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Protein

Unhealthy ribosome biogenesis protein 2 homolog

Gene

URB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Unhealthy ribosome biogenesis protein 2 homolog
Gene namesi
Name:URB2
Synonyms:KIAA0133
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28967. URB2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164727496.

Polymorphism and mutation databases

BioMutaiURB2.
DMDMi209572635.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15241524Unhealthy ribosome biogenesis protein 2 homologPRO_0000050720Add
BLAST

Proteomic databases

EPDiQ14146.
MaxQBiQ14146.
PaxDbiQ14146.
PeptideAtlasiQ14146.
PRIDEiQ14146.

PTM databases

iPTMnetiQ14146.
PhosphoSiteiQ14146.

Expressioni

Gene expression databases

BgeeiENSG00000135763.
CleanExiHS_URB2.
ExpressionAtlasiQ14146. baseline and differential.
GenevisibleiQ14146. HS.

Organism-specific databases

HPAiHPA008902.
HPA046788.

Interactioni

Protein-protein interaction databases

BioGridi115155. 27 interactions.
IntActiQ14146. 7 interactions.
MINTiMINT-4994948.
STRINGi9606.ENSP00000258243.

Structurei

3D structure databases

ProteinModelPortaliQ14146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IHVN. Eukaryota.
ENOG410ZP2S. LUCA.
GeneTreeiENSGT00390000009258.
HOGENOMiHOG000154789.
HOVERGENiHBG107151.
InParanoidiQ14146.
KOiK14862.
OMAiPVAHWHL.
OrthoDBiEOG091G00DX.
PhylomeDBiQ14146.
TreeFamiTF328770.

Family and domain databases

InterProiIPR018849. Urb2/Npa2_C.
[Graphical view]
PfamiPF10441. Urb2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14146-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVYSGISL KLKSKTTSWE DKLKLAHFAW ISHQCFLPNK EQVLLDWARQ
60 70 80 90 100
SLVAFYKKKL ELKEDIVERL WIYIDNILHS RKLQNLLKNG KTINLQISLV
110 120 130 140 150
KIINERVAEF SLSGSQRNIC AVLRCCQGIL STPALAVIYT AKQELMVALL
160 170 180 190 200
SQLCWSACRQ PEGAVVAQLF EVIHLALGHY LLILQQQVNP RRAFGDVTAH
210 220 230 240 250
LLQPCLVLRH LLSGGTWTQA GQGQLRQVLS RDIRSQIEAM FRGGIFQPEL
260 270 280 290 300
LSSYKEGLLD QQQGDVKTGA MKNLLAPMDT VLNRLVDAGY CAASLHTSVV
310 320 330 340 350
ANSVALLYKL FLDSYFKEGN QLLCFQVLPR LFGCLKISHL QEEQSKALST
360 370 380 390 400
SDWTTELLVV EQLLNSVANN NIYNIAADRI RHEEAQFRFY RHVAELLINH
410 420 430 440 450
AQAPIPAWFR CLKTLISLNH LILEPDLDDL LASAWIDAEV TEFRTKKAQE
460 470 480 490 500
ALIRTVFQTY AKLRQVPRLF EEVLGVICRP AAEALRQPVL ASGPSTVLSA
510 520 530 540 550
CLLELPPSQI LDTWSLVLEK FQSLVLPYLQ SDADMALKSL SLSLLLHCIM
560 570 580 590 600
FNMRSLDSST PLPIVRRTQC MMERMMRELV QPLLALLPDT PGPEPELWLQ
610 620 630 640 650
KVSDSVLLLS YTWAQVDAMF SLNCSQYHSM SGPLIGVALE ISNLPSLLPG
660 670 680 690 700
VKTQHWKKIE KFTAQFSSLG TYCLEQLYLQ KMKRTLMQTS FRSEGAIQSL
710 720 730 740 750
RCDAAFIIGS GRKSLNQRTT ASWDGQVGMV SGLTYPVAHW HLIVSNLTIL
760 770 780 790 800
ISYLCPDDVG YLASVLLRTL PMGKAQEVSI DEEAYITLEK ISKAFLHSPL
810 820 830 840 850
FPEMQSLHSA FLTCVTTSCS SILCSGAQRD SGLVSQQLPW LFEKDHMVVG
860 870 880 890 900
HWENRFAKAG PEGIEPRGEI AQNLLSLVKS DFPIQLEGEQ LESILGLLEV
910 920 930 940 950
ISALQLDSLL PPYHVHYFLV LLSMAVTKLG CSCSSSLALK FLTTCYQLLG
960 970 980 990 1000
YLQKGKSARS VFKIMYGSDI FEVVLTSLFR ASSRFLIEMD DPAWLEFLQV
1010 1020 1030 1040 1050
IGTFLEELMQ MLIQMKLSLV LNFRKITAFL SSSKPYTEAA SSKQLENQNP
1060 1070 1080 1090 1100
QGRQLLLVSL TRLCHVLGPF LKEQKLGQEA PAALSELLQQ VVLQTGAVLQ
1110 1120 1130 1140 1150
LCSVPGARGW RLPSVLISSV STLLEADLGQ HCRDGGADIS QGSDRTLLSH
1160 1170 1180 1190 1200
VALYQGVYSQ ILLELPALAG HDQSFQAALQ FLTLFFLAPE LHPKKDSVFT
1210 1220 1230 1240 1250
SMFHSVRRVL ADPEIPVQVT QDIEPHLGAL FTQMLEVGTT EDLRLVMQCI
1260 1270 1280 1290 1300
LQGLDVSNMW KADVQAVVSA VTLLRLLLNC PLSGEKASLL WRACPQIVTA
1310 1320 1330 1340 1350
LTLLNREASQ EQPVSLTVVG PVLDVLAALL RQGEEAIGNP HHVSLAFSIL
1360 1370 1380 1390 1400
LTVPLDHLKP LEYGSVFPRL HNVLFSILQC HPKVMLKAIP SFLNSFNRLV
1410 1420 1430 1440 1450
FSVMREGRQK DKGSIDDLPT VLKCARLVER MYSHIAARAE EFAVFSPFMV
1460 1470 1480 1490 1500
AQYVLEVQKV TLYPAVKSLL QEGIYLILDL CIEPDVQFLR ASLQPGMRDI
1510 1520
FKELYNDYLK YHKAKHEGEK RYTA
Length:1,524
Mass (Da):170,544
Last modified:October 14, 2008 - v2
Checksum:iD27CFF42B0892679
GO

Sequence cautioni

The sequence BAA09482 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti778 – 7781V → G.
Corresponds to variant rs3811473 [ dbSNP | Ensembl ].
VAR_034031
Natural varianti1400 – 14001V → M.
Corresponds to variant rs12142450 [ dbSNP | Ensembl ].
VAR_046975

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50923 mRNA. Translation: BAA09482.3. Different initiation.
AL354983, AL121990 Genomic DNA. Translation: CAH70043.1.
AL121990, AL354983 Genomic DNA. Translation: CAI22017.1.
BC114559 mRNA. Translation: AAI14560.1.
BC114963 mRNA. Translation: AAI14964.1.
CCDSiCCDS31052.1.
RefSeqiNP_001300950.1. NM_001314021.1.
NP_055592.2. NM_014777.3.
UniGeneiHs.533628.

Genome annotation databases

EnsembliENST00000258243; ENSP00000258243; ENSG00000135763.
GeneIDi9816.
KEGGihsa:9816.
UCSCiuc001hts.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50923 mRNA. Translation: BAA09482.3. Different initiation.
AL354983, AL121990 Genomic DNA. Translation: CAH70043.1.
AL121990, AL354983 Genomic DNA. Translation: CAI22017.1.
BC114559 mRNA. Translation: AAI14560.1.
BC114963 mRNA. Translation: AAI14964.1.
CCDSiCCDS31052.1.
RefSeqiNP_001300950.1. NM_001314021.1.
NP_055592.2. NM_014777.3.
UniGeneiHs.533628.

3D structure databases

ProteinModelPortaliQ14146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115155. 27 interactions.
IntActiQ14146. 7 interactions.
MINTiMINT-4994948.
STRINGi9606.ENSP00000258243.

PTM databases

iPTMnetiQ14146.
PhosphoSiteiQ14146.

Polymorphism and mutation databases

BioMutaiURB2.
DMDMi209572635.

Proteomic databases

EPDiQ14146.
MaxQBiQ14146.
PaxDbiQ14146.
PeptideAtlasiQ14146.
PRIDEiQ14146.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258243; ENSP00000258243; ENSG00000135763.
GeneIDi9816.
KEGGihsa:9816.
UCSCiuc001hts.1. human.

Organism-specific databases

CTDi9816.
GeneCardsiURB2.
HGNCiHGNC:28967. URB2.
HPAiHPA008902.
HPA046788.
neXtProtiNX_Q14146.
PharmGKBiPA164727496.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHVN. Eukaryota.
ENOG410ZP2S. LUCA.
GeneTreeiENSGT00390000009258.
HOGENOMiHOG000154789.
HOVERGENiHBG107151.
InParanoidiQ14146.
KOiK14862.
OMAiPVAHWHL.
OrthoDBiEOG091G00DX.
PhylomeDBiQ14146.
TreeFamiTF328770.

Miscellaneous databases

GenomeRNAii9816.
PROiQ14146.

Gene expression databases

BgeeiENSG00000135763.
CleanExiHS_URB2.
ExpressionAtlasiQ14146. baseline and differential.
GenevisibleiQ14146. HS.

Family and domain databases

InterProiIPR018849. Urb2/Npa2_C.
[Graphical view]
PfamiPF10441. Urb2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiURB2_HUMAN
AccessioniPrimary (citable) accession number: Q14146
Secondary accession number(s): Q5VYC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 14, 2008
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.