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Q14185

- DOCK1_HUMAN

UniProt

Q14185 - DOCK1_HUMAN

Protein

Dedicator of cytokinesis protein 1

Gene

DOCK1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.1 Publication

    GO - Molecular functioni

    1. GTPase activator activity Source: ProtInc
    2. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. apoptotic process Source: ProtInc
    2. axon guidance Source: Reactome
    3. blood coagulation Source: Reactome
    4. cell migration Source: Ensembl
    5. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
    6. innate immune response Source: Reactome
    7. integrin-mediated signaling pathway Source: ProtInc
    8. phagocytosis, engulfment Source: ProtInc
    9. positive regulation of GTPase activity Source: GOC
    10. signal transduction Source: ProtInc
    11. small GTPase mediated signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Keywords - Biological processi

    Apoptosis, Phagocytosis

    Enzyme and pathway databases

    ReactomeiREACT_160086. Regulation of actin dynamics for phagocytic cup formation.
    REACT_22351. DCC mediated attractive signaling.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dedicator of cytokinesis protein 1
    Alternative name(s):
    180 kDa protein downstream of CRK
    Short name:
    DOCK180
    Gene namesi
    Name:DOCK1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:2987. DOCK1.

    Subcellular locationi

    Cytoplasm Curated. Membrane Curated
    Note: Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate.Curated

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. membrane Source: UniProtKB-SubCell
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1401 – 14022YI → AA: Abolishes Rac GEF activity. 1 Publication
    Mutagenesisi1487 – 14893ISP → AAA: Abolishes Rac GEF activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA27453.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18651865Dedicator of cytokinesis protein 1PRO_0000189984Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1751 – 17511Phosphoserine1 Publication
    Modified residuei1756 – 17561PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ14185.
    PaxDbiQ14185.
    PRIDEiQ14185.

    PTM databases

    PhosphoSiteiQ14185.

    Expressioni

    Tissue specificityi

    Highly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.

    Gene expression databases

    BgeeiQ14185.
    CleanExiHS_DOCK1.
    GenevestigatoriQ14185.

    Organism-specific databases

    HPAiCAB004378.
    HPA048692.
    HPA053277.

    Interactioni

    Subunit structurei

    Interacts with the SH3 domains of CRK and NCK2 via multiple sites. Interacts with nucleotide-free RAC1 via its DHR-2 domain. Interacts with ELMO1, ELMO2 and probably ELMO3 via its SH3 domain. Interacts with RAC1 and BAI1.6 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ANKRD28O150844EBI-446740,EBI-359567
    ELMO1Q9255616EBI-446740,EBI-346417
    GRB2P629932EBI-446740,EBI-401755
    RAC1P6300010EBI-446740,EBI-413628

    Protein-protein interaction databases

    BioGridi108128. 13 interactions.
    DIPiDIP-29391N.
    IntActiQ14185. 13 interactions.
    MINTiMINT-190985.
    STRINGi9606.ENSP00000381107.

    Structurei

    Secondary structure

    1
    1865
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi426 – 43611
    Beta strandi440 – 4445
    Beta strandi448 – 4569
    Beta strandi493 – 4997
    Beta strandi507 – 5159
    Beta strandi528 – 53710
    Beta strandi546 – 55510
    Helixi558 – 5614
    Helixi564 – 5674
    Helixi574 – 5785
    Beta strandi595 – 60814

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3L4CX-ray2.37A/B422-619[»]
    ProteinModelPortaliQ14185.
    SMRiQ14185. Positions 1-168, 425-611, 1192-1617.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ14185.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 7062SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini425 – 609185DHR-1Add
    BLAST
    Domaini1207 – 1617411DHR-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1687 – 16959Phosphoinositide-bindingSequence Analysis
    Regioni1793 – 181927Interaction with NCK2 second and third SH3 domain (minor)Add
    BLAST
    Regioni1820 – 183617Interaction with NCK2 third SH3 domain (major)Add
    BLAST
    Regioni1837 – 185216Interaction with NCK2 (minor)Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1799 – 18057SH3-binding; interaction with CRKSequence Analysis
    Motifi1838 – 18436SH3-binding; interaction with CRKSequence Analysis

    Domaini

    The DHR-2 domain is necessary and sufficient for the GEF activity.

    Sequence similaritiesi

    Belongs to the DOCK family.Curated
    Contains 1 DHR-1 domain.Curated
    Contains 1 DHR-2 domain.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain, SH3-binding

    Phylogenomic databases

    eggNOGiNOG289808.
    HOGENOMiHOG000006631.
    HOVERGENiHBG051389.
    KOiK13708.
    OMAiNYVVKWS.
    OrthoDBiEOG7QNVK8.
    PhylomeDBiQ14185.
    TreeFamiTF300423.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR027007. DHR-1_domain.
    IPR027357. DHR-2.
    IPR026791. DOCK.
    IPR010703. DOCK_C.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR23317. PTHR23317. 1 hit.
    PfamiPF06920. Ded_cyto. 1 hit.
    PF14429. DOCK-C2. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS51650. DHR_1. 1 hit.
    PS51651. DHR_2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q14185-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRWVPTKRE EKYGVAFYNY DARGADELSL QIGDTVHILE TYEGWYRGYT     50
    LRKKSKKGIF PASYIHLKEA IVEGKGQHET VIPGDLPLIQ EVTTTLREWS 100
    TIWRQLYVQD NREMFRSVRH MIYDLIEWRS QILSGTLPQD ELKELKKKVT 150
    AKIDYGNRIL DLDLVVRDED GNILDPELTS TISLFRAHEI ASKQVEERLQ 200
    EEKSQKQNID INRQAKFAAT PSLALFVNLK NVVCKIGEDA EVLMSLYDPV 250
    ESKFISENYL VRWSSSGLPK DIDRLHNLRA VFTDLGSKDL KREKISFVCQ 300
    IVRVGRMELR DNNTRKLTSG LRRPFGVAVM DVTDIINGKV DDEDKQHFIP 350
    FQPVAGENDF LQTVINKVIA AKEVNHKGQG LWVTLKLLPG DIHQIRKEFP 400
    HLVDRTTAVA RKTGFPEIIM PGDVRNDIYV TLVQGDFDKG SKTTAKNVEV 450
    TVSVYDEDGK RLEHVIFPGA GDEAISEYKS VIYYQVKQPR WFETVKVAIP 500
    IEDVNRSHLR FTFRHRSSQD SKDKSEKIFA LAFVKLMRYD GTTLRDGEHD 550
    LIVYKAEAKK LEDAATYLSL PSTKAELEEK GHSATGKSMQ SLGSCTISKD 600
    SFQISTLVCS TKLTQNVDLL GLLKWRSNTS LLQQNLRQLM KVDGGEVVKF 650
    LQDTLDALFN IMMENSESET FDTLVFDALV FIIGLIADRK FQHFNPVLET 700
    YIKKHFSATL AYTKLTKVLK NYVDGAEKPG VNEQLYKAMK ALESIFKFIV 750
    RSRILFNQLY ENKGEADFVE SLLQLFRSIN DMMSSMSDQT VRVKGAALKY 800
    LPTIVNDVKL VFDPKELSKM FTEFILNVPM GLLTIQKLYC LIEIVHSDLF 850
    TQHDCREILL PMMTDQLKYH LERQEDLEAC CQLLSHILEV LYRKDVGPTQ 900
    RHVQIIMEKL LRTVNRTVIS MGRDSELIGN FVACMTAILR QMEDYHYAHL 950
    IKTFGKMRTD VVDFLMETFI MFKNLIGKNV YPFDWVIMNM VQNKVFLRAI 1000
    NQYADMLNKK FLDQANFELQ LWNNYFHLAV AFLTQESLQL ENFSSAKRAK 1050
    ILNKYGDMRR QIGFEIRDMW YNLGQHKIKF IPEMVGPILE MTLIPETELR 1100
    KATIPIFFDM MQCEFHSTRS FQMFENEIIT KLDHEVEGGR GDEQYKVLFD 1150
    KILLEHCRKH KYLAKTGETF VKLVVRLMER LLDYRTIMHD ENKENRMSCT 1200
    VNVLNFYKEI EREEMYIRYL YKLCDLHKEC DNYTEAAYTL LLHAKLLKWS 1250
    EDVCVAHLTQ RDGYQATTQG QLKEQLYQEI IHYFDKGKMW EEAIALGKEL 1300
    AEQYENEMFD YEQLSELLKK QAQFYENIVK VIRPKPDYFA VGYYGQGFPT 1350
    FLRGKVFIYR GKEYERREDF EARLLTQFPN AEKMKTTSPP GDDIKNSPGQ 1400
    YIQCFTVKPK LDLPPKFHRP VSEQIVSFYR VNEVQRFEYS RPIRKGEKNP 1450
    DNEFANMWIE RTIYTTAYKL PGILRWFEVK SVFMVEISPL ENAIETMQLT 1500
    NDKINSMVQQ HLDDPSLPIN PLSMLLNGIV DPAVMGGFAN YEKAFFTDRY 1550
    LQEHPEAHEK IEKLKDLIAW QIPFLAEGIR IHGDKVTEAL RPFHERMEAC 1600
    FKQLKEKVEK EYGVRIMPSS LDDRRGSRPR SMVRSFTMPS SSRPLSVASV 1650
    SSLSSDSTPS RPGSDGFALE PLLPKKMHSR SQDKLDKDDL EKEKKDKKKE 1700
    KRNSKHQEIF EKEFKPTDIS LQQSEAVILS ETISPLRPQR PKSQVMNVIG 1750
    SERRFSVSPS SPSSQQTPPP VTPRAKLSFS MQSSLELNGM TGADVADVPP 1800
    PLPLKGSVAD YGNLMENQDL LGSPTPPPPP PHQRHLPPPL PSKTPPPPPP 1850
    KTTRKQASVD SGIVQ 1865
    Length:1,865
    Mass (Da):215,346
    Last modified:October 14, 2008 - v2
    Checksum:i940C5AFD047EBEDE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1857 – 18571A → T in BAA09454. (PubMed:8657152)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1793 – 17931A → T.
    Corresponds to variant rs869801 [ dbSNP | Ensembl ].
    VAR_059971

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50857 mRNA. Translation: BAA09454.1.
    AL157711
    , AL355316, AL359094, AL390920, AL607029, BX470155, BX470201 Genomic DNA. Translation: CAH71463.2.
    AL359094
    , AL157711, AL355316, AL390920, AL607029, BX470155, BX470201 Genomic DNA. Translation: CAH71477.2.
    BX470201
    , AL157711, AL355316, AL359094, AL390920, AL607029, BX470155 Genomic DNA. Translation: CAH72560.2.
    AL390920
    , AL157711, AL355316, AL359094, AL607029, BX470155, BX470201 Genomic DNA. Translation: CAH73231.2.
    AL607029
    , AL157711, AL355316, AL359094, AL390920, BX470155, BX470201 Genomic DNA. Translation: CAI15329.2.
    AL355316
    , AL157711, AL359094, AL390920, AL607029, BX470155, BX470201 Genomic DNA. Translation: CAI16871.2.
    BX470155
    , AL157711, AL355316, AL359094, AL390920, AL607029, BX470201 Genomic DNA. Translation: CAI22477.2.
    RefSeqiNP_001371.1. NM_001380.4.
    UniGeneiHs.159195.

    Genome annotation databases

    EnsembliENST00000280333; ENSP00000280333; ENSG00000150760.
    GeneIDi1793.
    KEGGihsa:1793.
    UCSCiuc001ljt.3. human.

    Polymorphism databases

    DMDMi209572608.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50857 mRNA. Translation: BAA09454.1 .
    AL157711
    , AL355316 , AL359094 , AL390920 , AL607029 , BX470155 , BX470201 Genomic DNA. Translation: CAH71463.2 .
    AL359094
    , AL157711 , AL355316 , AL390920 , AL607029 , BX470155 , BX470201 Genomic DNA. Translation: CAH71477.2 .
    BX470201
    , AL157711 , AL355316 , AL359094 , AL390920 , AL607029 , BX470155 Genomic DNA. Translation: CAH72560.2 .
    AL390920
    , AL157711 , AL355316 , AL359094 , AL607029 , BX470155 , BX470201 Genomic DNA. Translation: CAH73231.2 .
    AL607029
    , AL157711 , AL355316 , AL359094 , AL390920 , BX470155 , BX470201 Genomic DNA. Translation: CAI15329.2 .
    AL355316
    , AL157711 , AL359094 , AL390920 , AL607029 , BX470155 , BX470201 Genomic DNA. Translation: CAI16871.2 .
    BX470155
    , AL157711 , AL355316 , AL359094 , AL390920 , AL607029 , BX470201 Genomic DNA. Translation: CAI22477.2 .
    RefSeqi NP_001371.1. NM_001380.4.
    UniGenei Hs.159195.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3L4C X-ray 2.37 A/B 422-619 [» ]
    ProteinModelPortali Q14185.
    SMRi Q14185. Positions 1-168, 425-611, 1192-1617.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108128. 13 interactions.
    DIPi DIP-29391N.
    IntActi Q14185. 13 interactions.
    MINTi MINT-190985.
    STRINGi 9606.ENSP00000381107.

    PTM databases

    PhosphoSitei Q14185.

    Polymorphism databases

    DMDMi 209572608.

    Proteomic databases

    MaxQBi Q14185.
    PaxDbi Q14185.
    PRIDEi Q14185.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000280333 ; ENSP00000280333 ; ENSG00000150760 .
    GeneIDi 1793.
    KEGGi hsa:1793.
    UCSCi uc001ljt.3. human.

    Organism-specific databases

    CTDi 1793.
    GeneCardsi GC10P128584.
    HGNCi HGNC:2987. DOCK1.
    HPAi CAB004378.
    HPA048692.
    HPA053277.
    MIMi 601403. gene.
    neXtProti NX_Q14185.
    PharmGKBi PA27453.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289808.
    HOGENOMi HOG000006631.
    HOVERGENi HBG051389.
    KOi K13708.
    OMAi NYVVKWS.
    OrthoDBi EOG7QNVK8.
    PhylomeDBi Q14185.
    TreeFami TF300423.

    Enzyme and pathway databases

    Reactomei REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
    REACT_22351. DCC mediated attractive signaling.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    ChiTaRSi DOCK1. human.
    EvolutionaryTracei Q14185.
    GeneWikii Dock180.
    GenomeRNAii 1793.
    NextBioi 7305.
    PROi Q14185.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q14185.
    CleanExi HS_DOCK1.
    Genevestigatori Q14185.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR027007. DHR-1_domain.
    IPR027357. DHR-2.
    IPR026791. DOCK.
    IPR010703. DOCK_C.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR23317. PTHR23317. 1 hit.
    Pfami PF06920. Ded_cyto. 1 hit.
    PF14429. DOCK-C2. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS51650. DHR_1. 1 hit.
    PS51651. DHR_2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane."
      Hasegawa H., Kiyokawa E., Tanaka S., Nagashima K., Gotoh N., Shibuya M., Kurata T., Matsuda M.
      Mol. Cell. Biol. 16:1770-1776(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CRK.
      Tissue: Placenta.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins."
      Matsuda M., Ota S., Tanimura R., Nakamura H., Matuoka K., Takenawa T., Nagashima K., Kurata T.
      J. Biol. Chem. 271:14468-14472(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRK.
    4. Cited for: GEF ACTIVITY, INTERACTION WITH RAC1.
    5. "Identification and kinetic analysis of the interaction between Nck-2 and DOCK180."
      Tu Y., Kucik D.F., Wu C.
      FEBS Lett. 491:193-199(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NCK2.
    6. "Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3."
      Kobayashi S., Shirai T., Kiyokawa E., Mochizuki N., Matsuda M., Fukui Y.
      Biochem. J. 354:73-78(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PTDINS(3,4,5)P3.
    7. Cited for: GEF ACTIVITY, INTERACTION WITH RAC1; ELMO1 AND ELMO2, SUBUNIT OF A COMPLEX CONTAINING ELMO1 AND DOCK1, MUTAGENESIS OF 1401-TYR-ILE-1402 AND 1487-ILE--PRO-1489.
    8. "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity."
      Cote J.-F., Vuori K.
      J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, GEF ACTIVITY.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1751, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDOCK1_HUMAN
    AccessioniPrimary (citable) accession number: Q14185
    Secondary accession number(s): A9Z1Z5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 3, 2003
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

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