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Protein

Dihydropyrimidinase-related protein 1

Gene

CRMP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.2 Publications

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: InterPro
  • microtubule cytoskeleton organization Source: InterPro
  • negative regulation of actin filament binding Source: WormBase
  • negative regulation of neuron projection development Source: WormBase
  • nervous system development Source: ProtInc
  • nucleobase-containing compound metabolic process Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000072832-MONOMER.
ReactomeiR-HSA-399956. CRMPs in Sema3A signaling.
SIGNORiQ14194.

Protein family/group databases

MEROPSiM38.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidinase-related protein 1
Short name:
DRP-1
Alternative name(s):
Collapsin response mediator protein 1
Short name:
CRMP-1
Unc-33-like phosphoprotein 3
Short name:
ULIP-3
Gene namesi
Name:CRMP1
Synonyms:DPYSL1, ULIP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:2365. CRMP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi101 – 102TT → AA: 2.5-fold increase in cells with a defect of cytokinesis. 1 Publication2

Organism-specific databases

DisGeNETi1400.
OpenTargetsiENSG00000072832.
PharmGKBiPA26885.

Polymorphism and mutation databases

BioMutaiCRMP1.
DMDMi3122031.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001659091 – 572Dihydropyrimidinase-related protein 1Add BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1
Modified residuei32PhosphotyrosineBy similarity1
Modified residuei101Phosphothreonine; by AURKA1 Publication1
Modified residuei102Phosphothreonine; by AURKA1 Publication1
Modified residuei258N6-succinyllysineBy similarity1
Modified residuei259PhosphoserineBy similarity1
Modified residuei316Nitrated tyrosineBy similarity1
Modified residuei431PhosphotyrosineBy similarity1
Modified residuei499PhosphotyrosineBy similarity1
Modified residuei509PhosphothreonineBy similarity1
Modified residuei514PhosphothreonineBy similarity1
Modified residuei518PhosphoserineBy similarity1
Modified residuei521PhosphoserineBy similarity1
Modified residuei522PhosphoserineBy similarity1
Modified residuei537PhosphoserineBy similarity1
Modified residuei540PhosphoserineBy similarity1
Modified residuei542PhosphoserineBy similarity1
Modified residuei565Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation, Nitration, Phosphoprotein

Proteomic databases

EPDiQ14194.
MaxQBiQ14194.
PaxDbiQ14194.
PeptideAtlasiQ14194.
PRIDEiQ14194.

PTM databases

iPTMnetiQ14194.
PhosphoSitePlusiQ14194.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSG00000072832.
CleanExiHS_CRMP1.
ExpressionAtlasiQ14194. baseline and differential.
GenevisibleiQ14194. HS.

Organism-specific databases

HPAiCAB037313.
HPA035640.

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5. Interacts with PLXNA1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AP3M1Q9Y2T25EBI-473101,EBI-2371151
AXIN1O151692EBI-473101,EBI-710484
DPYSL2Q165553EBI-473101,EBI-1104711
DPYSL3Q14195-25EBI-473101,EBI-10232496
HTTP428582EBI-473101,EBI-466029
VIMP086703EBI-473101,EBI-353844

GO - Molecular functioni

  • filamin binding Source: WormBase

Protein-protein interaction databases

BioGridi107790. 98 interactors.
IntActiQ14194. 74 interactors.
MINTiMINT-1423114.
STRINGi9606.ENSP00000321606.

Structurei

Secondary structure

1572
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi16 – 25Combined sources10
Beta strandi30 – 38Combined sources9
Beta strandi41 – 48Combined sources8
Beta strandi53 – 59Combined sources7
Beta strandi64 – 67Combined sources4
Beta strandi69 – 74Combined sources6
Helixi89 – 99Combined sources11
Beta strandi101 – 108Combined sources8
Helixi116 – 130Combined sources15
Beta strandi132 – 140Combined sources9
Helixi148 – 157Combined sources10
Beta strandi163 – 170Combined sources8
Turni171 – 174Combined sources4
Helixi178 – 190Combined sources13
Beta strandi194 – 198Combined sources5
Helixi202 – 213Combined sources12
Turni214 – 216Combined sources3
Helixi221 – 225Combined sources5
Helixi229 – 246Combined sources18
Beta strandi250 – 255Combined sources6
Helixi258 – 270Combined sources13
Beta strandi274 – 279Combined sources6
Helixi280 – 284Combined sources5
Helixi288 – 291Combined sources4
Helixi295 – 300Combined sources6
Helixi313 – 322Combined sources10
Helixi338 – 341Combined sources4
Helixi342 – 344Combined sources3
Helixi348 – 350Combined sources3
Turni358 – 360Combined sources3
Helixi361 – 369Combined sources9
Turni370 – 373Combined sources4
Helixi377 – 384Combined sources8
Helixi386 – 391Combined sources6
Turni395 – 397Combined sources3
Beta strandi409 – 419Combined sources11
Beta strandi426 – 430Combined sources5
Turni433 – 436Combined sources4
Beta strandi438 – 448Combined sources11
Beta strandi451 – 455Combined sources5
Helixi476 – 489Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B3ZX-ray3.05A/B/C/D1-572[»]
ProteinModelPortaliQ14194.
SMRiQ14194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2584. Eukaryota.
COG0044. LUCA.
GeneTreeiENSGT00760000119241.
HOGENOMiHOG000219145.
HOVERGENiHBG000806.
InParanoidiQ14194.
OMAiGINSFQV.
PhylomeDBiQ14194.
TreeFamiTF314706.

Family and domain databases

CDDicd01314. D-HYD. 1 hit.
Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR030624. CRMP1.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PANTHERiPTHR11647:SF54. PTHR11647:SF54. 1 hit.
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR02033. D-hydantoinase. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14194-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYQGKKSIP HITSDRLLIK GGRIINDDQS LYADVYLEDG LIKQIGENLI
60 70 80 90 100
VPGGVKTIEA NGRMVIPGGI DVNTYLQKPS QGMTAADDFF QGTRAALVGG
110 120 130 140 150
TTMIIDHVVP EPGSSLLTSF EKWHEAADTK SCCDYSLHVD ITSWYDGVRE
160 170 180 190 200
ELEVLVQDKG VNSFQVYMAY KDVYQMSDSQ LYEAFTFLKG LGAVILVHAE
210 220 230 240 250
NGDLIAQEQK RILEMGITGP EGHALSRPEE LEAEAVFRAI TIAGRINCPV
260 270 280 290 300
YITKVMSKSA ADIIALARKK GPLVFGEPIA ASLGTDGTHY WSKNWAKAAA
310 320 330 340 350
FVTSPPLSPD PTTPDYLTSL LACGDLQVTG SGHCPYSTAQ KAVGKDNFTL
360 370 380 390 400
IPEGVNGIEE RMTVVWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR
410 420 430 440 450
IAVGSDADVV IWDPDKLKTI TAKSHKSAVE YNIFEGMECH GSPLVVISQG
460 470 480 490 500
KIVFEDGNIN VNKGMGRFIP RKAFPEHLYQ RVKIRNKVFG LQGVSRGMYD
510 520 530 540 550
GPVYEVPATP KYATPAPSAK SSPSKHQPPP IRNLHQSNFS LSGAQIDDNN
560 570
PRRTGHRIVA PPGGRSNITS LG
Length:572
Mass (Da):62,184
Last modified:November 1, 1996 - v1
Checksum:iA5385FCC79328A30
GO
Isoform LCRMP-1 (identifier: Q14194-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MSYQGKKSIPHIT → MADRRRAWNT...DLPLGRDNGQ

Show »
Length:686
Mass (Da):74,262
Checksum:i2C897F656E5F34FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti351 – 370Missing in AAK55500 (PubMed:10048489).CuratedAdd BLAST20
Sequence conflicti504Y → H in AAA93201 (PubMed:7637782).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037745461V → I.Corresponds to variant rs34611001dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0425451 – 13MSYQG…IPHIT → MADRRRAWNTEDDLPVYLAR PGSAAQTPRQKYGGMFAAVE GAYENKTIDFDAYSVGRRGS ARTPRSAGRPDAVGLPGPGG SEDTASDVSEPSGSAVSSPG ERDERPPTLRIRRPAPRDLP LGRDNGQ in isoform LCRMP-1. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78012 mRNA. Translation: BAA11190.1.
DQ206871 mRNA. Translation: ABB22046.1.
BT006806 mRNA. Translation: AAP35452.1.
AC105915 Genomic DNA. Translation: AAY40959.1.
CH471131 Genomic DNA. Translation: EAW82405.1.
CH471131 Genomic DNA. Translation: EAW82407.1.
BC000252 mRNA. Translation: AAH00252.1.
BC007613 mRNA. Translation: AAH07613.1.
AH010780 Genomic DNA. Translation: AAK55500.1.
U17278 mRNA. Translation: AAA93201.1.
CCDSiCCDS33950.1. [Q14194-2]
CCDS43207.1. [Q14194-1]
PIRiJC5316.
RefSeqiNP_001014809.1. NM_001014809.2. [Q14194-2]
NP_001275590.1. NM_001288661.1.
NP_001275591.1. NM_001288662.1.
NP_001304.1. NM_001313.4. [Q14194-1]
UniGeneiHs.135270.

Genome annotation databases

EnsembliENST00000324989; ENSP00000321606; ENSG00000072832. [Q14194-2]
ENST00000397890; ENSP00000380987; ENSG00000072832. [Q14194-1]
GeneIDi1400.
KEGGihsa:1400.
UCSCiuc003giq.5. human. [Q14194-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78012 mRNA. Translation: BAA11190.1.
DQ206871 mRNA. Translation: ABB22046.1.
BT006806 mRNA. Translation: AAP35452.1.
AC105915 Genomic DNA. Translation: AAY40959.1.
CH471131 Genomic DNA. Translation: EAW82405.1.
CH471131 Genomic DNA. Translation: EAW82407.1.
BC000252 mRNA. Translation: AAH00252.1.
BC007613 mRNA. Translation: AAH07613.1.
AH010780 Genomic DNA. Translation: AAK55500.1.
U17278 mRNA. Translation: AAA93201.1.
CCDSiCCDS33950.1. [Q14194-2]
CCDS43207.1. [Q14194-1]
PIRiJC5316.
RefSeqiNP_001014809.1. NM_001014809.2. [Q14194-2]
NP_001275590.1. NM_001288661.1.
NP_001275591.1. NM_001288662.1.
NP_001304.1. NM_001313.4. [Q14194-1]
UniGeneiHs.135270.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4B3ZX-ray3.05A/B/C/D1-572[»]
ProteinModelPortaliQ14194.
SMRiQ14194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107790. 98 interactors.
IntActiQ14194. 74 interactors.
MINTiMINT-1423114.
STRINGi9606.ENSP00000321606.

Protein family/group databases

MEROPSiM38.974.

PTM databases

iPTMnetiQ14194.
PhosphoSitePlusiQ14194.

Polymorphism and mutation databases

BioMutaiCRMP1.
DMDMi3122031.

Proteomic databases

EPDiQ14194.
MaxQBiQ14194.
PaxDbiQ14194.
PeptideAtlasiQ14194.
PRIDEiQ14194.

Protocols and materials databases

DNASUi1400.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324989; ENSP00000321606; ENSG00000072832. [Q14194-2]
ENST00000397890; ENSP00000380987; ENSG00000072832. [Q14194-1]
GeneIDi1400.
KEGGihsa:1400.
UCSCiuc003giq.5. human. [Q14194-1]

Organism-specific databases

CTDi1400.
DisGeNETi1400.
GeneCardsiCRMP1.
HGNCiHGNC:2365. CRMP1.
HPAiCAB037313.
HPA035640.
MIMi602462. gene.
neXtProtiNX_Q14194.
OpenTargetsiENSG00000072832.
PharmGKBiPA26885.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2584. Eukaryota.
COG0044. LUCA.
GeneTreeiENSGT00760000119241.
HOGENOMiHOG000219145.
HOVERGENiHBG000806.
InParanoidiQ14194.
OMAiGINSFQV.
PhylomeDBiQ14194.
TreeFamiTF314706.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000072832-MONOMER.
ReactomeiR-HSA-399956. CRMPs in Sema3A signaling.
SIGNORiQ14194.

Miscellaneous databases

ChiTaRSiCRMP1. human.
GeneWikiiCRMP1.
GenomeRNAii1400.
PROiQ14194.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000072832.
CleanExiHS_CRMP1.
ExpressionAtlasiQ14194. baseline and differential.
GenevisibleiQ14194. HS.

Family and domain databases

CDDicd01314. D-HYD. 1 hit.
Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR030624. CRMP1.
IPR011778. Hydantoinase/dihydroPyrase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PANTHERiPTHR11647:SF54. PTHR11647:SF54. 1 hit.
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR02033. D-hydantoinase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDPYL1_HUMAN
AccessioniPrimary (citable) accession number: Q14194
Secondary accession number(s): A0EJG6
, Q13024, Q4W5F1, Q96TC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 168 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.