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Q14195

- DPYL3_HUMAN

UniProt

Q14195 - DPYL3_HUMAN

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Protein

Dihydropyrimidinase-related protein 3

Gene
DPYSL3, CRMP4, DRP3, ULIP, ULIP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration By similarity.

GO - Molecular functioni

  1. chondroitin sulfate binding Source: UniProtKB
  2. hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides Source: InterPro
  3. SH3 domain binding Source: UniProtKB

GO - Biological processi

  1. actin crosslink formation Source: UniProtKB
  2. actin filament bundle assembly Source: UniProtKB
  3. axon guidance Source: Reactome
  4. cellular response to cytokine stimulus Source: UniProtKB
  5. negative regulation of cell migration Source: UniProtKB
  6. negative regulation of neuron projection development Source: UniProtKB
  7. positive regulation of filopodium assembly Source: UniProtKB
  8. positive regulation of neuron projection development Source: UniProtKB
  9. protein homooligomerization Source: UniProtKB
  10. pyrimidine nucleobase catabolic process Source: InterPro
  11. response to axon injury Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_19199. CRMPs in Sema3A signaling.

Protein family/group databases

MEROPSiM38.976.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 3
Short name:
DRP-3
Alternative name(s):
Collapsin response mediator protein 4
Short name:
CRMP-4
Unc-33-like phosphoprotein 1
Short name:
ULIP-1
Gene namesi
Name:DPYSL3
Synonyms:CRMP4, DRP3, ULIP, ULIP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:3015. DPYSL3.

Subcellular locationi

Cytoplasm By similarity. Cell projectiongrowth cone By similarity
Note: Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone By similarity.

GO - Cellular componenti

  1. cell body Source: UniProtKB
  2. cytosol Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. filamentous actin Source: UniProtKB
  5. growth cone Source: UniProtKB
  6. lamellipodium Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

Orphaneti803. Amyotrophic lateral sclerosis.
PharmGKBiPA27473.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Dihydropyrimidinase-related protein 3PRO_0000165917Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei259 – 2591Phosphoserine1 Publication
Modified residuei431 – 4311Phosphotyrosine By similarity
Modified residuei509 – 5091Phosphothreonine; by GSK32 Publications
Modified residuei514 – 5141Phosphothreonine; by GSK32 Publications
Modified residuei518 – 5181Phosphoserine; by GSK31 Publication
Modified residuei522 – 5221Phosphoserine; by DYRK22 Publications

Post-translational modificationi

Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14195.
PaxDbiQ14195.
PRIDEiQ14195.

2D gel databases

REPRODUCTION-2DPAGEQ14195.
UCD-2DPAGEQ14195.

PTM databases

PhosphoSiteiQ14195.

Expressioni

Tissue specificityi

Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.

Gene expression databases

ArrayExpressiQ14195.
BgeeiQ14195.
CleanExiHS_DPYSL3.
GenevestigatoriQ14195.

Organism-specific databases

HPAiHPA010948.

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5 By similarity. Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin By similarity.

Protein-protein interaction databases

BioGridi108143. 15 interactions.
IntActiQ14195. 1 interaction.
STRINGi9606.ENSP00000381526.

Structurei

Secondary structure

1
570
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi17 – 259
Beta strandi30 – 389
Beta strandi41 – 488
Beta strandi56 – 594
Beta strandi64 – 674
Beta strandi69 – 746
Helixi89 – 9810
Beta strandi101 – 1088
Helixi116 – 13015
Beta strandi132 – 14110
Helixi146 – 15813
Beta strandi163 – 1686
Turni171 – 1744
Helixi178 – 19114
Beta strandi194 – 1985
Helixi202 – 21413
Helixi221 – 2255
Helixi229 – 24517
Beta strandi250 – 2556
Helixi258 – 27013
Beta strandi274 – 2796
Helixi280 – 2845
Helixi287 – 2915
Helixi295 – 3006
Helixi313 – 32210
Helixi338 – 3414
Helixi342 – 3443
Helixi348 – 3503
Turni358 – 3603
Helixi361 – 3699
Turni370 – 3734
Helixi377 – 3848
Helixi386 – 3916
Turni395 – 3973
Beta strandi409 – 41911
Turni422 – 4243
Beta strandi426 – 4283
Turni433 – 4364
Beta strandi438 – 44811
Beta strandi451 – 4555
Helixi476 – 48712

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BKNX-ray2.10A/B1-570[»]
4CNSX-ray2.40A/B/C/D13-490[»]
4CNUX-ray2.80A/B1-570[»]
ProteinModelPortaliQ14195.
SMRiQ14195. Positions 13-496.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0044.
HOGENOMiHOG000219145.
HOVERGENiHBG000806.
OMAiTPRSSQG.
OrthoDBiEOG7SJD48.
PhylomeDBiQ14195.
TreeFamiTF314706.

Family and domain databases

Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro_1.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR02033. D-hydantoinase. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14195-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSYQGKKNIP RITSDRLLIK GGRIVNDDQS FYADIYMEDG LIKQIGDNLI    50
VPGGVKTIEA NGKMVIPGGI DVHTHFQMPY KGMTTVDDFF QGTKAALAGG 100
TTMIIDHVVP EPESSLTEAY EKWREWADGK SCCDYALHVD ITHWNDSVKQ 150
EVQNLIKDKG VNSFMVYMAY KDLYQVSNTE LYEIFTCLGE LGAIAQVHAE 200
NGDIIAQEQT RMLEMGITGP EGHVLSRPEE LEAEAVFRAI TIASQTNCPL 250
YVTKVMSKSA ADLISQARKK GNVVFGEPIT ASLGIDGTHY WSKNWAKAAA 300
FVTSPPLSPD PTTPDYINSL LASGDLQLSG SAHCTFSTAQ KAIGKDNFTA 350
IPEGTNGVEE RMSVIWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR 400
ISVGSDSDLV IWDPDAVKIV SAKNHQSAAE YNIFEGMELR GAPLVVICQG 450
KIMLEDGNLH VTQGAGRFIP CSPFSDYVYK RIKARRKMAD LHAVPRGMYD 500
GPVFDLTTTP KGGTPAGSAR GSPTRPNPPV RNLHQSGFSL SGTQVDEGVR 550
SASKRIVAPP GGRSNITSLS 570
Length:570
Mass (Da):61,963
Last modified:November 1, 1996 - v1
Checksum:i9D6AFE86CBB33AD5
GO
Isoform LCRMP-4 (identifier: Q14195-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MSYQGKKNIPRIT → MASGRRGWDS...VLQNLGPKDK

Note: Contains a phosphoserine at position 102.

Show »
Length:684
Mass (Da):73,911
Checksum:i1729A3ED4DA83D30
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti442 – 4421A → S.
Corresponds to variant rs2304044 [ dbSNP | Ensembl ].
VAR_020485

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1313MSYQG…IPRIT → MASGRRGWDSSHEDDLPVYL ARPGTTDQVPRQKYGGMFCN VEGAFESKTLDFDALSVGQR GAKTPRSGQGSDRGSGSRPG IEGDTPRRGQGREESREPAP ASPAPAGVEIRSATGKEVLQ NLGPKDK in isoform LCRMP-4. VSP_042546Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491L → V in CAA69153. 1 Publication
Sequence conflicti142 – 1421T → A in CAA69153. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D78014 mRNA. Translation: BAA11192.1.
Y07818 mRNA. Translation: CAA69153.1.
EU007906 mRNA. Translation: ABV80252.1.
AC011373 Genomic DNA. No translation available.
CCDSiCCDS43381.1. [Q14195-1]
CCDS56387.1. [Q14195-2]
PIRiJC5318.
RefSeqiNP_001184223.1. NM_001197294.1. [Q14195-2]
NP_001378.1. NM_001387.2. [Q14195-1]
UniGeneiHs.519659.

Genome annotation databases

EnsembliENST00000343218; ENSP00000343690; ENSG00000113657. [Q14195-2]
ENST00000398514; ENSP00000381526; ENSG00000113657. [Q14195-1]
GeneIDi1809.
KEGGihsa:1809.
UCSCiuc003lon.1. human. [Q14195-1]
uc003loo.3. human. [Q14195-2]

Polymorphism databases

DMDMi3122050.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D78014 mRNA. Translation: BAA11192.1 .
Y07818 mRNA. Translation: CAA69153.1 .
EU007906 mRNA. Translation: ABV80252.1 .
AC011373 Genomic DNA. No translation available.
CCDSi CCDS43381.1. [Q14195-1 ]
CCDS56387.1. [Q14195-2 ]
PIRi JC5318.
RefSeqi NP_001184223.1. NM_001197294.1. [Q14195-2 ]
NP_001378.1. NM_001387.2. [Q14195-1 ]
UniGenei Hs.519659.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BKN X-ray 2.10 A/B 1-570 [» ]
4CNS X-ray 2.40 A/B/C/D 13-490 [» ]
4CNU X-ray 2.80 A/B 1-570 [» ]
ProteinModelPortali Q14195.
SMRi Q14195. Positions 13-496.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108143. 15 interactions.
IntActi Q14195. 1 interaction.
STRINGi 9606.ENSP00000381526.

Protein family/group databases

MEROPSi M38.976.

PTM databases

PhosphoSitei Q14195.

Polymorphism databases

DMDMi 3122050.

2D gel databases

REPRODUCTION-2DPAGE Q14195.
UCD-2DPAGE Q14195.

Proteomic databases

MaxQBi Q14195.
PaxDbi Q14195.
PRIDEi Q14195.

Protocols and materials databases

DNASUi 1809.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000343218 ; ENSP00000343690 ; ENSG00000113657 . [Q14195-2 ]
ENST00000398514 ; ENSP00000381526 ; ENSG00000113657 . [Q14195-1 ]
GeneIDi 1809.
KEGGi hsa:1809.
UCSCi uc003lon.1. human. [Q14195-1 ]
uc003loo.3. human. [Q14195-2 ]

Organism-specific databases

CTDi 1809.
GeneCardsi GC05M146750.
HGNCi HGNC:3015. DPYSL3.
HPAi HPA010948.
MIMi 601168. gene.
neXtProti NX_Q14195.
Orphaneti 803. Amyotrophic lateral sclerosis.
PharmGKBi PA27473.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0044.
HOGENOMi HOG000219145.
HOVERGENi HBG000806.
OMAi TPRSSQG.
OrthoDBi EOG7SJD48.
PhylomeDBi Q14195.
TreeFami TF314706.

Enzyme and pathway databases

Reactomei REACT_19199. CRMPs in Sema3A signaling.

Miscellaneous databases

ChiTaRSi DPYSL3. human.
GeneWikii DPYSL3.
GenomeRNAii 1809.
NextBioi 7373.
PROi Q14195.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q14195.
Bgeei Q14195.
CleanExi HS_DPYSL3.
Genevestigatori Q14195.

Family and domain databases

Gene3Di 2.30.40.10. 2 hits.
InterProi IPR006680. Amidohydro_1.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view ]
Pfami PF01979. Amidohydro_1. 1 hit.
[Graphical view ]
SUPFAMi SSF51338. SSF51338. 2 hits.
TIGRFAMsi TIGR02033. D-hydantoinase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution."
    Hamajima N., Matsuda K., Sakata S., Tamaki N., Sasaki M., Nonaka M.
    Gene 180:157-163(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene (hUlip) from neuroblastoma cells."
    Gaetano C., Matsuo T., Thiele C.J.
    J. Biol. Chem. 272:12195-12201(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Long form collapsin response mediator protein-1 (LCRMP-1) is a novel invasion enhancer: counter-regulation of cancer cell invasion by LCRMP-1 and CRMP-1."
    Pan S.-H., Hong T.-M., Chao Y.-C., Yang S.-C., Yang P.-C.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LCRMP-4).
  4. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 24-56; 82-122; 131-157; 239-254; 259-268; 346-368; 375-397; 401-418; 424-440; 452-480; 488-511 AND 532-550, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102 (ISOFORM LCRMP-4), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo."
    Cole A.R., Causeret F., Yadirgi G., Hastie C.J., McLauchlan H., McManus E.J., Hernandez F., Eickholt B.J., Nikolic M., Sutherland C.
    J. Biol. Chem. 281:16591-16598(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-522 BY DYRK2, PHOSPHORYLATION AT THR-509; THR-514 AND SER-518 BY GSK3.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-259; THR-509; THR-514 AND SER-522, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102 (ISOFORM LCRMP-4), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDPYL3_HUMAN
AccessioniPrimary (citable) accession number: Q14195
Secondary accession number(s): B3SXQ8, Q93012
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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