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Protein

Tubulin--tyrosine ligase-like protein 12

Gene

TTLL12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei468ATPBy similarity1
Binding sitei470ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi450 – 453ATP bindingBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8955332 Carboxyterminal post-translational modifications of tubulin

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin--tyrosine ligase-like protein 12
Gene namesi
Name:TTLL12
Synonyms:KIAA0153
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100304.12
HGNCiHGNC:28974 TTLL12
neXtProtiNX_Q14166

Pathology & Biotechi

Organism-specific databases

DisGeNETi23170
OpenTargetsiENSG00000100304
PharmGKBiPA143485663

Polymorphism and mutation databases

BioMutaiTTLL12
DMDMi20455527

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002124461 – 644Tubulin--tyrosine ligase-like protein 12Add BLAST644

Proteomic databases

EPDiQ14166
MaxQBiQ14166
PaxDbiQ14166
PeptideAtlasiQ14166
PRIDEiQ14166

PTM databases

iPTMnetiQ14166
PhosphoSitePlusiQ14166
SwissPalmiQ14166

Expressioni

Gene expression databases

BgeeiENSG00000100304
CleanExiHS_TTLL12
ExpressionAtlasiQ14166 baseline and differential
GenevisibleiQ14166 HS

Organism-specific databases

HPAiCAB046029
HPA003054

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EEF1A2Q056394EBI-923010,EBI-354943

Protein-protein interaction databases

BioGridi116782, 60 interactors
IntActiQ14166, 17 interactors
STRINGi9606.ENSP00000216129

Structurei

3D structure databases

ProteinModelPortaliQ14166
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini300 – 644TTLPROSITE-ProRule annotationAdd BLAST345

Phylogenomic databases

eggNOGiKOG2155 Eukaryota
ENOG410XQ0A LUCA
GeneTreeiENSGT00390000006760
HOGENOMiHOG000006517
HOVERGENiHBG055617
InParanoidiQ14166
KOiK16609
OMAiPKIAQKY
OrthoDBiEOG091G03PZ
PhylomeDBiQ14166
TreeFamiTF313037

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR013815 ATP_grasp_subdomain_1
IPR004344 TTL/TTLL_fam
IPR027749 TTLL12
PANTHERiPTHR12241:SF13 PTHR12241:SF13, 1 hit
PfamiView protein in Pfam
PF03133 TTL, 1 hit
PROSITEiView protein in PROSITE
PS51221 TTL, 1 hit

Sequencei

Sequence statusi: Complete.

Q14166-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAERGPERR PAERSSPGQT PEEGAQALAE FAALHGPALR ASGVPERYWG
60 70 80 90 100
RLLHKLEHEV FDAGEVFGIM QVEEVEEEED EAAREVRKQQ PNPGNELCYK
110 120 130 140 150
VIVTRESGLQ AAHPNSIFLI DHAWTCRVEH ARQQLQQVPG LLHRMANLMG
160 170 180 190 200
IEFHGELPST EAVALVLEEM WKFNQTYQLA HGTAEEKMPV WYIMDEFGSR
210 220 230 240 250
IQHADVPSFA TAPFFYMPQQ VAYTLLWPLR DLDTGEEVTR DFAYGETDPL
260 270 280 290 300
IRKCMLLPWA PTDMLDLSSC TPEPPAEHYQ AILEENKEKL PLDINPVVHP
310 320 330 340 350
HGHIFKVYTD VQQVASSLTH PRFTLTQSEA DADILFNFSH FKDYRKLSQE
360 370 380 390 400
RPGVLLNQFP CENLLTVKDC LASIARRAGG PEGPPWLPRT FNLRTELPQF
410 420 430 440 450
VSYFQQRERW GEDNHWICKP WNLARSLDTH VTKSLHSIIR HRESTPKVVS
460 470 480 490 500
KYIESPVLFL REDVGKVKFD IRYIVLLRSV RPLRLFVYDV FWLRFSNRAF
510 520 530 540 550
ALNDLDDYEK HFTVMNYDPD VVLKQVHCEE FIPEFEKQYP EFPWTDVQAE
560 570 580 590 600
IFRAFTELFQ VACAKPPPLG LCDYPSSRAM YAVDLMLKWD NGPDGRRVMQ
610 620 630 640
PQILEVNFNP DCERACRYHP TFFNDVFSTL FLDQPGGCHV TCLV
Length:644
Mass (Da):74,404
Last modified:May 2, 2002 - v2
Checksum:iBFF552774DF500EF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05241384R → W. Corresponds to variant dbSNP:rs138951Ensembl.1
Natural variantiVAR_05241495N → S. Corresponds to variant dbSNP:rs13058467Ensembl.1
Natural variantiVAR_052415297V → M. Corresponds to variant dbSNP:rs11704935Ensembl.1
Natural variantiVAR_052416464V → M. Corresponds to variant dbSNP:rs34074034Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT841516 mRNA Translation: CAJ86446.1
Z82214 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73291.1
BC001070 mRNA Translation: AAH01070.1
D63487 mRNA Translation: BAA09774.1
CCDSiCCDS14047.1
RefSeqiNP_055955.1, NM_015140.3
UniGeneiHs.517670

Genome annotation databases

EnsembliENST00000216129; ENSP00000216129; ENSG00000100304
GeneIDi23170
KEGGihsa:23170
UCSCiuc003bdq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTTL12_HUMAN
AccessioniPrimary (citable) accession number: Q14166
Secondary accession number(s): Q20WK5, Q9UGU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 2, 2002
Last modified: May 23, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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