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Q14162 (SREC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Scavenger receptor class F member 1
Alternative name(s):
Acetyl LDL receptor
Scavenger receptor expressed by endothelial cells 1
Short name=SREC-I
Gene names
Name:SCARF1
Synonyms:KIAA0149, SREC
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length830 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth By similarity.

Subunit structure

Heterophilic interaction with SREC2 via its extracellular domain. The heterophilic interaction is suppressed by the presence of ligand such as Ac-LDL. Interacts with AVIL By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Endothelial cells.

Sequence similarities

Contains 6 EGF-like domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainEGF-like domain
Repeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

cholesterol catabolic process

Inferred by curator Ref.1. Source: UniProtKB

dendrite development

Inferred from electronic annotation. Source: Ensembl

neuron remodeling

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of axon regeneration

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of neuron projection development

Inferred from sequence or structural similarity. Source: UniProtKB

receptor-mediated endocytosis

Traceable author statement Ref.1. Source: UniProtKB

signal transduction

Traceable author statement Ref.1. Source: GOC

   Cellular_componentendocytic vesicle membrane

Traceable author statement. Source: Reactome

integral component of membrane

Inferred from direct assay Ref.1. Source: UniProtKB

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionlow-density lipoprotein particle binding

Inferred from direct assay Ref.1. Source: UniProtKB

scavenger receptor activity

Inferred from direct assay Ref.1. Source: UniProtKB

transmembrane signaling receptor activity

Traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q14162-1)

Also known as: SREC-1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q14162-2)

Also known as: SREC-5;

The sequence of this isoform differs from the canonical sequence as follows:
     330-415: Missing.
Isoform 3 (identifier: Q14162-3)

Also known as: SREC-3;

The sequence of this isoform differs from the canonical sequence as follows:
     496-569: VSHHDPEVPF...AAGAFPPPED → ASSSRPLPAG...RHSPSRAPPA
     570-830: Missing.
Isoform 4 (identifier: Q14162-4)

Also known as: SREC-4;

The sequence of this isoform differs from the canonical sequence as follows:
     338-830: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 5 (identifier: Q14162-5)

Also known as: SREC-2;

The sequence of this isoform differs from the canonical sequence as follows:
     338-342: CEDPC → GPVIL
     343-830: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 830811Scavenger receptor class F member 1
PRO_0000007738

Regions

Topological domain20 – 421402Extracellular Potential
Transmembrane422 – 44221Helical; Potential
Topological domain443 – 830388Cytoplasmic Potential
Domain53 – 8735EGF-like 1
Domain95 – 13036EGF-like 2
Domain155 – 19137EGF-like 3
Domain215 – 24935EGF-like 4
Domain302 – 33938EGF-like 5
Domain351 – 38232EGF-like 6
Compositional bias431 – 4388Poly-Leu
Compositional bias476 – 620145Pro/Ser-rich
Compositional bias622 – 798177Gly-rich

Amino acid modifications

Glycosylation2891N-linked (GlcNAc...) Potential
Glycosylation3821N-linked (GlcNAc...) Potential
Glycosylation3931N-linked (GlcNAc...) Potential
Disulfide bond57 ↔ 69 By similarity
Disulfide bond63 ↔ 75 By similarity
Disulfide bond77 ↔ 86 By similarity
Disulfide bond99 ↔ 111 By similarity
Disulfide bond105 ↔ 118 By similarity
Disulfide bond120 ↔ 129 By similarity
Disulfide bond159 ↔ 172 By similarity
Disulfide bond165 ↔ 179 By similarity
Disulfide bond181 ↔ 190 By similarity
Disulfide bond219 ↔ 230 By similarity
Disulfide bond225 ↔ 237 By similarity
Disulfide bond239 ↔ 248 By similarity
Disulfide bond306 ↔ 319 By similarity
Disulfide bond313 ↔ 326 By similarity
Disulfide bond329 ↔ 338 By similarity
Disulfide bond355 ↔ 363 By similarity
Disulfide bond358 ↔ 370 By similarity
Disulfide bond372 ↔ 381 By similarity

Natural variations

Alternative sequence330 – 41586Missing in isoform 2.
VSP_039956
Alternative sequence338 – 830493Missing in isoform 4.
VSP_039957
Alternative sequence338 – 3425CEDPC → GPVIL in isoform 5.
VSP_039958
Alternative sequence343 – 830488Missing in isoform 5.
VSP_039959
Alternative sequence496 – 56974VSHHD…PPPED → ASSSRPLPAGPLMTPSHPIL SLERQMRFLPTVCHPKKGWS LWPRQGRQRPAWLQVLSRPL RTPPRHSPSRAPPA in isoform 3.
VSP_039960
Alternative sequence570 – 830261Missing in isoform 3.
VSP_039961
Natural variant4251A → V. Ref.1 Ref.2 Ref.3 Ref.5 Ref.6
Corresponds to variant rs2272011 [ dbSNP | Ensembl ].
VAR_047249
Natural variant6181R → K.
Corresponds to variant rs35455643 [ dbSNP | Ensembl ].
VAR_047250
Natural variant6391E → D. Ref.1 Ref.2 Ref.3 Ref.6
Corresponds to variant rs3744644 [ dbSNP | Ensembl ].
VAR_047251
Natural variant6621R → W. Ref.1 Ref.3
Corresponds to variant rs8072430 [ dbSNP | Ensembl ].
VAR_047252
Natural variant6671G → S. Ref.1 Ref.2 Ref.3 Ref.6
Corresponds to variant rs4790250 [ dbSNP | Ensembl ].
VAR_047253
Natural variant7481G → V.
Corresponds to variant rs3760460 [ dbSNP | Ensembl ].
VAR_047254

Experimental info

Sequence conflict328 – 3292RC → PG in BAC02696. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (SREC-1) [UniParc].

Last modified November 2, 2010. Version 3.
Checksum: 3D1CBF0D6F2BA055

FASTA83087,387
        10         20         30         40         50         60 
MGLGLLLPLL LLWTRGTQGS ELDPKGQHVC VASSPSAELQ CCAGWRQKDQ ECTIPICEGP 

        70         80         90        100        110        120 
DACQKDEVCV KPGLCRCKPG FFGAHCSSRC PGQYWGPDCR ESCPCHPHGQ CEPATGACQC 

       130        140        150        160        170        180 
QADRWGARCE FPCACGPHGR CDPATGVCHC EPGWWSSTCR RPCQCNTAAA RCEQATGACV 

       190        200        210        220        230        240 
CKPGWWGRRC SFRCNCHGSP CEQDSGRCAC RPGWWGPECQ QQCECVRGRC SAASGECTCP 

       250        260        270        280        290        300 
PGFRGARCEL PCPAGSHGVQ CAHSCGRCKH NEPCSPDTGS CESCEPGWNG TQCQQPCLPG 

       310        320        330        340        350        360 
TFGESCEQQC PHCRHGEACE PDTGHCQRCD PGWLGPRCED PCPTGTFGED CGSTCPTCVQ 

       370        380        390        400        410        420 
GSCDTVTGDC VCSAGYWGPS CNASCPAGFH GNNCSVPCEC PEGLCHPVSG SCQPGSGSRD 

       430        440        450        460        470        480 
TALIAGSLVP LLLLFLGLAC CACCCWAPRS DLKDRPARDG ATVSRMKLQV WGTLTSLGST 

       490        500        510        520        530        540 
LPCRSLSSHK LPWVTVSHHD PEVPFNHSFI EPPSAGWATD DSFSSDPESG EADEVPAYCV 

       550        560        570        580        590        600 
PPQEGMVPVA QAGSSEASLA AGAFPPPEDA STPFAIPRTS SLARAKRPSV SFAEGTKFAP 

       610        620        630        640        650        660 
QSRRSSGELS SPLRKPKRLS RGAQSGPEGR EAEESTGPEE AEAPESFPAA ASPGDSATGH 

       670        680        690        700        710        720 
RRPPLGGRTV AEHVEAIEGS VQESSGPVTT IYMLAGKPRG SEGPVRSVFR HFGSFQKGQA 

       730        740        750        760        770        780 
EAKVKRAIPK PPRQALNRKK GSPGLASGSV GQSPNSAPKA GLPGATGPMA VRPEEAVRGL 

       790        800        810        820        830 
GAGTESSRRA QEPVSGCGSP EQDPQKQAEE ERQEEPEYEN VVPISRPPEP 

« Hide

Isoform 2 (SREC-5) [UniParc].

Checksum: A924B3B4B76D6948
Show »

FASTA74478,783
Isoform 3 (SREC-3) [UniParc].

Checksum: 3ACECF49DBC21675
Show »

FASTA56960,820
Isoform 4 (SREC-4) [UniParc].

Checksum: B5F0FAE77445A44D
Show »

FASTA33736,240
Isoform 5 (SREC-2) [UniParc].

Checksum: E177E94FCE55F0FA
Show »

FASTA34236,720

References

« Hide 'large scale' references
[1]"Expression cloning of a novel scavenger receptor from human endothelial cells."
Adachi H., Tsujimoto M., Arai H., Inoue K.
J. Biol. Chem. 272:31217-31220(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-425; ASP-639; TRP-662 AND SER-667.
Tissue: Umbilical vein endothelial cell.
[2]"Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2."
Adachi H., Tsujimoto M.
J. Biol. Chem. 277:24014-24021(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5), VARIANTS VAL-425; ASP-639 AND SER-667.
Tissue: Peripheral blood leukocyte.
[3]"Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-425; ASP-639; TRP-662 AND SER-667.
Tissue: Bone marrow.
[4]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-425.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-425; ASP-639 AND SER-667.
Tissue: Testis.
[7]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Platelet.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D86864 mRNA. Translation: BAA24070.1.
AB052946 Genomic DNA. Translation: BAC02692.1.
AB052947 mRNA. Translation: BAC02693.1.
AB052948 mRNA. Translation: BAC02694.1.
AB052949 mRNA. Translation: BAC02695.1.
AB052950 mRNA. Translation: BAC02696.1.
D63483 mRNA. Translation: BAA09770.1.
AC130343 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90596.1.
BC039735 mRNA. Translation: AAH39735.1.
CCDSCCDS11007.1. [Q14162-1]
CCDS45564.1. [Q14162-3]
RefSeqNP_003684.2. NM_003693.3. [Q14162-1]
NP_663325.1. NM_145350.2. [Q14162-3]
UniGeneHs.647430.

3D structure databases

ProteinModelPortalQ14162.
SMRQ14162. Positions 37-415.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000263071.

PTM databases

PhosphoSiteQ14162.

Polymorphism databases

DMDM311033530.

Proteomic databases

PaxDbQ14162.
PRIDEQ14162.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000263071; ENSP00000263071; ENSG00000074660. [Q14162-1]
ENST00000348987; ENSP00000323964; ENSG00000074660. [Q14162-2]
ENST00000434376; ENSP00000411167; ENSG00000074660. [Q14162-5]
ENST00000571272; ENSP00000458174; ENSG00000074660. [Q14162-3]
GeneID8578.
KEGGhsa:8578.
UCSCuc002fsy.2. human. [Q14162-3]
uc002fsz.2. human. [Q14162-1]

Organism-specific databases

CTD8578.
GeneCardsGC17M001537.
H-InvDBHIX0013404.
HGNCHGNC:16820. SCARF1.
HPAHPA035108.
MIM607873. gene.
neXtProtNX_Q14162.
PharmGKBPA38420.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284054.
HOGENOMHOG000015093.
HOVERGENHBG099941.
InParanoidQ14162.
OMAPAYCVPP.
OrthoDBEOG77HDD8.
PhylomeDBQ14162.
TreeFamTF332598.

Enzyme and pathway databases

ReactomeREACT_160300. Binding and Uptake of Ligands by Scavenger Receptors.

Gene expression databases

ArrayExpressQ14162.
BgeeQ14162.
CleanExHS_SCARF1.
GenevestigatorQ14162.

Family and domain databases

InterProIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002049. EGF_laminin.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamPF12661. hEGF. 3 hits.
PF00053. Laminin_EGF. 1 hit.
[Graphical view]
SMARTSM00181. EGF. 5 hits.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
PROSITEPS00022. EGF_1. 6 hits.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi8578.
NextBio32179.
PROQ14162.
SOURCESearch...

Entry information

Entry nameSREC_HUMAN
AccessionPrimary (citable) accession number: Q14162
Secondary accession number(s): A8MQ05 expand/collapse secondary AC list , O43701, Q8NHD2, Q8NHD3, Q8NHD4, Q8NHD5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM