Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q14213 (IL27B_HUMAN)

Last modified March 2, 2010. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
Interleukin-27 subunit beta

Short name=IL-27 subunit beta
Short name=IL-27B
Alternative name(s):
Epstein-Barr virus-induced gene 3 protein
Short name=EBV-induced gene 3 protein
Gene names
Name:EBI3
Synonyms:IL27B
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. Ref.6

Subunit structure

Heterodimer with IL27. IL-27 is an heterodimer composed IL27 and EBI3. EBI3 is also a component of the IL-12 heterodimer. Interacts with SQSTM1. Ref.6 Ref.1

Subcellular location

Secreted.

Induction

By EBV. Ref.1

Sequence similarities

Belongs to the type I cytokine receptor family. Type 3 subfamily.

Contains 2 fibronectin type-III domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 229209Interleukin-27 subunit beta
PRO_0000010937

Regions

Domain24 – 124101Fibronectin type-III 1
Domain129 – 22193Fibronectin type-III 2

Amino acid modifications

Glycosylation551N-linked (GlcNAc...) Potential
Glycosylation1051N-linked (GlcNAc...) Potential

Natural variations

Natural variant1741A → V: dbSNP rs1803524.
VAR_049171
Natural variant2011V → I: dbSNP rs4740. Ref.2
VAR_024342

Experimental info

Sequence conflict144 – 1452QL → HV in AAA93193. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q14213-1 [UniParc].

Last modified May 24, 2004. Version 2.
Checksum: CFBAD72D91859EF0

FASTA22925,396
        10         20         30         40         50         60 
MTPQLLLALV LWASCPPCSG RKGPPAALTL PRVQCRASRY PIAVDCSWTL PPAPNSTSPV 

        70         80         90        100        110        120 
SFIATYRLGM AARGHSWPCL QQTPTSTSCT ITDVQLFSMA PYVLNVTAVH PWGSSSSFVP 

       130        140        150        160        170        180 
FITEHIIKPD PPEGVRLSPL AERQLQVQWE PPGSWPFPEI FSLKYWIRYK RQGAARFHRV 

       190        200        210        220 
GPIEATSFIL RAVRPRARYY VQVAAQDLTD YGELSDWSLP ATATMSLGK 

« Hide

References

« Hide 'large scale' references
[1]"A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes."
Devergne O., Hummel M., Koeppen H., Le Beau M.M., Nathanson E.C., Kieff E., Birkenbach M.
J. Virol. 70:1143-1153(1996) [PubMed: 8551575] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, GLYCOSYLATION, INTERACTION WITH SQSTM1.
Tissue: B-cell.
[2]Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-201.
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed: 15057824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-201.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
[6]"IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells."
Pflanz S., Timans J.C., Cheung J., Rosales R., Kanzler H., Gilbert J., Hibbert L., Churakova T., Travis M., Vaisberg E., Blumenschein W.M., Mattson J.D., Wagner J.L., To W., Zurawski S., McClanahan T.K., Gorman D.M., Bazan J.F. expand/collapse author list , de Waal Malefyt R., Rennick D., Kastelein R.A.
Immunity 16:779-790(2002) [PubMed: 12121660] [Abstract]
Cited for: FUNCTION, SUBUNIT.
[7]"The biology and therapeutic potential of interleukin 27."
Batten M., Ghilardi N.
J. Mol. Med. 85:661-672(2007) [PubMed: 17294231] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-27 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L08187 mRNA. Translation: AAA93193.1.
EF064740 Genomic DNA. Translation: ABK41923.1.
AC005578 Genomic DNA. Translation: AAC33488.1.
CH471139 Genomic DNA. Translation: EAW69245.1.
BC015364 mRNA. Translation: AAH15364.1.
BC046112 mRNA. Translation: AAH46112.1.
IPIIPI00034088.
RefSeqNP_005746.2.
UniGeneHs.501452

3D structure databases

SMRQ14213. Positions 30-221.
ModBaseSearch...

Protein-protein interaction databases

IntActQ14213. 1 interaction.
STRINGQ14213.

Proteomic databases

PRIDEQ14213.

Genome annotation databases

EnsemblENST00000221847; ENSP00000221847; ENSG00000105246; Homo sapiens. [Genome view]
GeneID10148.
KEGGhsa:10148.
UCSCuc002lzu.1. human.

Organism-specific databases

CTD10148.
GeneCardsGC19P004180.
H-InvDBHIX0014656.
HGNCHGNC:3129. EBI3.
MIM605816. gene.
PharmGKBPA27584.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHBG269481.
HOVERGENHBG052107.
InParanoidQ14213.
OMAYPVAVDC.
OrthoDBEOG9ZGRZ2.
PhylomeDBQ14213.

Enzyme and pathway databases

Pathway_Interaction_DBil27pathway. IL27-mediated signaling events.

Gene expression databases

ArrayExpressQ14213.
BgeeQ14213.
CleanExHS_EBI3.
GenevestigatorQ14213.
GermOnlineENSG00000105246. Homo sapiens.

Family and domain databases

InterProIPR008957. Fibronectin_typ-III-like_fold.
IPR003961. FN_III.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
[Graphical view]
Gene3DG3DSA:2.60.40.30. FN_III-like. 1 hit.
PfamPF00041. fn3. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 2 hits.
PROSITEPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio38403.
SOURCESearch...

Entry information

Entry nameIL27B_HUMAN
AccessionPrimary (citable) accession number: Q14213
Secondary accession number(s): A0N0N2, O75269
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: March 2, 2010
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents