Reviewed, UniProtKB/Swiss-Prot Q14195 (DPYL3_HUMAN)

Names and origin

Protein names

Recommended name:
Dihydropyrimidinase-related protein 3
Short name=DRP-3

Alternative name(s):
Unc-33-like phosphoprotein 1
Short name=ULIP-1
Collapsin response mediator protein 4
Short name=CRMP-4

Gene names

Name:	DPYSL3
Synonyms:	CRMP4, DRP3, ULIP, ULIP1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	570 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration By similarity.
Subunit structure	Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5 By similarity. Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin By similarity.
Subcellular location	Cytoplasm By similarity. Cell projection › growth cone By similarity. Note: Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone By similarity.
Tissue specificity	Mainly in heart and skeletal muscle. Also expressed strongly in fetal brain and spinal cord.
Sequence similarities	Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
Caution	Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.

Ontologies

Keywords
Cellular component	Cell projection Cytoplasm
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process Ref.1 Traceable author statement. Source: ProtInc nervous system development Ref.2 Traceable author statement. Source: ProtInc signal transduction Ref.2 Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from direct assay. Source: HPA cytoskeleton Inferred from direct assay. Source: HPA growth cone Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from direct assay. Source: HPA
Molecular function	dihydropyrimidinase activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 570	570	Dihydropyrimidinase-related protein 3		PRO_0000165917
Amino acid modifications
	Modified residue	499	1	Phosphotyrosine By similarity
	Modified residue	509	1	Phosphothreonine By similarity
	Modified residue	514	1	Phosphothreonine By similarity
	Modified residue	518	1	Phosphoserine By similarity
	Modified residue	522	1	Phosphoserine Ref.4
	Modified residue	541	1	Phosphoserine By similarity
	Modified residue	551	1	Phosphoserine Ref.4
Natural variations
	Natural variant	442	1	A → S: dbSNP rs2304044.		VAR_020485
Experimental info
	Sequence conflict	49	1	L → V in CAA69153. Ref.2
	Sequence conflict	142	1	T → A in CAA69153. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q14195-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 9D6AFE86CBB33AD5	FASTA	570	61,963
	10 20 30 40 50 60 MSYQGKKNIP RITSDRLLIK GGRIVNDDQS FYADIYMEDG LIKQIGDNLI VPGGVKTIEA 70 80 90 100 110 120 NGKMVIPGGI DVHTHFQMPY KGMTTVDDFF QGTKAALAGG TTMIIDHVVP EPESSLTEAY 130 140 150 160 170 180 EKWREWADGK SCCDYALHVD ITHWNDSVKQ EVQNLIKDKG VNSFMVYMAY KDLYQVSNTE 190 200 210 220 230 240 LYEIFTCLGE LGAIAQVHAE NGDIIAQEQT RMLEMGITGP EGHVLSRPEE LEAEAVFRAI 250 260 270 280 290 300 TIASQTNCPL YVTKVMSKSA ADLISQARKK GNVVFGEPIT ASLGIDGTHY WSKNWAKAAA 310 320 330 340 350 360 FVTSPPLSPD PTTPDYINSL LASGDLQLSG SAHCTFSTAQ KAIGKDNFTA IPEGTNGVEE 370 380 390 400 410 420 RMSVIWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR ISVGSDSDLV IWDPDAVKIV 430 440 450 460 470 480 SAKNHQSAAE YNIFEGMELR GAPLVVICQG KIMLEDGNLH VTQGAGRFIP CSPFSDYVYK 490 500 510 520 530 540 RIKARRKMAD LHAVPRGMYD GPVFDLTTTP KGGTPAGSAR GSPTRPNPPV RNLHQSGFSL 550 560 570 SGTQVDEGVR SASKRIVAPP GGRSNITSLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution." Hamajima N., Matsuda K., Sakata S., Tamaki N., Sasaki M., Nonaka M. Gene 180:157-163(1996) [PubMed: 8973361] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene (hUlip) from neuroblastoma cells." Gaetano C., Matsuo T., Thiele C.J. J. Biol. Chem. 272:12195-12201(1997) [PubMed: 9115293] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[3]	Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y. Submitted (DEC-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 24-56; 82-122; 131-157; 239-254; 259-268; 346-368; 375-397; 401-418; 424-440; 452-480; 488-511 AND 532-550, MASS SPECTROMETRY. Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-522 AND SER-551, MASS SPECTROMETRY. Tissue: Epithelium.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D78014 mRNA. Translation: BAA11192.1. Y07818 mRNA. Translation: CAA69153.1.
IPI	IPI00872788.
PIR	JC5318.
RefSeq	NP_001378.1.
UniGene	Hs.519659
3D structure databases
SMR	Q14195. Positions 15-489.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14195. 1 interaction.
STRING	Q14195.
Protein family/group databases
MEROPS	M38.976.
2-D gel databases
REPRODUCTION-2DPAGE	Q14195.
Proteomic databases
PRIDE	Q14195.
Genome annotation databases
Ensembl	ENST00000398514; ENSP00000381526; ENSG00000113657; Homo sapiens. [Genome view]
GeneID	1809.
KEGG	hsa:1809.
UCSC	uc003lon.1. human.
Organism-specific databases
CTD	1809.
GeneCards	GC05M146750.
H-InvDB	HIX0024842.
HGNC	HGNC:3015. DPYSL3.
HPA	HPA010948.
MIM	601168. gene.
PharmGKB	PA27473.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG04131.
HOVERGEN	HBG000806.
PhylomeDB	Q14195.
Enzyme and pathway databases
Reactome	REACT_18266. Axon guidance.
Gene expression databases
ArrayExpress	Q14195.
Bgee	Q14195.
CleanEx	HS_DPYSL3.
Genevestigator	Q14195.
GermOnline	ENSG00000113657. Homo sapiens.
Family and domain databases
InterPro	IPR006680. Amidohydro_1. IPR011778. D-hydantoinase. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
SUPFAM	SSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMs	TIGR02033. D-hydantoinase. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	7373.
SOURCE	Search...

Entry information

Entry name

DPYL3_HUMAN

Accession

Primary (citable) accession number: Q14195
Secondary accession number(s): Q93012

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	March 2, 2010
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.