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Protein

Transcription cofactor vestigial-like protein 4

Gene

VGLL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a specific coactivator for the mammalian TEFs.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription cofactor vestigial-like protein 4
Short name:
Vgl-4
Gene namesi
Name:VGLL4
Synonyms:KIAA0121
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28966. VGLL4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394553.

Polymorphism and mutation databases

DMDMi68068037.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Transcription cofactor vestigial-like protein 4PRO_0000191351Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei52 – 521PhosphoserineCombined sources
Modified residuei149 – 1491PhosphoserineCombined sources
Modified residuei153 – 1531PhosphothreonineCombined sources
Modified residuei274 – 2741PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14135.
MaxQBiQ14135.
PaxDbiQ14135.
PRIDEiQ14135.

PTM databases

iPTMnetiQ14135.
PhosphoSiteiQ14135.

Expressioni

Gene expression databases

BgeeiQ14135.
CleanExiHS_VGLL4.
ExpressionAtlasiQ14135. baseline and differential.
GenevisibleiQ14135. HS.

Organism-specific databases

HPAiHPA038225.
HPA038614.

Interactioni

Subunit structurei

Interacts with TEFs (By similarity). Interacts with IRF2BP2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TEAD4Q155613EBI-5278589,EBI-747736
TERF2IPQ9NYB02EBI-5278589,EBI-750109

Protein-protein interaction databases

BioGridi115039. 11 interactions.
IntActiQ14135. 5 interactions.
STRINGi9606.ENSP00000404251.

Structurei

3D structure databases

ProteinModelPortaliQ14135.
SMRiQ14135. Positions 206-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vestigial family.Curated

Phylogenomic databases

eggNOGiENOG410IFGD. Eukaryota.
ENOG410XX71. LUCA.
GeneTreeiENSGT00390000003282.
HOGENOMiHOG000290700.
HOVERGENiHBG054970.
InParanoidiQ14135.
OrthoDBiEOG7V7682.
PhylomeDBiQ14135.

Family and domain databases

InterProiIPR006627. TDU_repeat.
IPR028184. VGLL4.
[Graphical view]
PfamiPF15245. VGLL4. 1 hit.
[Graphical view]
SMARTiSM00711. TDU. 2 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14135-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METPLDVLSR AASLVHADDE KREAALRGEP RMQTLPVASA LSSHRTGPPP
60 70 80 90 100
ISPSKRKFSM EPGDEDLDCD NDHVSKMSRI FNPHLNKTAN GDCRRDPRER
110 120 130 140 150
SRSPIERAVA PTMSLHGSHL YTSLPSLGLE QPLALTKNSL DASRPAGLSP
160 170 180 190 200
TLTPGERQQN RPSVITCASA GARNCNLSHC PIAHSGCAAP GPASYRRPPS
210 220 230 240 250
AATTCDPVVE EHFRRSLGKN YKEPEPAPNS VSITGSVDDH FAKALGDTWL
260 270 280 290
QIKAAKDGAS SSPESASRRG QPASPSAHMV SHSHSPSVVS
Length:290
Mass (Da):30,948
Last modified:June 21, 2005 - v4
Checksum:iA5EA4C167CC8F0B4
GO
Isoform 2 (identifier: Q14135-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.

Show »
Length:259
Mass (Da):27,532
Checksum:i5FA3C906694B6801
GO
Isoform 3 (identifier: Q14135-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-41: REAALRGEPRMQTLPVASAL → PSPGNLLEMQNRSPRCGTDD
     42-290: Missing.

Note: Probable target of nonsense-mediated mRNA decay.
Show »
Length:41
Mass (Da):4,467
Checksum:iE2D1E5A12429DEC6
GO
Isoform 4 (identifier: Q14135-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: METPLDVLSRAASLVHADDEKR → MLFMKMDLLNYQYLDKMNNNIGILCYEG

Show »
Length:296
Mass (Da):31,883
Checksum:iDFA06E193A0EBF56
GO
Isoform 5 (identifier: Q14135-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
     85-85: L → M

Show »
Length:206
Mass (Da):21,705
Checksum:i3B2999D263D25A12
GO
Isoform 6 (identifier: Q14135-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
     81-85: FNPHL → MIKVR

Show »
Length:210
Mass (Da):22,202
Checksum:i69F674B9C9D8D9EE
GO

Sequence cautioni

The sequence AAH03038.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAA09470.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti32 – 321M → I.2 Publications
Corresponds to variant rs2276749 [ dbSNP | Ensembl ].
VAR_024689

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8484Missing in isoform 5. 1 PublicationVSP_040210Add
BLAST
Alternative sequencei1 – 8080Missing in isoform 6. 1 PublicationVSP_040211Add
BLAST
Alternative sequencei1 – 3131Missing in isoform 2. 1 PublicationVSP_010776Add
BLAST
Alternative sequencei1 – 2222METPL…DDEKR → MLFMKMDLLNYQYLDKMNNN IGILCYEG in isoform 4. 1 PublicationVSP_040212Add
BLAST
Alternative sequencei22 – 4120REAAL…VASAL → PSPGNLLEMQNRSPRCGTDD in isoform 3. 1 PublicationVSP_040213Add
BLAST
Alternative sequencei42 – 290249Missing in isoform 3. 1 PublicationVSP_040214Add
BLAST
Alternative sequencei81 – 855FNPHL → MIKVR in isoform 6. 1 PublicationVSP_040215
Alternative sequencei85 – 851L → M in isoform 5. 1 PublicationVSP_040216

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50911 mRNA. Translation: BAA09470.3. Different initiation.
AK130542 mRNA. Translation: BAC85375.1.
AK300344 mRNA. Translation: BAG62089.1.
AK307708 mRNA. No translation available.
AK308761 mRNA. No translation available.
DA770257 mRNA. No translation available.
AC022001 Genomic DNA. No translation available.
AC090939 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64104.1.
BC001514 mRNA. Translation: AAH01514.2.
BC003038 mRNA. Translation: AAH03038.1. Sequence problems.
CCDSiCCDS2606.1. [Q14135-1]
CCDS46754.1. [Q14135-4]
CCDS46755.1. [Q14135-6]
CCDS46756.1. [Q14135-5]
RefSeqiNP_001121691.1. NM_001128219.2.
NP_001121692.1. NM_001128220.2. [Q14135-6]
NP_001121693.1. NM_001128221.2. [Q14135-5]
NP_001271319.1. NM_001284390.1.
NP_001271320.1. NM_001284391.1.
NP_055482.2. NM_014667.3.
UniGeneiHs.740389.

Genome annotation databases

EnsembliENST00000424529; ENSP00000402878; ENSG00000144560. [Q14135-5]
ENST00000451674; ENSP00000416615; ENSG00000144560. [Q14135-6]
GeneIDi9686.
KEGGihsa:9686.
UCSCiuc010hdv.3. human. [Q14135-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50911 mRNA. Translation: BAA09470.3. Different initiation.
AK130542 mRNA. Translation: BAC85375.1.
AK300344 mRNA. Translation: BAG62089.1.
AK307708 mRNA. No translation available.
AK308761 mRNA. No translation available.
DA770257 mRNA. No translation available.
AC022001 Genomic DNA. No translation available.
AC090939 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64104.1.
BC001514 mRNA. Translation: AAH01514.2.
BC003038 mRNA. Translation: AAH03038.1. Sequence problems.
CCDSiCCDS2606.1. [Q14135-1]
CCDS46754.1. [Q14135-4]
CCDS46755.1. [Q14135-6]
CCDS46756.1. [Q14135-5]
RefSeqiNP_001121691.1. NM_001128219.2.
NP_001121692.1. NM_001128220.2. [Q14135-6]
NP_001121693.1. NM_001128221.2. [Q14135-5]
NP_001271319.1. NM_001284390.1.
NP_001271320.1. NM_001284391.1.
NP_055482.2. NM_014667.3.
UniGeneiHs.740389.

3D structure databases

ProteinModelPortaliQ14135.
SMRiQ14135. Positions 206-255.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115039. 11 interactions.
IntActiQ14135. 5 interactions.
STRINGi9606.ENSP00000404251.

PTM databases

iPTMnetiQ14135.
PhosphoSiteiQ14135.

Polymorphism and mutation databases

DMDMi68068037.

Proteomic databases

EPDiQ14135.
MaxQBiQ14135.
PaxDbiQ14135.
PRIDEiQ14135.

Protocols and materials databases

DNASUi9686.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000424529; ENSP00000402878; ENSG00000144560. [Q14135-5]
ENST00000451674; ENSP00000416615; ENSG00000144560. [Q14135-6]
GeneIDi9686.
KEGGihsa:9686.
UCSCiuc010hdv.3. human. [Q14135-1]

Organism-specific databases

CTDi9686.
GeneCardsiVGLL4.
HGNCiHGNC:28966. VGLL4.
HPAiHPA038225.
HPA038614.
neXtProtiNX_Q14135.
PharmGKBiPA128394553.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFGD. Eukaryota.
ENOG410XX71. LUCA.
GeneTreeiENSGT00390000003282.
HOGENOMiHOG000290700.
HOVERGENiHBG054970.
InParanoidiQ14135.
OrthoDBiEOG7V7682.
PhylomeDBiQ14135.

Miscellaneous databases

ChiTaRSiVGLL4. human.
GenomeRNAii9686.
NextBioi35534835.
PROiQ14135.

Gene expression databases

BgeeiQ14135.
CleanExiHS_VGLL4.
ExpressionAtlasiQ14135. baseline and differential.
GenevisibleiQ14135. HS.

Family and domain databases

InterProiIPR006627. TDU_repeat.
IPR028184. VGLL4.
[Graphical view]
PfamiPF15245. VGLL4. 1 hit.
[Graphical view]
SMARTiSM00711. TDU. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
    DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  2. Nagase T., Seki N., Tanaka A., Ishikawa K., Nomura N.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO N-TERMINUS; C-TERMINUS; 32 AND 113.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-167 (ISOFORM 4).
    Tissue: Brain, Placenta, Salivary gland and Trachea.
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-32.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ILE-32.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Lung.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52; SER-149 AND THR-153, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression."
    Teng A.C., Kuraitis D., Deeke S.A., Ahmadi A., Dugan S.G., Cheng B.L., Crowson M.G., Burgon P.G., Suuronen E.J., Chen H.H., Stewart A.F.
    FASEB J. 24:4825-4834(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IRF2BP2.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149; THR-153 AND SER-274, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiVGLL4_HUMAN
AccessioniPrimary (citable) accession number: Q14135
Secondary accession number(s): B4DTS7
, J3KN68, Q7L5V0, Q9BQ78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 21, 2005
Last modified: March 16, 2016
This is version 125 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.