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Protein

Death ligand signal enhancer

Gene

KIAA0141

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Death ligand signal enhancer
Gene namesi
Name:KIAA0141
Synonyms:DELE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:28969. KIAA0141.

Subcellular locationi

  • Mitochondrion 1 Publication

GO - Cellular componenti

  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134992099.

Polymorphism and mutation databases

BioMutaiKIAA0141.
DMDMi116242599.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 101101MitochondrionSequence analysisAdd
BLAST
Chaini102 – 515414Death ligand signal enhancerPRO_0000050721Add
BLAST

Proteomic databases

PaxDbiQ14154.
PeptideAtlasiQ14154.
PRIDEiQ14154.

PTM databases

iPTMnetiQ14154.
PhosphoSiteiQ14154.

Expressioni

Tissue specificityi

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.1 Publication

Gene expression databases

BgeeiQ14154.
CleanExiHS_KIAA0141.
ExpressionAtlasiQ14154. baseline and differential.
GenevisibleiQ14154. HS.

Organism-specific databases

HPAiHPA036548.
HPA036549.

Interactioni

Subunit structurei

Interacts with DAP3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CRXO431863EBI-2805660,EBI-748171

Protein-protein interaction databases

BioGridi115151. 4 interactions.
IntActiQ14154. 6 interactions.
STRINGi9606.ENSP00000194118.

Structurei

3D structure databases

ProteinModelPortaliQ14154.
SMRiQ14154. Positions 217-435.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati213 – 24432TPR 1Add
BLAST
Repeati245 – 27733TPR 2Add
BLAST
Repeati278 – 31235TPR 3Add
BLAST
Repeati313 – 35038TPR 4Add
BLAST
Repeati351 – 38434TPR 5Add
BLAST
Repeati385 – 42238TPR 6Add
BLAST
Repeati472 – 50433TPR 7Add
BLAST

Sequence similaritiesi

Contains 7 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG1550. Eukaryota.
COG0790. LUCA.
GeneTreeiENSGT00390000002137.
HOVERGENiHBG052169.
InParanoidiQ14154.
OMAiHGWKDAF.
OrthoDBiEOG7DNNXP.
PhylomeDBiQ14154.
TreeFamiTF329996.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF08238. Sel1. 5 hits.
[Graphical view]
SMARTiSM00671. SEL1. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14154-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRLPGLLGR ALPRTLGPSL WRVTPKSTSP DGPQTTSSTL LVPVPNLDRS
60 70 80 90 100
GPHGPGTSGG PRSHGWKDAF QWMSSRVSPN TLWDAISWGT LAVLALQLAR
110 120 130 140 150
QIHFQASLPA GPQRVEHCSW HSPLDRFFSS PLWHPCSSLR QHILPSPDGP
160 170 180 190 200
APRHTGLREP RLGQEEASAQ PRNFSHNSLR GARPQDPSEE GPGDFGFLHA
210 220 230 240 250
SSSIESEAKP AQPQPTGEKE QDKSKTLSLE EAVTSIQQLF QLSVSIAFNF
260 270 280 290 300
LGTENMKSGD HTAAFSYFQK AAARGYSKAQ YNAGLCHEHG RGTPRDISKA
310 320 330 340 350
VLYYQLAASQ GHSLAQYRYA RCLLRDPASS WNPERQRAVS LLKQAADSGL
360 370 380 390 400
REAQAFLGVL FTKEPYLDEQ RAVKYLWLAA NNGDSQSRYH LGICYEKGLG
410 420 430 440 450
VQRNLGEALR CYQQSAALGN EAAQERLRAL FSMGAAAPGP SDLTVTGLKS
460 470 480 490 500
FSSPSLCSLN TLLAGTSRLP HASSTGNLGL LCRSGHLGAS LEASSRAIPP
510
HPYPLERSVV RLGFG
Length:515
Mass (Da):55,920
Last modified:October 17, 2006 - v3
Checksum:i80818A18B6253BA8
GO

Sequence cautioni

The sequence BAA09490.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601G → D.
Corresponds to variant rs34438707 [ dbSNP | Ensembl ].
VAR_055940
Natural varianti95 – 951A → T.1 Publication
Corresponds to variant rs17850821 [ dbSNP | Ensembl ].
VAR_028197
Natural varianti128 – 1281F → L.
Corresponds to variant rs10036567 [ dbSNP | Ensembl ].
VAR_018272
Natural varianti247 – 2471A → T.1 Publication
Corresponds to variant rs351260 [ dbSNP | Ensembl ].
VAR_018273
Natural varianti468 – 4681R → C.
Corresponds to variant rs10056676 [ dbSNP | Ensembl ].
VAR_028198

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50931 mRNA. Translation: BAA09490.2. Different initiation.
BC007855 mRNA. Translation: AAH07855.1.
BC010452 mRNA. Translation: AAH10452.1.
BC011269 mRNA. Translation: AAH11269.1.
BC011926 mRNA. Translation: AAH11926.1.
CCDSiCCDS4268.1.
RefSeqiNP_001136075.1. NM_001142603.2.
NP_055588.3. NM_014773.4.
XP_005268604.1. XM_005268547.3.
XP_005268605.1. XM_005268548.3.
UniGeneiHs.210532.

Genome annotation databases

EnsembliENST00000194118; ENSP00000194118; ENSG00000081791.
ENST00000432126; ENSP00000396225; ENSG00000081791.
GeneIDi9812.
KEGGihsa:9812.
UCSCiuc003lls.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50931 mRNA. Translation: BAA09490.2. Different initiation.
BC007855 mRNA. Translation: AAH07855.1.
BC010452 mRNA. Translation: AAH10452.1.
BC011269 mRNA. Translation: AAH11269.1.
BC011926 mRNA. Translation: AAH11926.1.
CCDSiCCDS4268.1.
RefSeqiNP_001136075.1. NM_001142603.2.
NP_055588.3. NM_014773.4.
XP_005268604.1. XM_005268547.3.
XP_005268605.1. XM_005268548.3.
UniGeneiHs.210532.

3D structure databases

ProteinModelPortaliQ14154.
SMRiQ14154. Positions 217-435.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115151. 4 interactions.
IntActiQ14154. 6 interactions.
STRINGi9606.ENSP00000194118.

PTM databases

iPTMnetiQ14154.
PhosphoSiteiQ14154.

Polymorphism and mutation databases

BioMutaiKIAA0141.
DMDMi116242599.

Proteomic databases

PaxDbiQ14154.
PeptideAtlasiQ14154.
PRIDEiQ14154.

Protocols and materials databases

DNASUi9812.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000194118; ENSP00000194118; ENSG00000081791.
ENST00000432126; ENSP00000396225; ENSG00000081791.
GeneIDi9812.
KEGGihsa:9812.
UCSCiuc003lls.4. human.

Organism-specific databases

CTDi9812.
GeneCardsiKIAA0141.
H-InvDBHIX0023088.
HGNCiHGNC:28969. KIAA0141.
HPAiHPA036548.
HPA036549.
MIMi615741. gene.
neXtProtiNX_Q14154.
PharmGKBiPA134992099.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1550. Eukaryota.
COG0790. LUCA.
GeneTreeiENSGT00390000002137.
HOVERGENiHBG052169.
InParanoidiQ14154.
OMAiHGWKDAF.
OrthoDBiEOG7DNNXP.
PhylomeDBiQ14154.
TreeFamiTF329996.

Miscellaneous databases

ChiTaRSiKIAA0141. human.
GenomeRNAii9812.
PROiQ14154.
SOURCEiSearch...

Gene expression databases

BgeeiQ14154.
CleanExiHS_KIAA0141.
ExpressionAtlasiQ14154. baseline and differential.
GenevisibleiQ14154. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF08238. Sel1. 5 hits.
[Graphical view]
SMARTiSM00671. SEL1. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
    DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], TISSUE SPECIFICITY.
    Tissue: Bone marrow.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS THR-95 AND THR-247.
    Tissue: Brain and Uterus.
  3. "Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction."
    Harada T., Iwai A., Miyazaki T.
    Apoptosis 15:1247-1255(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH DAP3.
  4. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiDELE_HUMAN
AccessioniPrimary (citable) accession number: Q14154
Secondary accession number(s): Q969R4, Q96EU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: July 6, 2016
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.