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Protein

Dihydropyrimidinase-related protein 3

Gene

DPYSL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).By similarity

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-399956 CRMPs in Sema3A signaling
SIGNORiQ14195

Protein family/group databases

MEROPSiM38.976

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 3
Short name:
DRP-3
Alternative name(s):
Collapsin response mediator protein 4
Short name:
CRMP-4
Unc-33-like phosphoprotein 1
Short name:
ULIP-1
Gene namesi
Name:DPYSL3
Synonyms:CRMP4, DRP3, ULIP, ULIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000113657.12
HGNCiHGNC:3015 DPYSL3
MIMi601168 gene
neXtProtiNX_Q14195

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi1809
OpenTargetsiENSG00000113657
PharmGKBiPA27473

Polymorphism and mutation databases

BioMutaiDPYSL3
DMDMi3122050

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659171 – 570Dihydropyrimidinase-related protein 3Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei259PhosphoserineCombined sources1
Modified residuei431PhosphotyrosineBy similarity1
Modified residuei499PhosphotyrosineBy similarity1
Modified residuei509Phosphothreonine; by GSK3Combined sources1 Publication1
Modified residuei514Phosphothreonine; by GSK3Combined sources1 Publication1
Modified residuei518Phosphoserine; by GSK31 Publication1
Modified residuei522Phosphoserine; by DYRK2Combined sources1 Publication1
Modified residuei536PhosphoserineBy similarity1
Modified residuei539PhosphoserineBy similarity1
Modified residuei541PhosphoserineBy similarity1
Modified residuei543PhosphothreonineBy similarity1
Isoform LCRMP-4 (identifier: Q14195-2)
Modified residuei102PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14195
MaxQBiQ14195
PaxDbiQ14195
PeptideAtlasiQ14195
PRIDEiQ14195

2D gel databases

REPRODUCTION-2DPAGEQ14195
UCD-2DPAGEQ14195

PTM databases

iPTMnetiQ14195
PhosphoSitePlusiQ14195

Expressioni

Tissue specificityi

Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.

Gene expression databases

BgeeiENSG00000113657
CleanExiHS_DPYSL3
ExpressionAtlasiQ14195 baseline and differential
GenevisibleiQ14195 HS

Organism-specific databases

HPAiHPA010948

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5. Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • filamin binding Source: WormBase
  • SH3 domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108143, 41 interactors
IntActiQ14195, 12 interactors
STRINGi9606.ENSP00000343690

Structurei

Secondary structure

1570
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi17 – 25Combined sources9
Beta strandi30 – 38Combined sources9
Beta strandi41 – 48Combined sources8
Beta strandi56 – 59Combined sources4
Beta strandi64 – 67Combined sources4
Beta strandi69 – 74Combined sources6
Helixi89 – 98Combined sources10
Beta strandi101 – 108Combined sources8
Helixi116 – 130Combined sources15
Beta strandi132 – 141Combined sources10
Helixi146 – 158Combined sources13
Beta strandi163 – 168Combined sources6
Turni171 – 174Combined sources4
Helixi178 – 191Combined sources14
Beta strandi194 – 198Combined sources5
Helixi202 – 214Combined sources13
Helixi221 – 225Combined sources5
Helixi229 – 245Combined sources17
Beta strandi250 – 255Combined sources6
Helixi258 – 270Combined sources13
Beta strandi274 – 279Combined sources6
Helixi280 – 284Combined sources5
Helixi287 – 291Combined sources5
Helixi295 – 300Combined sources6
Helixi313 – 322Combined sources10
Helixi338 – 341Combined sources4
Helixi342 – 344Combined sources3
Helixi348 – 350Combined sources3
Turni358 – 360Combined sources3
Helixi361 – 369Combined sources9
Turni370 – 373Combined sources4
Helixi377 – 384Combined sources8
Helixi386 – 391Combined sources6
Turni395 – 397Combined sources3
Beta strandi409 – 419Combined sources11
Turni422 – 424Combined sources3
Beta strandi426 – 428Combined sources3
Turni433 – 436Combined sources4
Beta strandi438 – 448Combined sources11
Beta strandi451 – 455Combined sources5
Helixi476 – 487Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BKNX-ray2.10A/B1-570[»]
4CNSX-ray2.40A/B/C/D13-490[»]
4CNTX-ray2.65A/B/C/D1-570[»]
4CNUX-ray2.80A/B1-570[»]
ProteinModelPortaliQ14195
SMRiQ14195
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2584 Eukaryota
COG0044 LUCA
GeneTreeiENSGT00760000119241
HOGENOMiHOG000219145
HOVERGENiHBG000806
InParanoidiQ14195
OMAiYVCSPPP
OrthoDBiEOG091G05F3
PhylomeDBiQ14195
TreeFamiTF314706

Family and domain databases

CDDicd01314 D-HYD, 1 hit
Gene3Di2.30.40.10, 2 hits
InterProiView protein in InterPro
IPR006680 Amidohydro-rel
IPR030628 DRP3
IPR011778 Hydantoinase/dihydroPyrase
IPR011059 Metal-dep_hydrolase_composite
IPR032466 Metal_Hydrolase
PANTHERiPTHR11647:SF57 PTHR11647:SF57, 1 hit
PfamiView protein in Pfam
PF01979 Amidohydro_1, 1 hit
SUPFAMiSSF51338 SSF51338, 2 hits
SSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR02033 D-hydantoinase, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14195-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYQGKKNIP RITSDRLLIK GGRIVNDDQS FYADIYMEDG LIKQIGDNLI
60 70 80 90 100
VPGGVKTIEA NGKMVIPGGI DVHTHFQMPY KGMTTVDDFF QGTKAALAGG
110 120 130 140 150
TTMIIDHVVP EPESSLTEAY EKWREWADGK SCCDYALHVD ITHWNDSVKQ
160 170 180 190 200
EVQNLIKDKG VNSFMVYMAY KDLYQVSNTE LYEIFTCLGE LGAIAQVHAE
210 220 230 240 250
NGDIIAQEQT RMLEMGITGP EGHVLSRPEE LEAEAVFRAI TIASQTNCPL
260 270 280 290 300
YVTKVMSKSA ADLISQARKK GNVVFGEPIT ASLGIDGTHY WSKNWAKAAA
310 320 330 340 350
FVTSPPLSPD PTTPDYINSL LASGDLQLSG SAHCTFSTAQ KAIGKDNFTA
360 370 380 390 400
IPEGTNGVEE RMSVIWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR
410 420 430 440 450
ISVGSDSDLV IWDPDAVKIV SAKNHQSAAE YNIFEGMELR GAPLVVICQG
460 470 480 490 500
KIMLEDGNLH VTQGAGRFIP CSPFSDYVYK RIKARRKMAD LHAVPRGMYD
510 520 530 540 550
GPVFDLTTTP KGGTPAGSAR GSPTRPNPPV RNLHQSGFSL SGTQVDEGVR
560 570
SASKRIVAPP GGRSNITSLS
Length:570
Mass (Da):61,963
Last modified:November 1, 1996 - v1
Checksum:i9D6AFE86CBB33AD5
GO
Isoform LCRMP-4 (identifier: Q14195-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MSYQGKKNIPRIT → MASGRRGWDS...VLQNLGPKDK

Show »
Length:684
Mass (Da):73,911
Checksum:i1729A3ED4DA83D30
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49L → V in CAA69153 (PubMed:9115293).Curated1
Sequence conflicti142T → A in CAA69153 (PubMed:9115293).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020485442A → S. Corresponds to variant dbSNP:rs2304044Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0425461 – 13MSYQG…IPRIT → MASGRRGWDSSHEDDLPVYL ARPGTTDQVPRQKYGGMFCN VEGAFESKTLDFDALSVGQR GAKTPRSGQGSDRGSGSRPG IEGDTPRRGQGREESREPAP ASPAPAGVEIRSATGKEVLQ NLGPKDK in isoform LCRMP-4. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78014 mRNA Translation: BAA11192.1
Y07818 mRNA Translation: CAA69153.1
EU007906 mRNA Translation: ABV80252.1
AC011373 Genomic DNA No translation available.
CCDSiCCDS43381.1 [Q14195-1]
CCDS56387.1 [Q14195-2]
PIRiJC5318
RefSeqiNP_001184223.1, NM_001197294.1 [Q14195-2]
NP_001378.1, NM_001387.2 [Q14195-1]
UniGeneiHs.519659

Genome annotation databases

EnsembliENST00000343218; ENSP00000343690; ENSG00000113657 [Q14195-2]
ENST00000398514; ENSP00000381526; ENSG00000113657 [Q14195-1]
GeneIDi1809
KEGGihsa:1809
UCSCiuc003lon.2 human [Q14195-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDPYL3_HUMAN
AccessioniPrimary (citable) accession number: Q14195
Secondary accession number(s): B3SXQ8, Q93012
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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