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Q14140

- SRTD2_HUMAN

UniProt

Q14140 - SRTD2_HUMAN

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Protein

SERTA domain-containing protein 2

Gene

SERTAD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.1 Publication

GO - Molecular functioni

  1. transcription coactivator activity Source: Ensembl

GO - Biological processi

  1. negative regulation of cell growth Source: MGI
  2. positive regulation of transcription, DNA-templated Source: Ensembl
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SERTA domain-containing protein 2
Alternative name(s):
Transcriptional regulator interacting with the PHD-bromodomain 2
Short name:
TRIP-Br2
Gene namesi
Name:SERTAD2
Synonyms:KIAA0127
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:30784. SERTAD2.

Subcellular locationi

Nucleus 1 Publication. Cytoplasm 1 Publication
Note: Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome.

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi238 – 2381L → A: Abolishes the interaction with XPO1 as well as the nuclear export and the subsequent proteasomal degradation. 1 Publication
Mutagenesisi241 – 2411L → A: Slight resistance to proteasomal degradation, no effect on the interaction with XPO1 neither on nuclear export. 1 Publication
Mutagenesisi243 – 2431L → A: Slight decrease of interaction with XPO1 and resistance to proteasomal degradation, no effect on nuclear export. 1 Publication

Organism-specific databases

PharmGKBiPA134948884.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314SERTA domain-containing protein 2PRO_0000191613Add
BLAST

Post-translational modificationi

Polyubiquitinated, which promotes proteasomal degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ14140.
PRIDEiQ14140.

PTM databases

PhosphoSiteiQ14140.

Expressioni

Tissue specificityi

Expressed in adipose tissue.1 Publication

Developmental stagei

Transcript levels remain constant in all phases of the cell cycle. In contrast, protein levels accumulate at the G1/S phase boundary and decrease progressively through S phase until G2/M phase is reached, residual expression is observed in the G2/M and early G1 phases.1 Publication

Gene expression databases

BgeeiQ14140.
CleanExiHS_SERTAD2.
GenevestigatoriQ14140.

Organism-specific databases

HPAiHPA019021.
HPA020904.

Interactioni

Subunit structurei

Interacts with XPO1; which mediates nuclear export. Interacts with TFDP1; modulates transactivation activity of TFDP1/E2F complexes.2 Publications

Protein-protein interaction databases

BioGridi115136. 9 interactions.
IntActiQ14140. 1 interaction.
STRINGi9606.ENSP00000326933.

Structurei

3D structure databases

ProteinModelPortaliQ14140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 8048SERTAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni235 – 31177Required for transactivation activityAdd
BLAST
Regioni238 – 2436Nuclear export signal (NES)

Sequence similaritiesi

Contains 1 SERTA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG47551.
GeneTreeiENSGT00530000063867.
HOGENOMiHOG000111497.
HOVERGENiHBG097654.
InParanoidiQ14140.
OMAiPCDLGST.
OrthoDBiEOG7VTDNP.
PhylomeDBiQ14140.
TreeFamiTF331620.

Family and domain databases

InterProiIPR009263. SERTA_dom.
[Graphical view]
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14140-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGKGGKRKF DEHEDGLEGK IVSPCDGPSK VSYTLQRQTI FNISLMKLYN
60 70 80 90 100
HRPLTEPSLQ KTVLINNMLR RIQEELKQEG SLRPMFTPSS QPTTEPSDSY
110 120 130 140 150
REAPPAFSHL ASPSSHPCDL GSTTPLEACL TPASLLEDDD DTFCTSQAMQ
160 170 180 190 200
PTAPTKLSPP ALLPEKDSFS SALDEIEELC PTSTSTEAAT AATDSVKGTS
210 220 230 240 250
SEAGTQKLDG PQESRADDSK LMDSLPGNFE ITTSTGFLTD LTLDDILFAD
260 270 280 290 300
IDTSMYDFDP CTSSSGTASK MAPVSADDLL KTLAPYSSQP VTPSQPFKMD
310
LTELDHIMEV LVGS
Length:314
Mass (Da):33,897
Last modified:November 1, 1996 - v1
Checksum:iE43107FC565AAC31
GO

Sequence cautioni

The sequence BAA09476.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50917 mRNA. Translation: BAA09476.2. Different initiation.
AC007365 Genomic DNA. Translation: AAY14766.1.
BC074788 mRNA. Translation: AAH74788.1.
BC074789 mRNA. Translation: AAH74789.1.
BC101639 mRNA. Translation: AAI01640.1.
BC101641 mRNA. Translation: AAI01642.1.
CCDSiCCDS33210.1.
RefSeqiNP_055570.1. NM_014755.2.
XP_005264726.1. XM_005264669.1.
UniGeneiHs.591569.

Genome annotation databases

EnsembliENST00000313349; ENSP00000326933; ENSG00000179833.
GeneIDi9792.
KEGGihsa:9792.
UCSCiuc002sde.2. human.

Polymorphism databases

DMDMi3123047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50917 mRNA. Translation: BAA09476.2 . Different initiation.
AC007365 Genomic DNA. Translation: AAY14766.1 .
BC074788 mRNA. Translation: AAH74788.1 .
BC074789 mRNA. Translation: AAH74789.1 .
BC101639 mRNA. Translation: AAI01640.1 .
BC101641 mRNA. Translation: AAI01642.1 .
CCDSi CCDS33210.1.
RefSeqi NP_055570.1. NM_014755.2.
XP_005264726.1. XM_005264669.1.
UniGenei Hs.591569.

3D structure databases

ProteinModelPortali Q14140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115136. 9 interactions.
IntActi Q14140. 1 interaction.
STRINGi 9606.ENSP00000326933.

PTM databases

PhosphoSitei Q14140.

Polymorphism databases

DMDMi 3123047.

Proteomic databases

PaxDbi Q14140.
PRIDEi Q14140.

Protocols and materials databases

DNASUi 9792.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000313349 ; ENSP00000326933 ; ENSG00000179833 .
GeneIDi 9792.
KEGGi hsa:9792.
UCSCi uc002sde.2. human.

Organism-specific databases

CTDi 9792.
GeneCardsi GC02M064858.
HGNCi HGNC:30784. SERTAD2.
HPAi HPA019021.
HPA020904.
neXtProti NX_Q14140.
PharmGKBi PA134948884.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47551.
GeneTreei ENSGT00530000063867.
HOGENOMi HOG000111497.
HOVERGENi HBG097654.
InParanoidi Q14140.
OMAi PCDLGST.
OrthoDBi EOG7VTDNP.
PhylomeDBi Q14140.
TreeFami TF331620.

Miscellaneous databases

GenomeRNAii 9792.
NextBioi 36874.
PROi Q14140.

Gene expression databases

Bgeei Q14140.
CleanExi HS_SERTAD2.
Genevestigatori Q14140.

Family and domain databases

InterProi IPR009263. SERTA_dom.
[Graphical view ]
Pfami PF06031. SERTA. 1 hit.
[Graphical view ]
PROSITEi PS51053. SERTA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
    DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Brain cortex.
  4. "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1."
    Hsu S.-I., Yang C.M., Sim K.G., Hentschel D.M., O'Leary E., Bonventre J.V.
    EMBO J. 20:2273-2285(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS COREGULATOR, INTERACTION WITH TFDP1.
  5. "CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein."
    Cheong J.K., Gunaratnam L., Hsu S.I.
    J. Biol. Chem. 283:11661-11676(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH XPO1, DEVELOPMENTAL STAGE, NUCLEAR EXPORT SIGNAL, UBIQUITINATION, SUBCELLULAR LOCATION, MUTAGENESIS OF LEU-238; LEU-241 AND LEU-243.
  6. "Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance."
    Liew C.W., Boucher J., Cheong J.K., Vernochet C., Koh H.J., Mallol C., Townsend K., Langin D., Kawamori D., Hu J., Tseng Y.H., Hellerstein M.K., Farmer S.R., Goodyear L., Doria A., Blueher M., Hsu S.I., Kulkarni R.N.
    Nat. Med. 19:217-226(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiSRTD2_HUMAN
AccessioniPrimary (citable) accession number: Q14140
Secondary accession number(s): Q53TS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3