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Protein

SERTA domain-containing protein 2

Gene

SERTAD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179833-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
SERTA domain-containing protein 2
Alternative name(s):
Transcriptional regulator interacting with the PHD-bromodomain 2
Short name:
TRIP-Br2
Gene namesi
Name:SERTAD2
Synonyms:KIAA0127
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:30784. SERTAD2.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

  • Note: Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome.

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi238L → A: Abolishes the interaction with XPO1 as well as the nuclear export and the subsequent proteasomal degradation. 1 Publication1
Mutagenesisi241L → A: Slight resistance to proteasomal degradation, no effect on the interaction with XPO1 neither on nuclear export. 1 Publication1
Mutagenesisi243L → A: Slight decrease of interaction with XPO1 and resistance to proteasomal degradation, no effect on nuclear export. 1 Publication1

Organism-specific databases

DisGeNETi9792.
OpenTargetsiENSG00000179833.
PharmGKBiPA134948884.

Polymorphism and mutation databases

BioMutaiSERTAD2.
DMDMi3123047.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001916131 – 314SERTA domain-containing protein 2Add BLAST314

Post-translational modificationi

Polyubiquitinated, which promotes proteasomal degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ14140.
PRIDEiQ14140.

PTM databases

iPTMnetiQ14140.
PhosphoSitePlusiQ14140.

Expressioni

Tissue specificityi

Expressed in adipose tissue.1 Publication

Developmental stagei

Transcript levels remain constant in all phases of the cell cycle. In contrast, protein levels accumulate at the G1/S phase boundary and decrease progressively through S phase until G2/M phase is reached, residual expression is observed in the G2/M and early G1 phases.1 Publication

Gene expression databases

BgeeiENSG00000179833.
CleanExiHS_SERTAD2.
GenevisibleiQ14140. HS.

Organism-specific databases

HPAiHPA019021.
HPA020904.

Interactioni

Subunit structurei

Interacts with XPO1; which mediates nuclear export. Interacts with TFDP1; modulates transactivation activity of TFDP1/E2F complexes.2 Publications

Protein-protein interaction databases

BioGridi115136. 8 interactors.
IntActiQ14140. 12 interactors.
STRINGi9606.ENSP00000326933.

Structurei

3D structure databases

ProteinModelPortaliQ14140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 80SERTAPROSITE-ProRule annotationAdd BLAST48

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 311Required for transactivation activityAdd BLAST77

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi238 – 243Nuclear export signal (NES)6

Sequence similaritiesi

Contains 1 SERTA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IEG3. Eukaryota.
ENOG4110A16. LUCA.
GeneTreeiENSGT00530000063867.
HOGENOMiHOG000111497.
HOVERGENiHBG097654.
InParanoidiQ14140.
OMAiPCDLGST.
OrthoDBiEOG091G0F8L.
PhylomeDBiQ14140.
TreeFamiTF331620.

Family and domain databases

InterProiIPR009263. SERTA_dom.
[Graphical view]
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKGGKRKF DEHEDGLEGK IVSPCDGPSK VSYTLQRQTI FNISLMKLYN
60 70 80 90 100
HRPLTEPSLQ KTVLINNMLR RIQEELKQEG SLRPMFTPSS QPTTEPSDSY
110 120 130 140 150
REAPPAFSHL ASPSSHPCDL GSTTPLEACL TPASLLEDDD DTFCTSQAMQ
160 170 180 190 200
PTAPTKLSPP ALLPEKDSFS SALDEIEELC PTSTSTEAAT AATDSVKGTS
210 220 230 240 250
SEAGTQKLDG PQESRADDSK LMDSLPGNFE ITTSTGFLTD LTLDDILFAD
260 270 280 290 300
IDTSMYDFDP CTSSSGTASK MAPVSADDLL KTLAPYSSQP VTPSQPFKMD
310
LTELDHIMEV LVGS
Length:314
Mass (Da):33,897
Last modified:November 1, 1996 - v1
Checksum:iE43107FC565AAC31
GO

Sequence cautioni

The sequence BAA09476 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50917 mRNA. Translation: BAA09476.2. Different initiation.
AC007365 Genomic DNA. Translation: AAY14766.1.
BC074788 mRNA. Translation: AAH74788.1.
BC074789 mRNA. Translation: AAH74789.1.
BC101639 mRNA. Translation: AAI01640.1.
BC101641 mRNA. Translation: AAI01642.1.
CCDSiCCDS33210.1.
RefSeqiNP_055570.1. NM_014755.2.
XP_005264726.1. XM_005264669.2.
XP_011531507.1. XM_011533205.2.
UniGeneiHs.591569.
Hs.662573.

Genome annotation databases

EnsembliENST00000313349; ENSP00000326933; ENSG00000179833.
GeneIDi9792.
KEGGihsa:9792.
UCSCiuc002sde.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50917 mRNA. Translation: BAA09476.2. Different initiation.
AC007365 Genomic DNA. Translation: AAY14766.1.
BC074788 mRNA. Translation: AAH74788.1.
BC074789 mRNA. Translation: AAH74789.1.
BC101639 mRNA. Translation: AAI01640.1.
BC101641 mRNA. Translation: AAI01642.1.
CCDSiCCDS33210.1.
RefSeqiNP_055570.1. NM_014755.2.
XP_005264726.1. XM_005264669.2.
XP_011531507.1. XM_011533205.2.
UniGeneiHs.591569.
Hs.662573.

3D structure databases

ProteinModelPortaliQ14140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115136. 8 interactors.
IntActiQ14140. 12 interactors.
STRINGi9606.ENSP00000326933.

PTM databases

iPTMnetiQ14140.
PhosphoSitePlusiQ14140.

Polymorphism and mutation databases

BioMutaiSERTAD2.
DMDMi3123047.

Proteomic databases

PaxDbiQ14140.
PRIDEiQ14140.

Protocols and materials databases

DNASUi9792.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313349; ENSP00000326933; ENSG00000179833.
GeneIDi9792.
KEGGihsa:9792.
UCSCiuc002sde.3. human.

Organism-specific databases

CTDi9792.
DisGeNETi9792.
GeneCardsiSERTAD2.
HGNCiHGNC:30784. SERTAD2.
HPAiHPA019021.
HPA020904.
neXtProtiNX_Q14140.
OpenTargetsiENSG00000179833.
PharmGKBiPA134948884.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEG3. Eukaryota.
ENOG4110A16. LUCA.
GeneTreeiENSGT00530000063867.
HOGENOMiHOG000111497.
HOVERGENiHBG097654.
InParanoidiQ14140.
OMAiPCDLGST.
OrthoDBiEOG091G0F8L.
PhylomeDBiQ14140.
TreeFamiTF331620.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000179833-MONOMER.

Miscellaneous databases

GenomeRNAii9792.
PROiQ14140.

Gene expression databases

BgeeiENSG00000179833.
CleanExiHS_SERTAD2.
GenevisibleiQ14140. HS.

Family and domain databases

InterProiIPR009263. SERTA_dom.
[Graphical view]
PfamiPF06031. SERTA. 1 hit.
[Graphical view]
PROSITEiPS51053. SERTA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRTD2_HUMAN
AccessioniPrimary (citable) accession number: Q14140
Secondary accession number(s): Q53TS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.