Reviewed,
UniProtKB/Swiss-Prot Q14254 (FLOT2_HUMAN)
Last modified
February 9, 2010.
Version 84.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Flotillin-2 Alternative name(s): Epidermal surface antigen Short name=ESA Membrane component chromosome 17 surface marker 1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 428 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function. |
| Subunit structure | Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2 By similarity. |
| Subcellular location | Cell membrane; Peripheral membrane protein. Membrane › caveola; Peripheral membrane protein. Note: Membrane-associated protein of caveolae. |
| Tissue specificity | In skin, expressed in epidermis and epidermal appendages but not in dermis. Expressed in all layers of the epidermis except the basal layer. In hair follicles, expressed in the suprabasal layer but not the basal layer. Also expressed in melanoma and carcinoma cell lines, fibroblasts and foreskin melanocytes. |
| Sequence similarities | Belongs to the band 7/mec-2 family. Flotillin subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell adhesion |
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Polymorphism |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell adhesion Ref.2 Non-traceable author statement. Source: ProtInc epidermis development Ref.2Traceable author statement. Source: ProtInc |
| Cellular component | cell surface Inferred from direct assay. Source: UniProtKB extrinsic to membraneInferred from electronic annotation. Source: UniProtKB-SubCell membrane fractionInferred from direct assay. Source: UniProtKB plasma membraneNon-traceable author statement. Source: ProtInc |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CAV1 | Q03135 | 1 | EBI-348613,EBI-603614 | |
| DOM3Z | O77932 | 1 | EBI-348613,EBI-372173 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 428 | 428 | Flotillin-2 | PRO_0000094049 | |||||
Amino acid modifications | |||||||||
| Modified residue | 241 | 1 | Phosphotyrosine Ref.6 | ||||||
Natural variations | |||||||||
| Natural variant | 328 | 1 | A → T: dbSNP rs3736238. | VAR_024375 | |||||
Experimental info | |||||||||
| Sequence conflict | 8 | 1 | G → R in AAA65729. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. Nusbaum C.Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "Cloning and characterization of a novel epidermal cell surface antigen (ESA)." Schroeder W.T., Stewart-Galetka S., Mandavilli S., Parry D.A., Goldsmith L., Duvic M. J. Biol. Chem. 269:19983-19991(1994) [PubMed: 8051082] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-428. Tissue: Keratinocyte. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 20-428. Tissue: Pancreas. |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 50-428. |
| [5] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [6] | "An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells." Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A., Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D., Wiley H.S., Qian W.-J. J. Proteome Res. 8:3852-3861(2009) [PubMed: 19534553] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-241, MASS SPECTROMETRY. Tissue: Mammary epithelium. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AC024267 Genomic DNA. No translation available. M60922 mRNA. Translation: AAA65729.1. Different initiation. BC017292 mRNA. Translation: AAH17292.2. BT019478 mRNA. Translation: AAV38285.1. Different initiation. |
| IPI | IPI00789008. |
| PIR | A53664. |
| RefSeq | NP_004466.2. |
| UniGene | Hs.514038 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q14254. 4 interactions. |
| STRING | Q14254. |
PTM databases | |
| PhosphoSite | Q14254. |
Proteomic databases | |
| PRIDE | Q14254. |
Genome annotation databases | |
| Ensembl | ENST00000394908; ENSP00000378368; ENSG00000132589; Homo sapiens. [Genome view] |
| GeneID | 2319. |
| KEGG | hsa:2319. |
Organism-specific databases | |
| CTD | 2319. |
| GeneCards | GC17M024230. |
| H-InvDB | HIX0013665. |
| HGNC | HGNC:3758. FLOT2. |
| HPA | CAB004395. HPA001396. |
| MIM | 131560. gene. |
| PharmGKB | PA28176. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG18558. |
| HOGENOM | HBG729052. |
| HOVERGEN | Q14254. |
| InParanoid | Q14254. |
| OrthoDB | EOG92FW35. |
| PhylomeDB | Q14254. |
Gene expression databases | |
| ArrayExpress | Q14254. |
| Bgee | Q14254. |
| CleanEx | HS_FLOT2. |
| Genevestigator | Q14254. |
| GermOnline | ENSG00000132589. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001107. Band_7. [Graphical view] |
| Pfam | PF01145. Band_7. 1 hit. [Graphical view] |
| SMART | SM00244. PHB. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | FLOT2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q14254 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 17 Human chromosome 17: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


