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Protein

Transcription elongation factor B polypeptide 3

Gene

TCEB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000011007-MONOMER.
ReactomeiR-HSA-112382. Formation of RNA Pol II elongation complex.
R-HSA-112387. Elongation arrest and recovery.
R-HSA-167152. Formation of HIV elongation complex in the absence of HIV Tat.
R-HSA-167200. Formation of HIV-1 elongation complex containing HIV-1 Tat.
R-HSA-167238. Pausing and recovery of Tat-mediated HIV elongation.
R-HSA-167243. Tat-mediated HIV elongation arrest and recovery.
R-HSA-167246. Tat-mediated elongation of the HIV-1 transcript.
R-HSA-167287. HIV elongation arrest and recovery.
R-HSA-167290. Pausing and recovery of HIV elongation.
R-HSA-674695. RNA Polymerase II Pre-transcription Events.
R-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-HSA-75955. RNA Polymerase II Transcription Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor B polypeptide 3
Alternative name(s):
Elongin 110 kDa subunit
Elongin-A
Short name:
EloA
RNA polymerase II transcription factor SIII subunit A1
SIII p110
Gene namesi
Name:TCEB3
ORF Names:MSTP059
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11620. TCEB3.

Subcellular locationi

GO - Cellular componenti

  • elongin complex Source: GO_Central
  • extracellular space Source: UniProtKB
  • integral component of membrane Source: InterPro
  • nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6924.
OpenTargetsiENSG00000011007.
PharmGKBiPA36379.

Polymorphism and mutation databases

BioMutaiTCEB3.
DMDMi294862430.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869601 – 798Transcription elongation factor B polypeptide 3Add BLAST798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei222PhosphoserineBy similarity1
Modified residuei410PhosphoserineCombined sources1
Modified residuei413PhosphoserineCombined sources1
Modified residuei420PhosphothreonineCombined sources1
Modified residuei460N6-acetyllysineBy similarity1
Modified residuei542PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14241.
MaxQBiQ14241.
PaxDbiQ14241.
PeptideAtlasiQ14241.
PRIDEiQ14241.

PTM databases

iPTMnetiQ14241.
PhosphoSitePlusiQ14241.

Expressioni

Gene expression databases

BgeeiENSG00000011007.
ExpressionAtlasiQ14241. baseline and differential.
GenevisibleiQ14241. HS.

Organism-specific databases

HPAiHPA005910.

Interactioni

Subunit structurei

Heterotrimer of an A (A1, A2 or A3), B and C subunit. The C subunit mediates the binding of the elongin BC complex to subunit A (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP57L1Q8IYX8-23EBI-742350,EBI-10181988
CEP70Q8NHQ13EBI-742350,EBI-739624
FAM9BQ8IZU03EBI-742350,EBI-10175124
FLJ13057Q53SE73EBI-742350,EBI-10172181
HOMEZQ8IX15-33EBI-742350,EBI-10172004
JAKMIP2Q96AA83EBI-742350,EBI-752007
KRT40Q6A1623EBI-742350,EBI-10171697
MDFIQ997505EBI-742350,EBI-724076
MID2Q9UJV3-23EBI-742350,EBI-10172526
PLK4O004445EBI-742350,EBI-746202
SPERTQ8NA613EBI-742350,EBI-741724
TRIM54Q9BYV23EBI-742350,EBI-2130429

Protein-protein interaction databases

BioGridi112786. 52 interactors.
IntActiQ14241. 43 interactors.
MINTiMINT-1462212.
STRINGi9606.ENSP00000395574.

Structurei

Secondary structure

1798
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi607 – 609Combined sources3
Helixi612 – 619Combined sources8
Helixi623 – 625Combined sources3
Helixi630 – 636Combined sources7
Beta strandi648 – 650Combined sources3
Helixi652 – 671Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HFXX-ray2.54A/B/C/D597-682[»]
ProteinModelPortaliQ14241.
SMRiQ14241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 105TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST76
Domaini592 – 636F-boxPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni548 – 707Activation domainBy similarityAdd BLAST160
Regioni576 – 585Interacting with Elongin BC complex10

Domaini

The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 1 TFIIS N-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2821. Eukaryota.
ENOG4110PG3. LUCA.
GeneTreeiENSGT00390000002428.
HOGENOMiHOG000059565.
HOVERGENiHBG051467.
InParanoidiQ14241.
KOiK15076.
OMAiPHKVSHS.
OrthoDBiEOG091G0D2G.
PhylomeDBiQ14241.
TreeFamiTF317259.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR010684. RNA_pol_II_trans_fac_SIII_A.
IPR003617. TFIIS/CRSP70_N_sub.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF06881. Elongin_A. 1 hit.
PF08711. Med26. 1 hit.
[Graphical view]
SMARTiSM00509. TFS2N. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS51319. TFIIS_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGGRSCGPR TRREPSSGEE AAPVTAMAAE SALQVVEKLQ ARLAANPDPK
60 70 80 90 100
KLLKYLKKLS TLPITVDILA ETGVGKTVNS LRKHEHVGSF ARDLVAQWKK
110 120 130 140 150
LVPVERNAEP DEQDFEKSNS RKRPRDALQK EEEMEGDYQE TWKATGSRSY
160 170 180 190 200
SPDHRQKKHR KLSELERPHK VSHGHERRDE RKRCHRMSPT YSSDPESSDY
210 220 230 240 250
GHVQSPPSCT SPHQMYVDHY RSLEEDQEPI VSHQKPGKGH SNAFQDRLGA
260 270 280 290 300
SQERHLGEPH GKGVVSQNKE HKSSHKDKRP VDAKSDEKAS VVSREKSHKA
310 320 330 340 350
LSKEENRRPP SGDNAREKPP SSGVKKEKDR EGSSLKKKCL PPSEAASDNH
360 370 380 390 400
LKKPKHRDPE KAKLDKSKQG LDSFDTGKGA GDLLPKVKEK GSNNLKTPEG
410 420 430 440 450
KVKTNLDRKS LGSLPKVEET DMEDEFEQPT MSFESYLSYD QPRKKKKKIV
460 470 480 490 500
KTSATALGDK GLKKNDSKST GKNLDSVQKL PKVNKTKSEK PAGADLAKLR
510 520 530 540 550
KVPDVLPVLP DLPLPAIQAN YRPLPSLELI SSFQPKRKAF SSPQEEEEAG
560 570 580 590 600
FTGRRMNSKM QVYSGSKCAY LPKMMTLHQQ CIRVLKNNID SIFEVGGVPY
610 620 630 640 650
SVLEPVLERC TPDQLYRIEE YNHVLIEETD QLWKVHCHRD FKEERPEEYE
660 670 680 690 700
SWREMYLRLQ DAREQRLRVL TKNIQFAHAN KPKGRQAKMA FVNSVAKPPR
710 720 730 740 750
DVRRRQEKFG TGGAAVPEKI KIKPAPYPMG SSHASASSIS FNPSPEEPAY
760 770 780 790
DGPSTSSAHL APVVSSTVSY DPRKPTVKKI APMMAKTIKA FKNRFSRR
Length:798
Mass (Da):89,909
Last modified:April 20, 2010 - v2
Checksum:i2C8FD8710E27EE46
GO

Sequence cautioni

The sequence AAA75492 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH02883 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAO15305 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG35905 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB40157 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW95070 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020104145T → M.Corresponds to variant rs2235541dbSNPEnsembl.1
Natural variantiVAR_033850324V → I.Corresponds to variant rs520713dbSNPEnsembl.1
Natural variantiVAR_033851516A → V.Corresponds to variant rs550252dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313079 mRNA. Translation: BAG35905.1. Different initiation.
DA333869 mRNA. No translation available.
AL031295 Genomic DNA. Translation: CAB40157.1. Different initiation.
CH471134 Genomic DNA. Translation: EAW95070.1. Different initiation.
L47345 mRNA. Translation: AAA75492.1. Different initiation.
BC002883 mRNA. Translation: AAH02883.1. Different initiation.
AF116729 mRNA. Translation: AAO15305.1. Different initiation.
CCDSiCCDS239.2.
PIRiJC4636.
RefSeqiNP_003189.2. NM_003198.2.
UniGeneiHs.15535.

Genome annotation databases

EnsembliENST00000418390; ENSP00000395574; ENSG00000011007.
ENST00000613537; ENSP00000484196; ENSG00000011007.
GeneIDi6924.
KEGGihsa:6924.
UCSCiuc001bho.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313079 mRNA. Translation: BAG35905.1. Different initiation.
DA333869 mRNA. No translation available.
AL031295 Genomic DNA. Translation: CAB40157.1. Different initiation.
CH471134 Genomic DNA. Translation: EAW95070.1. Different initiation.
L47345 mRNA. Translation: AAA75492.1. Different initiation.
BC002883 mRNA. Translation: AAH02883.1. Different initiation.
AF116729 mRNA. Translation: AAO15305.1. Different initiation.
CCDSiCCDS239.2.
PIRiJC4636.
RefSeqiNP_003189.2. NM_003198.2.
UniGeneiHs.15535.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HFXX-ray2.54A/B/C/D597-682[»]
ProteinModelPortaliQ14241.
SMRiQ14241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112786. 52 interactors.
IntActiQ14241. 43 interactors.
MINTiMINT-1462212.
STRINGi9606.ENSP00000395574.

PTM databases

iPTMnetiQ14241.
PhosphoSitePlusiQ14241.

Polymorphism and mutation databases

BioMutaiTCEB3.
DMDMi294862430.

Proteomic databases

EPDiQ14241.
MaxQBiQ14241.
PaxDbiQ14241.
PeptideAtlasiQ14241.
PRIDEiQ14241.

Protocols and materials databases

DNASUi6924.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000418390; ENSP00000395574; ENSG00000011007.
ENST00000613537; ENSP00000484196; ENSG00000011007.
GeneIDi6924.
KEGGihsa:6924.
UCSCiuc001bho.4. human.

Organism-specific databases

CTDi6924.
DisGeNETi6924.
GeneCardsiTCEB3.
H-InvDBHIX0000251.
HGNCiHGNC:11620. TCEB3.
HPAiHPA005910.
MIMi600786. gene.
neXtProtiNX_Q14241.
OpenTargetsiENSG00000011007.
PharmGKBiPA36379.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2821. Eukaryota.
ENOG4110PG3. LUCA.
GeneTreeiENSGT00390000002428.
HOGENOMiHOG000059565.
HOVERGENiHBG051467.
InParanoidiQ14241.
KOiK15076.
OMAiPHKVSHS.
OrthoDBiEOG091G0D2G.
PhylomeDBiQ14241.
TreeFamiTF317259.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000011007-MONOMER.
ReactomeiR-HSA-112382. Formation of RNA Pol II elongation complex.
R-HSA-112387. Elongation arrest and recovery.
R-HSA-167152. Formation of HIV elongation complex in the absence of HIV Tat.
R-HSA-167200. Formation of HIV-1 elongation complex containing HIV-1 Tat.
R-HSA-167238. Pausing and recovery of Tat-mediated HIV elongation.
R-HSA-167243. Tat-mediated HIV elongation arrest and recovery.
R-HSA-167246. Tat-mediated elongation of the HIV-1 transcript.
R-HSA-167287. HIV elongation arrest and recovery.
R-HSA-167290. Pausing and recovery of HIV elongation.
R-HSA-674695. RNA Polymerase II Pre-transcription Events.
R-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-HSA-75955. RNA Polymerase II Transcription Elongation.

Miscellaneous databases

GeneWikiiTCEB3.
GenomeRNAii6924.
PROiQ14241.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000011007.
ExpressionAtlasiQ14241. baseline and differential.
GenevisibleiQ14241. HS.

Family and domain databases

Gene3Di1.20.930.10. 1 hit.
InterProiIPR001810. F-box_dom.
IPR010684. RNA_pol_II_trans_fac_SIII_A.
IPR003617. TFIIS/CRSP70_N_sub.
IPR017923. TFIIS_N.
[Graphical view]
PfamiPF06881. Elongin_A. 1 hit.
PF08711. Med26. 1 hit.
[Graphical view]
SMARTiSM00509. TFS2N. 1 hit.
[Graphical view]
SUPFAMiSSF47676. SSF47676. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS51319. TFIIS_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELOA1_HUMAN
AccessioniPrimary (citable) accession number: Q14241
Secondary accession number(s): B2R7Q8, Q8IXH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: April 20, 2010
Last modified: November 30, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-27 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.