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Q14156

- EFR3A_HUMAN

UniProt

Q14156 - EFR3A_HUMAN

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Protein
Protein EFR3 homolog A
Gene
EFR3A, KIAA0143
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein EFR3 homolog A
Alternative name(s):
Protein EFR3-like
Gene namesi
Name:EFR3A
Synonyms:KIAA0143
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:28970. EFR3A.

Subcellular locationi

Cell membrane By similarity
Note: Localizes to plasma membrane By similarity.

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. intracellular Source: Ensembl
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162384422.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 821821Protein EFR3 homolog A
PRO_0000050724Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei422 – 4221Phosphoserine1 Publication
Modified residuei694 – 6941Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14156.
PaxDbiQ14156.
PRIDEiQ14156.

PTM databases

PhosphoSiteiQ14156.

Expressioni

Gene expression databases

ArrayExpressiQ14156.
BgeeiQ14156.
CleanExiHS_EFR3A.
GenevestigatoriQ14156.

Organism-specific databases

HPAiHPA022859.
HPA023092.
HPA023402.

Interactioni

Protein-protein interaction databases

BioGridi116779. 3 interactions.
MINTiMINT-5006088.
STRINGi9606.ENSP00000254624.

Structurei

3D structure databases

ProteinModelPortaliQ14156.

Family & Domainsi

Sequence similaritiesi

Belongs to the EFR3 family.

Phylogenomic databases

eggNOGiNOG246896.
HOGENOMiHOG000007148.
HOVERGENiHBG060233.
InParanoidiQ14156.
OMAiNEFAVSC.
OrthoDBiEOG76T9RC.
PhylomeDBiQ14156.
TreeFamiTF314098.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14156-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPTRVCCCCS ALRPRYKRLV DNIFPEDPKD GLVKTDMEKL TFYAVSAPEK    50
LDRIGSYLAE RLSRDVVRHR SGYVLIAMEA LDQLLMACHS QSIKPFVESF 100
LHMVAKLLES GEPKLQVLGT NSFVKFANIE EDTPSYHRRY DFFVSRFSAM 150
CHSCHSDPEI RTEIRIAGIR GIQGVVRKTV NDELRATIWE PQHMDKIVPS 200
LLFNMQKIEE VDSRIGPPSS PSATDKEENP AVLAENCFRE LLGRATFGNM 250
NNAVRPVFAH LDHHKLWDPN EFAVHCFKII MYSIQAQYSH HVIQEILGHL 300
DARKKDAPRV RAGIIQVLLE AVAIAAKGSI GPTVLEVFNT LLKHLRLSVE 350
FEANDLQGGS VGSVNLNTSS KDNDEKIVQN AIIQTIGFFG SNLPDYQRSE 400
IMMFIMGKVP VFGTSTHTLD ISQLGDLGTR RIQIMLLRSL LMVTSGYKAK 450
TIVTALPGSF LDPLLSPSLM EDYELRQLVL EVMHNLMDRH DNRAKLRGIR 500
IIPDVADLKI KREKICRQDT SFMKKNGQQL YRHIYLGCKE EDNVQKNYEL 550
LYTSLALITI ELANEEVVID LIRLAIALQD SAIINEDNLP MFHRCGIMAL 600
VAAYLNFVSQ MIAVPAFCQH VSKVIEIRTM EAPYFLPEHI FRDKCMLPKS 650
LEKHEKDLYF LTNKIAESLG GSGYSVERLS VPYVPQVTDE DRLSRRKSIV 700
DTVSIQVDIL SNNVPSDDVV SNTEEITFEA LKKAIDTSGM EEQEKEKRRL 750
VIEKFQKAPF EEIAAQCESK ANLLHDRLAQ ILELTIRPPP SPSGTLTITS 800
GHAQYQSVPV YEMKFPDLCV Y 821
Length:821
Mass (Da):92,924
Last modified:January 9, 2007 - v2
Checksum:iA5FCEF6A189A5145
GO
Isoform 2 (identifier: Q14156-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.

Note: No experimental confirmation available.

Show »
Length:785
Mass (Da):88,801
Checksum:iB568D2B555309363
GO
Isoform 3 (identifier: Q14156-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     619-662: Missing.

Note: No experimental confirmation available.

Show »
Length:777
Mass (Da):87,580
Checksum:iBA03F601660F2195
GO

Sequence cautioni

The sequence AAI08668.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence AAH71611.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAI08668.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence BAA09764.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti358 – 3581G → R.
Corresponds to variant rs2270877 [ dbSNP | Ensembl ].
VAR_047247
Natural varianti365 – 3651N → D.2 Publications
Corresponds to variant rs1051221 [ dbSNP | Ensembl ].
VAR_047248

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3636Missing in isoform 2.
VSP_022217Add
BLAST
Alternative sequencei619 – 66244Missing in isoform 3.
VSP_022218Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti486 – 4861L → P in CAH56143. 1 Publication
Sequence conflicti696 – 6961R → G in CAH56143. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D63477 mRNA. Translation: BAA09764.1. Different initiation.
BX648595 mRNA. Translation: CAH56143.1.
CR749243 mRNA. Translation: CAH18099.1.
AC092817 Genomic DNA. No translation available.
BC071611 mRNA. Translation: AAH71611.1. Different initiation.
BC108667 mRNA. Translation: AAI08668.1. Sequence problems.
BC152442 mRNA. Translation: AAI52443.1.
CCDSiCCDS34942.2. [Q14156-1]
RefSeqiNP_055952.2. NM_015137.4. [Q14156-1]
XP_005250906.1. XM_005250849.1. [Q14156-2]
UniGeneiHs.204564.

Genome annotation databases

EnsembliENST00000254624; ENSP00000254624; ENSG00000132294. [Q14156-1]
ENST00000519656; ENSP00000428086; ENSG00000132294. [Q14156-2]
GeneIDi23167.
KEGGihsa:23167.
UCSCiuc003yte.3. human. [Q14156-1]

Polymorphism databases

DMDMi122065174.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D63477 mRNA. Translation: BAA09764.1 . Different initiation.
BX648595 mRNA. Translation: CAH56143.1 .
CR749243 mRNA. Translation: CAH18099.1 .
AC092817 Genomic DNA. No translation available.
BC071611 mRNA. Translation: AAH71611.1 . Different initiation.
BC108667 mRNA. Translation: AAI08668.1 . Sequence problems.
BC152442 mRNA. Translation: AAI52443.1 .
CCDSi CCDS34942.2. [Q14156-1 ]
RefSeqi NP_055952.2. NM_015137.4. [Q14156-1 ]
XP_005250906.1. XM_005250849.1. [Q14156-2 ]
UniGenei Hs.204564.

3D structure databases

ProteinModelPortali Q14156.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116779. 3 interactions.
MINTi MINT-5006088.
STRINGi 9606.ENSP00000254624.

PTM databases

PhosphoSitei Q14156.

Polymorphism databases

DMDMi 122065174.

Proteomic databases

MaxQBi Q14156.
PaxDbi Q14156.
PRIDEi Q14156.

Protocols and materials databases

DNASUi 23167.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000254624 ; ENSP00000254624 ; ENSG00000132294 . [Q14156-1 ]
ENST00000519656 ; ENSP00000428086 ; ENSG00000132294 . [Q14156-2 ]
GeneIDi 23167.
KEGGi hsa:23167.
UCSCi uc003yte.3. human. [Q14156-1 ]

Organism-specific databases

CTDi 23167.
GeneCardsi GC08P132985.
HGNCi HGNC:28970. EFR3A.
HPAi HPA022859.
HPA023092.
HPA023402.
MIMi 611798. gene.
neXtProti NX_Q14156.
PharmGKBi PA162384422.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG246896.
HOGENOMi HOG000007148.
HOVERGENi HBG060233.
InParanoidi Q14156.
OMAi NEFAVSC.
OrthoDBi EOG76T9RC.
PhylomeDBi Q14156.
TreeFami TF314098.

Miscellaneous databases

ChiTaRSi EFR3A. human.
GenomeRNAii 23167.
NextBioi 44564.
PROi Q14156.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q14156.
Bgeei Q14156.
CleanExi HS_EFR3A.
Genevestigatori Q14156.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
    DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 469-821 (ISOFORM 3), VARIANT ASP-365.
    Tissue: Rectum tumor and Retina.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-365.
    Tissue: Skin and Testis.
  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-694, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-422, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-694, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-694, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiEFR3A_HUMAN
AccessioniPrimary (citable) accession number: Q14156
Secondary accession number(s): A7MD19
, Q2VPK2, Q63HL7, Q68DX1, Q6IQ18
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 9, 2007
Last modified: September 3, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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