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Protein

Probable ATP-dependent RNA helicase DHX34

Gene

DHX34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable ATP-binding RNA helicase.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi185 – 192ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process Source: UniProtKB
  • RNA processing Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134815-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DHX34 (EC:3.6.4.13)
Alternative name(s):
DEAH box protein 34
Gene namesi
Name:DHX34
Synonyms:DDX34, KIAA0134
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16719. DHX34.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
  • mitochondrion Source: GO_Central
  • nucleus Source: GO_Central
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi9704.
OpenTargetsiENSG00000134815.
PharmGKBiPA27221.

Polymorphism and mutation databases

BioMutaiDHX34.
DMDMi311033371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000551661 – 1143Probable ATP-dependent RNA helicase DHX34Add BLAST1143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei749PhosphoserineCombined sources1
Modified residuei750PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14147.
MaxQBiQ14147.
PaxDbiQ14147.
PeptideAtlasiQ14147.
PRIDEiQ14147.

PTM databases

iPTMnetiQ14147.
PhosphoSitePlusiQ14147.

Expressioni

Gene expression databases

BgeeiENSG00000134815.
CleanExiHS_DHX34.
ExpressionAtlasiQ14147. baseline and differential.
GenevisibleiQ14147. HS.

Organism-specific databases

HPAiHPA042159.
HPA043558.

Interactioni

Protein-protein interaction databases

BioGridi115056. 8 interactors.
IntActiQ14147. 7 interactors.
MINTiMINT-7006070.
STRINGi9606.ENSP00000331907.

Structurei

3D structure databases

ProteinModelPortaliQ14147.
SMRiQ14147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 332Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST161
Domaini368 – 536Helicase C-terminalPROSITE-ProRule annotationAdd BLAST169

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi279 – 282DEAH box4

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0922. Eukaryota.
COG1643. LUCA.
GeneTreeiENSGT00840000129715.
HOGENOMiHOG000232193.
InParanoidiQ14147.
KOiK20101.
OMAiDSDQVFH.
OrthoDBiEOG091G016M.
PhylomeDBiQ14147.
TreeFamiTF313217.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14147-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPRTREGR DRRDHHRAPS EEEALEKWDW NCPETRRLLE DAFFREEDYI
60 70 80 90 100
RQGSEECQKF WTFFERLQRF QNLKTSRKEE KDPGQPKHSI PALADLPRTY
110 120 130 140 150
DPRYRINLSV LGPATRGSQG LGRHLPAERV AEFRRALLHY LDFGQKQAFG
160 170 180 190 200
RLAKLQRERA ALPIAQYGNR ILQTLKEHQV VVVAGDTGCG KSTQVPQYLL
210 220 230 240 250
AAGFSHVACT QPRRIACISL AKRVGFESLS QYGSQVGYQI RFESTRSAAT
260 270 280 290 300
KIVFLTVGLL LRQIQREPSL PQYEVLIVDE VHERHLHNDF LLGVLQRLLP
310 320 330 340 350
TRPDLKVILM SATINISLFS SYFSNAPVVQ VPGRLFPITV VYQPQEAEPT
360 370 380 390 400
TSKSEKLDPR PFLRVLESID HKYPPEERGD LLVFLSGMAE ISAVLEAAQT
410 420 430 440 450
YASHTQRWVV LPLHSALSVA DQDKVFDVAP PGVRKCILST NIAETSVTID
460 470 480 490 500
GIRFVVDSGK VKEMSYDPQA KLQRLQEFWI SQASAEQRKG RAGRTGPGVC
510 520 530 540 550
FRLYAESDYD AFAPYPVPEI RRVALDSLVL QMKSMSVGDP RTFPFIEPPP
560 570 580 590 600
PASLETAILY LRDQGALDSS EALTPIGSLL AQLPVDVVIG KMLILGSMFS
610 620 630 640 650
LVEPVLTIAA ALSVQSPFTR SAQSSPECAA ARRPLESDQG DPFTLFNVFN
660 670 680 690 700
AWVQVKSERS RNSRKWCRRR GIEEHRLYEM ANLRRQFKEL LEDHGLLAGA
710 720 730 740 750
QAAQVGDSYS RLQQRRERRA LHQLKRQHEE GAGRRRKVLR LQEEQDGGSS
760 770 780 790 800
DEDRAGPAPP GASDGVDIQD VKFKLRHDLA QLQAAASSAQ DLSREQLALL
810 820 830 840 850
KLVLGRGLYP QLAVPDAFNS SRKDSDQIFH TQAKQGAVLH PTCVFAGSPE
860 870 880 890 900
VLHAQELEAS NCDGSRDDKD KMSSKHQLLS FVSLLETNKP YLVNCVRIPA
910 920 930 940 950
LQSLLLFSRS LDTNGDCSRL VADGWLELQL ADSESAIRLL AASLRLRARW
960 970 980 990 1000
ESALDRQLAH QAQQQLEEEE EDTPVSPKEV ATLSKELLQF TASKIPYSLR
1010 1020 1030 1040 1050
RLTGLEVQNM YVGPQTIPAT PHLPGLFGSS TLSPHPTKGG YAVTDFLTYN
1060 1070 1080 1090 1100
CLTNDTDLYS DCLRTFWTCP HCGLHAPLTP LERIAHENTC PQAPQDGPPG
1110 1120 1130 1140
AEEAALETLQ KTSVLQRPYH CEACGKDFLF TPTEVLRHRK QHV
Length:1,143
Mass (Da):128,120
Last modified:November 2, 2010 - v2
Checksum:i4081CAC2D9B4B840
GO

Sequence cautioni

The sequence BAA09483 differs from that shown. Aberrant splicing.Curated
The sequence BAG60050 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05724117R → W.Corresponds to variant rs12984558dbSNPEnsembl.1
Natural variantiVAR_057242117G → D.Corresponds to variant rs8113564dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50924 mRNA. Translation: BAA09483.2. Sequence problems.
AC008754 Genomic DNA. No translation available.
AK297692 mRNA. Translation: BAG60050.1. Different initiation.
CCDSiCCDS12700.1.
RefSeqiNP_055496.2. NM_014681.5.
XP_005259500.1. XM_005259443.3.
XP_011525852.1. XM_011527550.2.
XP_011525853.1. XM_011527551.2.
XP_016883013.1. XM_017027524.1.
UniGeneiHs.151706.

Genome annotation databases

EnsembliENST00000328771; ENSP00000331907; ENSG00000134815.
GeneIDi9704.
KEGGihsa:9704.
UCSCiuc010xyn.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50924 mRNA. Translation: BAA09483.2. Sequence problems.
AC008754 Genomic DNA. No translation available.
AK297692 mRNA. Translation: BAG60050.1. Different initiation.
CCDSiCCDS12700.1.
RefSeqiNP_055496.2. NM_014681.5.
XP_005259500.1. XM_005259443.3.
XP_011525852.1. XM_011527550.2.
XP_011525853.1. XM_011527551.2.
XP_016883013.1. XM_017027524.1.
UniGeneiHs.151706.

3D structure databases

ProteinModelPortaliQ14147.
SMRiQ14147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115056. 8 interactors.
IntActiQ14147. 7 interactors.
MINTiMINT-7006070.
STRINGi9606.ENSP00000331907.

PTM databases

iPTMnetiQ14147.
PhosphoSitePlusiQ14147.

Polymorphism and mutation databases

BioMutaiDHX34.
DMDMi311033371.

Proteomic databases

EPDiQ14147.
MaxQBiQ14147.
PaxDbiQ14147.
PeptideAtlasiQ14147.
PRIDEiQ14147.

Protocols and materials databases

DNASUi9704.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328771; ENSP00000331907; ENSG00000134815.
GeneIDi9704.
KEGGihsa:9704.
UCSCiuc010xyn.2. human.

Organism-specific databases

CTDi9704.
DisGeNETi9704.
GeneCardsiDHX34.
HGNCiHGNC:16719. DHX34.
HPAiHPA042159.
HPA043558.
MIMi615475. gene.
neXtProtiNX_Q14147.
OpenTargetsiENSG00000134815.
PharmGKBiPA27221.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0922. Eukaryota.
COG1643. LUCA.
GeneTreeiENSGT00840000129715.
HOGENOMiHOG000232193.
InParanoidiQ14147.
KOiK20101.
OMAiDSDQVFH.
OrthoDBiEOG091G016M.
PhylomeDBiQ14147.
TreeFamiTF313217.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000134815-MONOMER.

Miscellaneous databases

ChiTaRSiDHX34. human.
GenomeRNAii9704.
PROiQ14147.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134815.
CleanExiHS_DHX34.
ExpressionAtlasiQ14147. baseline and differential.
GenevisibleiQ14147. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011709. DUF1605.
IPR007502. Helicase-assoc_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04408. HA2. 1 hit.
PF00271. Helicase_C. 1 hit.
PF07717. OB_NTP_bind. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00847. HA2. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHX34_HUMAN
AccessioniPrimary (citable) accession number: Q14147
Secondary accession number(s): B4DMY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.