Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Rho guanine nucleotide exchange factor 7

Gene

ARHGEF7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.By similarity3 Publications

GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: BHF-UCL
  • protein kinase binding Source: BHF-UCL
  • Rho guanyl-nucleotide exchange factor activity Source: Reactome

GO - Biological processi

  • ephrin receptor signaling pathway Source: Reactome
  • focal adhesion assembly Source: UniProtKB
  • Golgi organization Source: ParkinsonsUK-UCL
  • hematopoietic progenitor cell differentiation Source: Ensembl
  • intracellular signal transduction Source: InterPro
  • lamellipodium assembly Source: UniProtKB
  • negative regulation of epidermal growth factor receptor signaling pathway Source: Reactome
  • nervous system development Source: UniProtKB-KW
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of fibroblast migration Source: UniProtKB
  • positive regulation of growth hormone secretion Source: Ensembl
  • positive regulation of GTPase activity Source: UniProtKB
  • positive regulation of lamellipodium morphogenesis Source: UniProtKB
  • positive regulation of protein binding Source: Ensembl
  • positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
  • regulation of GTP binding Source: ParkinsonsUK-UCL
  • regulation of Rho protein signal transduction Source: InterPro
  • regulation of small GTPase mediated signal transduction Source: Reactome
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Neurogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102606-MONOMER.
ReactomeiR-HSA-182971. EGFR downregulation.
R-HSA-193648. NRAGE signals death through JNK.
R-HSA-194840. Rho GTPase cycle.
R-HSA-3928664. Ephrin signaling.
R-HSA-416482. G alpha (12/13) signalling events.
SignaLinkiQ14155.
SIGNORiQ14155.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 7
Alternative name(s):
Beta-Pix
COOL-1
PAK-interacting exchange factor beta
p85
Gene namesi
Name:ARHGEF7
Synonyms:COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
ORF Names:Nbla10314
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:15607. ARHGEF7.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: UniProtKB-SubCell
  • cytosol Source: Reactome
  • focal adhesion Source: UniProtKB
  • lamellipodium Source: UniProtKB
  • neuronal cell body Source: BHF-UCL
  • neuron projection Source: BHF-UCL
  • plasma membrane Source: Ensembl
  • protein complex Source: UniProtKB
  • ruffle Source: UniProtKB-SubCell
  • storage vacuole Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi8874.
OpenTargetsiENSG00000102606.
PharmGKBiPA24977.

Polymorphism and mutation databases

BioMutaiARHGEF7.
DMDMi50403776.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809211 – 803Rho guanine nucleotide exchange factor 7Add BLAST803
Isoform 1 (identifier: Q14155-1)
Initiator methionineiRemovedCombined sources
Isoform 6 (identifier: Q14155-6)
Initiator methionineiRemovedCombined sources

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei153PhosphoserineBy similarity1
Modified residuei176PhosphoserineBy similarity1
Modified residuei249PhosphoserineCombined sources1
Modified residuei257PhosphoserineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei694Phosphoserine; by CaMK1Combined sources1 Publication1
Isoform 1 (identifier: Q14155-1)
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonineCombined sources1
Modified residuei560PhosphoserineCombined sources1
Modified residuei579PhosphoserineCombined sources1
Isoform 6 (identifier: Q14155-6)
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonineCombined sources1
Isoform 5 (identifier: Q14155-5)
Modified residuei645PhosphoserineCombined sources1
Modified residuei664PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by CaMK1; enhancement of GEF activity and downstream activation of RAC1.By similarity1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14155.
PaxDbiQ14155.
PeptideAtlasiQ14155.
PRIDEiQ14155.

PTM databases

iPTMnetiQ14155.
PhosphoSitePlusiQ14155.

Expressioni

Gene expression databases

BgeeiENSG00000102606.
ExpressionAtlasiQ14155. baseline and differential.
GenevisibleiQ14155. HS.

Organism-specific databases

HPAiHPA004744.

Interactioni

Subunit structurei

Interacts with PAK kinases through the SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with PTK2/FAK1 and RAC1. Interacts with ITCH and PARVB (By similarity). Interacts with unphosphorylated PAK1. Interacts with SCRIB; interaction is direct and may play a role in regulation of apoptosis. Interacts with FRMPD4 (via N-terminus). Interacts with CaMK1. Interacts with BIN2. Isoform 1 and isoform 5 interact with SNX27.By similarity6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CBLP226819EBI-717515,EBI-518228
GIT1Q9Y2X74EBI-717515,EBI-466061
LRRK2Q5S0077EBI-717515,EBI-5323863
MEOX2A4D1273EBI-717515,EBI-10172134
NAA10P412273EBI-717515,EBI-747693
PAK1Q131537EBI-717515,EBI-1307
PAK2Q131774EBI-717515,EBI-1045887
RAC1P630008EBI-717515,EBI-413628
SCRIBQ141604EBI-717515,EBI-357345
SH2D1AO608807EBI-717515,EBI-6983382

GO - Molecular functioni

  • protein kinase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi114393. 43 interactors.
DIPiDIP-40794N.
IntActiQ14155. 25 interactors.
MINTiMINT-92779.
STRINGi9606.ENSP00000364893.

Structurei

Secondary structure

1803
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 13Combined sources11
Helixi27 – 35Combined sources9
Helixi39 – 48Combined sources10
Helixi63 – 79Combined sources17
Helixi109 – 113Combined sources5
Helixi118 – 135Combined sources18
Beta strandi188 – 191Combined sources4
Beta strandi210 – 215Combined sources6
Beta strandi218 – 226Combined sources9
Beta strandi229 – 240Combined sources12
Helixi271 – 301Combined sources31
Turni302 – 304Combined sources3
Beta strandi305 – 310Combined sources6
Helixi311 – 313Combined sources3
Helixi316 – 338Combined sources23
Helixi346 – 378Combined sources33
Turni379 – 381Combined sources3
Helixi382 – 385Combined sources4
Turni386 – 389Combined sources4
Turni395 – 397Combined sources3
Helixi398 – 402Combined sources5
Turni406 – 408Combined sources3
Helixi409 – 411Combined sources3
Helixi413 – 422Combined sources10
Beta strandi428 – 430Combined sources3
Helixi432 – 453Combined sources22
Turni454 – 456Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BY1NMR-A260-467[»]
1ZSGNMR-A179-243[»]
2L3GNMR-A1-137[»]
ProteinModelPortaliQ14155.
SMRiQ14155.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14155.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 132CHPROSITE-ProRule annotationAdd BLAST132
Domaini184 – 243SH3PROSITE-ProRule annotationAdd BLAST60
Domaini271 – 451DHPROSITE-ProRule annotationAdd BLAST181
Domaini473 – 578PHPROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 1 DH (DBL-homology) domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG2070. Eukaryota.
ENOG410XNNP. LUCA.
GeneTreeiENSGT00760000118925.
HOVERGENiHBG050569.
InParanoidiQ14155.
KOiK13710.
OrthoDBiEOG091G04XA.
PhylomeDBiQ14155.
TreeFamiTF316105.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 4 (identifier: Q14155-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP
60 70 80 90 100
GTIEKVYPEP RSESECLSNI REFLRGCGAS LRLELLFPPS QPPQHLVTTI
110 120 130 140 150
LLSASTFDAN DLYQGQNFNK VLSSLVTLNK VTADIGLGSD SVCARPSSHR
160 170 180 190 200
IKSFDSLGSQ SLHTRTSKLF QGQYRSLDMT DNSNNQLVVR AKFNFQQTNE
210 220 230 240 250
DELSFSKGDV IHVTRVEEGG WWEGTLNGRT GWFPSNYVRE VKASEKPVSP
260 270 280 290 300
KSGTLKSPPK GFDTTAINKS YYNVVLQNIL ETENEYSKEL QTVLSTYLRP
310 320 330 340 350
LQTSEKLSSA NISYLMGNLE EICSFQQMLV QSLEECTKLP EAQQRVGGCF
360 370 380 390 400
LNLMPQMKTL YLTYCANHPS AVNVLTEHSE ELGEFMETKG ASSPGILVLT
410 420 430 440 450
TGLSKPFMRL DKYPTLLKEL ERHMEDYHTD RQDIQKSMAA FKNLSAQCQE
460 470 480 490 500
VRKRKELELQ ILTEAIRNWE GDDIKTLGNV TYMSQVLIQC AGSEEKNERY
510 520 530 540 550
LLLFPNVLLM LSASPRMSGF IYQGKLPTTG MTITKLEDSE NHRNAFEISG
560 570 580 590 600
SMIERILVSC NNQQDLQEWV EHLQKQTKVT SVGNPTIKPH SVPSHTLPSH
610 620 630 640 650
PVTPSSKHAD SKPAPLTPAY HTLPHPSHHG TPHTTINWGP LEPPKTPKPW
660 670 680 690 700
SLSCLRPAPP LRPSAALCYK EDLSKSPKTM KKLLPKRKPE RKPSDEEFAS
710 720 730 740 750
RKSTAALEED AQILKVIEAY CTSAKTRQTL NSTWQGTDLM HNHVLADDDQ
760 770 780 790 800
PSLDSLGRRS SLSRLEPSDL SEDSDYDSIW TAHSYRMGST SRKSCCSYIS

HQN
Length:803
Mass (Da):90,012
Last modified:July 19, 2004 - v2
Checksum:i613EBA839E6FDBFD
GO
Isoform 1 (identifier: Q14155-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.
     733-803: TWQGTDLMHN...SCCSYISHQN → SSRKESAPQV...NDPAWDETNL

Show »
Length:646
Mass (Da):73,140
Checksum:iB5B5A83F0EBC28D2
GO
Isoform 2 (identifier: Q14155-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-105: Missing.

Show »
Length:753
Mass (Da):84,477
Checksum:i04178E64ACF43846
GO
Isoform 3 (identifier: Q14155-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-105: Missing.

Show »
Length:782
Mass (Da):87,770
Checksum:i9C602026D90A6D01
GO
Isoform 5 (identifier: Q14155-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-177: Missing.
     733-803: TWQGTDLMHN...SCCSYISHQN → SSRKESAPQV...NDPAWDETNL

Show »
Length:731
Mass (Da):82,571
Checksum:iE82D55E6187DADB2
GO
Isoform 6 (identifier: Q14155-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-178: Missing.

Show »
Length:625
Mass (Da):70,450
Checksum:i25DAD75DD4B0AC2E
GO

Sequence cautioni

The sequence AAH50521 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA09763 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD38906 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52 – 55TIEK → EEKR in BAD66827 (PubMed:15491607).Curated4
Sequence conflicti343Q → K in AAH33905 (PubMed:15489334).Curated1
Sequence conflicti552M → V in AAH33905 (PubMed:15489334).Curated1
Sequence conflicti595H → D in BAD66827 (PubMed:15491607).Curated1
Sequence conflicti636I → T in AAH50521 (PubMed:15489334).Curated1
Sequence conflicti740M → L in AAH33905 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064694790T → A Found in a clear cell renal carcinoma case; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0110321 – 178Missing in isoform 1 and isoform 6. 3 PublicationsAdd BLAST178
Alternative sequenceiVSP_01103356 – 105Missing in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_03463985 – 177Missing in isoform 5. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_01103485 – 105Missing in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_011035733 – 803TWQGT…ISHQN → SSRKESAPQVLLPEEEKIIV EETKSNGQTVIEEKSLVDTV YALKDEVQELRQDNKKMKKS LEEEQRARKDLEKLVRKVLK NMNDPAWDETNL in isoform 1 and isoform 5. 4 PublicationsAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63476 mRNA. Translation: BAA09763.2. Different initiation.
AL834228 mRNA. Translation: CAD38906.1. Different initiation.
AL390754, AL139086 Genomic DNA. Translation: CAI12461.1.
AL139086, AL390754 Genomic DNA. Translation: CAI14671.1.
AL390754, AL139086 Genomic DNA. Translation: CAM13628.1.
AL139086, AL390754 Genomic DNA. Translation: CAM20788.1.
CH471085 Genomic DNA. Translation: EAX09143.1.
BC033905 mRNA. Translation: AAH33905.1.
BC050521 mRNA. Translation: AAH50521.1. Different initiation.
BC060776 mRNA. Translation: AAH60776.1.
AB177849 mRNA. Translation: BAD66827.1.
AB075521 mRNA. Translation: BAE45764.1.
CCDSiCCDS32009.1. [Q14155-3]
CCDS45068.1. [Q14155-4]
CCDS45069.1. [Q14155-2]
CCDS9521.1. [Q14155-1]
RefSeqiNP_001106983.1. NM_001113511.2. [Q14155-4]
NP_001106984.1. NM_001113512.2. [Q14155-2]
NP_001106985.1. NM_001113513.1. [Q14155-1]
NP_001307780.1. NM_001320851.1. [Q14155-1]
NP_001307782.1. NM_001320853.1.
NP_001307783.1. NM_001320854.1.
NP_003890.1. NM_003899.3. [Q14155-1]
NP_663788.1. NM_145735.3. [Q14155-3]
XP_016876313.1. XM_017020824.1. [Q14155-1]
XP_016876314.1. XM_017020825.1. [Q14155-1]
UniGeneiHs.508738.

Genome annotation databases

EnsembliENST00000317133; ENSP00000325994; ENSG00000102606. [Q14155-3]
ENST00000375723; ENSP00000364875; ENSG00000102606. [Q14155-6]
ENST00000375736; ENSP00000364888; ENSG00000102606. [Q14155-1]
ENST00000375739; ENSP00000364891; ENSG00000102606. [Q14155-2]
ENST00000375741; ENSP00000364893; ENSG00000102606. [Q14155-4]
ENST00000426073; ENSP00000397068; ENSG00000102606. [Q14155-1]
GeneIDi8874.
KEGGihsa:8874.
UCSCiuc001vrr.3. human. [Q14155-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63476 mRNA. Translation: BAA09763.2. Different initiation.
AL834228 mRNA. Translation: CAD38906.1. Different initiation.
AL390754, AL139086 Genomic DNA. Translation: CAI12461.1.
AL139086, AL390754 Genomic DNA. Translation: CAI14671.1.
AL390754, AL139086 Genomic DNA. Translation: CAM13628.1.
AL139086, AL390754 Genomic DNA. Translation: CAM20788.1.
CH471085 Genomic DNA. Translation: EAX09143.1.
BC033905 mRNA. Translation: AAH33905.1.
BC050521 mRNA. Translation: AAH50521.1. Different initiation.
BC060776 mRNA. Translation: AAH60776.1.
AB177849 mRNA. Translation: BAD66827.1.
AB075521 mRNA. Translation: BAE45764.1.
CCDSiCCDS32009.1. [Q14155-3]
CCDS45068.1. [Q14155-4]
CCDS45069.1. [Q14155-2]
CCDS9521.1. [Q14155-1]
RefSeqiNP_001106983.1. NM_001113511.2. [Q14155-4]
NP_001106984.1. NM_001113512.2. [Q14155-2]
NP_001106985.1. NM_001113513.1. [Q14155-1]
NP_001307780.1. NM_001320851.1. [Q14155-1]
NP_001307782.1. NM_001320853.1.
NP_001307783.1. NM_001320854.1.
NP_003890.1. NM_003899.3. [Q14155-1]
NP_663788.1. NM_145735.3. [Q14155-3]
XP_016876313.1. XM_017020824.1. [Q14155-1]
XP_016876314.1. XM_017020825.1. [Q14155-1]
UniGeneiHs.508738.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BY1NMR-A260-467[»]
1ZSGNMR-A179-243[»]
2L3GNMR-A1-137[»]
ProteinModelPortaliQ14155.
SMRiQ14155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114393. 43 interactors.
DIPiDIP-40794N.
IntActiQ14155. 25 interactors.
MINTiMINT-92779.
STRINGi9606.ENSP00000364893.

PTM databases

iPTMnetiQ14155.
PhosphoSitePlusiQ14155.

Polymorphism and mutation databases

BioMutaiARHGEF7.
DMDMi50403776.

Proteomic databases

EPDiQ14155.
PaxDbiQ14155.
PeptideAtlasiQ14155.
PRIDEiQ14155.

Protocols and materials databases

DNASUi8874.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317133; ENSP00000325994; ENSG00000102606. [Q14155-3]
ENST00000375723; ENSP00000364875; ENSG00000102606. [Q14155-6]
ENST00000375736; ENSP00000364888; ENSG00000102606. [Q14155-1]
ENST00000375739; ENSP00000364891; ENSG00000102606. [Q14155-2]
ENST00000375741; ENSP00000364893; ENSG00000102606. [Q14155-4]
ENST00000426073; ENSP00000397068; ENSG00000102606. [Q14155-1]
GeneIDi8874.
KEGGihsa:8874.
UCSCiuc001vrr.3. human. [Q14155-4]

Organism-specific databases

CTDi8874.
DisGeNETi8874.
GeneCardsiARHGEF7.
H-InvDBHIX0037536.
HGNCiHGNC:15607. ARHGEF7.
HPAiHPA004744.
MIMi605477. gene.
neXtProtiNX_Q14155.
OpenTargetsiENSG00000102606.
PharmGKBiPA24977.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2070. Eukaryota.
ENOG410XNNP. LUCA.
GeneTreeiENSGT00760000118925.
HOVERGENiHBG050569.
InParanoidiQ14155.
KOiK13710.
OrthoDBiEOG091G04XA.
PhylomeDBiQ14155.
TreeFamiTF316105.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102606-MONOMER.
ReactomeiR-HSA-182971. EGFR downregulation.
R-HSA-193648. NRAGE signals death through JNK.
R-HSA-194840. Rho GTPase cycle.
R-HSA-3928664. Ephrin signaling.
R-HSA-416482. G alpha (12/13) signalling events.
SignaLinkiQ14155.
SIGNORiQ14155.

Miscellaneous databases

ChiTaRSiARHGEF7. human.
EvolutionaryTraceiQ14155.
GeneWikiiARHGEF7.
GenomeRNAii8874.
PROiQ14155.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102606.
ExpressionAtlasiQ14155. baseline and differential.
GenevisibleiQ14155. HS.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00033. CH. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARHG7_HUMAN
AccessioniPrimary (citable) accession number: Q14155
Secondary accession number(s): B1ALK6
, B1ALK8, Q3LIA4, Q5W9H0, Q6P9G3, Q6PII2, Q86W63, Q8N3M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 19, 2004
Last modified: November 30, 2016
This is version 185 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.