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Q14126

- DSG2_HUMAN

UniProt

Q14126 - DSG2_HUMAN

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Protein

Desmoglein-2

Gene

DSG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. apoptotic process Source: Reactome
  2. bundle of His cell to Purkinje myocyte communication Source: BHF-UCL
  3. cell adhesion Source: UniProtKB
  4. cellular component disassembly involved in execution phase of apoptosis Source: Reactome
  5. homophilic cell adhesion Source: InterPro
  6. maternal process involved in female pregnancy Source: Ensembl
  7. regulation of heart rate by cardiac conduction Source: BHF-UCL
  8. response to progesterone Source: Ensembl
  9. ventricular cardiac muscle cell action potential Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_13579. Apoptotic cleavage of cell adhesion proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Desmoglein-2
Alternative name(s):
Cadherin family member 5
HDGC
Gene namesi
Name:DSG2
Synonyms:CDHF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:3049. DSG2.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cell-cell junction Source: ProtInc
  3. cell surface Source: UniProtKB
  4. desmosome Source: Ensembl
  5. extracellular vesicular exosome Source: UniProt
  6. integral component of membrane Source: UniProtKB-KW
  7. lateral plasma membrane Source: Ensembl
  8. plasma membrane Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Arrhythmogenic right ventricular dysplasia, familial, 10 (ARVD10) [MIM:610193]: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.4 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461R → Q in ARVD10. 2 Publications
VAR_029365
Natural varianti49 – 491R → H in ARVD10. 4 Publications
VAR_029366
Natural varianti56 – 561V → M Associated with CMD1BB and ARVD10 although it may not be sufficient by itself to result in cardiomyopathy. 2 Publications
Corresponds to variant rs121913013 [ dbSNP | Ensembl ].
VAR_062387
Natural varianti335 – 3351T → A in ARVD10. 1 Publication
Corresponds to variant rs191564916 [ dbSNP | Ensembl ].
VAR_065686
Natural varianti507 – 5071C → Y in ARVD10. 2 Publications
VAR_029367
Natural varianti812 – 8121G → C in ARVD10. 2 Publications
VAR_029368
Cardiomyopathy, dilated 1BB (CMD1BB) [MIM:612877]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.1 Publication
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti56 – 561V → M Associated with CMD1BB and ARVD10 although it may not be sufficient by itself to result in cardiomyopathy. 2 Publications
Corresponds to variant rs121913013 [ dbSNP | Ensembl ].
VAR_062387

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

MIMi610193. phenotype.
612877. phenotype.
Orphaneti293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
154. Familial isolated dilated cardiomyopathy.
PharmGKBiPA27502.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Propeptidei24 – 4926Sequence AnalysisPRO_0000003845Add
BLAST
Chaini50 – 11181069Desmoglein-2PRO_0000003846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi112 – 1121N-linked (GlcNAc...)2 Publications
Glycosylationi182 – 1821N-linked (GlcNAc...)3 Publications
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi462 – 4621N-linked (GlcNAc...) (complex)2 Publications
Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
Modified residuei680 – 6801Phosphoserine6 Publications
Modified residuei703 – 7031Phosphoserine1 Publication
Modified residuei1118 – 11181Phosphoserine1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ14126.
PaxDbiQ14126.
PRIDEiQ14126.

PTM databases

PhosphoSiteiQ14126.

Miscellaneous databases

PMAP-CutDBQ14126.

Expressioni

Tissue specificityi

All of the tissues tested and carcinomas.

Gene expression databases

BgeeiQ14126.
CleanExiHS_DSG2.
ExpressionAtlasiQ14126. baseline and differential.
GenevestigatoriQ14126.

Organism-specific databases

HPAiCAB025122.
HPA004896.

Interactioni

Protein-protein interaction databases

BioGridi108163. 15 interactions.
DIPiDIP-46250N.
IntActiQ14126. 4 interactions.
MINTiMINT-4990532.
STRINGi9606.ENSP00000261590.

Structurei

Secondary structure

1
1118
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi56 – 627
Helixi77 – 815
Beta strandi86 – 916
Turni92 – 943
Beta strandi95 – 984
Beta strandi100 – 1056
Turni106 – 1094
Beta strandi110 – 1134
Turni119 – 1213
Beta strandi122 – 13211
Beta strandi138 – 1436
Beta strandi146 – 1505

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YQGNMR-A47-162[»]
ProteinModelPortaliQ14126.
SMRiQ14126. Positions 47-593.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14126.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini50 – 609560ExtracellularSequence AnalysisAdd
BLAST
Topological domaini635 – 1118484CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei610 – 63425HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 160111Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini161 – 273113Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini274 – 388115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini389 – 503115Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Repeati881 – 91232Desmoglein repeat 1Add
BLAST
Repeati913 – 94230Desmoglein repeat 2Add
BLAST
Repeati943 – 96826Desmoglein repeat 3Add
BLAST
Repeati969 – 99224Desmoglein repeat 4Add
BLAST
Repeati993 – 102129Desmoglein repeat 5Add
BLAST
Repeati1022 – 105130Desmoglein repeat 6Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 4 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293589.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000236266.
HOVERGENiHBG005532.
InParanoidiQ14126.
KOiK07597.
OMAiVMVRERE.
OrthoDBiEOG7HQN78.
PhylomeDBiQ14126.
TreeFamiTF331809.

Family and domain databases

Gene3Di2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q14126-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARSPGRAYA LLLLLICFNV GSGLHLQVLS TRNENKLLPK HPHLVRQKRA
60 70 80 90 100
WITAPVALRE GEDLSKKNPI AKIHSDLAEE RGLKITYKYT GKGITEPPFG
110 120 130 140 150
IFVFNKDTGE LNVTSILDRE ETPFFLLTGY ALDARGNNVE KPLELRIKVL
160 170 180 190 200
DINDNEPVFT QDVFVGSVEE LSAAHTLVMK INATDADEPN TLNSKISYRI
210 220 230 240 250
VSLEPAYPPV FYLNKDTGEI YTTSVTLDRE EHSSYTLTVE ARDGNGEVTD
260 270 280 290 300
KPVKQAQVQI RILDVNDNIP VVENKVLEGM VEENQVNVEV TRIKVFDADE
310 320 330 340 350
IGSDNWLANF TFASGNEGGY FHIETDAQTN EGIVTLIKEV DYEEMKNLDF
360 370 380 390 400
SVIVANKAAF HKSIRSKYKP TPIPIKVKVK NVKEGIHFKS SVISIYVSES
410 420 430 440 450
MDRSSKGQII GNFQAFDEDT GLPAHARYVK LEDRDNWISV DSVTSEIKLA
460 470 480 490 500
KLPDFESRYV QNGTYTVKIV AISEDYPRKT ITGTVLINVE DINDNCPTLI
510 520 530 540 550
EPVQTICHDA EYVNVTAEDL DGHPNSGPFS FSVIDKPPGM AEKWKIARQE
560 570 580 590 600
STSVLLQQSE KKLGRSEIQF LISDNQGFSC PEKQVLTLTV CECLHGSGCR
610 620 630 640 650
EAQHDSYVGL GPAAIALMIL AFLLLLLVPL LLLMCHCGKG AKGFTPIPGT
660 670 680 690 700
IEMLHPWNNE GAPPEDKVVP SFLPVDQGGS LVGRNGVGGM AKEATMKGSS
710 720 730 740 750
SASIVKGQHE MSEMDGRWEE HRSLLSGRAT QFTGATGAIM TTETTKTARA
760 770 780 790 800
TGASRDMAGA QAAAVALNEE FLRNYFTDKA ASYTEEDENH TAKDCLLVYS
810 820 830 840 850
QEETESLNAS IGCCSFIEGE LDDRFLDDLG LKFKTLAEVC LGQKIDINKE
860 870 880 890 900
IEQRQKPATE TSMNTASHSL CEQTMVNSEN TYSSGSSFPV PKSLQEANAE
910 920 930 940 950
KVTQEIVTER SVSSRQAQKV ATPLPDPMAS RNVIATETSY VTGSTMPPTT
960 970 980 990 1000
VILGPSQPQS LIVTERVYAP ASTLVDQPYA NEGTVVVTER VIQPHGGGSN
1010 1020 1030 1040 1050
PLEGTQHLQD VPYVMVRERE SFLAPSSGVQ PTLAMPNIAV GQNVTVTERV
1060 1070 1080 1090 1100
LAPASTLQSS YQIPTENSMT ARNTTVSGAG VPGPLPDFGL EESGHSNSTI
1110
TTSSTRVTKH STVQHSYS
Length:1,118
Mass (Da):122,294
Last modified:May 29, 2007 - v2
Checksum:iE1481AA1686DB80A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 107SPGRAYA → TRDRVR in CAA81226. (PubMed:8143788)Curated
Sequence conflicti593 – 5931C → V in CAA81226. (PubMed:8143788)Curated
Sequence conflicti643 – 6431G → A in CAA81226. (PubMed:8143788)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461R → Q in ARVD10. 2 Publications
VAR_029365
Natural varianti49 – 491R → H in ARVD10. 4 Publications
VAR_029366
Natural varianti56 – 561V → M Associated with CMD1BB and ARVD10 although it may not be sufficient by itself to result in cardiomyopathy. 2 Publications
Corresponds to variant rs121913013 [ dbSNP | Ensembl ].
VAR_062387
Natural varianti89 – 891Y → C.
Corresponds to variant rs2230232 [ dbSNP | Ensembl ].
VAR_048508
Natural varianti158 – 1581V → G.1 Publication
Corresponds to variant rs191143292 [ dbSNP | Ensembl ].
VAR_062388
Natural varianti293 – 2931I → V.2 Publications
Corresponds to variant rs2230234 [ dbSNP | Ensembl ].
VAR_048509
Natural varianti335 – 3351T → A in ARVD10. 1 Publication
Corresponds to variant rs191564916 [ dbSNP | Ensembl ].
VAR_065686
Natural varianti507 – 5071C → Y in ARVD10. 2 Publications
VAR_029367
Natural varianti515 – 5151V → I.
Corresponds to variant rs2230235 [ dbSNP | Ensembl ].
VAR_048510
Natural varianti713 – 7131E → K.2 Publications
Corresponds to variant rs79241126 [ dbSNP | Ensembl ].
VAR_062389
Natural varianti773 – 7731R → K.2 Publications
Corresponds to variant rs2278792 [ dbSNP | Ensembl ].
VAR_048511
Natural varianti812 – 8121G → C in ARVD10. 2 Publications
VAR_029368
Natural varianti863 – 8631M → L.
Corresponds to variant rs16962093 [ dbSNP | Ensembl ].
VAR_048512
Natural varianti903 – 9031T → I.
Corresponds to variant rs34065672 [ dbSNP | Ensembl ].
VAR_048513
Natural varianti920 – 9201V → G.2 Publications
Corresponds to variant rs142841727 [ dbSNP | Ensembl ].
VAR_062390

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z26317 mRNA. Translation: CAA81226.1.
BC099655 mRNA. Translation: AAH99655.1.
BC099656 mRNA. Translation: AAH99656.1.
BC099657 mRNA. Translation: AAH99657.1.
CCDSiCCDS42423.1.
PIRiS38673.
RefSeqiNP_001934.2. NM_001943.3.
UniGeneiHs.412597.

Genome annotation databases

EnsembliENST00000261590; ENSP00000261590; ENSG00000046604.
GeneIDi1829.
KEGGihsa:1829.
UCSCiuc002kwu.4. human.

Polymorphism databases

DMDMi148876773.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z26317 mRNA. Translation: CAA81226.1 .
BC099655 mRNA. Translation: AAH99655.1 .
BC099656 mRNA. Translation: AAH99656.1 .
BC099657 mRNA. Translation: AAH99657.1 .
CCDSi CCDS42423.1.
PIRi S38673.
RefSeqi NP_001934.2. NM_001943.3.
UniGenei Hs.412597.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YQG NMR - A 47-162 [» ]
ProteinModelPortali Q14126.
SMRi Q14126. Positions 47-593.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108163. 15 interactions.
DIPi DIP-46250N.
IntActi Q14126. 4 interactions.
MINTi MINT-4990532.
STRINGi 9606.ENSP00000261590.

PTM databases

PhosphoSitei Q14126.

Polymorphism databases

DMDMi 148876773.

Proteomic databases

MaxQBi Q14126.
PaxDbi Q14126.
PRIDEi Q14126.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261590 ; ENSP00000261590 ; ENSG00000046604 .
GeneIDi 1829.
KEGGi hsa:1829.
UCSCi uc002kwu.4. human.

Organism-specific databases

CTDi 1829.
GeneCardsi GC18P029101.
GeneReviewsi DSG2.
H-InvDB HIX0039840.
HGNCi HGNC:3049. DSG2.
HPAi CAB025122.
HPA004896.
MIMi 125671. gene.
610193. phenotype.
612877. phenotype.
neXtProti NX_Q14126.
Orphaneti 293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
154. Familial isolated dilated cardiomyopathy.
PharmGKBi PA27502.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293589.
GeneTreei ENSGT00760000118906.
HOGENOMi HOG000236266.
HOVERGENi HBG005532.
InParanoidi Q14126.
KOi K07597.
OMAi VMVRERE.
OrthoDBi EOG7HQN78.
PhylomeDBi Q14126.
TreeFami TF331809.

Enzyme and pathway databases

Reactomei REACT_13579. Apoptotic cleavage of cell adhesion proteins.

Miscellaneous databases

ChiTaRSi DSG2. human.
EvolutionaryTracei Q14126.
GeneWikii Desmoglein_2.
GenomeRNAii 1829.
NextBioi 7465.
PMAP-CutDB Q14126.
PROi Q14126.
SOURCEi Search...

Gene expression databases

Bgeei Q14126.
CleanExi HS_DSG2.
ExpressionAtlasi Q14126. baseline and differential.
Genevestigatori Q14126.

Family and domain databases

Gene3Di 2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view ]
PANTHERi PTHR24025. PTHR24025. 1 hit.
Pfami PF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTi SM00112. CA. 4 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 5 hits.
PROSITEi PS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins."
    Schaefer S., Koch P.J., Franke W.W.
    Exp. Cell Res. 211:391-399(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon carcinoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete amino acid sequence of the epidermal desmoglein precursor polypeptide and identification of a second type of desmoglein gene."
    Koch P.J., Goldschmidt M.D., Walsh M.J., Zimbelmann R., Franke W.W.
    Eur. J. Cell Biol. 55:200-208(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 778-1118.
  4. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
    Zhang H., Li X.-J., Martin D.B., Aebersold R.
    Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-112.
  5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-182.
    Tissue: Plasma.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112 AND ASN-182.
    Tissue: Liver.
  10. Cited for: GLYCOSYLATION AT ASN-462.
  11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-182 AND ASN-462.
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680 AND SER-1118, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680 AND SER-703, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "Solution structure of the first cadherin domain from human desmoglein-2."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 47-162.
  17. "DSG2 mutations contribute to arrhythmogenic right ventricular dysplasia/cardiomyopathy."
    Awad M.M., Dalal D., Cho E., Amat-Alarcon N., James C., Tichnell C., Tucker A., Russell S.D., Bluemke D.A., Dietz H.C., Calkins H., Judge D.P.
    Am. J. Hum. Genet. 79:136-142(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ARVD10 GLN-46; HIS-49; TYR-507 AND CYS-812.
  18. Cited for: VARIANTS MET-56; GLY-158; VAL-293; LYS-713; LYS-773 AND GLY-920, INVOLVEMENT IN SUSCEPTIBILITY TO CMD1BB.
  19. "Comprehensive desmosome mutation analysis in North Americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy."
    den Haan A.D., Tan B.Y., Zikusoka M.N., Llado L.I., Jain R., Daly A., Tichnell C., James C., Amat-Alarcon N., Abraham T., Russell S.D., Bluemke D.A., Calkins H., Dalal D., Judge D.P.
    Circ. Cardiovasc. Genet. 2:428-435(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ARVD10 GLN-46; HIS-49; ALA-335; TYR-507 AND CYS-812, VARIANT MET-56.
  20. "Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia."
    Barahona-Dussault C., Benito B., Campuzano O., Iglesias A., Leung T.L., Robb L., Talajic M., Brugada R.
    Clin. Genet. 77:37-48(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ARVD10 HIS-49, VARIANTS VAL-293; LYS-713; LYS-773 AND GLY-920.
  21. "Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations."
    Gehmlich K., Syrris P., Peskett E., Evans A., Ehler E., Asimaki A., Anastasakis A., Tsatsopoulou A., Vouliotis A.I., Stefanadis C., Saffitz J.E., Protonotarios N., McKenna W.J.
    Cardiovasc. Res. 90:77-87(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ARVD10 HIS-49.

Entry informationi

Entry nameiDSG2_HUMAN
AccessioniPrimary (citable) accession number: Q14126
Secondary accession number(s): Q4KKU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 29, 2007
Last modified: October 29, 2014
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3