Q14202 (ZMYM3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger MYM-type protein 3

Alternative name(s):
Zinc finger protein 261

Gene names

Name:	ZMYM3
Synonyms:	DXS6673E, KIAA0385, ZNF261

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1370 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role in the regulation of cell morphology and cytoskeletal organization. Ref.12
Subunit structure	May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.
Subcellular location	Nucleus By similarity.
Tissue specificity	Most abundant in brain, moderate in muscle and heart, low in other tissues except placenta.
Involvement in disease	Note=A chromosomal aberration involving ZMYM3 may be a cause of X-linked mental retardation in Xq13.1. Translocation t(X;13)(q13.1;?).
Sequence similarities	Contains 9 MYM-type zinc fingers.
Sequence caution	The sequence BAA20839.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Chromosomal rearrangement
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cytoskeleton organization Inferred from mutant phenotype Ref.12. Source: UniProtKB multicellular organismal development Traceable author statement. Source: ProtInc regulation of cell morphogenesis Inferred from mutant phenotype Ref.12. Source: UniProtKB
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14202-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14202-2)

The sequence of this isoform differs from the canonical sequence as follows:
     793-804: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1370	1370	Zinc finger MYM-type protein 3		PRO_0000191378
Regions
	Zinc finger	332 – 366	35	MYM-type 1
	Zinc finger	378 – 422	45	MYM-type 2
	Zinc finger	429 – 464	36	MYM-type 3
	Zinc finger	477 – 511	35	MYM-type 4
	Zinc finger	521 – 559	39	MYM-type 5
	Zinc finger	567 – 604	38	MYM-type 6
	Zinc finger	612 – 646	35	MYM-type 7
	Zinc finger	653 – 692	40	MYM-type 8
	Zinc finger	699 – 733	35	MYM-type 9
Amino acid modifications
	Modified residue	263	1	Phosphoserine Ref.7 Ref.8
	Modified residue	267	1	Phosphoserine Ref.7 Ref.8
	Modified residue	645	1	N6-acetyllysine Ref.11
	Modified residue	817	1	Phosphothreonine Ref.6 Ref.9
	Modified residue	826	1	Phosphothreonine Ref.9 Ref.10
Natural variations
	Alternative sequence	793 – 804	12	Missing in isoform 2.		VSP_004492

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2000. Version 2. Checksum: 088B5E01E7EE9C30	FASTA	1,370	152,379
	10 20 30 40 50 60 MDPSDFPSPF DPLTLPEKPL AGDLPVDMEF GEDLLESQTA PTRGWAPPGP SPSSGALDLL 70 80 90 100 110 120 DTPAGLEKDP GVLDGATELL GLGGLLYKAP SPPEVDHGPE GTLAWDAGDQ TLEPGPGGQT 130 140 150 160 170 180 PEVVPPDPGA GANSCSPEGL LEPLAPDSPI TLQSPHIEEE ETTSIATARR GSPGQEEELP 190 200 210 220 230 240 QGQPQSPNAP PSPSVGETLG DGINSSQTKP GGSSPPAHPS LPGDGLTAKA SEKPPERKRS 250 260 270 280 290 300 ERVRRAEPPK PEVVDSTESI PVSDEDSDAM VDDPNDEDFV PFRPRRSPRM SLRSSVSQRA 310 320 330 340 350 360 GRSAVGTKMT CAHCRTPLQK GQTAYQRKGL PQLFCSSSCL TTFSKKPSGK KTCTFCKKEI 370 380 390 400 410 420 WNTKDSVVAQ TGSGGSFHEF CTSVCLSLYE AQQQRPIPQS GDPADATRCS ICQKTGEVLH 430 440 450 460 470 480 EVSNGSVVHR LCSDSCFSKF RANKGLKTNC CDQCGAYIYT KTGSPGPELL FHEGQQKRFC 490 500 510 520 530 540 NTTCLGAYKK KNTRVYPCVW CKTLCKNFEM LSHVDRNGKT SLFCSLCCTT SYKVKQAGLT 550 560 570 580 590 600 GPPRPCSFCR RSLSDPCYYN KVDRTVYQFC SPSCWTKFQR TSPEGGIHLS CHYCHSLFSG 610 620 630 640 650 660 KPEVLDWQDQ VFQFCCRDCC EDFKRLRGVV SQCEHCRQEK LLHEKLRFSG VEKSFCSEGC 670 680 690 700 710 720 VLLYKQDFTK KLGLCCITCT YCSQTCQRGV TEQLDGSTWD FCSEDCKSKY LLWYCKAARC 730 740 750 760 770 780 HACKRQGKLL ETIHWRGQIR HFCNQQCLLR FYSQQNQPNL DTQSGPESLL NSQSPESKPQ 790 800 810 820 830 840 TPSQTKVENS NTVRTPEENG NLGKIPVKTR SAPTAPTPPP PPPPATPRKN KAAMCKPLMQ 850 860 870 880 890 900 NRGVSCKVEM KSKGSQTEEW KPQVIVLPIP VPIFVPVPMH LYCQKVPVPF SMPIPVPVPM 910 920 930 940 950 960 FLPTTLESTD KIVETIEELK VKIPSNPLEA DILAMAEMIA EAEELDKASS DLCDLVSNQS 970 980 990 1000 1010 1020 AEGLLEDCDL FGPARDDVLA MAVKMANVLD EPGQDLEADF PKNPLDINPS VDFLFDCGLV 1030 1040 1050 1060 1070 1080 GPEDVSTEQD LPRTMRKGQK RLVLSESCSR DSMSSQPSCT GLNYSYGVNA WKCWVQSKYA 1090 1100 1110 1120 1130 1140 NGETSKGDEL RFGPKPMRIK EDILACSAAE LNYGLAQFVR EITRPNGERY EPDSIYYLCL 1150 1160 1170 1180 1190 1200 GIQQYLLENN RMVNIFTDLY YLTFVQELNK SLSTWQPTLL PNNTVFSRVE EEHLWECKQL 1210 1220 1230 1240 1250 1260 GVYSPFVLLN TLMFFNTKFF GLQTAEEHMQ LSFTNVVRQS RKCTTPRGTT KVVSIRYYAP 1270 1280 1290 1300 1310 1320 VRQRKGRDTG PGKRKREDEA PILEQRENRM NPLRCPVKFY EFYLSKCPES LRTRNDVFYL 1330 1340 1350 1360 1370 QPERSCIAES PLWYSVIPMD RSMLESMLNR ILAVREIYEE LGRPGEEDLD
	Isoform 2 [UniParc]. Checksum: 8B636620F05DF82F	FASTA	1,358	151,084
	10 20 30 40 50 60 MDPSDFPSPF DPLTLPEKPL AGDLPVDMEF GEDLLESQTA PTRGWAPPGP SPSSGALDLL 70 80 90 100 110 120 DTPAGLEKDP GVLDGATELL GLGGLLYKAP SPPEVDHGPE GTLAWDAGDQ TLEPGPGGQT 130 140 150 160 170 180 PEVVPPDPGA GANSCSPEGL LEPLAPDSPI TLQSPHIEEE ETTSIATARR GSPGQEEELP 190 200 210 220 230 240 QGQPQSPNAP PSPSVGETLG DGINSSQTKP GGSSPPAHPS LPGDGLTAKA SEKPPERKRS 250 260 270 280 290 300 ERVRRAEPPK PEVVDSTESI PVSDEDSDAM VDDPNDEDFV PFRPRRSPRM SLRSSVSQRA 310 320 330 340 350 360 GRSAVGTKMT CAHCRTPLQK GQTAYQRKGL PQLFCSSSCL TTFSKKPSGK KTCTFCKKEI 370 380 390 400 410 420 WNTKDSVVAQ TGSGGSFHEF CTSVCLSLYE AQQQRPIPQS GDPADATRCS ICQKTGEVLH 430 440 450 460 470 480 EVSNGSVVHR LCSDSCFSKF RANKGLKTNC CDQCGAYIYT KTGSPGPELL FHEGQQKRFC 490 500 510 520 530 540 NTTCLGAYKK KNTRVYPCVW CKTLCKNFEM LSHVDRNGKT SLFCSLCCTT SYKVKQAGLT 550 560 570 580 590 600 GPPRPCSFCR RSLSDPCYYN KVDRTVYQFC SPSCWTKFQR TSPEGGIHLS CHYCHSLFSG 610 620 630 640 650 660 KPEVLDWQDQ VFQFCCRDCC EDFKRLRGVV SQCEHCRQEK LLHEKLRFSG VEKSFCSEGC 670 680 690 700 710 720 VLLYKQDFTK KLGLCCITCT YCSQTCQRGV TEQLDGSTWD FCSEDCKSKY LLWYCKAARC 730 740 750 760 770 780 HACKRQGKLL ETIHWRGQIR HFCNQQCLLR FYSQQNQPNL DTQSGPESLL NSQSPESKPQ 790 800 810 820 830 840 TPSQTKVENS NTIPVKTRSA PTAPTPPPPP PPATPRKNKA AMCKPLMQNR GVSCKVEMKS 850 860 870 880 890 900 KGSQTEEWKP QVIVLPIPVP IFVPVPMHLY CQKVPVPFSM PIPVPVPMFL PTTLESTDKI 910 920 930 940 950 960 VETIEELKVK IPSNPLEADI LAMAEMIAEA EELDKASSDL CDLVSNQSAE GLLEDCDLFG 970 980 990 1000 1010 1020 PARDDVLAMA VKMANVLDEP GQDLEADFPK NPLDINPSVD FLFDCGLVGP EDVSTEQDLP 1030 1040 1050 1060 1070 1080 RTMRKGQKRL VLSESCSRDS MSSQPSCTGL NYSYGVNAWK CWVQSKYANG ETSKGDELRF 1090 1100 1110 1120 1130 1140 GPKPMRIKED ILACSAAELN YGLAQFVREI TRPNGERYEP DSIYYLCLGI QQYLLENNRM 1150 1160 1170 1180 1190 1200 VNIFTDLYYL TFVQELNKSL STWQPTLLPN NTVFSRVEEE HLWECKQLGV YSPFVLLNTL 1210 1220 1230 1240 1250 1260 MFFNTKFFGL QTAEEHMQLS FTNVVRQSRK CTTPRGTTKV VSIRYYAPVR QRKGRDTGPG 1270 1280 1290 1300 1310 1320 KRKREDEAPI LEQRENRMNP LRCPVKFYEF YLSKCPESLR TRNDVFYLQP ERSCIAESPL 1330 1340 1350 WYSVIPMDRS MLESMLNRIL AVREIYEELG RPGEEDLD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of DXS6673E, a candidate gene for X-linked mental retardation in Xq13.1." van der Maarel S.M., Scholten I.H.G.M., Huber I., Phillippe C., Suijkerbuijk R.F., Gilgenkrantz S., Kere J., Cremers F.P.M., Ropers H.-H. Hum. Mol. Genet. 5:887-897(1996) [PubMed: 8817323] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Fetal brain.
[2]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed: 9205841] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lymph.
[5]	"A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes." Hakimi M.-A., Dong Y., Lane W.S., Speicher D.W., Shiekhattar R. J. Biol. Chem. 278:7234-7239(2003) [PubMed: 12493763] [Abstract] Cited for: IDENTIFICATION IN THE BHC COMPLEX WITH HDAC1; HDAC2; HMG20B; KDM1A; RCOR1; PHF21A; ZMYM2; ZNF217; KIAA0182 AND GTF2I.
[6]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-817, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263 AND SER-267, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263 AND SER-267, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-817 AND THR-826, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-826, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-645, MASS SPECTROMETRY.
[12]	"Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration." Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J. BMC Biol. 9:54-54(2011) [PubMed: 21834987] [Abstract] Cited for: FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X95808 mRNA. Translation: CAA65075.1. AB002383 mRNA. Translation: BAA20839.2. Different initiation. CH471132 Genomic DNA. Translation: EAX05302.1. CH471132 Genomic DNA. Translation: EAX05303.1. BC069057 mRNA. Translation: AAH69057.1.
IPI	IPI00029484. IPI00219027.
RefSeq	NP_001164633.1. NM_001171162.1. NP_005087.1. NM_005096.3. NP_963893.1. NM_201599.2.
UniGene	Hs.522684.
3D structure databases
ProteinModelPortal	Q14202.
SMR	Q14202. Positions 308-340.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14202. 4 interactions.
STRING	Q14202.
PTM databases
PhosphoSite	Q14202.
Polymorphism databases
DMDM	12644413.
Proteomic databases
PRIDE	Q14202.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000314425; ENSP00000322845; ENSG00000147130. ENST00000353904; ENSP00000343909; ENSG00000147130.
GeneID	9203.
KEGG	hsa:9203.
UCSC	uc004dzh.1. human. uc004dzj.1. human.
Organism-specific databases
CTD	9203.
GeneCards	GC0XM070459.
H-InvDB	HIX0016861.
HGNC	HGNC:13054. ZMYM3.
HPA	HPA003211.
MIM	300061. gene.
neXtProt	NX_Q14202.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG07189.
GeneTree	ENSGT00550000074408.
HOVERGEN	HBG057545.
PhylomeDB	Q14202.
Gene expression databases
ArrayExpress	Q14202.
Bgee	Q14202.
CleanEx	HS_ZMYM3.
Genevestigator	Q14202.
GermOnline	ENSG00000147130. Homo sapiens.
Family and domain databases
InterPro	IPR021893. DUF3504. IPR011017. TRASH. IPR010507. Znf_MYM. [Graphical view]
Pfam	PF12012. DUF3504. 1 hit. PF06467. zf-FCS. 10 hits. [Graphical view]
SMART	SM00746. TRASH. 10 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	34497.
SOURCE	Search...

Entry information

Entry name

ZMYM3_HUMAN

Accession

Primary (citable) accession number: Q14202
Secondary accession number(s): D3DVV3, O15089

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	December 1, 2000
Last modified:	January 25, 2012
This is version 98 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.