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Reviewed, UniProtKB/Swiss-Prot Q14194 (DPYL1_HUMAN)

Last modified November 3, 2009. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dihydropyrimidinase-related protein 1
      Short name=DRP-1
Alternative name(s):
    Collapsin response mediator protein 1
      Short name=CRMP-1
Gene names
Name: CRMP1
Synonyms: DPYSL1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Ref.8

Subunit structure

Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5. Interacts with PLXNA1 By similarity.

Subcellular location

Cytoplasm. Cytoplasmcytoskeletoncentrosome. Cytoplasmcytoskeletonspindle. Note: Associated with centrosomes and the mitotic spindle during metaphase. Ref.8

Tissue specificity

Brain.

Sequence similarities

Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

Caution

Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.

Ontologies

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 572572Dihydropyrimidinase-related protein 1
PRO_0000165909

Amino acid modifications

Modified residue4311Phosphotyrosine By similarity
Modified residue5041Phosphotyrosine By similarity
Modified residue5091Phosphothreonine By similarity

Natural variations

Natural variant4611V → I: dbSNP rs34611001.
VAR_037745

Experimental info

Sequence conflict351 – 37020Missing in AAK55500. Ref.4
Sequence conflict5041Y → H in AAA93201. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q14194-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: A5385FCC79328A30

FASTA57262,184
        10         20         30         40         50         60 
MSYQGKKSIP HITSDRLLIK GGRIINDDQS LYADVYLEDG LIKQIGENLI VPGGVKTIEA 

        70         80         90        100        110        120 
NGRMVIPGGI DVNTYLQKPS QGMTAADDFF QGTRAALVGG TTMIIDHVVP EPGSSLLTSF 

       130        140        150        160        170        180 
EKWHEAADTK SCCDYSLHVD ITSWYDGVRE ELEVLVQDKG VNSFQVYMAY KDVYQMSDSQ 

       190        200        210        220        230        240 
LYEAFTFLKG LGAVILVHAE NGDLIAQEQK RILEMGITGP EGHALSRPEE LEAEAVFRAI 

       250        260        270        280        290        300 
TIAGRINCPV YITKVMSKSA ADIIALARKK GPLVFGEPIA ASLGTDGTHY WSKNWAKAAA 

       310        320        330        340        350        360 
FVTSPPLSPD PTTPDYLTSL LACGDLQVTG SGHCPYSTAQ KAVGKDNFTL IPEGVNGIEE 

       370        380        390        400        410        420 
RMTVVWDKAV ATGKMDENQF VAVTSTNAAK IFNLYPRKGR IAVGSDADVV IWDPDKLKTI 

       430        440        450        460        470        480 
TAKSHKSAVE YNIFEGMECH GSPLVVISQG KIVFEDGNIN VNKGMGRFIP RKAFPEHLYQ 

       490        500        510        520        530        540 
RVKIRNKVFG LQGVSRGMYD GPVYEVPATP KYATPAPSAK SSPSKHQPPP IRNLHQSNFS 

       550        560        570 
LSGAQIDDNN PRRTGHRIVA PPGGRSNITS LG 

« Hide

References

« Hide 'large scale' references
[1]"A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution."
Hamajima N., Matsuda K., Sakata S., Tamaki N., Sasaki M., Nonaka M.
Gene 180:157-163(1996) [PubMed: 8973361] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[4]"Genomic organization and localization of the human CRMP-1 gene."
Torres R., Polymeropoulos M.H.
DNA Res. 5:393-395(1998) [PubMed: 10048489] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 14-572.
[5]"Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33."
Goshima Y., Nakamura F., Strittmatter P., Strittmatter S.M.
Nature 376:509-514(1995) [PubMed: 7637782] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 64-572.
Tissue: Brain.
[6]Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y.
Submitted (DEC-2008) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 44-56; 190-210; 246-254; 259-268; 346-361; 391-397; 452-463; 472-481; 488-511 AND 533-552, MASS SPECTROMETRY.
Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
[7]"Brain CRMP forms heterotetramers similar to liver dihydropyrimidinase."
Wang L.H., Strittmatter S.M.
J. Neurochem. 69:2261-2269(1997) [PubMed: 9375656] [Abstract]
Cited for: SUBUNIT, INTERACTION WITH DPYSL2 AND DPYSL4.
[8]"Collapsin response mediator protein-1 and the invasion and metastasis of cancer cells."
Shih J.-Y., Yang S.-C., Hong T.-M., Yuan A., Chen J.J.W., Yu C.-J., Chang Y.-L., Lee Y.-C., Peck K., Wu C.-W., Yang P.-C.
J. Natl. Cancer Inst. 93:1392-1400(2001) [PubMed: 11562390] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

D78012 mRNA. Translation: BAA11190.1.
BT006806 mRNA. Translation: AAP35452.1.
BC000252 mRNA. Translation: AAH00252.1.
BC007613 mRNA. Translation: AAH07613.1.
AF096152 expand/collapse EMBL AC list , AF096140, AF096141, AF096142, AF096143, AF096144, AF096145, AF096146, AF096147, AF096148, AF096149, AF096150, AF096151 Genomic DNA. Translation: AAK55500.1.
U17278 mRNA. Translation: AAA93201.1.
IPIIPI00414123.
PIRJC5316.
RefSeqNP_001304.1.
UniGeneHs.135270

3D structure databases

HSSPHSSP built from PDB template 1K1D based on UniProtKB Q45515.
SMRQ14194. Positions 15-490.
ModBaseSearch...

Protein-protein interaction databases

IntActQ14194. 54 interactions.
STRINGQ14194.

Protein family/group databases

MEROPSM38.974.

PTM databases

PhosphoSiteQ14194.

Proteomic databases

PRIDEQ14194.

Genome annotation databases

EnsemblENST00000324989; ENSP00000321606; ENSG00000072832; Homo sapiens. [Genome view]
ENST00000397890; ENSP00000380987; ENSG00000072832; Homo sapiens. [Genome view]
GeneID1400.
UCSCuc003gip.1. human.

Organism-specific databases

CTD1400.
GeneCardsGC04M005940.
H-InvDBHIX0004057.
HGNCHGNC:2365. CRMP1.
MIM602462. gene.
PharmGKBPA26885.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ14194.
HOVERGENQ14194.

Enzyme and pathway databases

ReactomeREACT_18266. Axon guidance.

Gene expression databases

ArrayExpressQ14194.
BgeeQ14194.
CleanExHS_CRMP1.
GenevestigatorQ14194.
GermOnlineENSG00000072832. Homo sapiens.

Family and domain databases

InterProIPR006680. Amidohydro_1.
IPR011778. D-hydantoinase.
[Graphical view]
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
ProDomPD000518. DHOase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR02033. D-hydantoinase. 1 hit.
ProtoNetSearch...

Other Resources

NextBio5731.
SOURCESearch...

Entry information

Entry nameDPYL1_HUMAN
AccessionPrimary (citable) accession number: Q14194
Secondary accession number(s): Q13024, Q96TC8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 3, 2009
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents