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Protein

Malectin

Gene

MLEC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei82CarbohydrateBy similarity1
Binding sitei104CarbohydrateBy similarity1
Binding sitei131CarbohydrateBy similarity1
Binding sitei132CarbohydrateBy similarity1
Binding sitei201CarbohydrateBy similarity1

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • enzyme binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCarbohydrate metabolism

Enzyme and pathway databases

ReactomeiR-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

CAZyiCBM57 Carbohydrate-Binding Module Family 57

Names & Taxonomyi

Protein namesi
Recommended name:
Malectin
Gene namesi
Name:MLEC
Synonyms:KIAA0152
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000110917.7
HGNCiHGNC:28973 MLEC
MIMi613802 gene
neXtProtiNX_Q14165

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 269LumenalSequence analysisAdd BLAST241
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Topological domaini291 – 292CytoplasmicSequence analysis2

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9761
OpenTargetsiENSG00000110917
PharmGKBiPA164723038

Polymorphism and mutation databases

BioMutaiMLEC
DMDMi2495712

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001398229 – 292MalectinAdd BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ14165
MaxQBiQ14165
PaxDbiQ14165
PeptideAtlasiQ14165
PRIDEiQ14165

2D gel databases

OGPiQ14165

PTM databases

iPTMnetiQ14165
PhosphoSitePlusiQ14165
SwissPalmiQ14165

Expressioni

Gene expression databases

BgeeiENSG00000110917
CleanExiHS_MLEC
ExpressionAtlasiQ14165 baseline and differential
GenevisibleiQ14165 HS

Interactioni

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115108, 24 interactors
IntActiQ14165, 21 interactors
MINTiQ14165
STRINGi9606.ENSP00000228506

Structurei

3D structure databases

ProteinModelPortaliQ14165
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi231 – 238Poly-Glu8

Sequence similaritiesi

Belongs to the malectin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3593 Eukaryota
ENOG410XNU5 LUCA
GeneTreeiENSGT00390000016504
HOGENOMiHOG000290695
HOVERGENiHBG108138
InParanoidiQ14165
OMAiLYRTERY
OrthoDBiEOG091G0J2K
PhylomeDBiQ14165
TreeFamiTF314856

Family and domain databases

InterProiView protein in InterPro
IPR021720 Malectin
PfamiView protein in Pfam
PF11721 Malectin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGAWAVEGT AVALLRLLLL LLPPAIRGPG LGVAGVAGAA GAGLPESVIW
60 70 80 90 100
AVNAGGEAHV DVHGIHFRKD PLEGRVGRAS DYGMKLPILR SNPEDQILYQ
110 120 130 140 150
TERYNEETFG YEVPIKEEGD YVLVLKFAEV YFAQSQQKVF DVRLNGHVVV
160 170 180 190 200
KDLDIFDRVG HSTAHDEIIP MSIRKGKLSV QGEVSTFTGK LYIEFVKGYY
210 220 230 240 250
DNPKVCALYI MAGTVDDVPK LQPHPGLEKK EEEEEEEEYD EGSNLKKQTN
260 270 280 290
KNRVQSGPRT PNPYASDNSS LMFPILVAFG VFIPTLFCLC RL
Length:292
Mass (Da):32,234
Last modified:November 1, 1996 - v1
Checksum:i448D673A5A1A8F09
GO

Sequence cautioni

The sequence BAA09773 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63486 mRNA Translation: BAA09773.2 Different initiation.
BC000371 mRNA Translation: AAH00371.1
BC016297 mRNA Translation: AAH16297.1
CCDSiCCDS9206.1
RefSeqiNP_055545.1, NM_014730.3
UniGeneiHs.744910

Genome annotation databases

EnsembliENST00000228506; ENSP00000228506; ENSG00000110917
GeneIDi9761
KEGGihsa:9761
UCSCiuc001tyy.2 human

Similar proteinsi

Entry informationi

Entry nameiMLEC_HUMAN
AccessioniPrimary (citable) accession number: Q14165
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health