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Protein

Endonuclease G, mitochondrial

Gene

ENDOG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity).By similarity

Cofactori

Mn2+By similarity, Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei141Proton acceptorPROSITE-ProRule annotation1
Metal bindingi172Magnesium or manganese; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167136-MONOMER.
SIGNORiQ14249.

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease G, mitochondrial (EC:3.1.30.-)
Short name:
Endo G
Gene namesi
Name:ENDOG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:3346. ENDOG.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi2021.
OpenTargetsiENSG00000167136.
PharmGKBiPA27783.

Polymorphism and mutation databases

BioMutaiENDOG.
DMDMi317373579.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 48MitochondrionBy similarityAdd BLAST48
ChainiPRO_000001991849 – 297Endonuclease G, mitochondrialAdd BLAST249

Proteomic databases

EPDiQ14249.
MaxQBiQ14249.
PaxDbiQ14249.
PeptideAtlasiQ14249.
PRIDEiQ14249.

PTM databases

iPTMnetiQ14249.
PhosphoSitePlusiQ14249.

Miscellaneous databases

PMAP-CutDBQ5T281.

Expressioni

Gene expression databases

BgeeiENSG00000167136.
CleanExiHS_ENDOG.
ExpressionAtlasiQ14249. baseline and differential.
GenevisibleiQ14249. HS.

Organism-specific databases

HPAiHPA021335.
HPA021830.

Interactioni

Subunit structurei

Homodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
DNAJA4Q8WW222EBI-9369928,EBI-2555157

Protein-protein interaction databases

BioGridi108336. 23 interactors.
IntActiQ14249. 2 interactors.
STRINGi9606.ENSP00000361725.

Structurei

3D structure databases

ProteinModelPortaliQ14249.
SMRiQ14249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3721. Eukaryota.
COG1864. LUCA.
GeneTreeiENSGT00530000063772.
HOGENOMiHOG000214172.
HOVERGENiHBG002851.
InParanoidiQ14249.
KOiK01173.
OMAiVRYQVIG.
OrthoDBiEOG091G0BHG.
PhylomeDBiQ14249.
TreeFamiTF105386.

Family and domain databases

Gene3Di3.40.570.10. 1 hit.
InterProiIPR018524. DNA/RNA_endonuclease_AS.
IPR001604. DNA/RNA_non-sp_Endonuclease.
IPR020821. Extracellular_endonuc_su_A.
[Graphical view]
PfamiPF01223. Endonuclease_NS. 1 hit.
[Graphical view]
SMARTiSM00892. Endonuclease_NS. 1 hit.
SM00477. NUC. 1 hit.
[Graphical view]
PROSITEiPS01070. NUCLEASE_NON_SPEC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALRAGLTL ASGAGLGAVV EGWRRRREDA RAAPGLLGRL PVLPVAAAAE
60 70 80 90 100
LPPVPGGPRG PGELAKYGLP GLAQLKSRES YVLCYDPRTR GALWVVEQLR
110 120 130 140 150
PERLRGDGDR RECDFREDDS VHAYHRATNA DYRGSGFDRG HLAAAANHRW
160 170 180 190 200
SQKAMDDTFY LSNVAPQVPH LNQNAWNNLE KYSRSLTRSY QNVYVCTGPL
210 220 230 240 250
FLPRTEADGK SYVKYQVIGK NHVAVPTHFF KVLILEAAGG QIELRTYVMP
260 270 280 290
NAPVDEAIPL ERFLVPIESI ERASGLLFVP NILARAGSLK AITAGSK
Length:297
Mass (Da):32,620
Last modified:January 11, 2011 - v4
Checksum:i33015E8A619781B7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34P → L in CAA55963 (Ref. 1) Curated1
Sequence conflicti163N → K in CAA55963 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03169112S → L.1 PublicationCorresponds to variant rs2293969dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79444 mRNA. Translation: CAA55963.1.
AL441992 Genomic DNA. Translation: CAI15412.1.
BC004922 mRNA. Translation: AAH04922.1.
BC016351 mRNA. Translation: AAH16351.1.
CCDSiCCDS6912.1.
PIRiT09542.
RefSeqiNP_004426.2. NM_004435.2.
UniGeneiHs.745161.

Genome annotation databases

EnsembliENST00000372642; ENSP00000361725; ENSG00000167136.
GeneIDi2021.
KEGGihsa:2021.
UCSCiuc004bwc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79444 mRNA. Translation: CAA55963.1.
AL441992 Genomic DNA. Translation: CAI15412.1.
BC004922 mRNA. Translation: AAH04922.1.
BC016351 mRNA. Translation: AAH16351.1.
CCDSiCCDS6912.1.
PIRiT09542.
RefSeqiNP_004426.2. NM_004435.2.
UniGeneiHs.745161.

3D structure databases

ProteinModelPortaliQ14249.
SMRiQ14249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108336. 23 interactors.
IntActiQ14249. 2 interactors.
STRINGi9606.ENSP00000361725.

PTM databases

iPTMnetiQ14249.
PhosphoSitePlusiQ14249.

Polymorphism and mutation databases

BioMutaiENDOG.
DMDMi317373579.

Proteomic databases

EPDiQ14249.
MaxQBiQ14249.
PaxDbiQ14249.
PeptideAtlasiQ14249.
PRIDEiQ14249.

Protocols and materials databases

DNASUi2021.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372642; ENSP00000361725; ENSG00000167136.
GeneIDi2021.
KEGGihsa:2021.
UCSCiuc004bwc.4. human.

Organism-specific databases

CTDi2021.
DisGeNETi2021.
GeneCardsiENDOG.
H-InvDBHIX0008437.
HIX0008438.
HGNCiHGNC:3346. ENDOG.
HPAiHPA021335.
HPA021830.
MIMi600440. gene.
neXtProtiNX_Q14249.
OpenTargetsiENSG00000167136.
PharmGKBiPA27783.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3721. Eukaryota.
COG1864. LUCA.
GeneTreeiENSGT00530000063772.
HOGENOMiHOG000214172.
HOVERGENiHBG002851.
InParanoidiQ14249.
KOiK01173.
OMAiVRYQVIG.
OrthoDBiEOG091G0BHG.
PhylomeDBiQ14249.
TreeFamiTF105386.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167136-MONOMER.
SIGNORiQ14249.

Miscellaneous databases

GeneWikiiENDOG.
GenomeRNAii2021.
PMAP-CutDBQ5T281.
PROiQ14249.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167136.
CleanExiHS_ENDOG.
ExpressionAtlasiQ14249. baseline and differential.
GenevisibleiQ14249. HS.

Family and domain databases

Gene3Di3.40.570.10. 1 hit.
InterProiIPR018524. DNA/RNA_endonuclease_AS.
IPR001604. DNA/RNA_non-sp_Endonuclease.
IPR020821. Extracellular_endonuc_su_A.
[Graphical view]
PfamiPF01223. Endonuclease_NS. 1 hit.
[Graphical view]
SMARTiSM00892. Endonuclease_NS. 1 hit.
SM00477. NUC. 1 hit.
[Graphical view]
PROSITEiPS01070. NUCLEASE_NON_SPEC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUCG_HUMAN
AccessioniPrimary (citable) accession number: Q14249
Secondary accession number(s): Q5T281, Q9BSP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 140 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.