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Protein

Calcipressin-2

Gene

RCAN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Calcipressin-2
Alternative name(s):
Down syndrome candidate region 1-like 1
Myocyte-enriched calcineurin-interacting protein 2
Short name:
MCIP2
Regulator of calcineurin 2
Thyroid hormone-responsive protein ZAKI-4
Gene namesi
Name:RCAN2
Synonyms:DSCR1L1, ZAKI4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:3041. RCAN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400959.

Polymorphism and mutation databases

BioMutaiRCAN2.
DMDMi158958336.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 197197Calcipressin-2PRO_0000211417Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei167 – 1671PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ14206.
PRIDEiQ14206.

PTM databases

PhosphoSiteiQ14206.

Expressioni

Tissue specificityi

Expressed in fibroblasts, heart, brain, liver, and skeletal muscle but not in placenta, lung, kidney and pancreas.

Inductioni

By thyroid hormone.

Gene expression databases

BgeeiQ14206.
CleanExiHS_RCAN2.
ExpressionAtlasiQ14206. baseline and differential.
GenevisibleiQ14206. HS.

Organism-specific databases

HPAiHPA053880.

Interactioni

Protein-protein interaction databases

BioGridi115525. 22 interactions.
IntActiQ14206. 1 interaction.
STRINGi9606.ENSP00000329454.

Structurei

3D structure databases

ProteinModelPortaliQ14206.
SMRiQ14206. Positions 11-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RCAN family.Curated

Phylogenomic databases

eggNOGiKOG4019. Eukaryota.
ENOG4111I50. LUCA.
GeneTreeiENSGT00400000022053.
HOVERGENiHBG018932.
InParanoidiQ14206.
KOiK17903.
OMAiRSMDCDV.
OrthoDBiEOG715Q51.
PhylomeDBiQ14206.
TreeFamiTF313579.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR006931. Calcipressin.
IPR012677. Nucleotide-bd_a/b_plait.
[Graphical view]
PANTHERiPTHR10300. PTHR10300. 1 hit.
PfamiPF04847. Calcipressin. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14206-1) [UniParc]FASTAAdd to basket

Also known as: ZAKI-4 alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD DCVTFQLFKS
60 70 80 90 100
FRRVRINFSN PKSAARARIE LHETQFRGKK LKLYFAQVQT PETDGDKLHL
110 120 130 140 150
APPQPAKQFL ISPPSSPPVG WQPINDATPV LNYDLLYAVA KLGPGEKYEL
160 170 180 190
HAGTESTPSV VVHVCDSDIE EEEDPKTSPK PKIIQTRRPG LPPSVSN
Length:197
Mass (Da):21,997
Last modified:July 24, 2007 - v3
Checksum:i9FD36B3DEDAE22B8
GO
Isoform 2 (identifier: Q14206-2) [UniParc]FASTAAdd to basket

Also known as: ZAKI-4 beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MPAPSMDCDVSTLVACVVDVEVFTNQEV → MRGESYFIGM...HQSVFEGEES

Show »
Length:243
Mass (Da):27,289
Checksum:i48EA6BCCA2669ABC
GO

Sequence cautioni

The sequence BAA11911.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331E → G in BAA11911 (PubMed:8662924).Curated
Sequence conflicti33 – 331E → G in AAK59805 (PubMed:12102656).Curated
Sequence conflicti33 – 331E → G in AAK59806 (PubMed:12102656).Curated
Sequence conflicti120 – 1201G → S in BAA11911 (PubMed:8662924).Curated
Sequence conflicti120 – 1201G → S in AAK59805 (PubMed:12102656).Curated
Sequence conflicti120 – 1201G → S in AAK59806 (PubMed:12102656).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2828MPAPS…TNQEV → MRGESYFIGMRSPGQQGHVP EDGGLFLLCCIDRDWAVTRC FAEEAFQAITDFNDLPNSLF ACNVHQSVFEGEES in isoform 2. 2 PublicationsVSP_026923Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83407 mRNA. Translation: BAA11911.1. Different initiation.
AY034085 mRNA. Translation: AAK59805.1.
AY034086 mRNA. Translation: AAK59806.1.
AK090990 mRNA. Translation: BAG52258.1.
AL390741 Genomic DNA. Translation: CAH73260.1.
AL390741, AL359633 Genomic DNA. Translation: CAH73259.1.
AL359633, AL390741 Genomic DNA. Translation: CAI16754.1.
CH471081 Genomic DNA. Translation: EAX04294.1.
CCDSiCCDS43469.1. [Q14206-1]
CCDS59023.1. [Q14206-2]
RefSeqiNP_001238902.1. NM_001251973.1. [Q14206-2]
NP_001238903.1. NM_001251974.1. [Q14206-2]
NP_005813.2. NM_005822.3. [Q14206-1]
XP_006715011.1. XM_006714948.2. [Q14206-2]
XP_011512528.1. XM_011514226.1. [Q14206-2]
UniGeneiHs.440168.
Hs.710016.

Genome annotation databases

EnsembliENST00000306764; ENSP00000305223; ENSG00000172348. [Q14206-2]
ENST00000330430; ENSP00000329454; ENSG00000172348. [Q14206-1]
ENST00000371374; ENSP00000360425; ENSG00000172348. [Q14206-2]
GeneIDi10231.
KEGGihsa:10231.
UCSCiuc003oyb.3. human. [Q14206-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83407 mRNA. Translation: BAA11911.1. Different initiation.
AY034085 mRNA. Translation: AAK59805.1.
AY034086 mRNA. Translation: AAK59806.1.
AK090990 mRNA. Translation: BAG52258.1.
AL390741 Genomic DNA. Translation: CAH73260.1.
AL390741, AL359633 Genomic DNA. Translation: CAH73259.1.
AL359633, AL390741 Genomic DNA. Translation: CAI16754.1.
CH471081 Genomic DNA. Translation: EAX04294.1.
CCDSiCCDS43469.1. [Q14206-1]
CCDS59023.1. [Q14206-2]
RefSeqiNP_001238902.1. NM_001251973.1. [Q14206-2]
NP_001238903.1. NM_001251974.1. [Q14206-2]
NP_005813.2. NM_005822.3. [Q14206-1]
XP_006715011.1. XM_006714948.2. [Q14206-2]
XP_011512528.1. XM_011514226.1. [Q14206-2]
UniGeneiHs.440168.
Hs.710016.

3D structure databases

ProteinModelPortaliQ14206.
SMRiQ14206. Positions 11-116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115525. 22 interactions.
IntActiQ14206. 1 interaction.
STRINGi9606.ENSP00000329454.

PTM databases

PhosphoSiteiQ14206.

Polymorphism and mutation databases

BioMutaiRCAN2.
DMDMi158958336.

Proteomic databases

PaxDbiQ14206.
PRIDEiQ14206.

Protocols and materials databases

DNASUi10231.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306764; ENSP00000305223; ENSG00000172348. [Q14206-2]
ENST00000330430; ENSP00000329454; ENSG00000172348. [Q14206-1]
ENST00000371374; ENSP00000360425; ENSG00000172348. [Q14206-2]
GeneIDi10231.
KEGGihsa:10231.
UCSCiuc003oyb.3. human. [Q14206-1]

Organism-specific databases

CTDi10231.
GeneCardsiRCAN2.
H-InvDBHIX0005935.
HGNCiHGNC:3041. RCAN2.
HPAiHPA053880.
MIMi604876. gene.
neXtProtiNX_Q14206.
PharmGKBiPA162400959.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4019. Eukaryota.
ENOG4111I50. LUCA.
GeneTreeiENSGT00400000022053.
HOVERGENiHBG018932.
InParanoidiQ14206.
KOiK17903.
OMAiRSMDCDV.
OrthoDBiEOG715Q51.
PhylomeDBiQ14206.
TreeFamiTF313579.

Miscellaneous databases

ChiTaRSiRCAN2. human.
GeneWikiiRCAN2.
GenomeRNAii10231.
NextBioi38740.
PROiQ14206.
SOURCEiSearch...

Gene expression databases

BgeeiQ14206.
CleanExiHS_RCAN2.
ExpressionAtlasiQ14206. baseline and differential.
GenevisibleiQ14206. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
InterProiIPR006931. Calcipressin.
IPR012677. Nucleotide-bd_a/b_plait.
[Graphical view]
PANTHERiPTHR10300. PTHR10300. 1 hit.
PfamiPF04847. Calcipressin. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts."
    Miyazaki T., Kanou Y., Murata Y., Ohmori S., Niwa T., Maeda K., Yamamura H., Seo H.
    J. Biol. Chem. 271:14567-14571(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fibroblast.
  2. "Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors."
    Cao X., Kambe F., Miyazaki T., Sarkar D., Ohmori S., Seo H.
    Biochem. J. 367:459-466(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRCAN2_HUMAN
AccessioniPrimary (citable) accession number: Q14206
Secondary accession number(s): A6ND07
, B3KR46, Q5VWF7, Q5VWF8, Q8N116
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 24, 2007
Last modified: May 11, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.