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Protein

Protein EFR3 homolog A

Gene

EFR3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein EFR3 homolog A
Alternative name(s):
Protein EFR3-like
Gene namesi
Name:EFR3A
Synonyms:KIAA0143
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:28970. EFR3A.

Subcellular locationi

  • Cell membrane By similarity

  • Note: Localizes to plasma membrane.By similarity

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • intracellular Source: Ensembl
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162384422.

Polymorphism and mutation databases

BioMutaiEFR3A.
DMDMi122065174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 821821Protein EFR3 homolog APRO_0000050724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei422 – 4221Phosphoserine1 Publication
Modified residuei694 – 6941Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14156.
PaxDbiQ14156.
PRIDEiQ14156.

PTM databases

PhosphoSiteiQ14156.

Expressioni

Gene expression databases

BgeeiQ14156.
CleanExiHS_EFR3A.
ExpressionAtlasiQ14156. baseline and differential.
GenevisibleiQ14156. HS.

Organism-specific databases

HPAiHPA022859.
HPA023092.
HPA023402.

Interactioni

Protein-protein interaction databases

BioGridi116779. 13 interactions.
MINTiMINT-5006088.
STRINGi9606.ENSP00000254624.

Structurei

3D structure databases

ProteinModelPortaliQ14156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EFR3 family.Curated

Phylogenomic databases

eggNOGiNOG246896.
GeneTreeiENSGT00390000002143.
HOGENOMiHOG000007148.
HOVERGENiHBG060233.
InParanoidiQ14156.
OMAiNEFAVSC.
OrthoDBiEOG76T9RC.
PhylomeDBiQ14156.
TreeFamiTF314098.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14156-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPTRVCCCCS ALRPRYKRLV DNIFPEDPKD GLVKTDMEKL TFYAVSAPEK
60 70 80 90 100
LDRIGSYLAE RLSRDVVRHR SGYVLIAMEA LDQLLMACHS QSIKPFVESF
110 120 130 140 150
LHMVAKLLES GEPKLQVLGT NSFVKFANIE EDTPSYHRRY DFFVSRFSAM
160 170 180 190 200
CHSCHSDPEI RTEIRIAGIR GIQGVVRKTV NDELRATIWE PQHMDKIVPS
210 220 230 240 250
LLFNMQKIEE VDSRIGPPSS PSATDKEENP AVLAENCFRE LLGRATFGNM
260 270 280 290 300
NNAVRPVFAH LDHHKLWDPN EFAVHCFKII MYSIQAQYSH HVIQEILGHL
310 320 330 340 350
DARKKDAPRV RAGIIQVLLE AVAIAAKGSI GPTVLEVFNT LLKHLRLSVE
360 370 380 390 400
FEANDLQGGS VGSVNLNTSS KDNDEKIVQN AIIQTIGFFG SNLPDYQRSE
410 420 430 440 450
IMMFIMGKVP VFGTSTHTLD ISQLGDLGTR RIQIMLLRSL LMVTSGYKAK
460 470 480 490 500
TIVTALPGSF LDPLLSPSLM EDYELRQLVL EVMHNLMDRH DNRAKLRGIR
510 520 530 540 550
IIPDVADLKI KREKICRQDT SFMKKNGQQL YRHIYLGCKE EDNVQKNYEL
560 570 580 590 600
LYTSLALITI ELANEEVVID LIRLAIALQD SAIINEDNLP MFHRCGIMAL
610 620 630 640 650
VAAYLNFVSQ MIAVPAFCQH VSKVIEIRTM EAPYFLPEHI FRDKCMLPKS
660 670 680 690 700
LEKHEKDLYF LTNKIAESLG GSGYSVERLS VPYVPQVTDE DRLSRRKSIV
710 720 730 740 750
DTVSIQVDIL SNNVPSDDVV SNTEEITFEA LKKAIDTSGM EEQEKEKRRL
760 770 780 790 800
VIEKFQKAPF EEIAAQCESK ANLLHDRLAQ ILELTIRPPP SPSGTLTITS
810 820
GHAQYQSVPV YEMKFPDLCV Y
Length:821
Mass (Da):92,924
Last modified:January 9, 2007 - v2
Checksum:iA5FCEF6A189A5145
GO
Isoform 2 (identifier: Q14156-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Note: No experimental confirmation available.
Show »
Length:785
Mass (Da):88,801
Checksum:iB568D2B555309363
GO
Isoform 3 (identifier: Q14156-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     619-662: Missing.

Note: No experimental confirmation available.
Show »
Length:777
Mass (Da):87,580
Checksum:iBA03F601660F2195
GO

Sequence cautioni

The sequence AAH71611.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI08668.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI08668.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA09764.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti486 – 4861L → P in CAH56143 (PubMed:17974005).Curated
Sequence conflicti696 – 6961R → G in CAH56143 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti358 – 3581G → R.
Corresponds to variant rs2270877 [ dbSNP | Ensembl ].
VAR_047247
Natural varianti365 – 3651N → D.2 Publications
Corresponds to variant rs1051221 [ dbSNP | Ensembl ].
VAR_047248

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3636Missing in isoform 2. 1 PublicationVSP_022217Add
BLAST
Alternative sequencei619 – 66244Missing in isoform 3. 1 PublicationVSP_022218Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63477 mRNA. Translation: BAA09764.1. Different initiation.
BX648595 mRNA. Translation: CAH56143.1.
CR749243 mRNA. Translation: CAH18099.1.
AC092817 Genomic DNA. No translation available.
BC071611 mRNA. Translation: AAH71611.1. Different initiation.
BC108667 mRNA. Translation: AAI08668.1. Sequence problems.
BC152442 mRNA. Translation: AAI52443.1.
CCDSiCCDS34942.2. [Q14156-1]
RefSeqiNP_055952.2. NM_015137.4. [Q14156-1]
XP_005250906.1. XM_005250849.1. [Q14156-2]
UniGeneiHs.204564.

Genome annotation databases

EnsembliENST00000254624; ENSP00000254624; ENSG00000132294. [Q14156-1]
ENST00000519656; ENSP00000428086; ENSG00000132294. [Q14156-2]
GeneIDi23167.
KEGGihsa:23167.
UCSCiuc003yte.3. human. [Q14156-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63477 mRNA. Translation: BAA09764.1. Different initiation.
BX648595 mRNA. Translation: CAH56143.1.
CR749243 mRNA. Translation: CAH18099.1.
AC092817 Genomic DNA. No translation available.
BC071611 mRNA. Translation: AAH71611.1. Different initiation.
BC108667 mRNA. Translation: AAI08668.1. Sequence problems.
BC152442 mRNA. Translation: AAI52443.1.
CCDSiCCDS34942.2. [Q14156-1]
RefSeqiNP_055952.2. NM_015137.4. [Q14156-1]
XP_005250906.1. XM_005250849.1. [Q14156-2]
UniGeneiHs.204564.

3D structure databases

ProteinModelPortaliQ14156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116779. 13 interactions.
MINTiMINT-5006088.
STRINGi9606.ENSP00000254624.

PTM databases

PhosphoSiteiQ14156.

Polymorphism and mutation databases

BioMutaiEFR3A.
DMDMi122065174.

Proteomic databases

MaxQBiQ14156.
PaxDbiQ14156.
PRIDEiQ14156.

Protocols and materials databases

DNASUi23167.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254624; ENSP00000254624; ENSG00000132294. [Q14156-1]
ENST00000519656; ENSP00000428086; ENSG00000132294. [Q14156-2]
GeneIDi23167.
KEGGihsa:23167.
UCSCiuc003yte.3. human. [Q14156-1]

Organism-specific databases

CTDi23167.
GeneCardsiGC08P132985.
HGNCiHGNC:28970. EFR3A.
HPAiHPA022859.
HPA023092.
HPA023402.
MIMi611798. gene.
neXtProtiNX_Q14156.
PharmGKBiPA162384422.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG246896.
GeneTreeiENSGT00390000002143.
HOGENOMiHOG000007148.
HOVERGENiHBG060233.
InParanoidiQ14156.
OMAiNEFAVSC.
OrthoDBiEOG76T9RC.
PhylomeDBiQ14156.
TreeFamiTF314098.

Miscellaneous databases

ChiTaRSiEFR3A. human.
GenomeRNAii23167.
NextBioi44564.
PROiQ14156.
SOURCEiSearch...

Gene expression databases

BgeeiQ14156.
CleanExiHS_EFR3A.
ExpressionAtlasiQ14156. baseline and differential.
GenevisibleiQ14156. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
    DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 469-821 (ISOFORM 3), VARIANT ASP-365.
    Tissue: Rectum tumor and Retina.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-365.
    Tissue: Skin and Testis.
  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-694, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-422, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-694, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-694, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiEFR3A_HUMAN
AccessioniPrimary (citable) accession number: Q14156
Secondary accession number(s): A7MD19
, Q2VPK2, Q63HL7, Q68DX1, Q6IQ18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 9, 2007
Last modified: June 24, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.