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Protein

Septin-6

Gene

SEPT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830).1 Publication2 Publications

Miscellaneous

Coordinated expression with SEPT2 and SEPT7.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei104GTP; via amide nitrogenBy similarity1
Binding sitei239GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei254GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 56GTP1 Publication8
Nucleotide bindingi185 – 193GTP1 Publication9

GO - Molecular functioni

  • GTP binding Source: UniProtKB

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • mitotic cytokinesis Source: UniProtKB
  • spermatogenesis Source: UniProtKB-KW
  • viral process Source: UniProtKB-KW

Keywordsi

Biological processCell cycle, Cell division, Differentiation, Host-virus interaction, Spermatogenesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

SIGNORiQ14141

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-6
Gene namesi
Name:SEPT6
Synonyms:KIAA0128, SEP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000125354.22
HGNCiHGNC:15848 SEPT6
MIMi300683 gene
neXtProtiNX_Q14141

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Centromere, Chromosome, Cilium, Cytoplasm, Cytoskeleton, Flagellum, Kinetochore

Pathology & Biotechi

Organism-specific databases

DisGeNETi23157
OpenTargetsiENSG00000125354
PharmGKBiPA134941944

Polymorphism and mutation databases

BioMutaiSEPT6
DMDMi20178343

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001735252 – 434Septin-6Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei27PhosphoserineCombined sources1
Modified residuei367N6-acetyllysineCombined sources1
Modified residuei416PhosphoserineCombined sources1
Modified residuei418PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14141
MaxQBiQ14141
PaxDbiQ14141
PeptideAtlasiQ14141
PRIDEiQ14141

2D gel databases

OGPiQ14141

PTM databases

iPTMnetiQ14141
PhosphoSitePlusiQ14141

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000125354
CleanExiHS_SEPT6
ExpressionAtlasiQ14141 baseline and differential
GenevisibleiQ14141 HS

Organism-specific databases

HPAiHPA003459
HPA005665

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT2 and SEPT7. Also interacts with SEPT9 and SEPT12. Interaction with SEPT12 alters filament structure. Component of a septin core octomeric complex consisting of SEPT12, SEPT7, SEPT6 and SEPT2 or SEPT4 in the order 12-7-6-2-2-6-7-12 or 12-7-6-4-4-6-7-12 and located in the sperm annulus. Interacts with SOCS7. Interacts with HCV NS5B and with HNRNPA1.7 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi116770, 41 interactors
DIPiDIP-38218N
IntActiQ14141, 27 interactors
MINTiQ14141
STRINGi9606.ENSP00000341524

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QAGX-ray4.00B1-427[»]
ProteinModelPortaliQ14141
SMRiQ14141
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14141

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 305Septin-type GPROSITE-ProRule annotationAdd BLAST267

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni49 – 56G1 motifPROSITE-ProRule annotation8
Regioni101 – 104G3 motifPROSITE-ProRule annotation4
Regioni184 – 187G4 motifPROSITE-ProRule annotation4

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili321 – 409Sequence analysisAdd BLAST89

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144070
HOVERGENiHBG065093
InParanoidiQ14141
KOiK16939
OMAiCRTVPLS
OrthoDBiEOG091G0IKM
PhylomeDBiQ14141
TreeFamiTF101080

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR030644 SEPT6
IPR016491 Septin
PANTHERiPTHR18884:SF55 PTHR18884:SF55, 1 hit
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform II (identifier: Q14141-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATDIARQV GEGCRTVPLA GHVGFDSLPD QLVNKSVSQG FCFNILCVGE
60 70 80 90 100
TGLGKSTLMD TLFNTKFEGE PATHTQPGVQ LQSNTYDLQE SNVRLKLTIV
110 120 130 140 150
STVGFGDQIN KEDSYKPIVE FIDAQFEAYL QEELKIRRVL HTYHDSRIHV
160 170 180 190 200
CLYFIAPTGH SLKSLDLVTM KKLDSKVNII PIIAKADAIS KSELTKFKIK
210 220 230 240 250
ITSELVSNGV QIYQFPTDDE SVAEINGTMN AHLPFAVIGS TEELKIGNKM
260 270 280 290 300
MRARQYPWGT VQVENEAHCD FVKLREMLIR VNMEDLREQT HTRHYELYRR
310 320 330 340 350
CKLEEMGFKD TDPDSKPFSL QETYEAKRNE FLGELQKKEE EMRQMFVQRV
360 370 380 390 400
KEKEAELKEA EKELHEKFDR LKKLHQDEKK KLEDKKKSLD DEVNAFKQRK
410 420 430
TAAELLQSQG SQAGGSQTLK RDKEKKNNPW LCTE
Length:434
Mass (Da):49,717
Last modified:January 23, 2007 - v4
Checksum:iE684AE6A93B32362
GO
Isoform I (identifier: Q14141-2) [UniParc]FASTAAdd to basket
Also known as: III

The sequence of this isoform differs from the canonical sequence as follows:
     428-434: Missing.

Show »
Length:427
Mass (Da):48,873
Checksum:i62EB88E308386ADE
GO
Isoform IV (identifier: Q14141-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-267: VENEA → AAREV
     268-434: Missing.

Show »
Length:267
Mass (Da):29,584
Checksum:i7DD6D37AE3844845
GO
Isoform V (identifier: Q14141-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     428-434: NPWLCTE → FF

Show »
Length:429
Mass (Da):49,167
Checksum:i3D8EE2EB88E30838
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti406L → P in AAH09291 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006051263 – 267VENEA → AAREV in isoform IV. 1 Publication5
Alternative sequenceiVSP_006052268 – 434Missing in isoform IV. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_006053428 – 434Missing in isoform I. 2 Publications7
Alternative sequenceiVSP_006054428 – 434NPWLCTE → FF in isoform V. 2 Publications7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403058 mRNA Translation: AAK98547.1
AF403059 mRNA Translation: AAK98548.1
AF403060 mRNA Translation: AAK98549.1
AF403061 mRNA Translation: AAK98550.1
AF403062 mRNA Translation: AAK98551.1
AC004913 Genomic DNA No translation available.
AC005052 Genomic DNA No translation available.
AL355348 Genomic DNA No translation available.
BC009291 mRNA Translation: AAH09291.1
BC011922 mRNA Translation: AAH11922.3
BC036240 mRNA Translation: AAH36240.1
D50918 mRNA Translation: BAA09477.1
CCDSiCCDS14583.1 [Q14141-4]
CCDS14584.1 [Q14141-1]
CCDS14585.1 [Q14141-2]
RefSeqiNP_055944.2, NM_015129.5 [Q14141-1]
NP_665798.1, NM_145799.3 [Q14141-2]
NP_665799.1, NM_145800.3 [Q14141-2]
NP_665801.1, NM_145802.3 [Q14141-4]
XP_006724813.1, XM_006724750.2 [Q14141-2]
UniGeneiHs.496666

Genome annotation databases

EnsembliENST00000343984; ENSP00000341524; ENSG00000125354 [Q14141-1]
ENST00000354228; ENSP00000346169; ENSG00000125354 [Q14141-4]
ENST00000360156; ENSP00000353278; ENSG00000125354 [Q14141-2]
ENST00000394610; ENSP00000378108; ENSG00000125354 [Q14141-2]
ENST00000460411; ENSP00000435818; ENSG00000125354 [Q14141-3]
ENST00000489216; ENSP00000418715; ENSG00000125354 [Q14141-2]
GeneIDi23157
KEGGihsa:23157
UCSCiuc004erv.4 human [Q14141-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSEPT6_HUMAN
AccessioniPrimary (citable) accession number: Q14141
Secondary accession number(s): Q5JTK0
, Q969W5, Q96A13, Q96GR1, Q96P86, Q96P87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 168 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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