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Protein

Malectin

Gene

MLEC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei82 – 821CarbohydrateBy similarity
Binding sitei104 – 1041CarbohydrateBy similarity
Binding sitei131 – 1311CarbohydrateBy similarity
Binding sitei132 – 1321CarbohydrateBy similarity
Binding sitei201 – 2011CarbohydrateBy similarity

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • enzyme binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

ReactomeiR-HSA-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Malectin
Gene namesi
Name:MLEC
Synonyms:KIAA0152
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:28973. MLEC.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 269241LumenalSequence analysisAdd
BLAST
Transmembranei270 – 29021HelicalSequence analysisAdd
BLAST
Topological domaini291 – 2922CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164723038.

Polymorphism and mutation databases

BioMutaiMLEC.
DMDMi2495712.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 292264MalectinPRO_0000013982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi268 – 2681N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ14165.
MaxQBiQ14165.
PaxDbiQ14165.
PRIDEiQ14165.

2D gel databases

OGPiQ14165.

PTM databases

iPTMnetiQ14165.
PhosphoSiteiQ14165.
SwissPalmiQ14165.

Expressioni

Gene expression databases

BgeeiQ14165.
CleanExiHS_MLEC.
ExpressionAtlasiQ14165. baseline and differential.
GenevisibleiQ14165. HS.

Organism-specific databases

HPAiHPA007538.

Interactioni

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115108. 18 interactions.
IntActiQ14165. 12 interactions.
STRINGi9606.ENSP00000228506.

Structurei

3D structure databases

ProteinModelPortaliQ14165.
SMRiQ14165. Positions 43-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi231 – 2388Poly-Glu

Sequence similaritiesi

Belongs to the malectin family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3593. Eukaryota.
ENOG410XNU5. LUCA.
GeneTreeiENSGT00390000016504.
HOGENOMiHOG000290695.
HOVERGENiHBG108138.
InParanoidiQ14165.
OMAiRTERYHT.
OrthoDBiEOG7Q2N61.
PhylomeDBiQ14165.
TreeFamiTF314856.

Family and domain databases

InterProiIPR021720. Malectin.
[Graphical view]
PfamiPF11721. Malectin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGAWAVEGT AVALLRLLLL LLPPAIRGPG LGVAGVAGAA GAGLPESVIW
60 70 80 90 100
AVNAGGEAHV DVHGIHFRKD PLEGRVGRAS DYGMKLPILR SNPEDQILYQ
110 120 130 140 150
TERYNEETFG YEVPIKEEGD YVLVLKFAEV YFAQSQQKVF DVRLNGHVVV
160 170 180 190 200
KDLDIFDRVG HSTAHDEIIP MSIRKGKLSV QGEVSTFTGK LYIEFVKGYY
210 220 230 240 250
DNPKVCALYI MAGTVDDVPK LQPHPGLEKK EEEEEEEEYD EGSNLKKQTN
260 270 280 290
KNRVQSGPRT PNPYASDNSS LMFPILVAFG VFIPTLFCLC RL
Length:292
Mass (Da):32,234
Last modified:November 1, 1996 - v1
Checksum:i448D673A5A1A8F09
GO

Sequence cautioni

The sequence BAA09773.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63486 mRNA. Translation: BAA09773.2. Different initiation.
BC000371 mRNA. Translation: AAH00371.1.
BC016297 mRNA. Translation: AAH16297.1.
CCDSiCCDS9206.1.
RefSeqiNP_055545.1. NM_014730.3.
UniGeneiHs.744910.

Genome annotation databases

EnsembliENST00000228506; ENSP00000228506; ENSG00000110917.
GeneIDi9761.
UCSCiuc001tyy.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63486 mRNA. Translation: BAA09773.2. Different initiation.
BC000371 mRNA. Translation: AAH00371.1.
BC016297 mRNA. Translation: AAH16297.1.
CCDSiCCDS9206.1.
RefSeqiNP_055545.1. NM_014730.3.
UniGeneiHs.744910.

3D structure databases

ProteinModelPortaliQ14165.
SMRiQ14165. Positions 43-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115108. 18 interactions.
IntActiQ14165. 12 interactions.
STRINGi9606.ENSP00000228506.

PTM databases

iPTMnetiQ14165.
PhosphoSiteiQ14165.
SwissPalmiQ14165.

Polymorphism and mutation databases

BioMutaiMLEC.
DMDMi2495712.

2D gel databases

OGPiQ14165.

Proteomic databases

EPDiQ14165.
MaxQBiQ14165.
PaxDbiQ14165.
PRIDEiQ14165.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228506; ENSP00000228506; ENSG00000110917.
GeneIDi9761.
UCSCiuc001tyy.2. human.

Organism-specific databases

CTDi9761.
GeneCardsiMLEC.
HGNCiHGNC:28973. MLEC.
HPAiHPA007538.
MIMi613802. gene.
neXtProtiNX_Q14165.
PharmGKBiPA164723038.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3593. Eukaryota.
ENOG410XNU5. LUCA.
GeneTreeiENSGT00390000016504.
HOGENOMiHOG000290695.
HOVERGENiHBG108138.
InParanoidiQ14165.
OMAiRTERYHT.
OrthoDBiEOG7Q2N61.
PhylomeDBiQ14165.
TreeFamiTF314856.

Enzyme and pathway databases

ReactomeiR-HSA-532668. N-glycan trimming in the ER and Calnexin/Calreticulin cycle.

Miscellaneous databases

ChiTaRSiMLEC. human.
GenomeRNAii9761.
NextBioi36741.
PROiQ14165.
SOURCEiSearch...

Gene expression databases

BgeeiQ14165.
CleanExiHS_MLEC.
ExpressionAtlasiQ14165. baseline and differential.
GenevisibleiQ14165. HS.

Family and domain databases

InterProiIPR021720. Malectin.
[Graphical view]
PfamiPF11721. Malectin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
    DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Skin.
  3. Bienvenut W.V.
    Submitted (JUN-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 91-103; 127-138; 144-151 AND 178-190, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMLEC_HUMAN
AccessioniPrimary (citable) accession number: Q14165
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.