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Protein

Septin-6

Gene

SEPT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei104GTP; via amide nitrogenBy similarity1
Binding sitei239GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei254GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi49 – 56GTP1 Publication8
Nucleotide bindingi185 – 193GTP1 Publication9

GO - Molecular functioni

  • GTP binding Source: UniProtKB

GO - Biological processi

  • cytokinesis Source: UniProtKB
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Host-virus interaction

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125354-MONOMER.
SIGNORiQ14141.

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-6
Gene namesi
Name:SEPT6
Synonyms:KIAA0128, SEP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:15848. SEPT6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Kinetochore

Pathology & Biotechi

Organism-specific databases

DisGeNETi23157.
OpenTargetsiENSG00000125354.
PharmGKBiPA134941944.

Polymorphism and mutation databases

BioMutaiSEPT6.
DMDMi20178343.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001735252 – 434Septin-6Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei27PhosphoserineCombined sources1
Modified residuei367N6-acetyllysineCombined sources1
Modified residuei416PhosphoserineCombined sources1
Modified residuei418PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14141.
MaxQBiQ14141.
PaxDbiQ14141.
PeptideAtlasiQ14141.
PRIDEiQ14141.

2D gel databases

OGPiQ14141.

PTM databases

iPTMnetiQ14141.
PhosphoSitePlusiQ14141.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000125354.
CleanExiHS_SEPT6.
ExpressionAtlasiQ14141. baseline and differential.
GenevisibleiQ14141. HS.

Organism-specific databases

HPAiHPA003459.
HPA005665.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPT2, SEPT6 and SEPT7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPT2 and SEPT7. Also interacts with SEPT9 and SEPT12. Interaction with SEPT12 alters filament structure. Interacts with SOCS7. Interacts with HCV NS5B and with HNRNPA1.6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
P279584EBI-745901,EBI-6904388From a different organism.
HNRNPA1P096513EBI-745901,EBI-352662
MORN4Q8NDC43EBI-745901,EBI-10269566
PLEKHF2Q9H8W43EBI-745901,EBI-742388
SEPT1Q8WYJ66EBI-745901,EBI-693002
SEPT12Q8IYM14EBI-745901,EBI-2585067
SEPT2Q150199EBI-745901,EBI-741220
SEPT3Q9UH033EBI-745901,EBI-727037
SEPT5Q997193EBI-745901,EBI-373345
SEPT9Q9UHD83EBI-745901,EBI-851542
SOCS7O14512-12EBI-745901,EBI-1539617

Protein-protein interaction databases

BioGridi116770. 40 interactors.
DIPiDIP-38218N.
IntActiQ14141. 24 interactors.
MINTiMINT-4532787.
STRINGi9606.ENSP00000341524.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QAGX-ray4.00B1-427[»]
ProteinModelPortaliQ14141.
SMRiQ14141.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14141.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 305Septin-type GAdd BLAST267

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili321 – 409Sequence analysisAdd BLAST89

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00860000133721.
HOVERGENiHBG065093.
InParanoidiQ14141.
KOiK16939.
OMAiNHGFCFN.
OrthoDBiEOG091G0IKM.
PhylomeDBiQ14141.
TreeFamiTF101080.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR030644. SEPT6.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PTHR18884:SF55. PTHR18884:SF55. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform II (identifier: Q14141-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATDIARQV GEGCRTVPLA GHVGFDSLPD QLVNKSVSQG FCFNILCVGE
60 70 80 90 100
TGLGKSTLMD TLFNTKFEGE PATHTQPGVQ LQSNTYDLQE SNVRLKLTIV
110 120 130 140 150
STVGFGDQIN KEDSYKPIVE FIDAQFEAYL QEELKIRRVL HTYHDSRIHV
160 170 180 190 200
CLYFIAPTGH SLKSLDLVTM KKLDSKVNII PIIAKADAIS KSELTKFKIK
210 220 230 240 250
ITSELVSNGV QIYQFPTDDE SVAEINGTMN AHLPFAVIGS TEELKIGNKM
260 270 280 290 300
MRARQYPWGT VQVENEAHCD FVKLREMLIR VNMEDLREQT HTRHYELYRR
310 320 330 340 350
CKLEEMGFKD TDPDSKPFSL QETYEAKRNE FLGELQKKEE EMRQMFVQRV
360 370 380 390 400
KEKEAELKEA EKELHEKFDR LKKLHQDEKK KLEDKKKSLD DEVNAFKQRK
410 420 430
TAAELLQSQG SQAGGSQTLK RDKEKKNNPW LCTE
Length:434
Mass (Da):49,717
Last modified:January 23, 2007 - v4
Checksum:iE684AE6A93B32362
GO
Isoform I (identifier: Q14141-2) [UniParc]FASTAAdd to basket
Also known as: III

The sequence of this isoform differs from the canonical sequence as follows:
     428-434: Missing.

Show »
Length:427
Mass (Da):48,873
Checksum:i62EB88E308386ADE
GO
Isoform IV (identifier: Q14141-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-267: VENEA → AAREV
     268-434: Missing.

Show »
Length:267
Mass (Da):29,584
Checksum:i7DD6D37AE3844845
GO
Isoform V (identifier: Q14141-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     428-434: NPWLCTE → FF

Show »
Length:429
Mass (Da):49,167
Checksum:i3D8EE2EB88E30838
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti406L → P in AAH09291 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006051263 – 267VENEA → AAREV in isoform IV. 1 Publication5
Alternative sequenceiVSP_006052268 – 434Missing in isoform IV. 1 PublicationAdd BLAST167
Alternative sequenceiVSP_006053428 – 434Missing in isoform I. 2 Publications7
Alternative sequenceiVSP_006054428 – 434NPWLCTE → FF in isoform V. 2 Publications7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403058 mRNA. Translation: AAK98547.1.
AF403059 mRNA. Translation: AAK98548.1.
AF403060 mRNA. Translation: AAK98549.1.
AF403061 mRNA. Translation: AAK98550.1.
AF403062 mRNA. Translation: AAK98551.1.
AL355348, AC004913, AC005052 Genomic DNA. Translation: CAI41426.1.
BC009291 mRNA. Translation: AAH09291.1.
BC011922 mRNA. Translation: AAH11922.3.
BC036240 mRNA. Translation: AAH36240.1.
D50918 mRNA. Translation: BAA09477.1.
CCDSiCCDS14583.1. [Q14141-4]
CCDS14584.1. [Q14141-1]
CCDS14585.1. [Q14141-2]
RefSeqiNP_055944.2. NM_015129.5. [Q14141-1]
NP_665798.1. NM_145799.3. [Q14141-2]
NP_665799.1. NM_145800.3. [Q14141-2]
NP_665801.1. NM_145802.3. [Q14141-4]
XP_006724813.1. XM_006724750.2. [Q14141-2]
UniGeneiHs.496666.

Genome annotation databases

EnsembliENST00000343984; ENSP00000341524; ENSG00000125354. [Q14141-1]
ENST00000354228; ENSP00000346169; ENSG00000125354. [Q14141-4]
ENST00000360156; ENSP00000353278; ENSG00000125354. [Q14141-2]
ENST00000394610; ENSP00000378108; ENSG00000125354. [Q14141-2]
ENST00000460411; ENSP00000435818; ENSG00000125354. [Q14141-3]
ENST00000489216; ENSP00000418715; ENSG00000125354. [Q14141-2]
GeneIDi23157.
KEGGihsa:23157.
UCSCiuc004erv.4. human. [Q14141-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403058 mRNA. Translation: AAK98547.1.
AF403059 mRNA. Translation: AAK98548.1.
AF403060 mRNA. Translation: AAK98549.1.
AF403061 mRNA. Translation: AAK98550.1.
AF403062 mRNA. Translation: AAK98551.1.
AL355348, AC004913, AC005052 Genomic DNA. Translation: CAI41426.1.
BC009291 mRNA. Translation: AAH09291.1.
BC011922 mRNA. Translation: AAH11922.3.
BC036240 mRNA. Translation: AAH36240.1.
D50918 mRNA. Translation: BAA09477.1.
CCDSiCCDS14583.1. [Q14141-4]
CCDS14584.1. [Q14141-1]
CCDS14585.1. [Q14141-2]
RefSeqiNP_055944.2. NM_015129.5. [Q14141-1]
NP_665798.1. NM_145799.3. [Q14141-2]
NP_665799.1. NM_145800.3. [Q14141-2]
NP_665801.1. NM_145802.3. [Q14141-4]
XP_006724813.1. XM_006724750.2. [Q14141-2]
UniGeneiHs.496666.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QAGX-ray4.00B1-427[»]
ProteinModelPortaliQ14141.
SMRiQ14141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116770. 40 interactors.
DIPiDIP-38218N.
IntActiQ14141. 24 interactors.
MINTiMINT-4532787.
STRINGi9606.ENSP00000341524.

PTM databases

iPTMnetiQ14141.
PhosphoSitePlusiQ14141.

Polymorphism and mutation databases

BioMutaiSEPT6.
DMDMi20178343.

2D gel databases

OGPiQ14141.

Proteomic databases

EPDiQ14141.
MaxQBiQ14141.
PaxDbiQ14141.
PeptideAtlasiQ14141.
PRIDEiQ14141.

Protocols and materials databases

DNASUi23157.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343984; ENSP00000341524; ENSG00000125354. [Q14141-1]
ENST00000354228; ENSP00000346169; ENSG00000125354. [Q14141-4]
ENST00000360156; ENSP00000353278; ENSG00000125354. [Q14141-2]
ENST00000394610; ENSP00000378108; ENSG00000125354. [Q14141-2]
ENST00000460411; ENSP00000435818; ENSG00000125354. [Q14141-3]
ENST00000489216; ENSP00000418715; ENSG00000125354. [Q14141-2]
GeneIDi23157.
KEGGihsa:23157.
UCSCiuc004erv.4. human. [Q14141-1]

Organism-specific databases

CTDi23157.
DisGeNETi23157.
GeneCardsiSEPT6.
HGNCiHGNC:15848. SEPT6.
HPAiHPA003459.
HPA005665.
MIMi300683. gene.
neXtProtiNX_Q14141.
OpenTargetsiENSG00000125354.
PharmGKBiPA134941944.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00860000133721.
HOVERGENiHBG065093.
InParanoidiQ14141.
KOiK16939.
OMAiNHGFCFN.
OrthoDBiEOG091G0IKM.
PhylomeDBiQ14141.
TreeFamiTF101080.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125354-MONOMER.
SIGNORiQ14141.

Miscellaneous databases

ChiTaRSiSEPT6. human.
EvolutionaryTraceiQ14141.
GeneWikiiSEPT6.
GenomeRNAii23157.
PROiQ14141.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125354.
CleanExiHS_SEPT6.
ExpressionAtlasiQ14141. baseline and differential.
GenevisibleiQ14141. HS.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR030644. SEPT6.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PTHR18884:SF55. PTHR18884:SF55. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT6_HUMAN
AccessioniPrimary (citable) accession number: Q14141
Secondary accession number(s): Q5JTK0
, Q969W5, Q96A13, Q96GR1, Q96P86, Q96P87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 156 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Coordinated expression with SEPT2 and SEPT7.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.