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Q14213 (IL27B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-27 subunit beta

Short name=IL-27 subunit beta
Short name=IL-27B
Alternative name(s):
Epstein-Barr virus-induced gene 3 protein
Short name=EBV-induced gene 3 protein
Gene names
Name:EBI3
Synonyms:IL27B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. Ref.6

Subunit structure

Heterodimer with IL27. IL-27 is a heterodimer composed IL27 and EBI3. EBI3 is also a component of the IL-12 heterodimer. Interacts with SQSTM1. Ref.1 Ref.6

Subcellular location

Secreted.

Induction

By Epstein-Barr virus (EBV). Ref.1

Sequence similarities

Belongs to the type I cytokine receptor family. Type 3 subfamily.

Contains 2 fibronectin type-III domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 229209Interleukin-27 subunit beta
PRO_0000010937

Regions

Domain24 – 130107Fibronectin type-III 1
Domain131 – 22797Fibronectin type-III 2

Amino acid modifications

Glycosylation551N-linked (GlcNAc...) Potential
Glycosylation1051N-linked (GlcNAc...) Potential

Natural variations

Natural variant1741A → V.
Corresponds to variant rs1803524 [ dbSNP | Ensembl ].
VAR_049171
Natural variant2011V → I. Ref.2 Ref.4
Corresponds to variant rs4740 [ dbSNP | Ensembl ].
VAR_024342

Experimental info

Sequence conflict144 – 1452QL → HV in AAA93193. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q14213 [UniParc].

Last modified May 24, 2004. Version 2.
Checksum: CFBAD72D91859EF0

FASTA22925,396
        10         20         30         40         50         60 
MTPQLLLALV LWASCPPCSG RKGPPAALTL PRVQCRASRY PIAVDCSWTL PPAPNSTSPV 

        70         80         90        100        110        120 
SFIATYRLGM AARGHSWPCL QQTPTSTSCT ITDVQLFSMA PYVLNVTAVH PWGSSSSFVP 

       130        140        150        160        170        180 
FITEHIIKPD PPEGVRLSPL AERQLQVQWE PPGSWPFPEI FSLKYWIRYK RQGAARFHRV 

       190        200        210        220 
GPIEATSFIL RAVRPRARYY VQVAAQDLTD YGELSDWSLP ATATMSLGK 

« Hide

References

« Hide 'large scale' references
[1]"A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes."
Devergne O., Hummel M., Koeppen H., Le Beau M.M., Nathanson E.C., Kieff E., Birkenbach M.
J. Virol. 70:1143-1153(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, GLYCOSYLATION, INTERACTION WITH SQSTM1.
Tissue: B-cell.
[2]Livingston R.J., Shaffer T., McFarland I., Nguyen C.P., Stanaway I.B., Rajkumar N., Johnson E.J., da Ponte S.H., Willa H., Ahearn M.O., Bertucci C., Acklestad J., Carroll A., Swanson J., Gildersleeve H.I., Nickerson D.A.
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-201.
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-201.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
[6]"IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells."
Pflanz S., Timans J.C., Cheung J., Rosales R., Kanzler H., Gilbert J., Hibbert L., Churakova T., Travis M., Vaisberg E., Blumenschein W.M., Mattson J.D., Wagner J.L., To W., Zurawski S., McClanahan T.K., Gorman D.M., Bazan J.F. expand/collapse author list , de Waal Malefyt R., Rennick D., Kastelein R.A.
Immunity 16:779-790(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT.
[7]"The biology and therapeutic potential of interleukin 27."
Batten M., Ghilardi N.
J. Mol. Med. 85:661-672(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
+Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-27 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L08187 mRNA. Translation: AAA93193.1.
EF064740 Genomic DNA. Translation: ABK41923.1.
AC005578 Genomic DNA. Translation: AAC33488.1.
CH471139 Genomic DNA. Translation: EAW69245.1.
BC015364 mRNA. Translation: AAH15364.1.
BC046112 mRNA. Translation: AAH46112.1.
RefSeqNP_005746.2. NM_005755.2.
UniGeneHs.501452.

3D structure databases

ProteinModelPortalQ14213.
SMRQ14213. Positions 32-228.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115450. 5 interactions.
DIPDIP-57556N.
IntActQ14213. 2 interactions.
MINTMINT-1189816.
STRING9606.ENSP00000221847.

Polymorphism databases

DMDM47605806.

Proteomic databases

PaxDbQ14213.
PRIDEQ14213.

Protocols and materials databases

DNASU10148.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000221847; ENSP00000221847; ENSG00000105246.
GeneID10148.
KEGGhsa:10148.
UCSCuc002lzu.3. human.

Organism-specific databases

CTD10148.
GeneCardsGC19P004231.
HGNCHGNC:3129. EBI3.
HPACAB032863.
HPA046635.
MIM605816. gene.
neXtProtNX_Q14213.
PharmGKBPA27584.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43082.
HOGENOMHOG000294168.
HOVERGENHBG052107.
InParanoidQ14213.
OMAPTSFIAT.
OrthoDBEOG789CCW.
PhylomeDBQ14213.
TreeFamTF331210.

Gene expression databases

BgeeQ14213.
CleanExHS_EBI3.
GenevestigatorQ14213.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR003961. Fibronectin_type3.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamPF00041. fn3. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
PROSITEPS50853. FN3. 2 hits.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiEBI3.
GenomeRNAi10148.
NextBio38403.
PROQ14213.
SOURCESearch...

Entry information

Entry nameIL27B_HUMAN
AccessionPrimary (citable) accession number: Q14213
Secondary accession number(s): A0N0N2, O75269
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: April 16, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM