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Protein

Tripartite motif-containing protein 14

Gene

TRIM14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits the transcriptional activity of SPI1 in a dose-dependent manner.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 61B box-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

GO - Biological processi

  • innate immune response Source: UniProtKB
  • negative regulation of viral transcription Source: UniProtKB
  • positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106785-MONOMER.
ReactomeiR-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 14
Gene namesi
Name:TRIM14
Synonyms:KIAA0129
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:16283. TRIM14.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000106785.
PharmGKBiPA38113.

Polymorphism and mutation databases

DMDMi20141957.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002203701 – 442Tripartite motif-containing protein 14Add BLAST442

Proteomic databases

EPDiQ14142.
MaxQBiQ14142.
PaxDbiQ14142.
PeptideAtlasiQ14142.
PRIDEiQ14142.

PTM databases

iPTMnetiQ14142.
PhosphoSitePlusiQ14142.

Expressioni

Tissue specificityi

Highest expression in liver; undetectable in skeletal muscle.

Inductioni

By interferons alpha and gamma.1 Publication

Gene expression databases

BgeeiENSG00000106785.
CleanExiHS_TRIM14.
ExpressionAtlasiQ14142. baseline and differential.
GenevisibleiQ14142. HS.

Organism-specific databases

HPAiHPA053217.

Interactioni

Subunit structurei

Interacts with SPI1.By similarity

Protein-protein interaction databases

BioGridi115168. 5 interactors.
IntActiQ14142. 36 interactors.
STRINGi9606.ENSP00000343990.

Structurei

3D structure databases

ProteinModelPortaliQ14142.
SMRiQ14142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini249 – 442B30.2/SPRYPROSITE-ProRule annotationAdd BLAST194

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili76 – 109Sequence analysisAdd BLAST34
Coiled coili135 – 156Sequence analysisAdd BLAST22

Domaini

The B-box zinc finger is responsible for inhibition of SPI1-mediated transcriptional activation.By similarity

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 61B box-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IJ3M. Eukaryota.
ENOG410YJX9. LUCA.
GeneTreeiENSGT00840000129835.
HOGENOMiHOG000013201.
HOVERGENiHBG054251.
InParanoidiQ14142.
KOiK12004.
OMAiARDCFAA.
OrthoDBiEOG091G09TT.
PhylomeDBiQ14142.
TreeFamiTF351014.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q14142-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGAATGSRT PGRSELVEGC GWRCPEHGDR VAELFCRRCR RCVCALCPVL
60 70 80 90 100
GAHRGHPVGL ALEAAVHVQK LSQECLKQLA IKKQQHIDNI TQIEDATEKL
110 120 130 140 150
KANAESSKTW LKGKFTELRL LLDEEEALAK KFIDKNTQLT LQVYREQADS
160 170 180 190 200
CREQLDIMND LSNRVWSISQ EPDPVQRLQA YTATEQEMQQ QMSLGELCHP
210 220 230 240 250
VPLSFEPVKS FFKGLVEAVE STLQTPLDIR LKESINCQLS DPSSTKPGTL
260 270 280 290 300
LKTSPSPERS LLLKYARTPT LDPDTMHARL RLSADRLTVR CGLLGSLGPV
310 320 330 340 350
PVLRFDALWQ VLARDCFATG RHYWEVDVQE AGAGWWVGAA YASLRRRGAS
360 370 380 390 400
AAARLGCNRQ SWCLKRYDLE YWAFHDGQRS RLRPRDDLDR LGVFLDYEAG
410 420 430 440
VLAFYDVTGG MSHLHTFRAT FQEPLYPALR LWEGAISIPR LP
Length:442
Mass (Da):49,773
Last modified:February 21, 2002 - v2
Checksum:i68990B2B57F1D083
GO
Isoform Beta (identifier: Q14142-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-253: KESINCQLSDPSSTKPGTLLKT → SPTNHAYSALKVSSPRLVSNRP
     254-442: Missing.

Show »
Length:253
Mass (Da):28,347
Checksum:iD3E44449E5113EAC
GO
Isoform 3 (identifier: Q14142-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-442: RLRPRDDLDR...EGAISIPRLP → ACGPATTSTGSASSWTTRPASSPSTT

Show »
Length:406
Mass (Da):45,112
Checksum:iE6E0BA0376315664
GO
Isoform 4 (identifier: Q14142-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.
     265-380: YARTPTLDPD...YWAFHDGQRS → SCWAAWGPCP...TGPSTTASAA
     381-442: RLRPRDDLDR...EGAISIPRLP → ACGPATTSTGSASSWTTRPASSPSTT

Show »
Length:222
Mass (Da):23,146
Checksum:i761C4E78AE472996
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 4 (identifier: Q14142-4)
Sequence conflicti106 – 108LKS → PIA in BAC05071 (PubMed:14702039).Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048399219V → M.Corresponds to variant rs2296079dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0440971 – 157Missing in isoform 4. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_000510232 – 253KESIN…TLLKT → SPTNHAYSALKVSSPRLVSN RP in isoform Beta. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_000511254 – 442Missing in isoform Beta. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_044098265 – 380YARTP…DGQRS → SCWAAWGPCPCCGSTRSGKC WLVTASPPAATTGRLTCRRR APAGGWARPTPPFGAAGPRP PPAWAATASPGASSATTLST GPSTTASAA in isoform 4. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_044099381 – 442RLRPR…IPRLP → ACGPATTSTGSASSWTTRPA SSPSTT in isoform 3 and isoform 4. 3 PublicationsAdd BLAST62

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220130 mRNA. Translation: AAG53503.1.
AF220131 mRNA. Translation: AAG53504.1.
D50919 mRNA. Translation: BAA09478.1.
AK097480 mRNA. Translation: BAC05071.1.
AK292825 mRNA. Translation: BAF85514.1.
AL137073 Genomic DNA. Translation: CAI13890.1.
AL137073 Genomic DNA. Translation: CAI13891.1.
CH471105 Genomic DNA. Translation: EAW58870.1.
CH471105 Genomic DNA. Translation: EAW58877.1.
BC006333 mRNA. Translation: AAH06333.1.
CCDSiCCDS6734.1. [Q14142-1]
RefSeqiNP_055603.2. NM_014788.3. [Q14142-1]
NP_150088.1. NM_033219.2. [Q14142-1]
XP_005252377.1. XM_005252320.3. [Q14142-1]
XP_016870841.1. XM_017015352.1. [Q14142-1]
XP_016870842.1. XM_017015353.1. [Q14142-1]
UniGeneiHs.575631.
Hs.665191.

Genome annotation databases

EnsembliENST00000341469; ENSP00000344208; ENSG00000106785. [Q14142-1]
ENST00000342043; ENSP00000343990; ENSG00000106785. [Q14142-1]
ENST00000375098; ENSP00000364239; ENSG00000106785. [Q14142-1]
GeneIDi9830.
KEGGihsa:9830.
UCSCiuc004ayg.3. human. [Q14142-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220130 mRNA. Translation: AAG53503.1.
AF220131 mRNA. Translation: AAG53504.1.
D50919 mRNA. Translation: BAA09478.1.
AK097480 mRNA. Translation: BAC05071.1.
AK292825 mRNA. Translation: BAF85514.1.
AL137073 Genomic DNA. Translation: CAI13890.1.
AL137073 Genomic DNA. Translation: CAI13891.1.
CH471105 Genomic DNA. Translation: EAW58870.1.
CH471105 Genomic DNA. Translation: EAW58877.1.
BC006333 mRNA. Translation: AAH06333.1.
CCDSiCCDS6734.1. [Q14142-1]
RefSeqiNP_055603.2. NM_014788.3. [Q14142-1]
NP_150088.1. NM_033219.2. [Q14142-1]
XP_005252377.1. XM_005252320.3. [Q14142-1]
XP_016870841.1. XM_017015352.1. [Q14142-1]
XP_016870842.1. XM_017015353.1. [Q14142-1]
UniGeneiHs.575631.
Hs.665191.

3D structure databases

ProteinModelPortaliQ14142.
SMRiQ14142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115168. 5 interactors.
IntActiQ14142. 36 interactors.
STRINGi9606.ENSP00000343990.

PTM databases

iPTMnetiQ14142.
PhosphoSitePlusiQ14142.

Polymorphism and mutation databases

DMDMi20141957.

Proteomic databases

EPDiQ14142.
MaxQBiQ14142.
PaxDbiQ14142.
PeptideAtlasiQ14142.
PRIDEiQ14142.

Protocols and materials databases

DNASUi9830.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341469; ENSP00000344208; ENSG00000106785. [Q14142-1]
ENST00000342043; ENSP00000343990; ENSG00000106785. [Q14142-1]
ENST00000375098; ENSP00000364239; ENSG00000106785. [Q14142-1]
GeneIDi9830.
KEGGihsa:9830.
UCSCiuc004ayg.3. human. [Q14142-1]

Organism-specific databases

CTDi9830.
GeneCardsiTRIM14.
HGNCiHGNC:16283. TRIM14.
HPAiHPA053217.
MIMi606556. gene.
neXtProtiNX_Q14142.
OpenTargetsiENSG00000106785.
PharmGKBiPA38113.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ3M. Eukaryota.
ENOG410YJX9. LUCA.
GeneTreeiENSGT00840000129835.
HOGENOMiHOG000013201.
HOVERGENiHBG054251.
InParanoidiQ14142.
KOiK12004.
OMAiARDCFAA.
OrthoDBiEOG091G09TT.
PhylomeDBiQ14142.
TreeFamiTF351014.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106785-MONOMER.
ReactomeiR-HSA-877300. Interferon gamma signaling.

Miscellaneous databases

ChiTaRSiTRIM14. human.
GenomeRNAii9830.
PROiQ14142.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106785.
CleanExiHS_TRIM14.
ExpressionAtlasiQ14142. baseline and differential.
GenevisibleiQ14142. HS.

Family and domain databases

Gene3Di4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI14_HUMAN
AccessioniPrimary (citable) accession number: Q14142
Secondary accession number(s): A8K9W0
, E7EQC4, F8W956, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 21, 2002
Last modified: November 30, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.