Q14135 (VGLL4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription cofactor vestigial-like protein 4
Short name=Vgl-4

Gene names

Name:	VGLL4
Synonyms:	KIAA0121

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as a specific coactivator for the mammalian TEFs By similarity.
Subunit structure	Interacts with TEFs By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the vestigial family.
Sequence caution	The sequence AAH03038.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS. The sequence BAA09470.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleolus Inferred from direct assay. Source: HPA
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14135-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14135-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Isoform 3 (identifier: Q14135-3)

The sequence of this isoform differs from the canonical sequence as follows:
     22-41: REAALRGEPRMQTLPVASAL → PSPGNLLEMQNRSPRCGTDD
     42-290: Missing.

Note: Probable target of nonsense-mediated mRNA decay.

Isoform 4 (identifier: Q14135-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: METPLDVLSRAASLVHADDEKR → MLFMKMDLLNYQYLDKMNNNIGILCYEG

Isoform 5 (identifier: Q14135-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
     85-85: L → M

Isoform 6 (identifier: Q14135-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
     81-85: FNPHL → MIKVR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Transcription cofactor vestigial-like protein 4		PRO_0000191351
Amino acid modifications
	Modified residue	52	1	Phosphoserine Ref.7 Ref.8 Ref.9
	Modified residue	149	1	Phosphoserine Ref.6 Ref.7
	Modified residue	153	1	Phosphothreonine Ref.7
	Modified residue	290	1	Phosphoserine Ref.9
Natural variations
	Alternative sequence	1 – 84	84	Missing in isoform 5.		VSP_040210
	Alternative sequence	1 – 80	80	Missing in isoform 6.		VSP_040211
	Alternative sequence	1 – 31	31	Missing in isoform 2.		VSP_010776
	Alternative sequence	1 – 22	22	METPL…DDEKR → MLFMKMDLLNYQYLDKMNNN IGILCYEG in isoform 4.		VSP_040212
	Alternative sequence	22 – 41	20	REAAL…VASAL → PSPGNLLEMQNRSPRCGTDD in isoform 3.		VSP_040213
	Alternative sequence	42 – 290	249	Missing in isoform 3.		VSP_040214
	Alternative sequence	81 – 85	5	FNPHL → MIKVR in isoform 6.		VSP_040215
	Alternative sequence	85	1	L → M in isoform 5.		VSP_040216
	Natural variant	32	1	M → I. Ref.4 Corresponds to variant rs2276749 [ dbSNP | Ensembl ].		VAR_024689

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 21, 2005. Version 4. Checksum: A5EA4C167CC8F0B4	FASTA	290	30,948
	10 20 30 40 50 60 METPLDVLSR AASLVHADDE KREAALRGEP RMQTLPVASA LSSHRTGPPP ISPSKRKFSM 70 80 90 100 110 120 EPGDEDLDCD NDHVSKMSRI FNPHLNKTAN GDCRRDPRER SRSPIERAVA PTMSLHGSHL 130 140 150 160 170 180 YTSLPSLGLE QPLALTKNSL DASRPAGLSP TLTPGERQQN RPSVITCASA GARNCNLSHC 190 200 210 220 230 240 PIAHSGCAAP GPASYRRPPS AATTCDPVVE EHFRRSLGKN YKEPEPAPNS VSITGSVDDH 250 260 270 280 290 FAKALGDTWL QIKAAKDGAS SSPESASRRG QPASPSAHMV SHSHSPSVVS
	Isoform 2 [UniParc]. Checksum: 5FA3C906694B6801	FASTA	259	27,532
	10 20 30 40 50 60 MQTLPVASAL SSHRTGPPPI SPSKRKFSME PGDEDLDCDN DHVSKMSRIF NPHLNKTANG 70 80 90 100 110 120 DCRRDPRERS RSPIERAVAP TMSLHGSHLY TSLPSLGLEQ PLALTKNSLD ASRPAGLSPT 130 140 150 160 170 180 LTPGERQQNR PSVITCASAG ARNCNLSHCP IAHSGCAAPG PASYRRPPSA ATTCDPVVEE 190 200 210 220 230 240 HFRRSLGKNY KEPEPAPNSV SITGSVDDHF AKALGDTWLQ IKAAKDGASS SPESASRRGQ 250 PASPSAHMVS HSHSPSVVS
	Isoform 3 [UniParc]. Checksum: E2D1E5A12429DEC6	FASTA	41	4,467
	10 20 30 40 METPLDVLSR AASLVHADDE KPSPGNLLEM QNRSPRCGTD D
	Isoform 4 [UniParc]. Checksum: DFA06E193A0EBF56	FASTA	296	31,883
	10 20 30 40 50 60 MLFMKMDLLN YQYLDKMNNN IGILCYEGEA ALRGEPRMQT LPVASALSSH RTGPPPISPS 70 80 90 100 110 120 KRKFSMEPGD EDLDCDNDHV SKMSRIFNPH LNKTANGDCR RDPRERSRSP IERAVAPTMS 130 140 150 160 170 180 LHGSHLYTSL PSLGLEQPLA LTKNSLDASR PAGLSPTLTP GERQQNRPSV ITCASAGARN 190 200 210 220 230 240 CNLSHCPIAH SGCAAPGPAS YRRPPSAATT CDPVVEEHFR RSLGKNYKEP EPAPNSVSIT 250 260 270 280 290 GSVDDHFAKA LGDTWLQIKA AKDGASSSPE SASRRGQPAS PSAHMVSHSH SPSVVS
	Isoform 5 [UniParc]. Checksum: 3B2999D263D25A12	FASTA	206	21,705
	10 20 30 40 50 60 MNKTANGDCR RDPRERSRSP IERAVAPTMS LHGSHLYTSL PSLGLEQPLA LTKNSLDASR 70 80 90 100 110 120 PAGLSPTLTP GERQQNRPSV ITCASAGARN CNLSHCPIAH SGCAAPGPAS YRRPPSAATT 130 140 150 160 170 180 CDPVVEEHFR RSLGKNYKEP EPAPNSVSIT GSVDDHFAKA LGDTWLQIKA AKDGASSSPE 190 200 SASRRGQPAS PSAHMVSHSH SPSVVS
	Isoform 6 [UniParc]. Checksum: 69F674B9C9D8D9EE	FASTA	210	22,202
	10 20 30 40 50 60 MIKVRNKTAN GDCRRDPRER SRSPIERAVA PTMSLHGSHL YTSLPSLGLE QPLALTKNSL 70 80 90 100 110 120 DASRPAGLSP TLTPGERQQN RPSVITCASA GARNCNLSHC PIAHSGCAAP GPASYRRPPS 130 140 150 160 170 180 AATTCDPVVE EHFRRSLGKN YKEPEPAPNS VSITGSVDDH FAKALGDTWL QIKAAKDGAS 190 200 210 SSPESASRRG QPASPSAHMV SHSHSPSVVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1." Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N. DNA Res. 2:167-174(1995) [PubMed: 8590280] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow.
[2]	Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO N-TERMINUS; C-TERMINUS; 32 AND 113.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-167 (ISOFORM 4). Tissue: Brain, Placenta, Salivary gland and Trachea.
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-32.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3). Tissue: Lung.
[6]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed: 18220336] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52; SER-149 AND THR-153, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52 AND SER-290, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D50911 mRNA. Translation: BAA09470.3. Different initiation. AK130542 mRNA. Translation: BAC85375.1. AK300344 mRNA. Translation: BAG62089.1. AK307708 mRNA. No translation available. AK308761 mRNA. No translation available. DA770257 mRNA. No translation available. AC022001 Genomic DNA. No translation available. AC090939 Genomic DNA. No translation available. BC001514 mRNA. Translation: AAH01514.2. BC003038 mRNA. Translation: AAH03038.1. Sequence problems.
IPI	IPI00430439. IPI00794952. IPI00795570. IPI00796548. IPI00925895. IPI00927718.
RefSeq	NP_001121691.1. NM_001128219.1. NP_001121692.1. NM_001128220.1. NP_001121693.1. NM_001128221.1. NP_055482.2. NM_014667.2.
UniGene	Hs.38032. Hs.728155.
3D structure databases
ProteinModelPortal	Q14135.
ModBase	Search...
Protein-protein interaction databases
STRING	Q14135.
PTM databases
PhosphoSite	Q14135.
Polymorphism databases
DMDM	68068037.
Proteomic databases
PRIDE	Q14135.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000273038; ENSP00000273038; ENSG00000144560.
GeneID	9686.
KEGG	hsa:9686.
Organism-specific databases
CTD	9686.
GeneCards	GC03M011574.
HGNC	HGNC:28966. VGLL4.
HPA	HPA038225.
neXtProt	NX_Q14135.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15674.
GeneTree	ENSGT00390000003282.
HOVERGEN	HBG054970.
OrthoDB	EOG4SJ5FH.
Gene expression databases
ArrayExpress	Q14135.
Bgee	Q14135.
CleanEx	HS_VGLL4.
Genevestigator	Q14135.
GermOnline	ENSG00000144560. Homo sapiens.
Family and domain databases
InterPro	IPR006627. TDU_repeat. [Graphical view]
SMART	SM00711. TDU. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VGLL4_HUMAN

Accession

Primary (citable) accession number: Q14135
Secondary accession number(s): B4DTS7, Q7L5V0, Q9BQ78

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	June 21, 2005
Last modified:	January 25, 2012
This is version 87 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.