Q14140 (SRTD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SERTA domain-containing protein 2

Alternative name(s):
Transcriptional regulator interacting with the PHD-bromodomain 2
Short name=TRIP-Br2

Gene names

Name:	SERTAD2
Synonyms:	KIAA0127

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors By similarity.
Sequence similarities	Contains 1 SERTA domain.
Sequence caution	The sequence BAA09476.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of cell growth Inferred from direct assay PubMed 16098148. Source: MGI positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay PubMed 16098148. Source: MGI nucleus Inferred from direct assay PubMed 16098148. Source: MGI
Molecular_function	transcription coactivator activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	SERTA domain-containing protein 2		PRO_0000191613
Regions
	Domain	33 – 80	48	SERTA

Sequences

	Sequence		Length	Mass (Da)
	Q14140 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E43107FC565AAC31	FASTA	314	33,897
	10 20 30 40 50 60 MLGKGGKRKF DEHEDGLEGK IVSPCDGPSK VSYTLQRQTI FNISLMKLYN HRPLTEPSLQ 70 80 90 100 110 120 KTVLINNMLR RIQEELKQEG SLRPMFTPSS QPTTEPSDSY REAPPAFSHL ASPSSHPCDL 130 140 150 160 170 180 GSTTPLEACL TPASLLEDDD DTFCTSQAMQ PTAPTKLSPP ALLPEKDSFS SALDEIEELC 190 200 210 220 230 240 PTSTSTEAAT AATDSVKGTS SEAGTQKLDG PQESRADDSK LMDSLPGNFE ITTSTGFLTD 250 260 270 280 290 300 LTLDDILFAD IDTSMYDFDP CTSSSGTASK MAPVSADDLL KTLAPYSSQP VTPSQPFKMD 310 LTELDHIMEV LVGS

References

[1]	"Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N. DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Brain cortex.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D50917 mRNA. Translation: BAA09476.2. Different initiation. AC007365 Genomic DNA. Translation: AAY14766.1. BC074788 mRNA. Translation: AAH74788.1. BC074789 mRNA. Translation: AAH74789.1. BC101639 mRNA. Translation: AAI01640.1. BC101641 mRNA. Translation: AAI01642.1.
IPI	IPI00028974.
RefSeq	NP_055570.1. NM_014755.2.
UniGene	Hs.591569.
3D structure databases
ProteinModelPortal	Q14140.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14140. 1 interaction.
STRING	9606.ENSP00000326933.
PTM databases
PhosphoSite	Q14140.
Polymorphism databases
DMDM	3123047.
Proteomic databases
PaxDb	Q14140.
PRIDE	Q14140.
Protocols and materials databases
DNASU	9792.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000313349; ENSP00000326933; ENSG00000179833.
GeneID	9792.
KEGG	hsa:9792.
UCSC	uc002sde.2. human.
Organism-specific databases
CTD	9792.
GeneCards	GC02M064770.
HGNC	HGNC:30784. SERTAD2.
HPA	HPA019021. HPA020904.
neXtProt	NX_Q14140.
PharmGKB	PA134948884.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47551.
HOGENOM	HOG000111497.
HOVERGEN	HBG097654.
InParanoid	Q14140.
OMA	DDDTFCT.
OrthoDB	EOG4HQDKJ.
PhylomeDB	Q14140.
Gene expression databases
Bgee	Q14140.
CleanEx	HS_SERTAD2.
Genevestigator	Q14140.
GermOnline	ENSG00000179833. Homo sapiens.
Family and domain databases
InterPro	IPR009263. SERTA. [Graphical view]
PANTHER	PTHR16277. PTHR16277. 1 hit.
Pfam	PF06031. SERTA. 1 hit. [Graphical view]
PROSITE	PS51053. SERTA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9792.
NextBio	36874.

Entry information

Entry name

SRTD2_HUMAN

Accession

Primary (citable) accession number: Q14140
Secondary accession number(s): Q53TS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.