    E6-binding protein
    Short name:
    E6BP
    Gene namesi
    Name:RCN2
    Synonyms:ERC55
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:9935. RCN2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: HPA
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    3. nucleolus Source: HPA

    Keywords - Cellular componenti

    Endoplasmic reticulum

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34304.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 317295Reticulocalbin-2PRO_0000004148Add
    BLAST

    Proteomic databases

    MaxQBiQ14257.
    PaxDbiQ14257.
    PRIDEiQ14257.

    PTM databases

    PhosphoSiteiQ14257.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ14257.
    BgeeiQ14257.
    CleanExiHS_RCN2.
    GenevestigatoriQ14257.

    Organism-specific databases

    HPAiHPA030694.
    HPA030695.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    E6P031262EBI-356710,EBI-1177242From a different organism.
    GABARAPL2P605203EBI-356710,EBI-720116

    Protein-protein interaction databases

    BioGridi111888. 31 interactions.
    IntActiQ14257. 28 interactions.
    MINTiMINT-1146851.
    STRINGi9606.ENSP00000378349.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14257.
    SMRiQ14257. Positions 55-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 9636EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini97 – 13236EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini150 – 18536EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini186 – 22136EF-hand 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini227 – 26236EF-hand 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini263 – 29836EF-hand 6PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi314 – 3174Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the CREC family.Curated
    Contains 6 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG124414.
    HOGENOMiHOG000230934.
    HOVERGENiHBG002834.
    OrthoDBiEOG73Z2TD.
    PhylomeDBiQ14257.
    TreeFamiTF314849.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13202. EF-hand_5. 1 hit.
    PF13499. EF-hand_7. 2 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 5 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 5 hits.
    PS50222. EF_HAND_2. 5 hits.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14257-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLGPRTAAL GLLLLCAAAA GAGKAEELHY PLGERRSDYD REALLGVQED    50
    VDEYVKLGHE EQQKRLQAII KKIDLDSDGF LTESELSSWI QMSFKHYAMQ 100
    EAKQQFVEYD KNSDDTVTWD EYNIQMYDRV IDFDENTALD DAEEESFRKL 150
    HLKDKKRFEK ANQDSGPGLS LEEFIAFEHP EEVDYMTEFV IQEALEEHDK 200
    NGDGFVSLEE FLGDYRWDPT ANEDPEWILV EKDRFVNDYD KDNDGRLDPQ 250
    ELLPWVVPNN QGIAQEEALH LIDEMDLNGD KKLSEEEILE NPDLFLTSEA 300
    TDYGRQLHDD YFYHDEL 317
    Length:317
    Mass (Da):36,876
    Last modified:November 1, 1997 - v1
    Checksum:iE7C0A4211DBF04AB
    GO
    Isoform 2 (identifier: Q14257-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         149-149: K → KEFAICKKQSFCFWLLRFN

    Note: Gene prediction based on EST data.

    Show »
    Length:335
    Mass (Da):39,139
    Checksum:i78B9EE873599B45C
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei149 – 1491K → KEFAICKKQSFCFWLLRFN in isoform 2. CuratedVSP_055139

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78669 mRNA. Translation: CAA55343.1.
    BT009790 mRNA. Translation: AAP88792.1.
    AK313833 mRNA. Translation: BAG36566.1.
    AC051643 Genomic DNA. No translation available.
    BC004892 mRNA. Translation: AAH04892.1.
    CCDSiCCDS10291.1. [Q14257-1]
    CCDS61719.1. [Q14257-2]
    PIRiI37371.
    RefSeqiNP_001258766.1. NM_001271837.1.
    NP_002893.1. NM_002902.2.
    UniGeneiHs.79088.

    Genome annotation databases

    EnsembliENST00000320963; ENSP00000319739; ENSG00000117906. [Q14257-2]
    ENST00000394885; ENSP00000378349; ENSG00000117906. [Q14257-1]
    GeneIDi5955.
    KEGGihsa:5955.
    UCSCiuc002bcd.3. human. [Q14257-1]

    Polymorphism databases

    DMDMi2493460.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78669 mRNA. Translation: CAA55343.1 .
    BT009790 mRNA. Translation: AAP88792.1 .
    AK313833 mRNA. Translation: BAG36566.1 .
    AC051643 Genomic DNA. No translation available.
    BC004892 mRNA. Translation: AAH04892.1 .
    CCDSi CCDS10291.1. [Q14257-1 ]
    CCDS61719.1. [Q14257-2 ]
    PIRi I37371.
    RefSeqi NP_001258766.1. NM_001271837.1.
    NP_002893.1. NM_002902.2.
    UniGenei Hs.79088.

    3D structure databases

    ProteinModelPortali Q14257.
    SMRi Q14257. Positions 55-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111888. 31 interactions.
    IntActi Q14257. 28 interactions.
    MINTi MINT-1146851.
    STRINGi 9606.ENSP00000378349.

    PTM databases

    PhosphoSitei Q14257.

    Polymorphism databases

    DMDMi 2493460.

    Proteomic databases

    MaxQBi Q14257.
    PaxDbi Q14257.
    PRIDEi Q14257.

    Protocols and materials databases

    DNASUi 5955.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320963 ; ENSP00000319739 ; ENSG00000117906 . [Q14257-2 ]
    ENST00000394885 ; ENSP00000378349 ; ENSG00000117906 . [Q14257-1 ]
    GeneIDi 5955.
    KEGGi hsa:5955.
    UCSCi uc002bcd.3. human. [Q14257-1 ]

    Organism-specific databases

    CTDi 5955.
    GeneCardsi GC15P077223.
    HGNCi HGNC:9935. RCN2.
    HPAi HPA030694.
    HPA030695.
    MIMi 602584. gene.
    neXtProti NX_Q14257.
    PharmGKBi PA34304.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG124414.
    HOGENOMi HOG000230934.
    HOVERGENi HBG002834.
    OrthoDBi EOG73Z2TD.
    PhylomeDBi Q14257.
    TreeFami TF314849.

    Miscellaneous databases

    GeneWikii RCN2.
    GenomeRNAii 5955.
    NextBioi 23192.
    PROi Q14257.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14257.
    Bgeei Q14257.
    CleanExi HS_RCN2.
    Genevestigatori Q14257.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13202. EF-hand_5. 1 hit.
    PF13499. EF-hand_7. 2 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 5 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 5 hits.
    PS50222. EF_HAND_2. 5 hits.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif."
      Weis K., Griffiths G., Lamond A.I.
      J. Biol. Chem. 269:19142-19150(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    6. Bienvenut W.V., Vousden K.H., Lukashchuk N.
      Submitted (MAR-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 42-56; 130-149 AND 283-305, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Lung carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRCN2_HUMAN
    AccessioniPrimary (citable) accession number: Q14257
    Secondary accession number(s): A8MTG6, F8WCY5, Q53XN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3