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Q14142

- TRI14_HUMAN

UniProt

Q14142 - TRI14_HUMAN

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Protein

Tripartite motif-containing protein 14

Gene

TRIM14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits the transcriptional activity of SPI1 in a dose-dependent manner.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri19 – 6143B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. innate immune response Source: UniProt
  2. negative regulation of viral transcription Source: UniProt
  3. positive regulation of NF-kappaB transcription factor activity Source: UniProt
  4. positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProt
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 14
Gene namesi
Name:TRIM14
Synonyms:KIAA0129
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:16283. TRIM14.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38113.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 442442Tripartite motif-containing protein 14PRO_0000220370Add
BLAST

Proteomic databases

MaxQBiQ14142.
PaxDbiQ14142.
PRIDEiQ14142.

PTM databases

PhosphoSiteiQ14142.

Expressioni

Tissue specificityi

Highest expression in liver; undetectable in skeletal muscle.

Inductioni

By interferons alpha and gamma.1 Publication

Gene expression databases

BgeeiQ14142.
CleanExiHS_TRIM14.
ExpressionAtlasiQ14142. baseline and differential.
GenevestigatoriQ14142.

Organism-specific databases

HPAiHPA053217.

Interactioni

Subunit structurei

Interacts with SPI1.By similarity

Protein-protein interaction databases

BioGridi115168. 3 interactions.
IntActiQ14142. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ14142.
SMRiQ14142. Positions 270-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini249 – 442194B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili76 – 10934Sequence AnalysisAdd
BLAST
Coiled coili135 – 15622Sequence AnalysisAdd
BLAST

Domaini

The B-box zinc finger is responsible for inhibition of SPI1-mediated transcriptional activation.By similarity

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri19 – 6143B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG148464.
GeneTreeiENSGT00760000119283.
HOGENOMiHOG000013201.
HOVERGENiHBG054251.
InParanoidiQ14142.
KOiK12004.
OMAiTVRCGLL.
OrthoDBiEOG7HQN85.
PhylomeDBiQ14142.
TreeFamiTF351014.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform Alpha (identifier: Q14142-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAATGSRT PGRSELVEGC GWRCPEHGDR VAELFCRRCR RCVCALCPVL
60 70 80 90 100
GAHRGHPVGL ALEAAVHVQK LSQECLKQLA IKKQQHIDNI TQIEDATEKL
110 120 130 140 150
KANAESSKTW LKGKFTELRL LLDEEEALAK KFIDKNTQLT LQVYREQADS
160 170 180 190 200
CREQLDIMND LSNRVWSISQ EPDPVQRLQA YTATEQEMQQ QMSLGELCHP
210 220 230 240 250
VPLSFEPVKS FFKGLVEAVE STLQTPLDIR LKESINCQLS DPSSTKPGTL
260 270 280 290 300
LKTSPSPERS LLLKYARTPT LDPDTMHARL RLSADRLTVR CGLLGSLGPV
310 320 330 340 350
PVLRFDALWQ VLARDCFATG RHYWEVDVQE AGAGWWVGAA YASLRRRGAS
360 370 380 390 400
AAARLGCNRQ SWCLKRYDLE YWAFHDGQRS RLRPRDDLDR LGVFLDYEAG
410 420 430 440
VLAFYDVTGG MSHLHTFRAT FQEPLYPALR LWEGAISIPR LP
Length:442
Mass (Da):49,773
Last modified:February 21, 2002 - v2
Checksum:i68990B2B57F1D083
GO
Isoform Beta (identifier: Q14142-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-253: KESINCQLSDPSSTKPGTLLKT → SPTNHAYSALKVSSPRLVSNRP
     254-442: Missing.

Show »
Length:253
Mass (Da):28,347
Checksum:iD3E44449E5113EAC
GO
Isoform 3 (identifier: Q14142-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-442: RLRPRDDLDR...EGAISIPRLP → ACGPATTSTGSASSWTTRPASSPSTT

Show »
Length:406
Mass (Da):45,112
Checksum:iE6E0BA0376315664
GO
Isoform 4 (identifier: Q14142-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.
     265-380: YARTPTLDPD...YWAFHDGQRS → SCWAAWGPCP...TGPSTTASAA
     381-442: RLRPRDDLDR...EGAISIPRLP → ACGPATTSTGSASSWTTRPASSPSTT

Show »
Length:222
Mass (Da):23,146
Checksum:i761C4E78AE472996
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 4 (identifier: Q14142-4)
Sequence conflicti106 – 1083LKS → PIA in BAC05071. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti219 – 2191V → M.
Corresponds to variant rs2296079 [ dbSNP | Ensembl ].
VAR_048399

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 157157Missing in isoform 4. 1 PublicationVSP_044097Add
BLAST
Alternative sequencei232 – 25322KESIN…TLLKT → SPTNHAYSALKVSSPRLVSN RP in isoform Beta. 1 PublicationVSP_000510Add
BLAST
Alternative sequencei254 – 442189Missing in isoform Beta. 1 PublicationVSP_000511Add
BLAST
Alternative sequencei265 – 380116YARTP…DGQRS → SCWAAWGPCPCCGSTRSGKC WLVTASPPAATTGRLTCRRR APAGGWARPTPPFGAAGPRP PPAWAATASPGASSATTLST GPSTTASAA in isoform 4. 1 PublicationVSP_044098Add
BLAST
Alternative sequencei381 – 44262RLRPR…IPRLP → ACGPATTSTGSASSWTTRPA SSPSTT in isoform 3 and isoform 4. 3 PublicationsVSP_044099Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF220130 mRNA. Translation: AAG53503.1.
AF220131 mRNA. Translation: AAG53504.1.
D50919 mRNA. Translation: BAA09478.1.
AK097480 mRNA. Translation: BAC05071.1.
AK292825 mRNA. Translation: BAF85514.1.
AL137073 Genomic DNA. Translation: CAI13890.1.
AL137073 Genomic DNA. Translation: CAI13891.1.
CH471105 Genomic DNA. Translation: EAW58870.1.
CH471105 Genomic DNA. Translation: EAW58877.1.
BC006333 mRNA. Translation: AAH06333.1.
CCDSiCCDS6734.1. [Q14142-1]
RefSeqiNP_055603.2. NM_014788.3. [Q14142-1]
NP_150088.1. NM_033219.2. [Q14142-1]
XP_005252377.1. XM_005252320.1. [Q14142-1]
XP_005252378.1. XM_005252321.1. [Q14142-1]
XP_005252379.1. XM_005252322.2. [Q14142-1]
XP_005252380.1. XM_005252323.2. [Q14142-1]
UniGeneiHs.575631.

Genome annotation databases

EnsembliENST00000341469; ENSP00000344208; ENSG00000106785. [Q14142-1]
ENST00000342043; ENSP00000343990; ENSG00000106785. [Q14142-1]
ENST00000375098; ENSP00000364239; ENSG00000106785. [Q14142-1]
GeneIDi9830.
KEGGihsa:9830.
UCSCiuc004ayd.2. human. [Q14142-1]

Polymorphism databases

DMDMi20141957.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF220130 mRNA. Translation: AAG53503.1 .
AF220131 mRNA. Translation: AAG53504.1 .
D50919 mRNA. Translation: BAA09478.1 .
AK097480 mRNA. Translation: BAC05071.1 .
AK292825 mRNA. Translation: BAF85514.1 .
AL137073 Genomic DNA. Translation: CAI13890.1 .
AL137073 Genomic DNA. Translation: CAI13891.1 .
CH471105 Genomic DNA. Translation: EAW58870.1 .
CH471105 Genomic DNA. Translation: EAW58877.1 .
BC006333 mRNA. Translation: AAH06333.1 .
CCDSi CCDS6734.1. [Q14142-1 ]
RefSeqi NP_055603.2. NM_014788.3. [Q14142-1 ]
NP_150088.1. NM_033219.2. [Q14142-1 ]
XP_005252377.1. XM_005252320.1. [Q14142-1 ]
XP_005252378.1. XM_005252321.1. [Q14142-1 ]
XP_005252379.1. XM_005252322.2. [Q14142-1 ]
XP_005252380.1. XM_005252323.2. [Q14142-1 ]
UniGenei Hs.575631.

3D structure databases

ProteinModelPortali Q14142.
SMRi Q14142. Positions 270-427.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115168. 3 interactions.
IntActi Q14142. 2 interactions.

PTM databases

PhosphoSitei Q14142.

Polymorphism databases

DMDMi 20141957.

Proteomic databases

MaxQBi Q14142.
PaxDbi Q14142.
PRIDEi Q14142.

Protocols and materials databases

DNASUi 9830.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341469 ; ENSP00000344208 ; ENSG00000106785 . [Q14142-1 ]
ENST00000342043 ; ENSP00000343990 ; ENSG00000106785 . [Q14142-1 ]
ENST00000375098 ; ENSP00000364239 ; ENSG00000106785 . [Q14142-1 ]
GeneIDi 9830.
KEGGi hsa:9830.
UCSCi uc004ayd.2. human. [Q14142-1 ]

Organism-specific databases

CTDi 9830.
GeneCardsi GC09M100831.
HGNCi HGNC:16283. TRIM14.
HPAi HPA053217.
MIMi 606556. gene.
neXtProti NX_Q14142.
PharmGKBi PA38113.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148464.
GeneTreei ENSGT00760000119283.
HOGENOMi HOG000013201.
HOVERGENi HBG054251.
InParanoidi Q14142.
KOi K12004.
OMAi TVRCGLL.
OrthoDBi EOG7HQN85.
PhylomeDBi Q14142.
TreeFami TF351014.

Miscellaneous databases

ChiTaRSi TRIM14. human.
GenomeRNAii 9830.
NextBioi 37034.
PROi Q14142.
SOURCEi Search...

Gene expression databases

Bgeei Q14142.
CleanExi HS_TRIM14.
ExpressionAtlasi Q14142. baseline and differential.
Genevestigatori Q14142.

Family and domain databases

Gene3Di 4.10.45.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
[Graphical view ]
Pfami PF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view ]
PRINTSi PR01407. BUTYPHLNCDUF.
SMARTi SM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BETA AND 3).
  2. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
    DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Bone marrow.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA AND 4).
    Tissue: Testis and Trachea.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
    Tissue: Eye.
  7. "Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication."
    Metz P., Dazert E., Ruggieri A., Mazur J., Kaderali L., Kaul A., Zeuge U., Trippler M., Lohmann V., Binder M., Frese M., Bartenschlager R.
    Hepatology 56:2082-2093(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY INTERFERONS.

Entry informationi

Entry nameiTRI14_HUMAN
AccessioniPrimary (citable) accession number: Q14142
Secondary accession number(s): A8K9W0
, E7EQC4, F8W956, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 21, 2002
Last modified: October 29, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3