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Protein

Tripartite motif-containing protein 29

Gene

TRIM29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri220 – 260B box-typePROSITE-ProRule annotationAdd BLAST41

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • identical protein binding Source: IntAct
  • p53 binding Source: Ensembl
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-877300. Interferon gamma signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 29
Alternative name(s):
Ataxia telangiectasia group D-associated protein
Gene namesi
Name:TRIM29
Synonyms:ATDC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000137699.16.
HGNCiHGNC:17274. TRIM29.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi23650.
OpenTargetsiENSG00000137699.
PharmGKBiPA38218.

Polymorphism and mutation databases

BioMutaiTRIM29.
DMDMi116242825.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562421 – 588Tripartite motif-containing protein 29Add BLAST588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei58PhosphoserineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Modified residuei106PhosphotyrosineCombined sources1
Modified residuei476PhosphothreonineCombined sources1
Modified residuei489PhosphoserineCombined sources1

Post-translational modificationi

Constitutively phosphorylated by PKC on serine/threonine in A431 cells.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14134.
MaxQBiQ14134.
PaxDbiQ14134.
PeptideAtlasiQ14134.
PRIDEiQ14134.

PTM databases

iPTMnetiQ14134.
PhosphoSitePlusiQ14134.

Expressioni

Tissue specificityi

Expressed in placenta, prostate and thymus.1 Publication

Gene expression databases

BgeeiENSG00000137699.
CleanExiHS_TRIM29.
ExpressionAtlasiQ14134. baseline and differential.
GenevisibleiQ14134. HS.

Organism-specific databases

HPAiHPA020053.

Interactioni

Subunit structurei

Interacts with VIM and HINT1.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • identical protein binding Source: IntAct
  • p53 binding Source: Ensembl

Protein-protein interaction databases

BioGridi117177. 112 interactors.
IntActiQ14134. 51 interactors.
MINTiMINT-1183268.
STRINGi9606.ENSP00000343129.

Structurei

Secondary structure

1588
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi217 – 221Combined sources5
Turni226 – 228Combined sources3
Beta strandi234 – 239Combined sources6
Helixi245 – 249Combined sources5
Turni250 – 252Combined sources3
Beta strandi253 – 255Combined sources3
Beta strandi257 – 259Combined sources3
Helixi260 – 267Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CSVNMR-A212-270[»]
ProteinModelPortaliQ14134.
SMRiQ14134.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14134.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili259 – 352Sequence analysisAdd BLAST94

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri220 – 260B box-typePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IK88. Eukaryota.
ENOG410YEFV. LUCA.
GeneTreeiENSGT00760000118995.
HOGENOMiHOG000154677.
HOVERGENiHBG061597.
InParanoidiQ14134.
KOiK12010.
OMAiCMRHVEK.
OrthoDBiEOG091G056X.
PhylomeDBiQ14134.
TreeFamiTF351086.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR000315. Znf_B-box.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF00643. zf-B_box. 1 hit.
SMARTiView protein in SMART
SM00336. BBOX. 1 hit.
PROSITEiView protein in PROSITE
PS50119. ZF_BBOX. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q14134-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAADASRSN GSSPEARDAR SPSGPSGSLE NGTKADGKDA KTTNGHGGEA
60 70 80 90 100
AEGKSLGSAL KPGEGRSALF AGNEWRRPII QFVESGDDKN SNYFSMDSME
110 120 130 140 150
GKRSPYAGLQ LGAAKKPPVT FAEKGELRKS IFSESRKPTV SIMEPGETRR
160 170 180 190 200
NSYPRADTGL FSRSKSGSEE VLCDSCIGNK QKAVKSCLVC QASFCELHLK
210 220 230 240 250
PHLEGAAFRD HQLLEPIRDF EARKCPVHGK TMELFCQTDQ TCICYLCMFQ
260 270 280 290 300
EHKNHSTVTV EEAKAEKETE LSLQKEQLQL KIIEIEDEAE KWQKEKDRIK
310 320 330 340 350
SFTTNEKAIL EQNFRDLVRD LEKQKEEVRA ALEQREQDAV DQVKVIMDAL
360 370 380 390 400
DERAKVLHED KQTREQLHSI SDSVLFLQEF GALMSNYSLP PPLPTYHVLL
410 420 430 440 450
EGEGLGQSLG NFKDDLLNVC MRHVEKMCKA DLSRNFIERN HMENGGDHRY
460 470 480 490 500
VNNYTNSFGG EWSAPDTMKR YSMYLTPKGG VRTSYQPSSP GRFTKETTQK
510 520 530 540 550
NFNNLYGTKG NYTSRVWEYS SSIQNSDNDL PVVQGSSSFS LKGYPSLMRS
560 570 580
QSPKAQPQTW KSGKQTMLSH YRPFYVNKGN GIGSNEAP
Length:588
Mass (Da):65,835
Last modified:October 17, 2006 - v2
Checksum:i7CBAD7A4C43A311C
GO
Isoform Beta (identifier: Q14134-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-588: SHYRPFYVNKGNGIGSNEAP → VV

Note: No experimental confirmation available.
Show »
Length:570
Mass (Da):63,844
Checksum:iD5A14625B49E5FAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126 – 127EL → DV (PubMed:8188213).Curated2
Sequence conflicti126 – 127EL → DV (PubMed:11331580).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035962514S → F in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs112973609Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011999569 – 588SHYRP…SNEAP → VV in isoform Beta. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24203 mRNA. Translation: AAA35762.1.
AF230388 mRNA. Translation: AAG50167.1.
AF230389 mRNA. Translation: AAG50168.1.
BC017352 mRNA. Translation: AAH17352.1.
CCDSiCCDS8428.1. [Q14134-1]
PIRiA49618.
RefSeqiNP_036233.2. NM_012101.3. [Q14134-1]
UniGeneiHs.504115.

Genome annotation databases

EnsembliENST00000341846; ENSP00000343129; ENSG00000137699. [Q14134-1]
GeneIDi23650.
KEGGihsa:23650.
UCSCiuc001pwz.4. human. [Q14134-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRI29_HUMAN
AccessioniPrimary (citable) accession number: Q14134
Secondary accession number(s): Q96AA9, Q9BZY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 17, 2006
Last modified: September 27, 2017
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references