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Q14213

- IL27B_HUMAN

UniProt

Q14213 - IL27B_HUMAN

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Protein
Interleukin-27 subunit beta
Gene
EBI3, IL27B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.1 Publication

GO - Molecular functioni

  1. cytokine receptor activity Source: UniProtKB
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. T-helper 1 type immune response Source: UniProtKB
  2. cytokine-mediated signaling pathway Source: GOC
  3. humoral immune response Source: ProtInc
  4. positive regulation of alpha-beta T cell proliferation Source: UniProtKB
  5. positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-27 subunit beta
Short name:
IL-27 subunit beta
Short name:
IL-27B
Alternative name(s):
Epstein-Barr virus-induced gene 3 protein
Short name:
EBV-induced gene 3 protein
Gene namesi
Name:EBI3
Synonyms:IL27B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:3129. EBI3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: ProtInc
  2. plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27584.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 229209Interleukin-27 subunit beta
PRO_0000010937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi55 – 551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi105 – 1051N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ14213.
PaxDbiQ14213.
PRIDEiQ14213.

Expressioni

Inductioni

By Epstein-Barr virus (EBV).1 Publication

Gene expression databases

BgeeiQ14213.
CleanExiHS_EBI3.
GenevestigatoriQ14213.

Organism-specific databases

HPAiCAB032863.
HPA046635.

Interactioni

Subunit structurei

Heterodimer with IL27/IL27A; not disulfide-linked. This heterodimer is known as interleukin IL-27. EBI3 is also a component of the IL-12 heterodimer. Interacts with SQSTM1. Heterodimer with IL12A; this heterodimer is known as interleukin IL-35.3 Publications

Protein-protein interaction databases

BioGridi115450. 5 interactions.
DIPiDIP-57556N.
IntActiQ14213. 2 interactions.
MINTiMINT-1189816.
STRINGi9606.ENSP00000221847.

Structurei

3D structure databases

ProteinModelPortaliQ14213.
SMRiQ14213. Positions 101-222.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 130107Fibronectin type-III 1
Add
BLAST
Domaini131 – 22797Fibronectin type-III 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG43082.
HOGENOMiHOG000294168.
HOVERGENiHBG052107.
InParanoidiQ14213.
OMAiPTSFIAT.
OrthoDBiEOG789CCW.
PhylomeDBiQ14213.
TreeFamiTF331210.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14213-1 [UniParc]FASTAAdd to Basket

« Hide

MTPQLLLALV LWASCPPCSG RKGPPAALTL PRVQCRASRY PIAVDCSWTL    50
PPAPNSTSPV SFIATYRLGM AARGHSWPCL QQTPTSTSCT ITDVQLFSMA 100
PYVLNVTAVH PWGSSSSFVP FITEHIIKPD PPEGVRLSPL AERQLQVQWE 150
PPGSWPFPEI FSLKYWIRYK RQGAARFHRV GPIEATSFIL RAVRPRARYY 200
VQVAAQDLTD YGELSDWSLP ATATMSLGK 229
Length:229
Mass (Da):25,396
Last modified:May 24, 2004 - v2
Checksum:iCFBAD72D91859EF0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti174 – 1741A → V.
Corresponds to variant rs1803524 [ dbSNP | Ensembl ].
VAR_049171
Natural varianti201 – 2011V → I.2 Publications
Corresponds to variant rs4740 [ dbSNP | Ensembl ].
VAR_024342

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti144 – 1452QL → HV in AAA93193. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08187 mRNA. Translation: AAA93193.1.
EF064740 Genomic DNA. Translation: ABK41923.1.
AC005578 Genomic DNA. Translation: AAC33488.1.
CH471139 Genomic DNA. Translation: EAW69245.1.
BC015364 mRNA. Translation: AAH15364.1.
BC046112 mRNA. Translation: AAH46112.1.
CCDSiCCDS12123.1.
RefSeqiNP_005746.2. NM_005755.2.
UniGeneiHs.501452.

Genome annotation databases

EnsembliENST00000221847; ENSP00000221847; ENSG00000105246.
GeneIDi10148.
KEGGihsa:10148.
UCSCiuc002lzu.3. human.

Polymorphism databases

DMDMi47605806.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-27 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L08187 mRNA. Translation: AAA93193.1 .
EF064740 Genomic DNA. Translation: ABK41923.1 .
AC005578 Genomic DNA. Translation: AAC33488.1 .
CH471139 Genomic DNA. Translation: EAW69245.1 .
BC015364 mRNA. Translation: AAH15364.1 .
BC046112 mRNA. Translation: AAH46112.1 .
CCDSi CCDS12123.1.
RefSeqi NP_005746.2. NM_005755.2.
UniGenei Hs.501452.

3D structure databases

ProteinModelPortali Q14213.
SMRi Q14213. Positions 101-222.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115450. 5 interactions.
DIPi DIP-57556N.
IntActi Q14213. 2 interactions.
MINTi MINT-1189816.
STRINGi 9606.ENSP00000221847.

Polymorphism databases

DMDMi 47605806.

Proteomic databases

MaxQBi Q14213.
PaxDbi Q14213.
PRIDEi Q14213.

Protocols and materials databases

DNASUi 10148.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000221847 ; ENSP00000221847 ; ENSG00000105246 .
GeneIDi 10148.
KEGGi hsa:10148.
UCSCi uc002lzu.3. human.

Organism-specific databases

CTDi 10148.
GeneCardsi GC19P004231.
HGNCi HGNC:3129. EBI3.
HPAi CAB032863.
HPA046635.
MIMi 605816. gene.
neXtProti NX_Q14213.
PharmGKBi PA27584.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43082.
HOGENOMi HOG000294168.
HOVERGENi HBG052107.
InParanoidi Q14213.
OMAi PTSFIAT.
OrthoDBi EOG789CCW.
PhylomeDBi Q14213.
TreeFami TF331210.

Miscellaneous databases

GeneWikii EBI3.
GenomeRNAii 10148.
NextBioi 38403.
PROi Q14213.
SOURCEi Search...

Gene expression databases

Bgeei Q14213.
CleanExi HS_EBI3.
Genevestigatori Q14213.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF00041. fn3. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
PROSITEi PS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes."
    Devergne O., Hummel M., Koeppen H., Le Beau M.M., Nathanson E.C., Kieff E., Birkenbach M.
    J. Virol. 70:1143-1153(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, GLYCOSYLATION, INTERACTION WITH SQSTM1.
    Tissue: B-cell.
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-201.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-201.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  6. "Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin."
    Devergne O., Birkenbach M., Kieff E.
    Proc. Natl. Acad. Sci. U.S.A. 94:12041-12046(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, INTERACTION WITH IL12A.
  7. Cited for: FUNCTION, SUBUNIT.
  8. "The biology and therapeutic potential of interleukin 27."
    Batten M., Ghilardi N.
    J. Mol. Med. 85:661-672(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON IL-27.

Entry informationi

Entry nameiIL27B_HUMAN
AccessioniPrimary (citable) accession number: Q14213
Secondary accession number(s): A0N0N2, O75269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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