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Protein

Interleukin-27 subunit beta

Gene

EBI3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.1 Publication

GO - Molecular functioni

  • cytokine receptor activity Source: UniProtKB

GO - Biological processi

  • humoral immune response Source: ProtInc
  • positive regulation of alpha-beta T cell proliferation Source: UniProtKB
  • positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
  • T cell proliferation Source: Ensembl
  • T-helper 1 type immune response Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiR-HSA-6788467. IL-6-type cytokine receptor ligand interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-27 subunit beta
Short name:
IL-27 subunit beta
Short name:
IL-27B
Alternative name(s):
Epstein-Barr virus-induced gene 3 protein
Short name:
EBV-induced gene 3 protein
Gene namesi
Name:EBI3
Synonyms:IL27B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:3129. EBI3.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: ProtInc
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10148.
OpenTargetsiENSG00000105246.
PharmGKBiPA27584.

Polymorphism and mutation databases

BioMutaiEBI3.
DMDMi47605806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001093721 – 229Interleukin-27 subunit betaAdd BLAST209

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...)Sequence analysis1
Glycosylationi105N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ14213.
MaxQBiQ14213.
PaxDbiQ14213.
PeptideAtlasiQ14213.
PRIDEiQ14213.

Expressioni

Inductioni

By Epstein-Barr virus (EBV).1 Publication

Gene expression databases

BgeeiENSG00000105246.
CleanExiHS_EBI3.
GenevisibleiQ14213. HS.

Organism-specific databases

HPAiHPA046635.

Interactioni

Subunit structurei

Heterodimer with IL27/IL27A; not disulfide-linked. This heterodimer is known as interleukin IL-27. EBI3 is also a component of the IL-12 heterodimer. Interacts with SQSTM1. Heterodimer with IL12A; this heterodimer is known as interleukin IL-35.3 Publications

Protein-protein interaction databases

BioGridi115450. 5 interactors.
DIPiDIP-57556N.
IntActiQ14213. 2 interactors.
MINTiMINT-1189816.
STRINGi9606.ENSP00000221847.

Structurei

3D structure databases

ProteinModelPortaliQ14213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 130Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST107
Domaini131 – 227Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IX61. Eukaryota.
ENOG4111KU8. LUCA.
GeneTreeiENSGT00530000063103.
HOGENOMiHOG000294168.
HOVERGENiHBG052107.
InParanoidiQ14213.
OMAiYPVAVDC.
OrthoDBiEOG091G0P18.
PhylomeDBiQ14213.
TreeFamiTF331210.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14213-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPQLLLALV LWASCPPCSG RKGPPAALTL PRVQCRASRY PIAVDCSWTL
60 70 80 90 100
PPAPNSTSPV SFIATYRLGM AARGHSWPCL QQTPTSTSCT ITDVQLFSMA
110 120 130 140 150
PYVLNVTAVH PWGSSSSFVP FITEHIIKPD PPEGVRLSPL AERQLQVQWE
160 170 180 190 200
PPGSWPFPEI FSLKYWIRYK RQGAARFHRV GPIEATSFIL RAVRPRARYY
210 220
VQVAAQDLTD YGELSDWSLP ATATMSLGK
Length:229
Mass (Da):25,396
Last modified:May 24, 2004 - v2
Checksum:iCFBAD72D91859EF0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144 – 145QL → HV in AAA93193 (PubMed:8551575).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049171174A → V.Corresponds to variant rs1803524dbSNPEnsembl.1
Natural variantiVAR_024342201V → I.2 PublicationsCorresponds to variant rs4740dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08187 mRNA. Translation: AAA93193.1.
EF064740 Genomic DNA. Translation: ABK41923.1.
AC005578 Genomic DNA. Translation: AAC33488.1.
CH471139 Genomic DNA. Translation: EAW69245.1.
BC015364 mRNA. Translation: AAH15364.1.
BC046112 mRNA. Translation: AAH46112.1.
CCDSiCCDS12123.1.
RefSeqiNP_005746.2. NM_005755.2.
XP_011525921.1. XM_011527619.2.
UniGeneiHs.501452.

Genome annotation databases

EnsembliENST00000221847; ENSP00000221847; ENSG00000105246.
GeneIDi10148.
KEGGihsa:10148.
UCSCiuc002lzu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-27 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08187 mRNA. Translation: AAA93193.1.
EF064740 Genomic DNA. Translation: ABK41923.1.
AC005578 Genomic DNA. Translation: AAC33488.1.
CH471139 Genomic DNA. Translation: EAW69245.1.
BC015364 mRNA. Translation: AAH15364.1.
BC046112 mRNA. Translation: AAH46112.1.
CCDSiCCDS12123.1.
RefSeqiNP_005746.2. NM_005755.2.
XP_011525921.1. XM_011527619.2.
UniGeneiHs.501452.

3D structure databases

ProteinModelPortaliQ14213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115450. 5 interactors.
DIPiDIP-57556N.
IntActiQ14213. 2 interactors.
MINTiMINT-1189816.
STRINGi9606.ENSP00000221847.

Polymorphism and mutation databases

BioMutaiEBI3.
DMDMi47605806.

Proteomic databases

EPDiQ14213.
MaxQBiQ14213.
PaxDbiQ14213.
PeptideAtlasiQ14213.
PRIDEiQ14213.

Protocols and materials databases

DNASUi10148.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221847; ENSP00000221847; ENSG00000105246.
GeneIDi10148.
KEGGihsa:10148.
UCSCiuc002lzu.4. human.

Organism-specific databases

CTDi10148.
DisGeNETi10148.
GeneCardsiEBI3.
HGNCiHGNC:3129. EBI3.
HPAiHPA046635.
MIMi605816. gene.
neXtProtiNX_Q14213.
OpenTargetsiENSG00000105246.
PharmGKBiPA27584.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX61. Eukaryota.
ENOG4111KU8. LUCA.
GeneTreeiENSGT00530000063103.
HOGENOMiHOG000294168.
HOVERGENiHBG052107.
InParanoidiQ14213.
OMAiYPVAVDC.
OrthoDBiEOG091G0P18.
PhylomeDBiQ14213.
TreeFamiTF331210.

Enzyme and pathway databases

ReactomeiR-HSA-6788467. IL-6-type cytokine receptor ligand interactions.

Miscellaneous databases

ChiTaRSiEBI3. human.
GeneWikiiEBI3.
GenomeRNAii10148.
PROiQ14213.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105246.
CleanExiHS_EBI3.
GenevisibleiQ14213. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL27B_HUMAN
AccessioniPrimary (citable) accession number: Q14213
Secondary accession number(s): A0N0N2, O75269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 30, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.