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Q14162

- SREC_HUMAN

UniProt

Q14162 - SREC_HUMAN

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Protein
Scavenger receptor class F member 1
Gene
SCARF1, KIAA0149, SREC
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth By similarity.

GO - Molecular functioni

  1. low-density lipoprotein particle binding Source: UniProtKB
  2. scavenger receptor activity Source: UniProtKB
  3. transmembrane signaling receptor activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cholesterol catabolic process Source: UniProtKB
  3. dendrite development Source: Ensembl
  4. neuron remodeling Source: UniProtKB
  5. positive regulation of axon regeneration Source: UniProtKB
  6. positive regulation of neuron projection development Source: UniProtKB
  7. receptor-mediated endocytosis Source: UniProtKB
  8. signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_163813. Scavenging by Class F Receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Scavenger receptor class F member 1
Alternative name(s):
Acetyl LDL receptor
Scavenger receptor expressed by endothelial cells 1
Short name:
SREC-I
Gene namesi
Name:SCARF1
Synonyms:KIAA0149, SREC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:16820. SCARF1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 421402Extracellular Reviewed prediction
Add
BLAST
Transmembranei422 – 44221Helical; Reviewed prediction
Add
BLAST
Topological domaini443 – 830388Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endocytic vesicle membrane Source: Reactome
  2. integral component of membrane Source: UniProtKB
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38420.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 830811Scavenger receptor class F member 1
PRO_0000007738Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 69 By similarity
Disulfide bondi63 ↔ 75 By similarity
Disulfide bondi77 ↔ 86 By similarity
Disulfide bondi99 ↔ 111 By similarity
Disulfide bondi105 ↔ 118 By similarity
Disulfide bondi120 ↔ 129 By similarity
Disulfide bondi159 ↔ 172 By similarity
Disulfide bondi165 ↔ 179 By similarity
Disulfide bondi181 ↔ 190 By similarity
Disulfide bondi219 ↔ 230 By similarity
Disulfide bondi225 ↔ 237 By similarity
Disulfide bondi239 ↔ 248 By similarity
Glycosylationi289 – 2891N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi306 ↔ 319 By similarity
Disulfide bondi313 ↔ 326 By similarity
Disulfide bondi329 ↔ 338 By similarity
Disulfide bondi355 ↔ 363 By similarity
Disulfide bondi358 ↔ 370 By similarity
Disulfide bondi372 ↔ 381 By similarity
Glycosylationi382 – 3821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi393 – 3931N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ14162.
PRIDEiQ14162.

PTM databases

PhosphoSiteiQ14162.

Expressioni

Tissue specificityi

Endothelial cells.

Gene expression databases

ArrayExpressiQ14162.
BgeeiQ14162.
CleanExiHS_SCARF1.
GenevestigatoriQ14162.

Organism-specific databases

HPAiHPA035108.

Interactioni

Subunit structurei

Heterophilic interaction with SREC2 via its extracellular domain. The heterophilic interaction is suppressed by the presence of ligand such as Ac-LDL. Interacts with AVIL By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000263071.

Structurei

3D structure databases

ProteinModelPortaliQ14162.
SMRiQ14162. Positions 37-415.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 8735EGF-like 1
Add
BLAST
Domaini95 – 13036EGF-like 2
Add
BLAST
Domaini155 – 19137EGF-like 3
Add
BLAST
Domaini215 – 24935EGF-like 4
Add
BLAST
Domaini302 – 33938EGF-like 5
Add
BLAST
Domaini351 – 38232EGF-like 6
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi431 – 4388Poly-Leu
Compositional biasi476 – 620145Pro/Ser-rich
Add
BLAST
Compositional biasi622 – 798177Gly-rich
Add
BLAST

Sequence similaritiesi

Contains 6 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG284054.
HOGENOMiHOG000015093.
HOVERGENiHBG099941.
InParanoidiQ14162.
OMAiPAYCVPP.
OrthoDBiEOG77HDD8.
PhylomeDBiQ14162.
TreeFamiTF332598.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002049. EGF_laminin.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view]
PfamiPF12661. hEGF. 3 hits.
PF00053. Laminin_EGF. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 5 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00022. EGF_1. 6 hits.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14162-1) [UniParc]FASTAAdd to Basket

Also known as: SREC-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGLGLLLPLL LLWTRGTQGS ELDPKGQHVC VASSPSAELQ CCAGWRQKDQ    50
ECTIPICEGP DACQKDEVCV KPGLCRCKPG FFGAHCSSRC PGQYWGPDCR 100
ESCPCHPHGQ CEPATGACQC QADRWGARCE FPCACGPHGR CDPATGVCHC 150
EPGWWSSTCR RPCQCNTAAA RCEQATGACV CKPGWWGRRC SFRCNCHGSP 200
CEQDSGRCAC RPGWWGPECQ QQCECVRGRC SAASGECTCP PGFRGARCEL 250
PCPAGSHGVQ CAHSCGRCKH NEPCSPDTGS CESCEPGWNG TQCQQPCLPG 300
TFGESCEQQC PHCRHGEACE PDTGHCQRCD PGWLGPRCED PCPTGTFGED 350
CGSTCPTCVQ GSCDTVTGDC VCSAGYWGPS CNASCPAGFH GNNCSVPCEC 400
PEGLCHPVSG SCQPGSGSRD TALIAGSLVP LLLLFLGLAC CACCCWAPRS 450
DLKDRPARDG ATVSRMKLQV WGTLTSLGST LPCRSLSSHK LPWVTVSHHD 500
PEVPFNHSFI EPPSAGWATD DSFSSDPESG EADEVPAYCV PPQEGMVPVA 550
QAGSSEASLA AGAFPPPEDA STPFAIPRTS SLARAKRPSV SFAEGTKFAP 600
QSRRSSGELS SPLRKPKRLS RGAQSGPEGR EAEESTGPEE AEAPESFPAA 650
ASPGDSATGH RRPPLGGRTV AEHVEAIEGS VQESSGPVTT IYMLAGKPRG 700
SEGPVRSVFR HFGSFQKGQA EAKVKRAIPK PPRQALNRKK GSPGLASGSV 750
GQSPNSAPKA GLPGATGPMA VRPEEAVRGL GAGTESSRRA QEPVSGCGSP 800
EQDPQKQAEE ERQEEPEYEN VVPISRPPEP 830
Length:830
Mass (Da):87,387
Last modified:November 2, 2010 - v3
Checksum:i3D1CBF0D6F2BA055
GO
Isoform 2 (identifier: Q14162-2) [UniParc]FASTAAdd to Basket

Also known as: SREC-5

The sequence of this isoform differs from the canonical sequence as follows:
     330-415: Missing.

Show »
Length:744
Mass (Da):78,783
Checksum:iA924B3B4B76D6948
GO
Isoform 3 (identifier: Q14162-3) [UniParc]FASTAAdd to Basket

Also known as: SREC-3

The sequence of this isoform differs from the canonical sequence as follows:
     496-569: VSHHDPEVPF...AAGAFPPPED → ASSSRPLPAG...RHSPSRAPPA
     570-830: Missing.

Show »
Length:569
Mass (Da):60,820
Checksum:i3ACECF49DBC21675
GO
Isoform 4 (identifier: Q14162-4) [UniParc]FASTAAdd to Basket

Also known as: SREC-4

The sequence of this isoform differs from the canonical sequence as follows:
     338-830: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:337
Mass (Da):36,240
Checksum:iB5F0FAE77445A44D
GO
Isoform 5 (identifier: Q14162-5) [UniParc]FASTAAdd to Basket

Also known as: SREC-2

The sequence of this isoform differs from the canonical sequence as follows:
     338-342: CEDPC → GPVIL
     343-830: Missing.

Note: No experimental confirmation available.

Show »
Length:342
Mass (Da):36,720
Checksum:iE177E94FCE55F0FA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti425 – 4251A → V.5 Publications
Corresponds to variant rs2272011 [ dbSNP | Ensembl ].
VAR_047249
Natural varianti618 – 6181R → K.
Corresponds to variant rs35455643 [ dbSNP | Ensembl ].
VAR_047250
Natural varianti639 – 6391E → D.4 Publications
Corresponds to variant rs3744644 [ dbSNP | Ensembl ].
VAR_047251
Natural varianti662 – 6621R → W.2 Publications
Corresponds to variant rs8072430 [ dbSNP | Ensembl ].
VAR_047252
Natural varianti667 – 6671G → S.4 Publications
Corresponds to variant rs4790250 [ dbSNP | Ensembl ].
VAR_047253
Natural varianti748 – 7481G → V.
Corresponds to variant rs3760460 [ dbSNP | Ensembl ].
VAR_047254

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei330 – 41586Missing in isoform 2.
VSP_039956Add
BLAST
Alternative sequencei338 – 830493Missing in isoform 4.
VSP_039957Add
BLAST
Alternative sequencei338 – 3425CEDPC → GPVIL in isoform 5.
VSP_039958
Alternative sequencei343 – 830488Missing in isoform 5.
VSP_039959Add
BLAST
Alternative sequencei496 – 56974VSHHD…PPPED → ASSSRPLPAGPLMTPSHPIL SLERQMRFLPTVCHPKKGWS LWPRQGRQRPAWLQVLSRPL RTPPRHSPSRAPPA in isoform 3.
VSP_039960Add
BLAST
Alternative sequencei570 – 830261Missing in isoform 3.
VSP_039961Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti328 – 3292RC → PG in BAC02696. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86864 mRNA. Translation: BAA24070.1.
AB052946 Genomic DNA. Translation: BAC02692.1.
AB052947 mRNA. Translation: BAC02693.1.
AB052948 mRNA. Translation: BAC02694.1.
AB052949 mRNA. Translation: BAC02695.1.
AB052950 mRNA. Translation: BAC02696.1.
D63483 mRNA. Translation: BAA09770.1.
AC130343 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90596.1.
BC039735 mRNA. Translation: AAH39735.1.
CCDSiCCDS11007.1. [Q14162-1]
CCDS45564.1. [Q14162-3]
RefSeqiNP_003684.2. NM_003693.3. [Q14162-1]
NP_663325.1. NM_145350.2. [Q14162-3]
UniGeneiHs.647430.

Genome annotation databases

EnsembliENST00000263071; ENSP00000263071; ENSG00000074660. [Q14162-1]
ENST00000348987; ENSP00000323964; ENSG00000074660. [Q14162-2]
ENST00000434376; ENSP00000411167; ENSG00000074660. [Q14162-5]
ENST00000571272; ENSP00000458174; ENSG00000074660. [Q14162-3]
GeneIDi8578.
KEGGihsa:8578.
UCSCiuc002fsy.2. human. [Q14162-3]
uc002fsz.2. human. [Q14162-1]

Polymorphism databases

DMDMi311033530.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86864 mRNA. Translation: BAA24070.1 .
AB052946 Genomic DNA. Translation: BAC02692.1 .
AB052947 mRNA. Translation: BAC02693.1 .
AB052948 mRNA. Translation: BAC02694.1 .
AB052949 mRNA. Translation: BAC02695.1 .
AB052950 mRNA. Translation: BAC02696.1 .
D63483 mRNA. Translation: BAA09770.1 .
AC130343 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90596.1 .
BC039735 mRNA. Translation: AAH39735.1 .
CCDSi CCDS11007.1. [Q14162-1 ]
CCDS45564.1. [Q14162-3 ]
RefSeqi NP_003684.2. NM_003693.3. [Q14162-1 ]
NP_663325.1. NM_145350.2. [Q14162-3 ]
UniGenei Hs.647430.

3D structure databases

ProteinModelPortali Q14162.
SMRi Q14162. Positions 37-415.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000263071.

PTM databases

PhosphoSitei Q14162.

Polymorphism databases

DMDMi 311033530.

Proteomic databases

PaxDbi Q14162.
PRIDEi Q14162.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263071 ; ENSP00000263071 ; ENSG00000074660 . [Q14162-1 ]
ENST00000348987 ; ENSP00000323964 ; ENSG00000074660 . [Q14162-2 ]
ENST00000434376 ; ENSP00000411167 ; ENSG00000074660 . [Q14162-5 ]
ENST00000571272 ; ENSP00000458174 ; ENSG00000074660 . [Q14162-3 ]
GeneIDi 8578.
KEGGi hsa:8578.
UCSCi uc002fsy.2. human. [Q14162-3 ]
uc002fsz.2. human. [Q14162-1 ]

Organism-specific databases

CTDi 8578.
GeneCardsi GC17M001537.
H-InvDB HIX0013404.
HGNCi HGNC:16820. SCARF1.
HPAi HPA035108.
MIMi 607873. gene.
neXtProti NX_Q14162.
PharmGKBi PA38420.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284054.
HOGENOMi HOG000015093.
HOVERGENi HBG099941.
InParanoidi Q14162.
OMAi PAYCVPP.
OrthoDBi EOG77HDD8.
PhylomeDBi Q14162.
TreeFami TF332598.

Enzyme and pathway databases

Reactomei REACT_163813. Scavenging by Class F Receptors.

Miscellaneous databases

GenomeRNAii 8578.
NextBioi 32179.
PROi Q14162.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q14162.
Bgeei Q14162.
CleanExi HS_SCARF1.
Genevestigatori Q14162.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR002049. EGF_laminin.
IPR009030. Growth_fac_rcpt_N_dom.
[Graphical view ]
Pfami PF12661. hEGF. 3 hits.
PF00053. Laminin_EGF. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 5 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
PROSITEi PS00022. EGF_1. 6 hits.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning of a novel scavenger receptor from human endothelial cells."
    Adachi H., Tsujimoto M., Arai H., Inoue K.
    J. Biol. Chem. 272:31217-31220(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-425; ASP-639; TRP-662 AND SER-667.
    Tissue: Umbilical vein endothelial cell.
  2. "Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2."
    Adachi H., Tsujimoto M.
    J. Biol. Chem. 277:24014-24021(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5), VARIANTS VAL-425; ASP-639 AND SER-667.
    Tissue: Peripheral blood leukocyte.
  3. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
    DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-425; ASP-639; TRP-662 AND SER-667.
    Tissue: Bone marrow.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT VAL-425.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-425; ASP-639 AND SER-667.
    Tissue: Testis.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.

Entry informationi

Entry nameiSREC_HUMAN
AccessioniPrimary (citable) accession number: Q14162
Secondary accession number(s): A8MQ05
, O43701, Q8NHD2, Q8NHD3, Q8NHD4, Q8NHD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 2, 2010
Last modified: September 3, 2014
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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