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Q14161

- GIT2_HUMAN

UniProt

Q14161 - GIT2_HUMAN

Protein

ARF GTPase-activating protein GIT2

Gene

GIT2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 2 (18 Oct 2001)
      Previous versions | rss
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    Functioni

    GTPase-activating protein for the ADP ribosylation factor family.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri11 – 3424C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ARF GTPase activator activity Source: InterPro
    2. protein binding Source: IntAct
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of ARF GTPase activity Source: InterPro
    2. regulation of G-protein coupled receptor protein signaling pathway Source: ProtInc

    Keywords - Molecular functioni

    GTPase activation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ARF GTPase-activating protein GIT2
    Short name:
    ARF GAP GIT2
    Alternative name(s):
    Cool-interacting tyrosine-phosphorylated protein 2
    Short name:
    CAT-2
    Short name:
    CAT2
    G protein-coupled receptor kinase-interactor 2
    GRK-interacting protein 2
    Gene namesi
    Name:GIT2
    Synonyms:KIAA0148
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:4273. GIT2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28684.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 759759ARF GTPase-activating protein GIT2PRO_0000074203Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei394 – 3941Phosphoserine2 Publications
    Modified residuei397 – 3971Phosphoserine2 Publications
    Modified residuei401 – 4011PhosphothreonineBy similarity
    Modified residuei415 – 4151Phosphoserine1 Publication
    Modified residuei418 – 4181Phosphoserine1 Publication
    Modified residuei421 – 4211Phosphoserine2 Publications
    Modified residuei484 – 4841Phosphotyrosine1 Publication
    Modified residuei559 – 5591Phosphoserine1 Publication
    Modified residuei614 – 6141Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ14161.
    PaxDbiQ14161.
    PRIDEiQ14161.

    PTM databases

    PhosphoSiteiQ14161.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14161.
    BgeeiQ14161.
    CleanExiHS_GIT2.
    GenevestigatoriQ14161.

    Organism-specific databases

    HPAiCAB004681.

    Interactioni

    Subunit structurei

    Interacts with TGFB1I1 By similarity. Interacts with G protein-coupled receptor kinases. Associates with paxillin. Also interacts with PIX exchange factors. Identified in a complex with ARHGEF6 and BIN2.By similarity2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Arhgef7Q9ES282EBI-1046878,EBI-642580From a different organism.
    IKBKGQ9Y6K96EBI-1046878,EBI-81279
    PXNP490232EBI-1046878,EBI-702209
    TNIP1Q150253EBI-1046878,EBI-357849
    TRAF1Q130772EBI-1046878,EBI-359224
    TSNQ156312EBI-1046878,EBI-1044160

    Protein-protein interaction databases

    BioGridi115154. 45 interactions.
    IntActiQ14161. 45 interactions.
    MINTiMINT-1953372.
    STRINGi9606.ENSP00000347464.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14161.
    SMRiQ14161. Positions 1-281, 420-477, 633-756.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 124124Arf-GAPPROSITE-ProRule annotationAdd
    BLAST
    Repeati132 – 16130ANK 1Add
    BLAST
    Repeati166 – 19530ANK 2Add
    BLAST
    Repeati199 – 22830ANK 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 ANK repeats.PROSITE-ProRule annotation
    Contains 1 Arf-GAP domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri11 – 3424C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    ANK repeat, Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5347.
    HOGENOMiHOG000232135.
    HOVERGENiHBG012506.
    InParanoidiQ14161.
    KOiK12487.
    OMAiNKAEFIR.
    OrthoDBiEOG7KQ212.
    PhylomeDBiQ14161.
    TreeFamiTF317762.

    Family and domain databases

    Gene3Di1.25.40.20. 2 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001164. ArfGAP.
    IPR022018. GIT1_C.
    IPR013724. GIT_SHD.
    [Graphical view]
    PfamiPF00023. Ank. 1 hit.
    PF01412. ArfGap. 1 hit.
    PF12205. GIT1_C. 1 hit.
    PF08518. GIT_SHD. 2 hits.
    [Graphical view]
    PRINTSiPR00405. REVINTRACTNG.
    SMARTiSM00248. ANK. 3 hits.
    SM00105. ArfGap. 1 hit.
    SM00555. GIT. 2 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS50115. ARFGAP. 1 hit.
    [Graphical view]

    Sequences (11)i

    Sequence statusi: Complete.

    This entry describes 11 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform 1 (identifier: Q14161-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSKRLRSSEV CADCSGPDPS WASVNRGTFL CDECCSVHRS LGRHISQVRH    50
    LKHTPWPPTL LQMVETLYNN GANSIWEHSL LDPASIMSGR RKANPQDKVH 100
    PNKAEFIRAK YQMLAFVHRL PCRDDDSVTA KDLSKQLHSS VRTGNLETCL 150
    RLLSLGAQAN FFHPEKGNTP LHVASKAGQI LQAELLAVYG ADPGTQDSSG 200
    KTPVDYARQG GHHELAERLV EIQYELTDRL AFYLCGRKPD HKNGQHFIIP 250
    QMADSSLDLS ELAKAAKKKL QSLSNHLFEE LAMDVYDEVD RRETDAVWLA 300
    TQNHSALVTE TTVVPFLPVN PEYSSTRNQG RQKLARFNAH EFATLVIDIL 350
    SDAKRRQQGS SLSGSKDNVE LILKTINNQH SVESQDNDQP DYDSVASDED 400
    TDLETTASKT NRQKSLDSDL SDGPVTVQEF MEVKNALVAS EAKIQQLMKV 450
    NNNLSDELRI MQKKLQTLQS ENSNLRKQAT TNVYQVQTGS EYTDTSNHSS 500
    LKRRPSARGS RPMSMYETGS GQKPYLPMGE ASRPEESRMR LQPFPAHIGR 550
    SALVTSSSSL PSFPSTLSWS RDESARRASR LEKQNSTPES DYDNTPNDME 600
    PDGMGSSRKG RQRSMVWPGD GLVPDTAEPH VAPSPTLPST EDVIRKTEQI 650
    TKNIQELLRA AQENKHDSYI PCSERIHVAV TEMAALFPKK PKSDMVRTSL 700
    RLLTSSAYRL QSECKKTLPG DPGSPTDVQL VTQQVIQCAY DIAKAAKQLV 750
    TITTKENNN 759
    Length:759
    Mass (Da):84,543
    Last modified:October 18, 2001 - v2
    Checksum:i07EFE266DB2F3258
    GO
    Isoform 2 (identifier: Q14161-2) [UniParc]FASTAAdd to Basket

    Also known as: GIT2-short

    The sequence of this isoform differs from the canonical sequence as follows:
         466-471: QTLQSE → LGKDAN
         472-759: Missing.

    Show »
    Length:471
    Mass (Da):52,577
    Checksum:i4C82BB94EA3634DA
    GO
    Isoform 3 (identifier: Q14161-3) [UniParc]FASTAAdd to Basket

    Also known as: C-

    The sequence of this isoform differs from the canonical sequence as follows:
         450-464: Missing.

    Show »
    Length:744
    Mass (Da):82,759
    Checksum:iFE6EB7D7BA75DF1D
    GO
    Isoform 4 (identifier: Q14161-4) [UniParc]FASTAAdd to Basket

    Also known as: BC-

    The sequence of this isoform differs from the canonical sequence as follows:
         415-449: Missing.
         450-464: Missing.

    Show »
    Length:709
    Mass (Da):78,954
    Checksum:i5D6679379A84F684
    GO
    Isoform 5 (identifier: Q14161-5) [UniParc]FASTAAdd to Basket

    Also known as: E-

    The sequence of this isoform differs from the canonical sequence as follows:
         548-577: Missing.

    Show »
    Length:729
    Mass (Da):81,322
    Checksum:i6B3A644B9F357C11
    GO
    Isoform 6 (identifier: Q14161-6) [UniParc]FASTAAdd to Basket

    Also known as: CD-

    The sequence of this isoform differs from the canonical sequence as follows:
         450-464: Missing.
         465-547: Missing.

    Show »
    Length:661
    Mass (Da):73,403
    Checksum:iDD63B22D57DE9FAA
    GO
    Isoform 7 (identifier: Q14161-7) [UniParc]FASTAAdd to Basket

    Also known as: DE-

    The sequence of this isoform differs from the canonical sequence as follows:
         465-547: Missing.
         548-577: Missing.

    Show »
    Length:646
    Mass (Da):71,967
    Checksum:i5A146DE59620E062
    GO
    Isoform 8 (identifier: Q14161-8) [UniParc]FASTAAdd to Basket

    Also known as: BE-

    The sequence of this isoform differs from the canonical sequence as follows:
         415-449: Missing.
         548-577: Missing.

    Show »
    Length:694
    Mass (Da):77,518
    Checksum:i40D620FE62406931
    GO
    Isoform 9 (identifier: Q14161-9) [UniParc]FASTAAdd to Basket

    Also known as: AE-

    The sequence of this isoform differs from the canonical sequence as follows:
         334-414: Missing.
         548-577: Missing.

    Show »
    Length:648
    Mass (Da):72,318
    Checksum:i3FE0E683427F3E09
    GO
    Isoform 10 (identifier: Q14161-10) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         255-255: S → RRL
         414-463: Missing.
         548-577: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:681
    Mass (Da):76,072
    Checksum:iDADC7AB863457F3D
    GO
    Isoform 11 (identifier: Q14161-11) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         450-464: Missing.
         465-547: Missing.
         548-577: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:631
    Mass (Da):70,183
    Checksum:iC14DEB3FF1A577CD
    GO

    Sequence cautioni

    The sequence BAA09769.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti285 – 2851V → M in AAP35976. 1 PublicationCurated
    Sequence conflicti285 – 2851V → M in AAH01379. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti338 – 3381N → S.
    Corresponds to variant rs9804905 [ dbSNP | Ensembl ].
    VAR_048324
    Natural varianti387 – 3871N → S.
    Corresponds to variant rs925368 [ dbSNP | Ensembl ].
    VAR_024368
    Natural varianti552 – 5521A → V.
    Corresponds to variant rs11068997 [ dbSNP | Ensembl ].
    VAR_048325

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei255 – 2551S → RRL in isoform 10. 1 PublicationVSP_026456
    Alternative sequencei334 – 41481Missing in isoform 9. 1 PublicationVSP_000305Add
    BLAST
    Alternative sequencei414 – 46350Missing in isoform 10. 1 PublicationVSP_008654Add
    BLAST
    Alternative sequencei415 – 44935Missing in isoform 4 and isoform 8. 1 PublicationVSP_000306Add
    BLAST
    Alternative sequencei450 – 46415Missing in isoform 3, isoform 4, isoform 6 and isoform 11. 2 PublicationsVSP_000307Add
    BLAST
    Alternative sequencei465 – 54783Missing in isoform 6, isoform 7 and isoform 11. 2 PublicationsVSP_000308Add
    BLAST
    Alternative sequencei466 – 4716QTLQSE → LGKDAN in isoform 2. 3 PublicationsVSP_000303
    Alternative sequencei472 – 759288Missing in isoform 2. 3 PublicationsVSP_000304Add
    BLAST
    Alternative sequencei548 – 57730Missing in isoform 5, isoform 7, isoform 8, isoform 9, isoform 10 and isoform 11. 3 PublicationsVSP_000309Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF124491 mRNA. Translation: AAD28047.1.
    D63482 mRNA. Translation: BAA09769.2. Different initiation.
    BT007312 mRNA. Translation: AAP35976.1.
    BC001379 mRNA. Translation: AAH01379.1.
    BC014223 mRNA. Translation: AAH14223.2.
    CCDSiCCDS44968.1. [Q14161-5]
    CCDS44969.1. [Q14161-11]
    CCDS55884.1. [Q14161-10]
    CCDS9138.1. [Q14161-1]
    CCDS9139.1. [Q14161-2]
    RefSeqiNP_001128685.1. NM_001135213.1. [Q14161-10]
    NP_001128686.1. NM_001135214.1. [Q14161-5]
    NP_055591.2. NM_014776.3.
    NP_476510.1. NM_057169.3. [Q14161-1]
    NP_476511.1. NM_057170.3. [Q14161-11]
    XP_006719770.1. XM_006719707.1. [Q14161-3]
    XP_006719772.1. XM_006719709.1. [Q14161-4]
    UniGeneiHs.434996.

    Genome annotation databases

    EnsembliENST00000355312; ENSP00000347464; ENSG00000139436. [Q14161-1]
    ENST00000361006; ENSP00000354282; ENSG00000139436. [Q14161-5]
    ENST00000457474; ENSP00000391813; ENSG00000139436. [Q14161-10]
    ENST00000547815; ENSP00000450348; ENSG00000139436. [Q14161-2]
    ENST00000553118; ENSP00000447465; ENSG00000139436. [Q14161-11]
    GeneIDi9815.
    KEGGihsa:9815.
    UCSCiuc001tpq.2. human. [Q14161-5]
    uc001tps.2. human. [Q14161-1]
    uc001tpt.2. human. [Q14161-11]
    uc001tpv.2. human. [Q14161-10]

    Polymorphism databases

    DMDMi17376322.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF124491 mRNA. Translation: AAD28047.1 .
    D63482 mRNA. Translation: BAA09769.2 . Different initiation.
    BT007312 mRNA. Translation: AAP35976.1 .
    BC001379 mRNA. Translation: AAH01379.1 .
    BC014223 mRNA. Translation: AAH14223.2 .
    CCDSi CCDS44968.1. [Q14161-5 ]
    CCDS44969.1. [Q14161-11 ]
    CCDS55884.1. [Q14161-10 ]
    CCDS9138.1. [Q14161-1 ]
    CCDS9139.1. [Q14161-2 ]
    RefSeqi NP_001128685.1. NM_001135213.1. [Q14161-10 ]
    NP_001128686.1. NM_001135214.1. [Q14161-5 ]
    NP_055591.2. NM_014776.3.
    NP_476510.1. NM_057169.3. [Q14161-1 ]
    NP_476511.1. NM_057170.3. [Q14161-11 ]
    XP_006719770.1. XM_006719707.1. [Q14161-3 ]
    XP_006719772.1. XM_006719709.1. [Q14161-4 ]
    UniGenei Hs.434996.

    3D structure databases

    ProteinModelPortali Q14161.
    SMRi Q14161. Positions 1-281, 420-477, 633-756.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115154. 45 interactions.
    IntActi Q14161. 45 interactions.
    MINTi MINT-1953372.
    STRINGi 9606.ENSP00000347464.

    PTM databases

    PhosphoSitei Q14161.

    Polymorphism databases

    DMDMi 17376322.

    Proteomic databases

    MaxQBi Q14161.
    PaxDbi Q14161.
    PRIDEi Q14161.

    Protocols and materials databases

    DNASUi 9815.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355312 ; ENSP00000347464 ; ENSG00000139436 . [Q14161-1 ]
    ENST00000361006 ; ENSP00000354282 ; ENSG00000139436 . [Q14161-5 ]
    ENST00000457474 ; ENSP00000391813 ; ENSG00000139436 . [Q14161-10 ]
    ENST00000547815 ; ENSP00000450348 ; ENSG00000139436 . [Q14161-2 ]
    ENST00000553118 ; ENSP00000447465 ; ENSG00000139436 . [Q14161-11 ]
    GeneIDi 9815.
    KEGGi hsa:9815.
    UCSCi uc001tpq.2. human. [Q14161-5 ]
    uc001tps.2. human. [Q14161-1 ]
    uc001tpt.2. human. [Q14161-11 ]
    uc001tpv.2. human. [Q14161-10 ]

    Organism-specific databases

    CTDi 9815.
    GeneCardsi GC12M110367.
    HGNCi HGNC:4273. GIT2.
    HPAi CAB004681.
    MIMi 608564. gene.
    neXtProti NX_Q14161.
    PharmGKBi PA28684.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5347.
    HOGENOMi HOG000232135.
    HOVERGENi HBG012506.
    InParanoidi Q14161.
    KOi K12487.
    OMAi NKAEFIR.
    OrthoDBi EOG7KQ212.
    PhylomeDBi Q14161.
    TreeFami TF317762.

    Miscellaneous databases

    ChiTaRSi GIT2. human.
    GeneWikii GIT2.
    GenomeRNAii 9815.
    NextBioi 36954.
    PROi Q14161.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14161.
    Bgeei Q14161.
    CleanExi HS_GIT2.
    Genevestigatori Q14161.

    Family and domain databases

    Gene3Di 1.25.40.20. 2 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR001164. ArfGAP.
    IPR022018. GIT1_C.
    IPR013724. GIT_SHD.
    [Graphical view ]
    Pfami PF00023. Ank. 1 hit.
    PF01412. ArfGap. 1 hit.
    PF12205. GIT1_C. 1 hit.
    PF08518. GIT_SHD. 2 hits.
    [Graphical view ]
    PRINTSi PR00405. REVINTRACTNG.
    SMARTi SM00248. ANK. 3 hits.
    SM00105. ArfGap. 1 hit.
    SM00555. GIT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    PS50115. ARFGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing."
      Premont R.T., Claing A., Vitale N., Perry S.J., Lefkowitz R.J.
      J. Biol. Chem. 275:22373-22380(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8 AND 9), CHARACTERIZATION.
    2. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
      DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 10).
      Tissue: Bone marrow.
    3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 29-759 (ISOFORM 11).
      Tissue: B-cell and Skin.
    6. "An ADP-ribosylation factor GTPase-activating protein Git2-short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization."
      Mazaki Y., Hashimoto S., Okawa K., Tsubouchi A., Nakamura K., Yagi R., Yano H., Kondo A., Iwamatsu A., Mizoguchi A., Sabe H.
      Mol. Biol. Cell 12:645-662(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PAXILLIN.
    7. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M., Salomon A.R., Ficarro S.B., Mukherji M., Stettler-Gill M., Peters E.C.
      Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
      Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-484, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-415; SER-418 AND SER-421, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-614, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394 AND SER-397, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394; SER-397; SER-559 AND SER-614, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Bin2 is a membrane sculpting N-BAR protein that influences leucocyte podosomes, motility and phagocytosis."
      Sanchez-Barrena M.J., Vallis Y., Clatworthy M.R., Doherty G.J., Veprintsev D.B., Evans P.R., McMahon H.T.
      PLoS ONE 7:E52401-E52401(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH BIN2 AND ARHGEF6.

    Entry informationi

    Entry nameiGIT2_HUMAN
    AccessioniPrimary (citable) accession number: Q14161
    Secondary accession number(s): Q86U59
    , Q96CI2, Q9BV91, Q9Y5V2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 18, 2001
    Last modified: October 1, 2014
    This is version 152 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3