Reviewed, UniProtKB/Swiss-Prot Q14201 (BTG3_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein BTG3
Alternative name(s):
    BTG family member 3
    Protein Tob5
    Abundant in neuroepithelium area protein

Gene names

Name:	BTG3
Synonyms:	ANA, TOB5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase.
Tissue specificity	Ubiquitous. High expression in the ventricular zone of the developing central nervous system. High in ovary, testis, prostate, thymus and lung. Ref.3
Developmental stage	Expression is cell cycle dependent with the highest levels at the end of G1 phase, peaking at the G1-S transition. Ref.3
Sequence similarities	Belongs to the BTG family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Gene Ontology (GO)
Biological process	negative regulation of cell proliferation Ref.1 Traceable author statement. Source: ProtInc negative regulation of mitotic cell cycle Ref.1 Inferred from direct assay. Source: MGI
Cellular component	cytoplasm Ref.1 Inferred from direct assay. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14201-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14201-2)

The sequence of this isoform differs from the canonical sequence as follows:
     104-104: R → RRDGVSPCWPDCSQTPDLVIRPPWPPKALDYRREPLRPASSFLIM

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	Protein BTG3		PRO_0000143807
Regions
	Compositional bias	144 – 149	6	Poly-Ser
Natural variations
	Alternative sequence	104	1	R → RRDGVSPCWPDCSQTPDLVI RPPWPPKALDYRREPLRPAS SFLIM in isoform 2.		VSP_000578
Experimental info
	Sequence conflict	40	1	E → G in BAA33788. Ref.1
	Sequence conflict	45	1	H → P in BAA33788. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 10, 2002. Version 3. Checksum: BEBE7E15709D2CC7	FASTA	252	29,116
	10 20 30 40 50 60 MKNEIAAVVF FFTRLVRKHD KLKKEAVERF AEKLTLILQE KYKNHWYPEK PSKGQAYRCI 70 80 90 100 110 120 RVNKFQRVDP DVLKACENSC ILYSDLGLPK ELTLWVDPCE VCCRYGEKNN AFIVASFENK 130 140 150 160 170 180 DENKDEISRK VTRALDKVTS DYHSGSSSSD EETSKEMEVK PSSVTAAASP VYQISELIFP 190 200 210 220 230 240 PLPMWHPLPR KKPGMYRGNG HQNHYPPPVP FGYPNQGRKN KPYRPIPVTW VPPPGMHCDR 250 NHWINPHMLA PH
	Isoform 2. Checksum: 0AC870F223ECE2DE	FASTA	296	34,163
	10 20 30 40 50 60 MKNEIAAVVF FFTRLVRKHD KLKKEAVERF AEKLTLILQE KYKNHWYPEK PSKGQAYRCI 70 80 90 100 110 120 RVNKFQRVDP DVLKACENSC ILYSDLGLPK ELTLWVDPCE VCCRRDGVSP CWPDCSQTPD 130 140 150 160 170 180 LVIRPPWPPK ALDYRREPLR PASSFLIMYG EKNNAFIVAS FENKDENKDE ISRKVTRALD 190 200 210 220 230 240 KVTSDYHSGS SSSDEETSKE MEVKPSSVTA AASPVYQISE LIFPPLPMWH PLPRKKPGMY 250 260 270 280 290 RGNGHQNHYP PPVPFGYPNQ GRKNKPYRPI PVTWVPPPGM HCDRNHWINP HMLAPH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ANA, a novel member of Tob/BTG1 family, is expressed in the ventricular zone of the developing central nervous system." Yoshida Y., Matsuda S., Ikematsu N., Kawamura-Tsuzuku J., Inazawa J., Umemori H., Yamamoto T. Oncogene 16:2687-2693(1998) [PubMed: 9632145] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Ovary.
[3]	"Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle." Guehenneux F., Duret L., Callanan M.B., Bouhas R., Hayette S., Berthet C., Samarut C., Rimokh R., Birot A.-M., Wang Q., Magaud J.-P., Rouault J.-P. Leukemia 11:370-375(1997) [PubMed: 9067576] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D64110 mRNA. Translation: BAA33788.1. BC011957 mRNA. Translation: AAH11957.1.
IPI	IPI00183697. IPI00334053.
PIR	T09539.
RefSeq	NP_001124386.1. NP_006797.3.
UniGene	Hs.473420
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14201. 1 interaction.
PTM databases
PhosphoSite	Q14201.
Proteomic databases
PRIDE	Q14201.
Genome annotation databases
Ensembl	ENSG00000154640. Homo sapiens. [Contig view]
GeneID	10950.
KEGG	hsa:10950.
Organism-specific databases
GeneCards	GC21M017887.
H-InvDB	HIX0020731.
HGNC	HGNC:1132. BTG3.
HPA	HPA018400.
MIM	605674. gene.
PharmGKB	PA25452.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q14201.
OMA	Q14201. HYPPPVP.
Gene expression databases
Bgee	Q14201.
CleanEx	HS_BTG3.
GermOnline	ENSG00000154640. Homo sapiens.
Family and domain databases
InterPro	IPR002087. Anti_prolifrtn. [Graphical view]
Pfam	PF07742. BTG. 1 hit. [Graphical view]
PRINTS	PR00310. ANTIPRLFBTG1.
SMART	SM00099. btg1. 1 hit. [Graphical view]
PROSITE	PS00960. BTG_1. 1 hit. PS01203. BTG_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	41605.
SOURCE	Search...

Entry information

Entry name

BTG3_HUMAN

Accession

Primary (citable) accession number: Q14201
Secondary accession number(s): Q96ET7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	October 10, 2002
Last modified:	June 16, 2009
This is version 74 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)