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Protein

Ribosome biogenesis protein BOP1

Gene

BOP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.UniRule annotation1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • ribonucleoprotein complex binding Source: GO_Central

GO - Biological processi

  • cell proliferation Source: UniProtKB
  • cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: Ensembl
  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: UniProtKB
  • regulation of cell cycle Source: UniProtKB
  • ribosome biogenesis Source: UniProtKB
  • rRNA processing Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170727-MONOMER.
ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
SignaLinkiQ14137.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis protein BOP1UniRule annotation
Alternative name(s):
Block of proliferation 1 proteinUniRule annotation
Gene namesi
Name:BOP1UniRule annotation
Synonyms:KIAA0124
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:15519. BOP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • intracellular ribonucleoprotein complex Source: MGI
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: HPA
  • PeBoW complex Source: UniProtKB
  • preribosome, large subunit precursor Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23246.
OpenTargetsiENSG00000261236.
PharmGKBiPA25398.

Polymorphism and mutation databases

BioMutaiBOP1.
DMDMi23830903.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508851 – 746Ribosome biogenesis protein BOP1Add BLAST746

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei106PhosphothreonineCombined sources1
Modified residuei122PhosphotyrosineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14137.
MaxQBiQ14137.
PaxDbiQ14137.
PeptideAtlasiQ14137.
PRIDEiQ14137.

2D gel databases

SWISS-2DPAGEQ14137.

PTM databases

iPTMnetiQ14137.
PhosphoSitePlusiQ14137.
SwissPalmiQ14137.

Expressioni

Inductioni

By MYC.1 Publication

Gene expression databases

BgeeiENSG00000170727.
CleanExiHS_BOP1.
ExpressionAtlasiQ14137. baseline and differential.
GenevisibleiQ14137. HS.

Organism-specific databases

HPAiHPA042481.
HPA047869.

Interactioni

Subunit structurei

Component of the PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:16043514, PubMed:16738141, PubMed:17189298, PubMed:17353269). The complex is held together by BOP1, which interacts with PES1 via its N-terminal domain and with WDR12 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome (By similarity). The PeBoW complex associates with DDX27, BOP1 interacts directly with DDX27 (PubMed:25825154).UniRule annotation5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PES1O005413EBI-1050828,EBI-1053271
WDR12Q9GZL73EBI-1050828,EBI-2490660

Protein-protein interaction databases

BioGridi116850. 52 interactors.
IntActiQ14137. 12 interactors.
MINTiMINT-3029124.
STRINGi9606.ENSP00000304151.

Structurei

3D structure databases

ProteinModelPortaliQ14137.
SMRiQ14137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati411 – 450WD 1Add BLAST40
Repeati452 – 492WD 2Add BLAST41
Repeati532 – 576WD 3Add BLAST45
Repeati577 – 615WD 4Add BLAST39
Repeati618 – 657WD 5Add BLAST40
Repeati661 – 700WD 6Add BLAST40
Repeati716 – 746WD 7Add BLAST31

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni265 – 427Sufficient for nucleolar localizationBy similarityAdd BLAST163

Sequence similaritiesi

Belongs to the WD repeat BOP1/ERB1 family.UniRule annotation
Contains 7 WD repeats.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0650. Eukaryota.
ENOG410XRBX. LUCA.
GeneTreeiENSGT00390000018422.
HOGENOMiHOG000029368.
HOVERGENiHBG008113.
InParanoidiQ14137.
KOiK14824.
OMAiRTVKDPQ.
OrthoDBiEOG091G0389.
PhylomeDBiQ14137.
TreeFamiTF300437.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
HAMAPiMF_03027. BOP1. 1 hit.
InterProiIPR028598. BOP1/Erb1.
IPR012953. BOP1_N_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08145. BOP1NT. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM01035. BOP1NT. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14137-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGSRGAGRT AAPSVRPEKR RSEPELEPEP EPEPPLLCTS PLSHSTGSDS
60 70 80 90 100
GVSDSEESVF SGLEDSGSDS SEDDDEGDEE GEDGALDDEG HSGIKKTTEE
110 120 130 140 150
QVQASTPCPR TEMASARIGD EYAEDSSDEE DIRNTVGNVP LEWYDDFPHV
160 170 180 190 200
GYDLDGRRIY KPLRTRDELD QFLDKMDDPD YWRTVQDPMT GRDLRLTDEQ
210 220 230 240 250
VALVRRLQSG QFGDVGFNPY EPAVDFFSGD VMIHPVTNRP ADKRSFIPSL
260 270 280 290 300
VEKEKVSRMV HAIKMGWIQP RRPRDPTPSF YDLWAQEDPN AVLGRHKMHV
310 320 330 340 350
PAPKLALPGH AESYNPPPEY LLSEEERLAW EQQEPGERKL SFLPRKFPSL
360 370 380 390 400
RAVPAYGRFI QERFERCLDL YLCPRQRKMR VNVDPEDLIP KLPRPRDLQP
410 420 430 440 450
FPTCQALVYR GHSDLVRCLS VSPGGQWLVS GSDDGSLRLW EVATARCVRT
460 470 480 490 500
VPVGGVVKSV AWNPSPAVCL VAAAVEDSVL LLNPALGDRL VAGSTDQLLS
510 520 530 540 550
AFVPPEEPPL QPARWLEASE EERQVGLRLR ICHGKPVTQV TWHGRGDYLA
560 570 580 590 600
VVLATQGHTQ VLIHQLSRRR SQSPFRRSHG QVQRVAFHPA RPFLLVASQR
610 620 630 640 650
SVRLYHLLRQ ELTKKLMPNC KWVSSLAVHP AGDNVICGSY DSKLVWFDLD
660 670 680 690 700
LSTKPYRMLR HHKKALRAVA FHPRYPLFAS GSDDGSVIVC HGMVYNDLLQ
710 720 730 740
NPLLVPVKVL KGHVLTRDLG VLDVIFHPTQ PWVFSSGADG TVRLFT
Length:746
Mass (Da):83,630
Last modified:October 10, 2002 - v2
Checksum:i49A97BE21B0EB3DD
GO
Isoform 2 (identifier: Q14137-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Show »
Length:634
Mass (Da):71,930
Checksum:iE7A5608B28D65C36
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti577R → H in BAA09473 (PubMed:8590280).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563911 – 112Missing in isoform 2. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060694 mRNA. Translation: BAB70666.1.
AC145291 Genomic DNA. No translation available.
AC231662 Genomic DNA. No translation available.
BC001086 mRNA. Translation: AAH01086.2.
BC005160 mRNA. Translation: AAH05160.2.
BC007274 mRNA. Translation: AAH07274.1.
BC013787 mRNA. Translation: AAH13787.1.
BC013980 mRNA. Translation: AAH13980.1.
BC017674 mRNA. Translation: AAH17674.1.
D50914 mRNA. Translation: BAA09473.1.
CCDSiCCDS6418.2. [Q14137-1]
RefSeqiNP_056016.1. NM_015201.4. [Q14137-1]
UniGeneiHs.535901.
Hs.645279.

Genome annotation databases

EnsembliENST00000569669; ENSP00000455106; ENSG00000261236. [Q14137-1]
GeneIDi23246.
KEGGihsa:23246.
UCSCiuc033ccj.2. human. [Q14137-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB060694 mRNA. Translation: BAB70666.1.
AC145291 Genomic DNA. No translation available.
AC231662 Genomic DNA. No translation available.
BC001086 mRNA. Translation: AAH01086.2.
BC005160 mRNA. Translation: AAH05160.2.
BC007274 mRNA. Translation: AAH07274.1.
BC013787 mRNA. Translation: AAH13787.1.
BC013980 mRNA. Translation: AAH13980.1.
BC017674 mRNA. Translation: AAH17674.1.
D50914 mRNA. Translation: BAA09473.1.
CCDSiCCDS6418.2. [Q14137-1]
RefSeqiNP_056016.1. NM_015201.4. [Q14137-1]
UniGeneiHs.535901.
Hs.645279.

3D structure databases

ProteinModelPortaliQ14137.
SMRiQ14137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116850. 52 interactors.
IntActiQ14137. 12 interactors.
MINTiMINT-3029124.
STRINGi9606.ENSP00000304151.

PTM databases

iPTMnetiQ14137.
PhosphoSitePlusiQ14137.
SwissPalmiQ14137.

Polymorphism and mutation databases

BioMutaiBOP1.
DMDMi23830903.

2D gel databases

SWISS-2DPAGEQ14137.

Proteomic databases

EPDiQ14137.
MaxQBiQ14137.
PaxDbiQ14137.
PeptideAtlasiQ14137.
PRIDEiQ14137.

Protocols and materials databases

DNASUi23246.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000569669; ENSP00000455106; ENSG00000261236. [Q14137-1]
GeneIDi23246.
KEGGihsa:23246.
UCSCiuc033ccj.2. human. [Q14137-1]

Organism-specific databases

CTDi23246.
DisGeNETi23246.
GeneCardsiBOP1.
H-InvDBHIX0168814.
HGNCiHGNC:15519. BOP1.
HPAiHPA042481.
HPA047869.
MIMi610596. gene.
neXtProtiNX_Q14137.
OpenTargetsiENSG00000261236.
PharmGKBiPA25398.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0650. Eukaryota.
ENOG410XRBX. LUCA.
GeneTreeiENSGT00390000018422.
HOGENOMiHOG000029368.
HOVERGENiHBG008113.
InParanoidiQ14137.
KOiK14824.
OMAiRTVKDPQ.
OrthoDBiEOG091G0389.
PhylomeDBiQ14137.
TreeFamiTF300437.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170727-MONOMER.
ReactomeiR-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
SignaLinkiQ14137.

Miscellaneous databases

ChiTaRSiBOP1. human.
GeneWikiiBOP1.
GenomeRNAii23246.
PROiQ14137.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170727.
CleanExiHS_BOP1.
ExpressionAtlasiQ14137. baseline and differential.
GenevisibleiQ14137. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
HAMAPiMF_03027. BOP1. 1 hit.
InterProiIPR028598. BOP1/Erb1.
IPR012953. BOP1_N_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08145. BOP1NT. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM01035. BOP1NT. 1 hit.
SM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBOP1_HUMAN
AccessioniPrimary (citable) accession number: Q14137
Secondary accession number(s): Q969Z6
, Q96IS8, Q96Q25, Q9BSA7, Q9BVM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 10, 2002
Last modified: November 2, 2016
This is version 176 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.