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Q14156

- EFR3A_HUMAN

UniProt

Q14156 - EFR3A_HUMAN

Protein

Protein EFR3 homolog A

Gene

EFR3A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein EFR3 homolog A
    Alternative name(s):
    Protein EFR3-like
    Gene namesi
    Name:EFR3A
    Synonyms:KIAA0143
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:28970. EFR3A.

    Subcellular locationi

    Cell membrane By similarity
    Note: Localizes to plasma membrane.By similarity

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. intracellular Source: Ensembl
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162384422.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 821821Protein EFR3 homolog APRO_0000050724Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei422 – 4221Phosphoserine1 Publication
    Modified residuei694 – 6941Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ14156.
    PaxDbiQ14156.
    PRIDEiQ14156.

    PTM databases

    PhosphoSiteiQ14156.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14156.
    BgeeiQ14156.
    CleanExiHS_EFR3A.
    GenevestigatoriQ14156.

    Organism-specific databases

    HPAiHPA022859.
    HPA023092.
    HPA023402.

    Interactioni

    Protein-protein interaction databases

    BioGridi116779. 3 interactions.
    MINTiMINT-5006088.
    STRINGi9606.ENSP00000254624.

    Structurei

    3D structure databases

    ProteinModelPortaliQ14156.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EFR3 family.Curated

    Phylogenomic databases

    eggNOGiNOG246896.
    HOGENOMiHOG000007148.
    HOVERGENiHBG060233.
    InParanoidiQ14156.
    OMAiNEFAVSC.
    OrthoDBiEOG76T9RC.
    PhylomeDBiQ14156.
    TreeFamiTF314098.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14156-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPTRVCCCCS ALRPRYKRLV DNIFPEDPKD GLVKTDMEKL TFYAVSAPEK    50
    LDRIGSYLAE RLSRDVVRHR SGYVLIAMEA LDQLLMACHS QSIKPFVESF 100
    LHMVAKLLES GEPKLQVLGT NSFVKFANIE EDTPSYHRRY DFFVSRFSAM 150
    CHSCHSDPEI RTEIRIAGIR GIQGVVRKTV NDELRATIWE PQHMDKIVPS 200
    LLFNMQKIEE VDSRIGPPSS PSATDKEENP AVLAENCFRE LLGRATFGNM 250
    NNAVRPVFAH LDHHKLWDPN EFAVHCFKII MYSIQAQYSH HVIQEILGHL 300
    DARKKDAPRV RAGIIQVLLE AVAIAAKGSI GPTVLEVFNT LLKHLRLSVE 350
    FEANDLQGGS VGSVNLNTSS KDNDEKIVQN AIIQTIGFFG SNLPDYQRSE 400
    IMMFIMGKVP VFGTSTHTLD ISQLGDLGTR RIQIMLLRSL LMVTSGYKAK 450
    TIVTALPGSF LDPLLSPSLM EDYELRQLVL EVMHNLMDRH DNRAKLRGIR 500
    IIPDVADLKI KREKICRQDT SFMKKNGQQL YRHIYLGCKE EDNVQKNYEL 550
    LYTSLALITI ELANEEVVID LIRLAIALQD SAIINEDNLP MFHRCGIMAL 600
    VAAYLNFVSQ MIAVPAFCQH VSKVIEIRTM EAPYFLPEHI FRDKCMLPKS 650
    LEKHEKDLYF LTNKIAESLG GSGYSVERLS VPYVPQVTDE DRLSRRKSIV 700
    DTVSIQVDIL SNNVPSDDVV SNTEEITFEA LKKAIDTSGM EEQEKEKRRL 750
    VIEKFQKAPF EEIAAQCESK ANLLHDRLAQ ILELTIRPPP SPSGTLTITS 800
    GHAQYQSVPV YEMKFPDLCV Y 821
    Length:821
    Mass (Da):92,924
    Last modified:January 9, 2007 - v2
    Checksum:iA5FCEF6A189A5145
    GO
    Isoform 2 (identifier: Q14156-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-36: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:785
    Mass (Da):88,801
    Checksum:iB568D2B555309363
    GO
    Isoform 3 (identifier: Q14156-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         619-662: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:777
    Mass (Da):87,580
    Checksum:iBA03F601660F2195
    GO

    Sequence cautioni

    The sequence AAI08668.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
    The sequence AAH71611.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI08668.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAA09764.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti486 – 4861L → P in CAH56143. (PubMed:17974005)Curated
    Sequence conflicti696 – 6961R → G in CAH56143. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti358 – 3581G → R.
    Corresponds to variant rs2270877 [ dbSNP | Ensembl ].
    VAR_047247
    Natural varianti365 – 3651N → D.2 Publications
    Corresponds to variant rs1051221 [ dbSNP | Ensembl ].
    VAR_047248

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3636Missing in isoform 2. 1 PublicationVSP_022217Add
    BLAST
    Alternative sequencei619 – 66244Missing in isoform 3. 1 PublicationVSP_022218Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D63477 mRNA. Translation: BAA09764.1. Different initiation.
    BX648595 mRNA. Translation: CAH56143.1.
    CR749243 mRNA. Translation: CAH18099.1.
    AC092817 Genomic DNA. No translation available.
    BC071611 mRNA. Translation: AAH71611.1. Different initiation.
    BC108667 mRNA. Translation: AAI08668.1. Sequence problems.
    BC152442 mRNA. Translation: AAI52443.1.
    CCDSiCCDS34942.2. [Q14156-1]
    RefSeqiNP_055952.2. NM_015137.4. [Q14156-1]
    XP_005250906.1. XM_005250849.1. [Q14156-2]
    UniGeneiHs.204564.

    Genome annotation databases

    EnsembliENST00000254624; ENSP00000254624; ENSG00000132294. [Q14156-1]
    ENST00000519656; ENSP00000428086; ENSG00000132294. [Q14156-2]
    GeneIDi23167.
    KEGGihsa:23167.
    UCSCiuc003yte.3. human. [Q14156-1]

    Polymorphism databases

    DMDMi122065174.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D63477 mRNA. Translation: BAA09764.1 . Different initiation.
    BX648595 mRNA. Translation: CAH56143.1 .
    CR749243 mRNA. Translation: CAH18099.1 .
    AC092817 Genomic DNA. No translation available.
    BC071611 mRNA. Translation: AAH71611.1 . Different initiation.
    BC108667 mRNA. Translation: AAI08668.1 . Sequence problems.
    BC152442 mRNA. Translation: AAI52443.1 .
    CCDSi CCDS34942.2. [Q14156-1 ]
    RefSeqi NP_055952.2. NM_015137.4. [Q14156-1 ]
    XP_005250906.1. XM_005250849.1. [Q14156-2 ]
    UniGenei Hs.204564.

    3D structure databases

    ProteinModelPortali Q14156.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116779. 3 interactions.
    MINTi MINT-5006088.
    STRINGi 9606.ENSP00000254624.

    PTM databases

    PhosphoSitei Q14156.

    Polymorphism databases

    DMDMi 122065174.

    Proteomic databases

    MaxQBi Q14156.
    PaxDbi Q14156.
    PRIDEi Q14156.

    Protocols and materials databases

    DNASUi 23167.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254624 ; ENSP00000254624 ; ENSG00000132294 . [Q14156-1 ]
    ENST00000519656 ; ENSP00000428086 ; ENSG00000132294 . [Q14156-2 ]
    GeneIDi 23167.
    KEGGi hsa:23167.
    UCSCi uc003yte.3. human. [Q14156-1 ]

    Organism-specific databases

    CTDi 23167.
    GeneCardsi GC08P132985.
    HGNCi HGNC:28970. EFR3A.
    HPAi HPA022859.
    HPA023092.
    HPA023402.
    MIMi 611798. gene.
    neXtProti NX_Q14156.
    PharmGKBi PA162384422.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG246896.
    HOGENOMi HOG000007148.
    HOVERGENi HBG060233.
    InParanoidi Q14156.
    OMAi NEFAVSC.
    OrthoDBi EOG76T9RC.
    PhylomeDBi Q14156.
    TreeFami TF314098.

    Miscellaneous databases

    ChiTaRSi EFR3A. human.
    GenomeRNAii 23167.
    NextBioi 44564.
    PROi Q14156.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14156.
    Bgeei Q14156.
    CleanExi HS_EFR3A.
    Genevestigatori Q14156.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
      Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
      DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 469-821 (ISOFORM 3), VARIANT ASP-365.
      Tissue: Rectum tumor and Retina.
    3. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-365.
      Tissue: Skin and Testis.
    5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-694, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-422, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-694, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-694, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiEFR3A_HUMAN
    AccessioniPrimary (citable) accession number: Q14156
    Secondary accession number(s): A7MD19
    , Q2VPK2, Q63HL7, Q68DX1, Q6IQ18
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3