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Q14257

- RCN2_HUMAN

UniProt

Q14257 - RCN2_HUMAN

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Protein

Reticulocalbin-2

Gene

RCN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Not known. Binds calcium.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi74 – 85121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi110 – 121122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi162 – 173123; possibly ancestralPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi199 – 210124PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi240 – 251125PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi276 – 287126PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-2
Alternative name(s):
Calcium-binding protein ERC-55
E6-binding protein
Short name:
E6BP
Gene namesi
Name:RCN2
Synonyms:ERC55
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:9935. RCN2.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: HPA
  2. nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34304.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222By similarityAdd
BLAST
Chaini23 – 317295Reticulocalbin-2PRO_0000004148Add
BLAST

Proteomic databases

MaxQBiQ14257.
PaxDbiQ14257.
PRIDEiQ14257.

PTM databases

PhosphoSiteiQ14257.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ14257.
CleanExiHS_RCN2.
ExpressionAtlasiQ14257. baseline and differential.
GenevestigatoriQ14257.

Organism-specific databases

HPAiHPA030694.
HPA030695.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
E6P031262EBI-356710,EBI-1177242From a different organism.
GABARAPL2P605203EBI-356710,EBI-720116

Protein-protein interaction databases

BioGridi111888. 38 interactions.
IntActiQ14257. 28 interactions.
MINTiMINT-1146851.
STRINGi9606.ENSP00000378349.

Structurei

3D structure databases

ProteinModelPortaliQ14257.
SMRiQ14257. Positions 52-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 9636EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini97 – 13236EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini150 – 18536EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini186 – 22136EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini227 – 26236EF-hand 5PROSITE-ProRule annotationAdd
BLAST
Domaini263 – 29836EF-hand 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi314 – 3174Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the CREC family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG124414.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ14257.
OrthoDBiEOG73Z2TD.
PhylomeDBiQ14257.
TreeFamiTF314849.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14257-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLGPRTAAL GLLLLCAAAA GAGKAEELHY PLGERRSDYD REALLGVQED
60 70 80 90 100
VDEYVKLGHE EQQKRLQAII KKIDLDSDGF LTESELSSWI QMSFKHYAMQ
110 120 130 140 150
EAKQQFVEYD KNSDDTVTWD EYNIQMYDRV IDFDENTALD DAEEESFRKL
160 170 180 190 200
HLKDKKRFEK ANQDSGPGLS LEEFIAFEHP EEVDYMTEFV IQEALEEHDK
210 220 230 240 250
NGDGFVSLEE FLGDYRWDPT ANEDPEWILV EKDRFVNDYD KDNDGRLDPQ
260 270 280 290 300
ELLPWVVPNN QGIAQEEALH LIDEMDLNGD KKLSEEEILE NPDLFLTSEA
310
TDYGRQLHDD YFYHDEL
Length:317
Mass (Da):36,876
Last modified:November 1, 1997 - v1
Checksum:iE7C0A4211DBF04AB
GO
Isoform 2 (identifier: Q14257-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-149: K → KEFAICKKQSFCFWLLRFN

Note: Gene prediction based on EST data.

Show »
Length:335
Mass (Da):39,139
Checksum:i78B9EE873599B45C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei149 – 1491K → KEFAICKKQSFCFWLLRFN in isoform 2. CuratedVSP_055139

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78669 mRNA. Translation: CAA55343.1.
BT009790 mRNA. Translation: AAP88792.1.
AK313833 mRNA. Translation: BAG36566.1.
AC051643 Genomic DNA. No translation available.
BC004892 mRNA. Translation: AAH04892.1.
CCDSiCCDS10291.1. [Q14257-1]
CCDS61719.1. [Q14257-2]
PIRiI37371.
RefSeqiNP_001258766.1. NM_001271837.1. [Q14257-2]
NP_002893.1. NM_002902.2. [Q14257-1]
UniGeneiHs.79088.

Genome annotation databases

EnsembliENST00000320963; ENSP00000319739; ENSG00000117906. [Q14257-2]
ENST00000394885; ENSP00000378349; ENSG00000117906. [Q14257-1]
GeneIDi5955.
KEGGihsa:5955.
UCSCiuc002bcd.3. human. [Q14257-1]

Polymorphism databases

DMDMi2493460.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78669 mRNA. Translation: CAA55343.1 .
BT009790 mRNA. Translation: AAP88792.1 .
AK313833 mRNA. Translation: BAG36566.1 .
AC051643 Genomic DNA. No translation available.
BC004892 mRNA. Translation: AAH04892.1 .
CCDSi CCDS10291.1. [Q14257-1 ]
CCDS61719.1. [Q14257-2 ]
PIRi I37371.
RefSeqi NP_001258766.1. NM_001271837.1. [Q14257-2 ]
NP_002893.1. NM_002902.2. [Q14257-1 ]
UniGenei Hs.79088.

3D structure databases

ProteinModelPortali Q14257.
SMRi Q14257. Positions 52-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111888. 38 interactions.
IntActi Q14257. 28 interactions.
MINTi MINT-1146851.
STRINGi 9606.ENSP00000378349.

PTM databases

PhosphoSitei Q14257.

Polymorphism databases

DMDMi 2493460.

Proteomic databases

MaxQBi Q14257.
PaxDbi Q14257.
PRIDEi Q14257.

Protocols and materials databases

DNASUi 5955.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320963 ; ENSP00000319739 ; ENSG00000117906 . [Q14257-2 ]
ENST00000394885 ; ENSP00000378349 ; ENSG00000117906 . [Q14257-1 ]
GeneIDi 5955.
KEGGi hsa:5955.
UCSCi uc002bcd.3. human. [Q14257-1 ]

Organism-specific databases

CTDi 5955.
GeneCardsi GC15P077223.
HGNCi HGNC:9935. RCN2.
HPAi HPA030694.
HPA030695.
MIMi 602584. gene.
neXtProti NX_Q14257.
PharmGKBi PA34304.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG124414.
GeneTreei ENSGT00550000074546.
HOGENOMi HOG000230934.
HOVERGENi HBG002834.
InParanoidi Q14257.
OrthoDBi EOG73Z2TD.
PhylomeDBi Q14257.
TreeFami TF314849.

Miscellaneous databases

ChiTaRSi RCN2. human.
GeneWikii RCN2.
GenomeRNAii 5955.
NextBioi 23192.
PROi Q14257.
SOURCEi Search...

Gene expression databases

Bgeei Q14257.
CleanExi HS_RCN2.
ExpressionAtlasi Q14257. baseline and differential.
Genevestigatori Q14257.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view ]
SMARTi SM00054. EFh. 5 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The endoplasmic reticulum calcium-binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif."
    Weis K., Griffiths G., Lamond A.I.
    J. Biol. Chem. 269:19142-19150(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  6. Bienvenut W.V., Vousden K.H., Lukashchuk N.
    Submitted (MAR-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 42-56; 130-149 AND 283-305, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Lung carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRCN2_HUMAN
AccessioniPrimary (citable) accession number: Q14257
Secondary accession number(s): A8MTG6, F8WCY5, Q53XN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3