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Protein

Protein FAM53B

Gene

FAM53B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization.1 Publication

GO - Biological processi

  • catenin import into nucleus Source: UniProtKB
  • positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM53BCurated
Alternative name(s):
Protein simplet1 Publication
Gene namesi
Name:FAM53BImported
Synonyms:KIAA01401 Publication, SMP1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000189319.13.
HGNCiHGNC:28968. FAM53B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi9679.
OpenTargetsiENSG00000189319.
PharmGKBiPA134957918.

Polymorphism and mutation databases

BioMutaiFAM53B.
DMDMi215273981.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895441 – 422Protein FAM53BAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei118PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei169PhosphoserineCombined sources1
Modified residuei179PhosphoserineCombined sources1
Modified residuei212PhosphoserineBy similarity1
Modified residuei268PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ14153.
PaxDbiQ14153.
PeptideAtlasiQ14153.
PRIDEiQ14153.

PTM databases

iPTMnetiQ14153.
PhosphoSitePlusiQ14153.

Expressioni

Tissue specificityi

Detected in skeletal muscle, kidney, spleen, thyroid, testis, ovary, small intestine, colon and peripheral blood.1 Publication

Gene expression databases

BgeeiENSG00000189319.
CleanExiHS_FAM53B.
GenevisibleiQ14153. HS.

Organism-specific databases

HPAiHPA037751.
HPA037752.

Interactioni

Subunit structurei

Interacts with CTNNB1.1 Publication

Protein-protein interaction databases

BioGridi115033. 1 interactor.
IntActiQ14153. 5 interactors.
MINTiMINT-3976476.
STRINGi9606.ENSP00000338532.

Structurei

3D structure databases

ProteinModelPortaliQ14153.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi281 – 284Nuclear localization signalBy similarity4

Sequence similaritiesi

Belongs to the FAM53 family.Curated

Phylogenomic databases

eggNOGiENOG410IE5U. Eukaryota.
ENOG410YBVC. LUCA.
GeneTreeiENSGT00530000063371.
HOGENOMiHOG000059662.
HOVERGENiHBG051537.
InParanoidiQ14153.
OMAiECLPEKC.
OrthoDBiEOG091G09FX.
PhylomeDBiQ14153.
TreeFamiTF332095.

Family and domain databases

InterProiView protein in InterPro
IPR029356. FAM53.
PfamiView protein in Pfam
PF15242. FAM53. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14153-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVMVLSESLS TRGADSIACG TFSRELHTPK KMSQGPTLFS CGIMENDRWR
60 70 80 90 100
DLDRKCPLQI DQPSTSIWEC LPEKDSSLWH REAVTACAVT SLIKDLSISD
110 120 130 140 150
HNGNPSAPPS KRQCRSLSFS DEMSSCRTSW RPLGSKVWTP VEKRRCYSGG
160 170 180 190 200
SVQRYSNGFS TMQRSSSFSL PSRANVLSSP CDQAGLHHRF GGQPCQGVPG
210 220 230 240 250
SAPCGQAGDT WSPDLHPVGG GRLDLQRSLS CSHEQFSFVE YCPPSANSTP
260 270 280 290 300
ASTPELARRS SGLSRSRSQP CVLNDKKVGV KRRRPEEVQE QRPSLDLAKM
310 320 330 340 350
AQNCQTFSSL SCLSAGTEDC GPQSPFARHV SNTRAWTALL SASGPGGRTP
360 370 380 390 400
AGTPVPEPLP PSFDDHLACQ EDLSCEESDS CALDEDCGRR AEPAAAWRDR
410 420
GAPGNSLCSL DGELDIEQIE KN
Length:422
Mass (Da):45,768
Last modified:November 25, 2008 - v2
Checksum:i7F7768093408D791
GO
Isoform 2 (identifier: Q14153-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     303-305: NCQ → IAP
     306-422: Missing.

Note: No experimental confirmation available.
Show »
Length:305
Mass (Da):33,446
Checksum:iD1743235823004B7
GO

Sequence cautioni

The sequence BAA09489 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti368A → V in BAA09489 (PubMed:8590280).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009932303 – 305NCQ → IAP in isoform 2. 1 Publication3
Alternative sequenceiVSP_009933306 – 422Missing in isoform 2. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50930 mRNA. Translation: BAA09489.2. Different initiation.
AK127343 mRNA. Translation: BAG54488.1.
AL513190, AC068896 Genomic DNA. Translation: CAH70375.1.
AL513190, AC068896 Genomic DNA. Translation: CAH70376.1.
CH471066 Genomic DNA. Translation: EAW49259.1.
CH471066 Genomic DNA. Translation: EAW49260.1.
CH471066 Genomic DNA. Translation: EAW49261.1.
CH471066 Genomic DNA. Translation: EAW49262.1.
BC031654 mRNA. Translation: AAH31654.1.
CCDSiCCDS7641.1. [Q14153-1]
RefSeqiNP_055476.3. NM_014661.3. [Q14153-1]
UniGeneiHs.129195.

Genome annotation databases

EnsembliENST00000280780; ENSP00000280780; ENSG00000189319. [Q14153-2]
ENST00000337318; ENSP00000338532; ENSG00000189319. [Q14153-1]
ENST00000392754; ENSP00000376509; ENSG00000189319. [Q14153-1]
GeneIDi9679.
KEGGihsa:9679.
UCSCiuc001lhv.2. human. [Q14153-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFA53B_HUMAN
AccessioniPrimary (citable) accession number: Q14153
Secondary accession number(s): D3DRF1
, Q5VUW1, Q5VUW2, Q8N5S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 25, 2008
Last modified: September 27, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families