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Protein

Scavenger receptor class F member 1

Gene

SCARF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity).By similarity

GO - Molecular functioni

  • low-density lipoprotein particle binding Source: UniProtKB
  • scavenger receptor activity Source: UniProtKB
  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:ENSG00000074660-MONOMER.
ReactomeiR-HSA-3000484. Scavenging by Class F Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Scavenger receptor class F member 1
Alternative name(s):
Acetyl LDL receptor
Scavenger receptor expressed by endothelial cells 1
Short name:
SREC-I
Gene namesi
Name:SCARF1
Synonyms:KIAA0149, SREC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16820. SCARF1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 421ExtracellularSequence analysisAdd BLAST402
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443 – 830CytoplasmicSequence analysisAdd BLAST388

GO - Cellular componenti

  • endocytic vesicle membrane Source: Reactome
  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000074660.
ENSG00000276336.
PharmGKBiPA38420.

Polymorphism and mutation databases

DMDMi311033530.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000000773820 – 830Scavenger receptor class F member 1Add BLAST811

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 69PROSITE-ProRule annotation
Disulfide bondi63 ↔ 75PROSITE-ProRule annotation
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
Disulfide bondi99 ↔ 111PROSITE-ProRule annotation
Disulfide bondi105 ↔ 118PROSITE-ProRule annotation
Disulfide bondi120 ↔ 129PROSITE-ProRule annotation
Disulfide bondi159 ↔ 172PROSITE-ProRule annotation
Disulfide bondi165 ↔ 179PROSITE-ProRule annotation
Disulfide bondi181 ↔ 190PROSITE-ProRule annotation
Disulfide bondi219 ↔ 230PROSITE-ProRule annotation
Disulfide bondi225 ↔ 237PROSITE-ProRule annotation
Disulfide bondi239 ↔ 248PROSITE-ProRule annotation
Glycosylationi289N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi306 ↔ 319PROSITE-ProRule annotation
Disulfide bondi313 ↔ 326PROSITE-ProRule annotation
Disulfide bondi329 ↔ 338PROSITE-ProRule annotation
Disulfide bondi355 ↔ 363PROSITE-ProRule annotation
Disulfide bondi358 ↔ 370PROSITE-ProRule annotation
Disulfide bondi372 ↔ 381PROSITE-ProRule annotation
Glycosylationi382N-linked (GlcNAc...)Sequence analysis1
Glycosylationi393N-linked (GlcNAc...)Sequence analysis1
Modified residuei589PhosphoserineBy similarity1
Modified residuei606PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ14162.
PeptideAtlasiQ14162.
PRIDEiQ14162.

PTM databases

iPTMnetiQ14162.
PhosphoSitePlusiQ14162.
SwissPalmiQ14162.

Expressioni

Tissue specificityi

Endothelial cells.

Gene expression databases

BgeeiENSG00000074660.
CleanExiHS_SCARF1.
ExpressionAtlasiQ14162. baseline and differential.
GenevisibleiQ14162. HS.

Organism-specific databases

HPAiHPA035108.

Interactioni

Subunit structurei

Heterophilic interaction with SREC2 via its extracellular domain. The heterophilic interaction is suppressed by the presence of ligand such as Ac-LDL. Interacts with AVIL (By similarity).By similarity

Protein-protein interaction databases

IntActiQ14162. 4 interactors.
STRINGi9606.ENSP00000263071.

Structurei

3D structure databases

ProteinModelPortaliQ14162.
SMRiQ14162.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 87EGF-like 1PROSITE-ProRule annotationAdd BLAST35
Domaini95 – 130EGF-like 2PROSITE-ProRule annotationAdd BLAST36
Domaini155 – 191EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini215 – 249EGF-like 4PROSITE-ProRule annotationAdd BLAST35
Domaini302 – 339EGF-like 5PROSITE-ProRule annotationAdd BLAST38
Domaini351 – 382EGF-like 6PROSITE-ProRule annotationAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi431 – 438Poly-Leu8
Compositional biasi476 – 620Pro/Ser-richAdd BLAST145
Compositional biasi622 – 798Gly-richAdd BLAST177

Sequence similaritiesi

Contains 6 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
GeneTreeiENSGT00730000110380.
HOGENOMiHOG000015093.
HOVERGENiHBG099941.
InParanoidiQ14162.
OMAiPHGRCDP.
OrthoDBiEOG091G03V8.
PhylomeDBiQ14162.
TreeFamiTF332598.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR009030. Growth_fac_rcpt_.
IPR002049. Laminin_EGF.
IPR033329. SCARF1.
[Graphical view]
PANTHERiPTHR24043:SF0. PTHR24043:SF0. 1 hit.
PfamiPF00053. Laminin_EGF. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 9 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00022. EGF_1. 6 hits.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14162-1) [UniParc]FASTAAdd to basket
Also known as: SREC-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLGLLLPLL LLWTRGTQGS ELDPKGQHVC VASSPSAELQ CCAGWRQKDQ
60 70 80 90 100
ECTIPICEGP DACQKDEVCV KPGLCRCKPG FFGAHCSSRC PGQYWGPDCR
110 120 130 140 150
ESCPCHPHGQ CEPATGACQC QADRWGARCE FPCACGPHGR CDPATGVCHC
160 170 180 190 200
EPGWWSSTCR RPCQCNTAAA RCEQATGACV CKPGWWGRRC SFRCNCHGSP
210 220 230 240 250
CEQDSGRCAC RPGWWGPECQ QQCECVRGRC SAASGECTCP PGFRGARCEL
260 270 280 290 300
PCPAGSHGVQ CAHSCGRCKH NEPCSPDTGS CESCEPGWNG TQCQQPCLPG
310 320 330 340 350
TFGESCEQQC PHCRHGEACE PDTGHCQRCD PGWLGPRCED PCPTGTFGED
360 370 380 390 400
CGSTCPTCVQ GSCDTVTGDC VCSAGYWGPS CNASCPAGFH GNNCSVPCEC
410 420 430 440 450
PEGLCHPVSG SCQPGSGSRD TALIAGSLVP LLLLFLGLAC CACCCWAPRS
460 470 480 490 500
DLKDRPARDG ATVSRMKLQV WGTLTSLGST LPCRSLSSHK LPWVTVSHHD
510 520 530 540 550
PEVPFNHSFI EPPSAGWATD DSFSSDPESG EADEVPAYCV PPQEGMVPVA
560 570 580 590 600
QAGSSEASLA AGAFPPPEDA STPFAIPRTS SLARAKRPSV SFAEGTKFAP
610 620 630 640 650
QSRRSSGELS SPLRKPKRLS RGAQSGPEGR EAEESTGPEE AEAPESFPAA
660 670 680 690 700
ASPGDSATGH RRPPLGGRTV AEHVEAIEGS VQESSGPVTT IYMLAGKPRG
710 720 730 740 750
SEGPVRSVFR HFGSFQKGQA EAKVKRAIPK PPRQALNRKK GSPGLASGSV
760 770 780 790 800
GQSPNSAPKA GLPGATGPMA VRPEEAVRGL GAGTESSRRA QEPVSGCGSP
810 820 830
EQDPQKQAEE ERQEEPEYEN VVPISRPPEP
Length:830
Mass (Da):87,387
Last modified:November 2, 2010 - v3
Checksum:i3D1CBF0D6F2BA055
GO
Isoform 2 (identifier: Q14162-2) [UniParc]FASTAAdd to basket
Also known as: SREC-5

The sequence of this isoform differs from the canonical sequence as follows:
     330-415: Missing.

Show »
Length:744
Mass (Da):78,783
Checksum:iA924B3B4B76D6948
GO
Isoform 3 (identifier: Q14162-3) [UniParc]FASTAAdd to basket
Also known as: SREC-3

The sequence of this isoform differs from the canonical sequence as follows:
     496-569: VSHHDPEVPF...AAGAFPPPED → ASSSRPLPAG...RHSPSRAPPA
     570-830: Missing.

Show »
Length:569
Mass (Da):60,820
Checksum:i3ACECF49DBC21675
GO
Isoform 4 (identifier: Q14162-4) [UniParc]FASTAAdd to basket
Also known as: SREC-4

The sequence of this isoform differs from the canonical sequence as follows:
     338-830: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:337
Mass (Da):36,240
Checksum:iB5F0FAE77445A44D
GO
Isoform 5 (identifier: Q14162-5) [UniParc]FASTAAdd to basket
Also known as: SREC-2

The sequence of this isoform differs from the canonical sequence as follows:
     338-342: CEDPC → GPVIL
     343-830: Missing.

Note: No experimental confirmation available.
Show »
Length:342
Mass (Da):36,720
Checksum:iE177E94FCE55F0FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti328 – 329RC → PG in BAC02696 (PubMed:11978792).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047249425A → V.5 PublicationsCorresponds to variant rs2272011dbSNPEnsembl.1
Natural variantiVAR_047250618R → K.Corresponds to variant rs35455643dbSNPEnsembl.1
Natural variantiVAR_047251639E → D.4 PublicationsCorresponds to variant rs3744644dbSNPEnsembl.1
Natural variantiVAR_047252662R → W.2 PublicationsCorresponds to variant rs8072430dbSNPEnsembl.1
Natural variantiVAR_047253667G → S.4 PublicationsCorresponds to variant rs4790250dbSNPEnsembl.1
Natural variantiVAR_047254748G → V.Corresponds to variant rs3760460dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039956330 – 415Missing in isoform 2. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_039957338 – 830Missing in isoform 4. 1 PublicationAdd BLAST493
Alternative sequenceiVSP_039958338 – 342CEDPC → GPVIL in isoform 5. 1 Publication5
Alternative sequenceiVSP_039959343 – 830Missing in isoform 5. 1 PublicationAdd BLAST488
Alternative sequenceiVSP_039960496 – 569VSHHD…PPPED → ASSSRPLPAGPLMTPSHPIL SLERQMRFLPTVCHPKKGWS LWPRQGRQRPAWLQVLSRPL RTPPRHSPSRAPPA in isoform 3. 1 PublicationAdd BLAST74
Alternative sequenceiVSP_039961570 – 830Missing in isoform 3. 1 PublicationAdd BLAST261

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86864 mRNA. Translation: BAA24070.1.
AB052946 Genomic DNA. Translation: BAC02692.1.
AB052947 mRNA. Translation: BAC02693.1.
AB052948 mRNA. Translation: BAC02694.1.
AB052949 mRNA. Translation: BAC02695.1.
AB052950 mRNA. Translation: BAC02696.1.
D63483 mRNA. Translation: BAA09770.1.
AC130343 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90596.1.
BC039735 mRNA. Translation: AAH39735.1.
CCDSiCCDS11007.1. [Q14162-1]
CCDS45564.1. [Q14162-3]
RefSeqiNP_003684.2. NM_003693.3. [Q14162-1]
NP_663325.1. NM_145350.2. [Q14162-3]
UniGeneiHs.647430.

Genome annotation databases

EnsembliENST00000263071; ENSP00000263071; ENSG00000074660. [Q14162-1]
ENST00000434376; ENSP00000411167; ENSG00000074660. [Q14162-5]
ENST00000571272; ENSP00000458174; ENSG00000074660. [Q14162-3]
ENST00000621348; ENSP00000481595; ENSG00000276336. [Q14162-1]
ENST00000631462; ENSP00000487665; ENSG00000276336. [Q14162-5]
ENST00000632317; ENSP00000488776; ENSG00000276336. [Q14162-3]
GeneIDi8578.
KEGGihsa:8578.
UCSCiuc002fsy.3. human. [Q14162-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86864 mRNA. Translation: BAA24070.1.
AB052946 Genomic DNA. Translation: BAC02692.1.
AB052947 mRNA. Translation: BAC02693.1.
AB052948 mRNA. Translation: BAC02694.1.
AB052949 mRNA. Translation: BAC02695.1.
AB052950 mRNA. Translation: BAC02696.1.
D63483 mRNA. Translation: BAA09770.1.
AC130343 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90596.1.
BC039735 mRNA. Translation: AAH39735.1.
CCDSiCCDS11007.1. [Q14162-1]
CCDS45564.1. [Q14162-3]
RefSeqiNP_003684.2. NM_003693.3. [Q14162-1]
NP_663325.1. NM_145350.2. [Q14162-3]
UniGeneiHs.647430.

3D structure databases

ProteinModelPortaliQ14162.
SMRiQ14162.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ14162. 4 interactors.
STRINGi9606.ENSP00000263071.

PTM databases

iPTMnetiQ14162.
PhosphoSitePlusiQ14162.
SwissPalmiQ14162.

Polymorphism and mutation databases

DMDMi311033530.

Proteomic databases

PaxDbiQ14162.
PeptideAtlasiQ14162.
PRIDEiQ14162.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263071; ENSP00000263071; ENSG00000074660. [Q14162-1]
ENST00000434376; ENSP00000411167; ENSG00000074660. [Q14162-5]
ENST00000571272; ENSP00000458174; ENSG00000074660. [Q14162-3]
ENST00000621348; ENSP00000481595; ENSG00000276336. [Q14162-1]
ENST00000631462; ENSP00000487665; ENSG00000276336. [Q14162-5]
ENST00000632317; ENSP00000488776; ENSG00000276336. [Q14162-3]
GeneIDi8578.
KEGGihsa:8578.
UCSCiuc002fsy.3. human. [Q14162-1]

Organism-specific databases

CTDi8578.
GeneCardsiSCARF1.
H-InvDBHIX0013404.
HGNCiHGNC:16820. SCARF1.
HPAiHPA035108.
MIMi607873. gene.
neXtProtiNX_Q14162.
OpenTargetsiENSG00000074660.
ENSG00000276336.
PharmGKBiPA38420.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
GeneTreeiENSGT00730000110380.
HOGENOMiHOG000015093.
HOVERGENiHBG099941.
InParanoidiQ14162.
OMAiPHGRCDP.
OrthoDBiEOG091G03V8.
PhylomeDBiQ14162.
TreeFamiTF332598.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000074660-MONOMER.
ReactomeiR-HSA-3000484. Scavenging by Class F Receptors.

Miscellaneous databases

GenomeRNAii8578.
PROiQ14162.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000074660.
CleanExiHS_SCARF1.
ExpressionAtlasiQ14162. baseline and differential.
GenevisibleiQ14162. HS.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR009030. Growth_fac_rcpt_.
IPR002049. Laminin_EGF.
IPR033329. SCARF1.
[Graphical view]
PANTHERiPTHR24043:SF0. PTHR24043:SF0. 1 hit.
PfamiPF00053. Laminin_EGF. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 9 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00022. EGF_1. 6 hits.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSREC_HUMAN
AccessioniPrimary (citable) accession number: Q14162
Secondary accession number(s): A8MQ05
, O43701, Q8NHD2, Q8NHD3, Q8NHD4, Q8NHD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 153 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.