Q14246 (EMR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
EGF-like module-containing mucin-like hormone receptor-like 1

Alternative name(s):
EGF-like module receptor 1
EMR1 hormone receptor

Gene names

Name:	EMR1
Synonyms:	TM7LN3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	886 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Could be involved in cell-cell interactions.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Wide expression; increased levels in peripheral blood mononuclear cells.
Sequence similarities	Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 6 EGF-like domains. Contains 1 GPS domain.
Sequence caution	The sequence BAC06133.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Repeat Signal Transmembrane Transmembrane helix
Ligand	Calcium
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Traceable author statement Ref.1. Source: ProtInc neuropeptide signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	external side of plasma membrane Inferred from electronic annotation. Source: Compara integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Molecular_function	G-protein coupled receptor activity Traceable author statement Ref.1. Source: ProtInc calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Note: Comment=Additional isoforms seem to exist.

Isoform 1 (identifier: Q14246-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14246-2)

The sequence of this isoform differs from the canonical sequence as follows:
     599-663: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q14246-3)

The sequence of this isoform differs from the canonical sequence as follows:
     80-131: Missing.
     764-764: I → VSKYYNSLAKCVLKEEQGDLRDLEFPGTCAAERI

Note: No experimental confirmation available.

Isoform 4 (identifier: Q14246-4)

The sequence of this isoform differs from the canonical sequence as follows:
     140-316: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q14246-5)

The sequence of this isoform differs from the canonical sequence as follows:
     80-131: Missing.
     132-220: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 886	866	EGF-like module-containing mucin-like hormone receptor-like 1		PRO_0000012873
Regions
	Topological domain	21 – 599	579	Extracellular Potential
	Transmembrane	600 – 627	28	Helical; Name=1; Potential
	Topological domain	628 – 634	7	Cytoplasmic Potential
	Transmembrane	635 – 656	22	Helical; Name=2; Potential
	Topological domain	657 – 666	10	Extracellular Potential
	Transmembrane	667 – 690	24	Helical; Name=3; Potential
	Topological domain	691 – 709	19	Cytoplasmic Potential
	Transmembrane	710 – 731	22	Helical; Name=4; Potential
	Topological domain	732 – 747	16	Extracellular Potential
	Transmembrane	748 – 776	29	Helical; Name=5; Potential
	Topological domain	777 – 794	18	Cytoplasmic Potential
	Transmembrane	795 – 814	20	Helical; Name=6; Potential
	Topological domain	815 – 829	15	Extracellular Potential
	Transmembrane	830 – 852	23	Helical; Name=7; Potential
	Topological domain	853 – 886	34	Cytoplasmic Potential
	Domain	31 – 79	49	EGF-like 1
	Domain	80 – 131	52	EGF-like 2; calcium-binding Potential
	Domain	132 – 171	40	EGF-like 3; calcium-binding Potential
	Domain	172 – 220	49	EGF-like 4; calcium-binding Potential
	Domain	221 – 267	47	EGF-like 5; calcium-binding Potential
	Domain	268 – 316	49	EGF-like 6; calcium-binding Potential
	Domain	547 – 596	50	GPS
	Compositional bias	317 – 599	283	Ser/Thr-rich
Amino acid modifications
	Glycosylation	94	1	N-linked (GlcNAc...) Potential
	Glycosylation	99	1	N-linked (GlcNAc...) Potential
	Glycosylation	127	1	N-linked (GlcNAc...) Potential
	Glycosylation	167	1	N-linked (GlcNAc...) Potential
	Glycosylation	189	1	N-linked (GlcNAc...) Potential
	Glycosylation	194	1	N-linked (GlcNAc...) Potential
	Glycosylation	232	1	N-linked (GlcNAc...) Potential
	Glycosylation	258	1	N-linked (GlcNAc...) Potential
	Glycosylation	312	1	N-linked (GlcNAc...) Potential
	Glycosylation	366	1	N-linked (GlcNAc...) Potential
	Glycosylation	375	1	N-linked (GlcNAc...) Potential
	Glycosylation	448	1	N-linked (GlcNAc...) Potential
	Disulfide bond	35 ↔ 47		By similarity
	Disulfide bond	41 ↔ 56		By similarity
	Disulfide bond	58 ↔ 78		By similarity
	Disulfide bond	84 ↔ 97		By similarity
	Disulfide bond	91 ↔ 106		By similarity
	Disulfide bond	108 ↔ 130		By similarity
	Disulfide bond	136 ↔ 148		By similarity
	Disulfide bond	142 ↔ 157		By similarity
	Disulfide bond	159 ↔ 170		By similarity
	Disulfide bond	176 ↔ 188		By similarity
	Disulfide bond	182 ↔ 197		By similarity
	Disulfide bond	199 ↔ 219		By similarity
	Disulfide bond	225 ↔ 235		By similarity
	Disulfide bond	229 ↔ 244		By similarity
	Disulfide bond	246 ↔ 266		By similarity
	Disulfide bond	272 ↔ 285		By similarity
	Disulfide bond	279 ↔ 294		By similarity
	Disulfide bond	296 ↔ 315		By similarity
Natural variations
	Alternative sequence	80 – 131	52	Missing in isoform 3 and isoform 5.		VSP_045521
	Alternative sequence	132 – 220	89	Missing in isoform 5.		VSP_045522
	Alternative sequence	140 – 316	177	Missing in isoform 4.		VSP_045523
	Alternative sequence	599 – 663	65	Missing in isoform 2.		VSP_009594
	Alternative sequence	764	1	I → VSKYYNSLAKCVLKEEQGDL RDLEFPGTCAAERI in isoform 3.		VSP_045524
	Natural variant	2	1	R → L. Corresponds to variant rs34176643 [ dbSNP | Ensembl ].		VAR_046976
	Natural variant	57	1	A → T. Ref.1 Ref.4 Corresponds to variant rs330877 [ dbSNP | Ensembl ].		VAR_027616
	Natural variant	140	1	S → R. Ref.1 Corresponds to variant rs330880 [ dbSNP | Ensembl ].		VAR_027617
	Natural variant	174	1	D → N. Ref.1 Corresponds to variant rs897738 [ dbSNP | Ensembl ].		VAR_027618
	Natural variant	254	1	N → S. Ref.1 Corresponds to variant rs443658 [ dbSNP | Ensembl ].		VAR_027619
	Natural variant	298	1	A → V. Ref.1 Corresponds to variant rs370094 [ dbSNP | Ensembl ].		VAR_027620
	Natural variant	389	1	T → M. Ref.1 Corresponds to variant rs466876 [ dbSNP | Ensembl ].		VAR_027621
	Natural variant	424	1	I → V. Ref.1 Ref.2 Ref.4 Corresponds to variant rs457857 [ dbSNP | Ensembl ].		VAR_027622
	Natural variant	496	1	K → Q. Ref.1 Ref.2 Ref.4 Corresponds to variant rs373533 [ dbSNP | Ensembl ].		VAR_027623
	Natural variant	539	1	I → V. Ref.1 Ref.2 Ref.4 Corresponds to variant rs461645 [ dbSNP | Ensembl ].		VAR_027624
	Natural variant	589	1	V → I. Ref.4 Ref.6 Corresponds to variant rs7256147 [ dbSNP | Ensembl ].		VAR_027625
	Natural variant	663	1	M → T. Ref.1 Corresponds to variant rs2228539 [ dbSNP | Ensembl ].		VAR_046977
	Natural variant	691	1	F → C. Corresponds to variant rs2229769 [ dbSNP | Ensembl ].		VAR_027626
	Natural variant	724	1	V → L. Corresponds to variant rs10406580 [ dbSNP | Ensembl ].		VAR_027627
Experimental info
	Sequence conflict	61	1	G → R in BAH12472. Ref.4
	Sequence conflict	212	1	F → C in CAA57232. Ref.1
	Sequence conflict	424	1	I → A in BAH12475. Ref.4
	Sequence conflict	430	1	T → A in CAA57232. Ref.1
	Sequence conflict	545	1	F → L in BAH12475. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 2, 2010. Version 3. Checksum: 07322996EEF5A6F1	FASTA	886	97,683
	10 20 30 40 50 60 MRGFNLLLFW GCCVMHSWEG HIRPTRKPNT KGNNCRDSTL CPAYATCTNT VDSYYCACKQ 70 80 90 100 110 120 GFLSSNGQNH FKDPGVRCKD IDECSQSPQP CGPNSSCKNL SGRYKCSCLD GFSSPTGNDW 130 140 150 160 170 180 VPGKPGNFSC TDINECLTSS VCPEHSDCVN SMGSYSCSCQ VGFISRNSTC EDVDECADPR 190 200 210 220 230 240 ACPEHATCNN TVGNYSCFCN PGFESSSGHL SFQGLKASCE DIDECTEMCP INSTCTNTPG 250 260 270 280 290 300 SYFCTCHPGF APSNGQLNFT DQGVECRDID ECRQDPSTCG PNSICTNALG SYSCGCIAGF 310 320 330 340 350 360 HPNPEGSQKD GNFSCQRVLF KCKEDVIPDN KQIQQCQEGT AVKPAYVSFC AQINNIFSVL 370 380 390 400 410 420 DKVCENKTTV VSLKNTTESF VPVLKQISTW TKFTKEETSS LATVFLESVE SMTLASFWKP 430 440 450 460 470 480 SANITPAVRT EYLDIESKVI NKECSEENVT LDLVAKGDKM KIGCSTIEES ESTETTGVAF 490 500 510 520 530 540 VSFVGMESVL NERFFKDHQA PLTTSEIKLK MNSRVVGGIM TGEKKDGFSD PIIYTLENIQ 550 560 570 580 590 600 PKQKFERPIC VSWSTDVKGG RWTSFGCVIL EASETYTICS CNQMANLAVI MASGELTMDF 610 620 630 640 650 660 SLYIISHVGI IISLVCLVLA IATFLLCRSI RNHNTYLHLH LCVCLLLAKT LFLAGIHKTD 670 680 690 700 710 720 NKMGCAIIAG FLHYLFLACF FWMLVEAVIL FLMVRNLKVV NYFSSRNIKM LHICAFGYGL 730 740 750 760 770 780 PMLVVVISAS VQPQGYGMHN RCWLNTETGF IWSFLGPVCT VIVINSLLLT WTLWILRQRL 790 800 810 820 830 840 SSVNAEVSTL KDTRLLTFKA FAQLFILGCS WVLGIFQIGP VAGVMAYLFT IINSLQGAFI 850 860 870 880 FLIHCLLNGQ VREEYKRWIT GKTKPSSQSQ TSRILLSSMP SASKTG
	Isoform 2 [UniParc]. Checksum: 3F57FE01A3F8AC7F	FASTA	821	90,379
	10 20 30 40 50 60 MRGFNLLLFW GCCVMHSWEG HIRPTRKPNT KGNNCRDSTL CPAYATCTNT VDSYYCACKQ 70 80 90 100 110 120 GFLSSNGQNH FKDPGVRCKD IDECSQSPQP CGPNSSCKNL SGRYKCSCLD GFSSPTGNDW 130 140 150 160 170 180 VPGKPGNFSC TDINECLTSS VCPEHSDCVN SMGSYSCSCQ VGFISRNSTC EDVDECADPR 190 200 210 220 230 240 ACPEHATCNN TVGNYSCFCN PGFESSSGHL SFQGLKASCE DIDECTEMCP INSTCTNTPG 250 260 270 280 290 300 SYFCTCHPGF APSNGQLNFT DQGVECRDID ECRQDPSTCG PNSICTNALG SYSCGCIAGF 310 320 330 340 350 360 HPNPEGSQKD GNFSCQRVLF KCKEDVIPDN KQIQQCQEGT AVKPAYVSFC AQINNIFSVL 370 380 390 400 410 420 DKVCENKTTV VSLKNTTESF VPVLKQISTW TKFTKEETSS LATVFLESVE SMTLASFWKP 430 440 450 460 470 480 SANITPAVRT EYLDIESKVI NKECSEENVT LDLVAKGDKM KIGCSTIEES ESTETTGVAF 490 500 510 520 530 540 VSFVGMESVL NERFFKDHQA PLTTSEIKLK MNSRVVGGIM TGEKKDGFSD PIIYTLENIQ 550 560 570 580 590 600 PKQKFERPIC VSWSTDVKGG RWTSFGCVIL EASETYTICS CNQMANLAVI MASGELTMGC 610 620 630 640 650 660 AIIAGFLHYL FLACFFWMLV EAVILFLMVR NLKVVNYFSS RNIKMLHICA FGYGLPMLVV 670 680 690 700 710 720 VISASVQPQG YGMHNRCWLN TETGFIWSFL GPVCTVIVIN SLLLTWTLWI LRQRLSSVNA 730 740 750 760 770 780 EVSTLKDTRL LTFKAFAQLF ILGCSWVLGI FQIGPVAGVM AYLFTIINSL QGAFIFLIHC 790 800 810 820 LLNGQVREEY KRWITGKTKP SSQSQTSRIL LSSMPSASKT G
	Isoform 3 [UniParc]. Checksum: DEC584294CD20916	FASTA	867	95,944
	10 20 30 40 50 60 MRGFNLLLFW GCCVMHSWEG HIRPTRKPNT KGNNCRDSTL CPAYATCTNT VDSYYCACKQ 70 80 90 100 110 120 GFLSSNGQNH FKDPGVRCKD INECLTSSVC PEHSDCVNSM GSYSCSCQVG FISRNSTCED 130 140 150 160 170 180 VDECADPRAC PEHATCNNTV GNYSCFCNPG FESSSGHLSF QGLKASCEDI DECTEMCPIN 190 200 210 220 230 240 STCTNTPGSY FCTCHPGFAP SNGQLNFTDQ GVECRDIDEC RQDPSTCGPN SICTNALGSY 250 260 270 280 290 300 SCGCIAGFHP NPEGSQKDGN FSCQRVLFKC KEDVIPDNKQ IQQCQEGTAV KPAYVSFCAQ 310 320 330 340 350 360 INNIFSVLDK VCENKTTVVS LKNTTESFVP VLKQISTWTK FTKEETSSLA TVFLESVESM 370 380 390 400 410 420 TLASFWKPSA NITPAVRTEY LDIESKVINK ECSEENVTLD LVAKGDKMKI GCSTIEESES 430 440 450 460 470 480 TETTGVAFVS FVGMESVLNE RFFKDHQAPL TTSEIKLKMN SRVVGGIMTG EKKDGFSDPI 490 500 510 520 530 540 IYTLENIQPK QKFERPICVS WSTDVKGGRW TSFGCVILEA SETYTICSCN QMANLAVIMA 550 560 570 580 590 600 SGELTMDFSL YIISHVGIII SLVCLVLAIA TFLLCRSIRN HNTYLHLHLC VCLLLAKTLF 610 620 630 640 650 660 LAGIHKTDNK MGCAIIAGFL HYLFLACFFW MLVEAVILFL MVRNLKVVNY FSSRNIKMLH 670 680 690 700 710 720 ICAFGYGLPM LVVVISASVQ PQGYGMHNRC WLNTETGFIW SFLGPVCTVI VVSKYYNSLA 730 740 750 760 770 780 KCVLKEEQGD LRDLEFPGTC AAERINSLLL TWTLWILRQR LSSVNAEVST LKDTRLLTFK 790 800 810 820 830 840 AFAQLFILGC SWVLGIFQIG PVAGVMAYLF TIINSLQGAF IFLIHCLLNG QVREEYKRWI 850 860 TGKTKPSSQS QTSRILLSSM PSASKTG
	Isoform 4 [UniParc]. Checksum: 8A817BC4B479F950	FASTA	709	78,907
	10 20 30 40 50 60 MRGFNLLLFW GCCVMHSWEG HIRPTRKPNT KGNNCRDSTL CPAYATCTNT VDSYYCACKQ 70 80 90 100 110 120 GFLSSNGQNH FKDPGVRCKD IDECSQSPQP CGPNSSCKNL SGRYKCSCLD GFSSPTGNDW 130 140 150 160 170 180 VPGKPGNFSC TDINECLTSR VLFKCKEDVI PDNKQIQQCQ EGTAVKPAYV SFCAQINNIF 190 200 210 220 230 240 SVLDKVCENK TTVVSLKNTT ESFVPVLKQI STWTKFTKEE TSSLATVFLE SVESMTLASF 250 260 270 280 290 300 WKPSANITPA VRTEYLDIES KVINKECSEE NVTLDLVAKG DKMKIGCSTI EESESTETTG 310 320 330 340 350 360 VAFVSFVGME SVLNERFFKD HQAPLTTSEI KLKMNSRVVG GIMTGEKKDG FSDPIIYTLE 370 380 390 400 410 420 NIQPKQKFER PICVSWSTDV KGGRWTSFGC VILEASETYT ICSCNQMANL AVIMASGELT 430 440 450 460 470 480 MDFSLYIISH VGIIISLVCL VLAIATFLLC RSIRNHNTYL HLHLCVCLLL AKTLFLAGIH 490 500 510 520 530 540 KTDNKMGCAI IAGFLHYLFL ACFFWMLVEA VILFLMVRNL KVVNYFSSRN IKMLHICAFG 550 560 570 580 590 600 YGLPMLVVVI SASVQPQGYG MHNRCWLNTE TGFIWSFLGP VCTVIVINSL LLTWTLWILR 610 620 630 640 650 660 QRLSSVNAEV STLKDTRLLT FKAFAQLFIL GCSWVLGIFQ IGPVAGVMAY LFTIINSLQG 670 680 690 700 AFIFLIHCLL NGQVREEYKR WITGKTKPSS QSQTSRILLS SMPSASKTG
	Isoform 5 [UniParc]. Checksum: 23007B9E3859C5C7	FASTA	745	82,771
	10 20 30 40 50 60 MRGFNLLLFW GCCVMHSWEG HIRPTRKPNT KGNNCRDSTL CPAYATCTNT VDSYYCACKQ 70 80 90 100 110 120 GFLSSNGQNH FKDPGVRCKD IDECTEMCPI NSTCTNTPGS YFCTCHPGFA PSNGQLNFTD 130 140 150 160 170 180 QGVECRDIDE CRQDPSTCGP NSICTNALGS YSCGCIAGFH PNPEGSQKDG NFSCQRVLFK 190 200 210 220 230 240 CKEDVIPDNK QIQQCQEGTA VKPAYVSFCA QINNIFSVLD KVCENKTTVV SLKNTTESFV 250 260 270 280 290 300 PVLKQISTWT KFTKEETSSL ATVFLESVES MTLASFWKPS ANITPAVRTE YLDIESKVIN 310 320 330 340 350 360 KECSEENVTL DLVAKGDKMK IGCSTIEESE STETTGVAFV SFVGMESVLN ERFFKDHQAP 370 380 390 400 410 420 LTTSEIKLKM NSRVVGGIMT GEKKDGFSDP IIYTLENIQP KQKFERPICV SWSTDVKGGR 430 440 450 460 470 480 WTSFGCVILE ASETYTICSC NQMANLAVIM ASGELTMDFS LYIISHVGII ISLVCLVLAI 490 500 510 520 530 540 ATFLLCRSIR NHNTYLHLHL CVCLLLAKTL FLAGIHKTDN KMGCAIIAGF LHYLFLACFF 550 560 570 580 590 600 WMLVEAVILF LMVRNLKVVN YFSSRNIKML HICAFGYGLP MLVVVISASV QPQGYGMHNR 610 620 630 640 650 660 CWLNTETGFI WSFLGPVCTV IVINSLLLTW TLWILRQRLS SVNAEVSTLK DTRLLTFKAF 670 680 690 700 710 720 AQLFILGCSW VLGIFQIGPV AGVMAYLFTI INSLQGAFIF LIHCLLNGQV REEYKRWITG 730 740 KTKPSSQSQT SRILLSSMPS ASKTG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments." Baud V., Chissoe S.L., Viegas-Pequignot E., Diriong S., N'Guyen V.C., Roe B.A., Lipinski M. Genomics 26:334-344(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS THR-57; ARG-140; ASN-174; SER-254; VAL-298; MET-389; VAL-424; GLN-496; VAL-539 AND THR-663.
[2]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-424; GLN-496 AND VAL-539.
[3]	"Genetic variation in EMR1 gene." Tan J., Davila S., Hibberd M.L., Seielstad M. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5), VARIANTS THR-57; VAL-424; GLN-496; VAL-539 AND ILE-589. Tissue: Thymus and Umbilical cord blood.
[5]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ILE-589. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X81479 mRNA. Translation: CAA57232.1. AB065918 Genomic DNA. Translation: BAC06133.1. Sequence problems. DQ217942 Genomic DNA. Translation: ABB70739.1. AK131562 mRNA. Translation: BAD18695.1. AK297003 mRNA. Translation: BAH12472.1. AK297011 mRNA. Translation: BAH12475.1. AC020895 Genomic DNA. No translation available. AC025278 Genomic DNA. No translation available. BC059395 mRNA. Translation: AAH59395.1.
IPI	IPI00409744. IPI00441994. IPI00922168. IPI00940086. IPI01018981.
PIR	A57172.
RefSeq	NP_001243181.1. NM_001256252.1. NP_001243182.1. NM_001256253.1. NP_001243183.1. NM_001256254.1. NP_001243184.1. NM_001256255.1. NP_001965.3. NM_001974.4.
UniGene	Hs.2375.
3D structure databases
ProteinModelPortal	Q14246.
SMR	Q14246. Positions 38-367.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14246. 1 interaction.
STRING	9606.ENSP00000311545.
Protein family/group databases
MEROPS	S63.004.
GPCRDB	Search...
PTM databases
PhosphoSite	Q14246.
Polymorphism databases
DMDM	290457673.
Proteomic databases
PaxDb	Q14246.
PRIDE	Q14246.
Protocols and materials databases
DNASU	2015.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000250572; ENSP00000250572; ENSG00000174837. ENST00000312053; ENSP00000311545; ENSG00000174837. ENST00000381404; ENSP00000370811; ENSG00000174837. ENST00000381407; ENSP00000370814; ENSG00000174837. ENST00000450315; ENSP00000405974; ENSG00000174837.
GeneID	2015.
KEGG	hsa:2015.
UCSC	uc002mfw.3. human. uc010dvc.3. human.
Organism-specific databases
CTD	2015.
GeneCards	GC19P006838.
H-InvDB	HIX0021954. HIX0174373.
HGNC	HGNC:3336. EMR1.
HPA	HPA052809.
MIM	600493. gene.
neXtProt	NX_Q14246.
PharmGKB	PA27773.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG239437.
HOGENOM	HOG000294115.
HOVERGEN	HBG048917.
InParanoid	Q14246.
KO	K04591.
OMA	QVGFISR.
PhylomeDB	Q14246.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q14246.
Bgee	Q14246.
CleanEx	HS_EMR1.
Genevestigator	Q14246.
GermOnline	ENSG00000174837. Homo sapiens.
Family and domain databases
InterPro	IPR026823. cEGF. IPR000742. EG-like_dom. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR018097. EGF_Ca-bd_CS. IPR017981. GPCR_2-like. IPR001740. GPCR_2_EMR1_rcpt. IPR000832. GPCR_2_secretin-like. IPR017983. GPCR_2_secretin-like_CS. IPR000203. GPS_dom. [Graphical view]
Pfam	PF00002. 7tm_2. 1 hit. PF12662. cEGF. 1 hit. PF07645. EGF_CA. 4 hits. PF01825. GPS. 1 hit. [Graphical view]
PRINTS	PR01128. EMR1HORMONER. PR00249. GPCRSECRETIN.
SMART	SM00181. EGF. 1 hit. SM00179. EGF_CA. 5 hits. SM00303. GPS. 1 hit. [Graphical view]
PROSITE	PS00010. ASX_HYDROXYL. 6 hits. PS00022. EGF_1. False negative. PS01186. EGF_2. 1 hit. PS50026. EGF_3. 6 hits. PS01187. EGF_CA. 5 hits. PS00650. G_PROTEIN_RECEP_F2_2. 1 hit. PS50261. G_PROTEIN_RECEP_F2_4. 1 hit. PS50221. GPS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	2015.
NextBio	8163.
SOURCE	Search...

Entry information

Entry name

EMR1_HUMAN

Accession

Primary (citable) accession number: Q14246
Secondary accession number(s): A6NHV2 , B7Z486, B7Z489, E7EPX9, E9PD45, H9KV79, Q2I7G5, Q6ZMN0, Q8NGA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	March 2, 2010
Last modified:	May 1, 2013
This is version 139 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.