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Q14213

- IL27B_HUMAN

UniProt

Q14213 - IL27B_HUMAN

Protein

Interleukin-27 subunit beta

Gene

EBI3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (24 May 2004)
      Previous versions | rss
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    Functioni

    Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.1 Publication

    GO - Molecular functioni

    1. cytokine receptor activity Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: GOC
    2. humoral immune response Source: ProtInc
    3. positive regulation of alpha-beta T cell proliferation Source: UniProtKB
    4. positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
    5. T-helper 1 type immune response Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-27 subunit beta
    Short name:
    IL-27 subunit beta
    Short name:
    IL-27B
    Alternative name(s):
    Epstein-Barr virus-induced gene 3 protein
    Short name:
    EBV-induced gene 3 protein
    Gene namesi
    Name:EBI3
    Synonyms:IL27B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:3129. EBI3.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: ProtInc
    2. plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27584.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 229209Interleukin-27 subunit betaPRO_0000010937Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi55 – 551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ14213.
    PaxDbiQ14213.
    PRIDEiQ14213.

    Expressioni

    Inductioni

    By Epstein-Barr virus (EBV).1 Publication

    Gene expression databases

    BgeeiQ14213.
    CleanExiHS_EBI3.
    GenevestigatoriQ14213.

    Organism-specific databases

    HPAiCAB032863.
    HPA046635.

    Interactioni

    Subunit structurei

    Heterodimer with IL27/IL27A; not disulfide-linked. This heterodimer is known as interleukin IL-27. EBI3 is also a component of the IL-12 heterodimer. Interacts with SQSTM1. Heterodimer with IL12A; this heterodimer is known as interleukin IL-35.3 Publications

    Protein-protein interaction databases

    BioGridi115450. 5 interactions.
    DIPiDIP-57556N.
    IntActiQ14213. 2 interactions.
    MINTiMINT-1189816.
    STRINGi9606.ENSP00000221847.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14213.
    SMRiQ14213. Positions 101-222.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 130107Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini131 – 22797Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG43082.
    HOGENOMiHOG000294168.
    HOVERGENiHBG052107.
    InParanoidiQ14213.
    OMAiPTSFIAT.
    OrthoDBiEOG789CCW.
    PhylomeDBiQ14213.
    TreeFamiTF331210.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR003530. Hematopoietin_rcpt_L_F3_CS.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF00041. fn3. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    PROSITEiPS50853. FN3. 2 hits.
    PS01354. HEMATOPO_REC_L_F3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q14213-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPQLLLALV LWASCPPCSG RKGPPAALTL PRVQCRASRY PIAVDCSWTL    50
    PPAPNSTSPV SFIATYRLGM AARGHSWPCL QQTPTSTSCT ITDVQLFSMA 100
    PYVLNVTAVH PWGSSSSFVP FITEHIIKPD PPEGVRLSPL AERQLQVQWE 150
    PPGSWPFPEI FSLKYWIRYK RQGAARFHRV GPIEATSFIL RAVRPRARYY 200
    VQVAAQDLTD YGELSDWSLP ATATMSLGK 229
    Length:229
    Mass (Da):25,396
    Last modified:May 24, 2004 - v2
    Checksum:iCFBAD72D91859EF0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti144 – 1452QL → HV in AAA93193. (PubMed:8551575)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti174 – 1741A → V.
    Corresponds to variant rs1803524 [ dbSNP | Ensembl ].
    VAR_049171
    Natural varianti201 – 2011V → I.2 Publications
    Corresponds to variant rs4740 [ dbSNP | Ensembl ].
    VAR_024342

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08187 mRNA. Translation: AAA93193.1.
    EF064740 Genomic DNA. Translation: ABK41923.1.
    AC005578 Genomic DNA. Translation: AAC33488.1.
    CH471139 Genomic DNA. Translation: EAW69245.1.
    BC015364 mRNA. Translation: AAH15364.1.
    BC046112 mRNA. Translation: AAH46112.1.
    CCDSiCCDS12123.1.
    RefSeqiNP_005746.2. NM_005755.2.
    UniGeneiHs.501452.

    Genome annotation databases

    EnsembliENST00000221847; ENSP00000221847; ENSG00000105246.
    GeneIDi10148.
    KEGGihsa:10148.
    UCSCiuc002lzu.3. human.

    Polymorphism databases

    DMDMi47605806.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Interleukin-27 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L08187 mRNA. Translation: AAA93193.1 .
    EF064740 Genomic DNA. Translation: ABK41923.1 .
    AC005578 Genomic DNA. Translation: AAC33488.1 .
    CH471139 Genomic DNA. Translation: EAW69245.1 .
    BC015364 mRNA. Translation: AAH15364.1 .
    BC046112 mRNA. Translation: AAH46112.1 .
    CCDSi CCDS12123.1.
    RefSeqi NP_005746.2. NM_005755.2.
    UniGenei Hs.501452.

    3D structure databases

    ProteinModelPortali Q14213.
    SMRi Q14213. Positions 101-222.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115450. 5 interactions.
    DIPi DIP-57556N.
    IntActi Q14213. 2 interactions.
    MINTi MINT-1189816.
    STRINGi 9606.ENSP00000221847.

    Polymorphism databases

    DMDMi 47605806.

    Proteomic databases

    MaxQBi Q14213.
    PaxDbi Q14213.
    PRIDEi Q14213.

    Protocols and materials databases

    DNASUi 10148.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000221847 ; ENSP00000221847 ; ENSG00000105246 .
    GeneIDi 10148.
    KEGGi hsa:10148.
    UCSCi uc002lzu.3. human.

    Organism-specific databases

    CTDi 10148.
    GeneCardsi GC19P004231.
    HGNCi HGNC:3129. EBI3.
    HPAi CAB032863.
    HPA046635.
    MIMi 605816. gene.
    neXtProti NX_Q14213.
    PharmGKBi PA27584.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43082.
    HOGENOMi HOG000294168.
    HOVERGENi HBG052107.
    InParanoidi Q14213.
    OMAi PTSFIAT.
    OrthoDBi EOG789CCW.
    PhylomeDBi Q14213.
    TreeFami TF331210.

    Miscellaneous databases

    GeneWikii EBI3.
    GenomeRNAii 10148.
    NextBioi 38403.
    PROi Q14213.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q14213.
    CleanExi HS_EBI3.
    Genevestigatori Q14213.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR003530. Hematopoietin_rcpt_L_F3_CS.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF00041. fn3. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    PROSITEi PS50853. FN3. 2 hits.
    PS01354. HEMATOPO_REC_L_F3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes."
      Devergne O., Hummel M., Koeppen H., Le Beau M.M., Nathanson E.C., Kieff E., Birkenbach M.
      J. Virol. 70:1143-1153(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, GLYCOSYLATION, INTERACTION WITH SQSTM1.
      Tissue: B-cell.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-201.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-201.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    6. "Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin."
      Devergne O., Birkenbach M., Kieff E.
      Proc. Natl. Acad. Sci. U.S.A. 94:12041-12046(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, INTERACTION WITH IL12A.
    7. Cited for: FUNCTION, SUBUNIT.
    8. "The biology and therapeutic potential of interleukin 27."
      Batten M., Ghilardi N.
      J. Mol. Med. 85:661-672(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON IL-27.

    Entry informationi

    Entry nameiIL27B_HUMAN
    AccessioniPrimary (citable) accession number: Q14213
    Secondary accession number(s): A0N0N2, O75269
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3