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Q14142 (TRI14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite motif-containing protein 14
Gene names
Name:TRIM14
Synonyms:KIAA0129
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits the transcriptional activity of SPI1 in a dose-dependent manner By similarity.

Subunit structure

Interacts with SPI1 By similarity.

Tissue specificity

Highest expression in liver; undetectable in skeletal muscle.

Induction

By interferons alpha and gamma. Ref.7

Domain

The B-box zinc finger is responsible for inhibition of SPI1-mediated transcriptional activation By similarity.

Sequence similarities

Belongs to the TRIM/RBCC family.

Contains 1 B box-type zinc finger.

Contains 1 B30.2/SPRY domain.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform Alpha (identifier: Q14142-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Beta (identifier: Q14142-2)

The sequence of this isoform differs from the canonical sequence as follows:
     232-253: KESINCQLSDPSSTKPGTLLKT → SPTNHAYSALKVSSPRLVSNRP
     254-442: Missing.
Isoform 3 (identifier: Q14142-3)

The sequence of this isoform differs from the canonical sequence as follows:
     381-442: RLRPRDDLDR...EGAISIPRLP → ACGPATTSTGSASSWTTRPASSPSTT
Isoform 4 (identifier: Q14142-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.
     265-380: YARTPTLDPD...YWAFHDGQRS → SCWAAWGPCP...TGPSTTASAA
     381-442: RLRPRDDLDR...EGAISIPRLP → ACGPATTSTGSASSWTTRPASSPSTT
Note: Ref.3 (BAC05071) sequence is in conflict in position: 106-108:LKS->PIA.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442Tripartite motif-containing protein 14
PRO_0000220370

Regions

Domain249 – 442194B30.2/SPRY
Zinc finger19 – 6143B box-type
Coiled coil76 – 10934 Potential
Coiled coil135 – 15622 Potential

Natural variations

Alternative sequence1 – 157157Missing in isoform 4.
VSP_044097
Alternative sequence232 – 25322KESIN…TLLKT → SPTNHAYSALKVSSPRLVSN RP in isoform Beta.
VSP_000510
Alternative sequence254 – 442189Missing in isoform Beta.
VSP_000511
Alternative sequence265 – 380116YARTP…DGQRS → SCWAAWGPCPCCGSTRSGKC WLVTASPPAATTGRLTCRRR APAGGWARPTPPFGAAGPRP PPAWAATASPGASSATTLST GPSTTASAA in isoform 4.
VSP_044098
Alternative sequence381 – 44262RLRPR…IPRLP → ACGPATTSTGSASSWTTRPA SSPSTT in isoform 3 and isoform 4.
VSP_044099
Natural variant2191V → M.
Corresponds to variant rs2296079 [ dbSNP | Ensembl ].
VAR_048399

Sequences

Sequence LengthMass (Da)Tools
Isoform Alpha [UniParc].

Last modified February 21, 2002. Version 2.
Checksum: 68990B2B57F1D083

FASTA44249,773
        10         20         30         40         50         60 
MAGAATGSRT PGRSELVEGC GWRCPEHGDR VAELFCRRCR RCVCALCPVL GAHRGHPVGL 

        70         80         90        100        110        120 
ALEAAVHVQK LSQECLKQLA IKKQQHIDNI TQIEDATEKL KANAESSKTW LKGKFTELRL 

       130        140        150        160        170        180 
LLDEEEALAK KFIDKNTQLT LQVYREQADS CREQLDIMND LSNRVWSISQ EPDPVQRLQA 

       190        200        210        220        230        240 
YTATEQEMQQ QMSLGELCHP VPLSFEPVKS FFKGLVEAVE STLQTPLDIR LKESINCQLS 

       250        260        270        280        290        300 
DPSSTKPGTL LKTSPSPERS LLLKYARTPT LDPDTMHARL RLSADRLTVR CGLLGSLGPV 

       310        320        330        340        350        360 
PVLRFDALWQ VLARDCFATG RHYWEVDVQE AGAGWWVGAA YASLRRRGAS AAARLGCNRQ 

       370        380        390        400        410        420 
SWCLKRYDLE YWAFHDGQRS RLRPRDDLDR LGVFLDYEAG VLAFYDVTGG MSHLHTFRAT 

       430        440 
FQEPLYPALR LWEGAISIPR LP 

« Hide

Isoform Beta [UniParc].

Checksum: D3E44449E5113EAC
Show »

FASTA25328,347
Isoform 3 [UniParc].

Checksum: E6E0BA0376315664
Show »

FASTA40645,112
Isoform 4 [UniParc].

Checksum: 761C4E78AE472996
Show »

FASTA22223,146

References

« Hide 'large scale' references
[1]"The tripartite motif family identifies cell compartments."
Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., Minucci S., Pelicci P.G., Ballabio A.
EMBO J. 20:2140-2151(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS BETA AND 3).
[2]"Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Bone marrow.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA AND 4).
Tissue: Testis and Trachea.
[4]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
Tissue: Eye.
[7]"Identification of type I and type II interferon-induced effectors controlling hepatitis C virus replication."
Metz P., Dazert E., Ruggieri A., Mazur J., Kaderali L., Kaul A., Zeuge U., Trippler M., Lohmann V., Binder M., Frese M., Bartenschlager R.
Hepatology 56:2082-2093(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY INTERFERONS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF220130 mRNA. Translation: AAG53503.1.
AF220131 mRNA. Translation: AAG53504.1.
D50919 mRNA. Translation: BAA09478.1.
AK097480 mRNA. Translation: BAC05071.1.
AK292825 mRNA. Translation: BAF85514.1.
AL137073 Genomic DNA. Translation: CAI13890.1.
AL137073 Genomic DNA. Translation: CAI13891.1.
CH471105 Genomic DNA. Translation: EAW58870.1.
CH471105 Genomic DNA. Translation: EAW58877.1.
BC006333 mRNA. Translation: AAH06333.1.
CCDSCCDS6734.1. [Q14142-1]
RefSeqNP_055603.2. NM_014788.3. [Q14142-1]
NP_150088.1. NM_033219.2. [Q14142-1]
XP_005252377.1. XM_005252320.1. [Q14142-1]
XP_005252378.1. XM_005252321.1. [Q14142-1]
XP_005252379.1. XM_005252322.2. [Q14142-1]
XP_005252380.1. XM_005252323.2. [Q14142-1]
UniGeneHs.575631.

3D structure databases

ProteinModelPortalQ14142.
SMRQ14142. Positions 20-63, 270-427.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115168. 3 interactions.
IntActQ14142. 2 interactions.

PTM databases

PhosphoSiteQ14142.

Polymorphism databases

DMDM20141957.

Proteomic databases

MaxQBQ14142.
PaxDbQ14142.
PRIDEQ14142.

Protocols and materials databases

DNASU9830.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341469; ENSP00000344208; ENSG00000106785. [Q14142-1]
ENST00000342043; ENSP00000343990; ENSG00000106785. [Q14142-1]
ENST00000375098; ENSP00000364239; ENSG00000106785. [Q14142-1]
GeneID9830.
KEGGhsa:9830.
UCSCuc004ayd.2. human. [Q14142-1]

Organism-specific databases

CTD9830.
GeneCardsGC09M100831.
HGNCHGNC:16283. TRIM14.
HPAHPA053217.
MIM606556. gene.
neXtProtNX_Q14142.
PharmGKBPA38113.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG148464.
HOGENOMHOG000013201.
HOVERGENHBG054251.
InParanoidQ14142.
KOK12004.
OMATVRCGLL.
OrthoDBEOG7HQN85.
PhylomeDBQ14142.
TreeFamTF351014.

Gene expression databases

ArrayExpressQ14142.
BgeeQ14142.
CleanExHS_TRIM14.
GenevestigatorQ14142.

Family and domain databases

Gene3D4.10.45.10. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR006574. PRY.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
[Graphical view]
PfamPF13765. PRY. 1 hit.
PF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSPR01407. BUTYPHLNCDUF.
SMARTSM00336. BBOX. 1 hit.
SM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTRIM14. human.
GenomeRNAi9830.
NextBio37034.
PROQ14142.
SOURCESearch...

Entry information

Entry nameTRI14_HUMAN
AccessionPrimary (citable) accession number: Q14142
Secondary accession number(s): A8K9W0 expand/collapse secondary AC list , E7EQC4, F8W956, Q548W9, Q5TBQ8, Q6ZWL7, Q9BRD8, Q9C020
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 21, 2002
Last modified: July 9, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM