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Protein

Interleukin-27 subunit beta

Gene

EBI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.1 Publication

GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • cytokine receptor activity Source: UniProtKB
  • interleukin-27 receptor binding Source: Ensembl

GO - Biological processi

  • humoral immune response Source: ProtInc
  • interleukin-27-mediated signaling pathway Source: Reactome
  • interleukin-35-mediated signaling pathway Source: Reactome
  • positive regulation of alpha-beta T cell proliferation Source: UniProtKB
  • positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
  • T cell proliferation Source: Ensembl
  • T-helper 1 type immune response Source: UniProtKB

Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

ReactomeiR-HSA-8984722 Interleukin-35 Signalling
R-HSA-9020956 Interleukin-27 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-27 subunit beta
Short name:
IL-27 subunit beta
Short name:
IL-27B
Alternative name(s):
Epstein-Barr virus-induced gene 3 protein
Short name:
EBV-induced gene 3 protein
Gene namesi
Name:EBI3
Synonyms:IL27B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105246.5
HGNCiHGNC:3129 EBI3
MIMi605816 gene
neXtProtiNX_Q14213

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10148
OpenTargetsiENSG00000105246
PharmGKBiPA27584

Polymorphism and mutation databases

BioMutaiEBI3
DMDMi47605806

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001093721 – 229Interleukin-27 subunit betaAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ14213
PaxDbiQ14213
PeptideAtlasiQ14213
PRIDEiQ14213

Expressioni

Inductioni

By Epstein-Barr virus (EBV).1 Publication

Gene expression databases

BgeeiENSG00000105246
CleanExiHS_EBI3
GenevisibleiQ14213 HS

Organism-specific databases

HPAiHPA046635

Interactioni

Subunit structurei

Heterodimer with IL27/IL27A; not disulfide-linked. This heterodimer is known as interleukin IL-27. EBI3 is also a component of the IL-12 heterodimer. Interacts with SQSTM1. Heterodimer with IL12A; this heterodimer is known as interleukin IL-35.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IL27Q8NEV92EBI-742959,EBI-15887997

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115450, 11 interactors
DIPiDIP-57556N
IntActiQ14213, 5 interactors
MINTiQ14213
STRINGi9606.ENSP00000221847

Structurei

3D structure databases

ProteinModelPortaliQ14213
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 130Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST107
Domaini131 – 227Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IX61 Eukaryota
ENOG4111KU8 LUCA
GeneTreeiENSGT00530000063103
HOGENOMiHOG000294168
HOVERGENiHBG052107
InParanoidiQ14213
OMAiFIATYRL
OrthoDBiEOG091G0P18
PhylomeDBiQ14213
TreeFamiTF331210

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003530 Hematopoietin_rcpt_L_F3_CS
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SUPFAMiSSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS01354 HEMATOPO_REC_L_F3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPQLLLALV LWASCPPCSG RKGPPAALTL PRVQCRASRY PIAVDCSWTL
60 70 80 90 100
PPAPNSTSPV SFIATYRLGM AARGHSWPCL QQTPTSTSCT ITDVQLFSMA
110 120 130 140 150
PYVLNVTAVH PWGSSSSFVP FITEHIIKPD PPEGVRLSPL AERQLQVQWE
160 170 180 190 200
PPGSWPFPEI FSLKYWIRYK RQGAARFHRV GPIEATSFIL RAVRPRARYY
210 220
VQVAAQDLTD YGELSDWSLP ATATMSLGK
Length:229
Mass (Da):25,396
Last modified:May 24, 2004 - v2
Checksum:iCFBAD72D91859EF0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144 – 145QL → HV in AAA93193 (PubMed:8551575).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049171174A → V. Corresponds to variant dbSNP:rs1803524Ensembl.1
Natural variantiVAR_024342201V → I2 PublicationsCorresponds to variant dbSNP:rs4740Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08187 mRNA Translation: AAA93193.1
EF064740 Genomic DNA Translation: ABK41923.1
AC005578 Genomic DNA Translation: AAC33488.1
CH471139 Genomic DNA Translation: EAW69245.1
BC015364 mRNA Translation: AAH15364.1
BC046112 mRNA Translation: AAH46112.1
CCDSiCCDS12123.1
RefSeqiNP_005746.2, NM_005755.2
XP_011525921.1, XM_011527619.2
UniGeneiHs.501452

Genome annotation databases

EnsembliENST00000221847; ENSP00000221847; ENSG00000105246
GeneIDi10148
KEGGihsa:10148
UCSCiuc002lzu.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIL27B_HUMAN
AccessioniPrimary (citable) accession number: Q14213
Secondary accession number(s): A0N0N2, O75269
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: May 23, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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