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Protein

Tubulin--tyrosine ligase-like protein 12

Gene

TTLL12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei468 – 4681ATPBy similarity
Binding sitei470 – 4701ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi450 – 4534ATP bindingBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin--tyrosine ligase-like protein 12
Gene namesi
Name:TTLL12
Synonyms:KIAA0153
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:28974. TTLL12.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485663.

Polymorphism and mutation databases

BioMutaiTTLL12.
DMDMi20455527.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 644644Tubulin--tyrosine ligase-like protein 12PRO_0000212446Add
BLAST

Proteomic databases

EPDiQ14166.
MaxQBiQ14166.
PaxDbiQ14166.
PeptideAtlasiQ14166.
PRIDEiQ14166.

PTM databases

iPTMnetiQ14166.
PhosphoSiteiQ14166.
SwissPalmiQ14166.

Expressioni

Gene expression databases

BgeeiQ14166.
CleanExiHS_TTLL12.
ExpressionAtlasiQ14166. baseline and differential.
GenevisibleiQ14166. HS.

Organism-specific databases

HPAiCAB046029.
HPA003054.

Interactioni

Protein-protein interaction databases

BioGridi116782. 58 interactions.
IntActiQ14166. 12 interactions.
STRINGi9606.ENSP00000216129.

Structurei

3D structure databases

ProteinModelPortaliQ14166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini300 – 644345TTLPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 TTL domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2155. Eukaryota.
ENOG410XQ0A. LUCA.
GeneTreeiENSGT00390000006760.
HOGENOMiHOG000006517.
HOVERGENiHBG055617.
InParanoidiQ14166.
KOiK16609.
OMAiPKIAQKY.
OrthoDBiEOG7KDF98.
PhylomeDBiQ14166.
TreeFamiTF313037.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
IPR027749. TTLL12.
[Graphical view]
PANTHERiPTHR12241:SF13. PTHR12241:SF13. 1 hit.
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14166-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAERGPERR PAERSSPGQT PEEGAQALAE FAALHGPALR ASGVPERYWG
60 70 80 90 100
RLLHKLEHEV FDAGEVFGIM QVEEVEEEED EAAREVRKQQ PNPGNELCYK
110 120 130 140 150
VIVTRESGLQ AAHPNSIFLI DHAWTCRVEH ARQQLQQVPG LLHRMANLMG
160 170 180 190 200
IEFHGELPST EAVALVLEEM WKFNQTYQLA HGTAEEKMPV WYIMDEFGSR
210 220 230 240 250
IQHADVPSFA TAPFFYMPQQ VAYTLLWPLR DLDTGEEVTR DFAYGETDPL
260 270 280 290 300
IRKCMLLPWA PTDMLDLSSC TPEPPAEHYQ AILEENKEKL PLDINPVVHP
310 320 330 340 350
HGHIFKVYTD VQQVASSLTH PRFTLTQSEA DADILFNFSH FKDYRKLSQE
360 370 380 390 400
RPGVLLNQFP CENLLTVKDC LASIARRAGG PEGPPWLPRT FNLRTELPQF
410 420 430 440 450
VSYFQQRERW GEDNHWICKP WNLARSLDTH VTKSLHSIIR HRESTPKVVS
460 470 480 490 500
KYIESPVLFL REDVGKVKFD IRYIVLLRSV RPLRLFVYDV FWLRFSNRAF
510 520 530 540 550
ALNDLDDYEK HFTVMNYDPD VVLKQVHCEE FIPEFEKQYP EFPWTDVQAE
560 570 580 590 600
IFRAFTELFQ VACAKPPPLG LCDYPSSRAM YAVDLMLKWD NGPDGRRVMQ
610 620 630 640
PQILEVNFNP DCERACRYHP TFFNDVFSTL FLDQPGGCHV TCLV
Length:644
Mass (Da):74,404
Last modified:May 2, 2002 - v2
Checksum:iBFF552774DF500EF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti84 – 841R → W.
Corresponds to variant rs138951 [ dbSNP | Ensembl ].
VAR_052413
Natural varianti95 – 951N → S.
Corresponds to variant rs13058467 [ dbSNP | Ensembl ].
VAR_052414
Natural varianti297 – 2971V → M.
Corresponds to variant rs11704935 [ dbSNP | Ensembl ].
VAR_052415
Natural varianti464 – 4641V → M.
Corresponds to variant rs34074034 [ dbSNP | Ensembl ].
VAR_052416

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT841516 mRNA. Translation: CAJ86446.1.
Z82214 Genomic DNA. Translation: CAB55886.1.
CH471138 Genomic DNA. Translation: EAW73291.1.
BC001070 mRNA. Translation: AAH01070.1.
D63487 mRNA. Translation: BAA09774.1.
CCDSiCCDS14047.1.
RefSeqiNP_055955.1. NM_015140.3.
UniGeneiHs.517670.

Genome annotation databases

EnsembliENST00000216129; ENSP00000216129; ENSG00000100304.
GeneIDi23170.
KEGGihsa:23170.
UCSCiuc003bdq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT841516 mRNA. Translation: CAJ86446.1.
Z82214 Genomic DNA. Translation: CAB55886.1.
CH471138 Genomic DNA. Translation: EAW73291.1.
BC001070 mRNA. Translation: AAH01070.1.
D63487 mRNA. Translation: BAA09774.1.
CCDSiCCDS14047.1.
RefSeqiNP_055955.1. NM_015140.3.
UniGeneiHs.517670.

3D structure databases

ProteinModelPortaliQ14166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116782. 58 interactions.
IntActiQ14166. 12 interactions.
STRINGi9606.ENSP00000216129.

PTM databases

iPTMnetiQ14166.
PhosphoSiteiQ14166.
SwissPalmiQ14166.

Polymorphism and mutation databases

BioMutaiTTLL12.
DMDMi20455527.

Proteomic databases

EPDiQ14166.
MaxQBiQ14166.
PaxDbiQ14166.
PeptideAtlasiQ14166.
PRIDEiQ14166.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216129; ENSP00000216129; ENSG00000100304.
GeneIDi23170.
KEGGihsa:23170.
UCSCiuc003bdq.4. human.

Organism-specific databases

CTDi23170.
GeneCardsiTTLL12.
HGNCiHGNC:28974. TTLL12.
HPAiCAB046029.
HPA003054.
neXtProtiNX_Q14166.
PharmGKBiPA143485663.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2155. Eukaryota.
ENOG410XQ0A. LUCA.
GeneTreeiENSGT00390000006760.
HOGENOMiHOG000006517.
HOVERGENiHBG055617.
InParanoidiQ14166.
KOiK16609.
OMAiPKIAQKY.
OrthoDBiEOG7KDF98.
PhylomeDBiQ14166.
TreeFamiTF313037.

Miscellaneous databases

GenomeRNAii23170.
PROiQ14166.

Gene expression databases

BgeeiQ14166.
CleanExiHS_TTLL12.
ExpressionAtlasiQ14166. baseline and differential.
GenevisibleiQ14166. HS.

Family and domain databases

InterProiIPR004344. TTL/TTLL_fam.
IPR027749. TTLL12.
[Graphical view]
PANTHERiPTHR12241:SF13. PTHR12241:SF13. 1 hit.
PfamiPF03133. TTL. 1 hit.
[Graphical view]
PROSITEiPS51221. TTL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
    DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 7-644.
    Tissue: Bone marrow.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTTL12_HUMAN
AccessioniPrimary (citable) accession number: Q14166
Secondary accession number(s): Q20WK5, Q9UGU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 2, 2002
Last modified: June 8, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.