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Q14126

- DSG2_HUMAN

UniProt

Q14126 - DSG2_HUMAN

Protein

Desmoglein-2

Gene

DSG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
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    Functioni

    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: Reactome
    2. bundle of His cell to Purkinje myocyte communication Source: BHF-UCL
    3. cell adhesion Source: UniProtKB
    4. cellular component disassembly involved in execution phase of apoptosis Source: Reactome
    5. homophilic cell adhesion Source: InterPro
    6. maternal process involved in female pregnancy Source: Ensembl
    7. regulation of heart rate by cardiac conduction Source: BHF-UCL
    8. response to progesterone Source: Ensembl
    9. ventricular cardiac muscle cell action potential Source: BHF-UCL

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_13579. Apoptotic cleavage of cell adhesion proteins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Desmoglein-2
    Alternative name(s):
    Cadherin family member 5
    HDGC
    Gene namesi
    Name:DSG2
    Synonyms:CDHF5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:3049. DSG2.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. cell-cell junction Source: ProtInc
    3. desmosome Source: UniProtKB-SubCell
    4. extracellular vesicular exosome Source: UniProt
    5. integral component of membrane Source: UniProtKB-KW
    6. lateral plasma membrane Source: Ensembl
    7. plasma membrane Source: UniProt

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Arrhythmogenic right ventricular dysplasia, familial, 10 (ARVD10) [MIM:610193]: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.4 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti46 – 461R → Q in ARVD10. 2 Publications
    VAR_029365
    Natural varianti49 – 491R → H in ARVD10. 4 Publications
    VAR_029366
    Natural varianti56 – 561V → M Associated with CMD1BB and ARVD10 although it may not be sufficient by itself to result in cardiomyopathy. 2 Publications
    Corresponds to variant rs121913013 [ dbSNP | Ensembl ].
    VAR_062387
    Natural varianti335 – 3351T → A in ARVD10. 1 Publication
    Corresponds to variant rs191564916 [ dbSNP | Ensembl ].
    VAR_065686
    Natural varianti507 – 5071C → Y in ARVD10. 2 Publications
    VAR_029367
    Natural varianti812 – 8121G → C in ARVD10. 2 Publications
    VAR_029368
    Cardiomyopathy, dilated 1BB (CMD1BB) [MIM:612877]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti56 – 561V → M Associated with CMD1BB and ARVD10 although it may not be sufficient by itself to result in cardiomyopathy. 2 Publications
    Corresponds to variant rs121913013 [ dbSNP | Ensembl ].
    VAR_062387

    Keywords - Diseasei

    Cardiomyopathy, Disease mutation

    Organism-specific databases

    MIMi610193. phenotype.
    612877. phenotype.
    Orphaneti293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
    293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
    293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
    154. Familial isolated dilated cardiomyopathy.
    PharmGKBiPA27502.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 4926Sequence AnalysisPRO_0000003845Add
    BLAST
    Chaini50 – 11181069Desmoglein-2PRO_0000003846Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi112 – 1121N-linked (GlcNAc...)2 Publications
    Glycosylationi182 – 1821N-linked (GlcNAc...)3 Publications
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi462 – 4621N-linked (GlcNAc...) (complex)2 Publications
    Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
    Modified residuei680 – 6801Phosphoserine6 Publications
    Modified residuei703 – 7031Phosphoserine1 Publication
    Modified residuei1118 – 11181Phosphoserine1 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ14126.
    PaxDbiQ14126.
    PRIDEiQ14126.

    PTM databases

    PhosphoSiteiQ14126.

    Miscellaneous databases

    PMAP-CutDBQ14126.

    Expressioni

    Tissue specificityi

    All of the tissues tested and carcinomas.

    Gene expression databases

    ArrayExpressiQ14126.
    BgeeiQ14126.
    CleanExiHS_DSG2.
    GenevestigatoriQ14126.

    Organism-specific databases

    HPAiCAB025122.
    HPA004896.

    Interactioni

    Protein-protein interaction databases

    BioGridi108163. 14 interactions.
    DIPiDIP-46250N.
    IntActiQ14126. 4 interactions.
    MINTiMINT-4990532.
    STRINGi9606.ENSP00000261590.

    Structurei

    Secondary structure

    1
    1118
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi56 – 627
    Helixi77 – 815
    Beta strandi86 – 916
    Turni92 – 943
    Beta strandi95 – 984
    Beta strandi100 – 1056
    Turni106 – 1094
    Beta strandi110 – 1134
    Turni119 – 1213
    Beta strandi122 – 13211
    Beta strandi138 – 1436
    Beta strandi146 – 1505

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YQGNMR-A47-162[»]
    ProteinModelPortaliQ14126.
    SMRiQ14126. Positions 47-593.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ14126.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini50 – 609560ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini635 – 1118484CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei610 – 63425HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 160111Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini161 – 273113Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini274 – 388115Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini389 – 503115Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Repeati881 – 91232Desmoglein repeat 1Add
    BLAST
    Repeati913 – 94230Desmoglein repeat 2Add
    BLAST
    Repeati943 – 96826Desmoglein repeat 3Add
    BLAST
    Repeati969 – 99224Desmoglein repeat 4Add
    BLAST
    Repeati993 – 102129Desmoglein repeat 5Add
    BLAST
    Repeati1022 – 105130Desmoglein repeat 6Add
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 4 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293589.
    HOGENOMiHOG000236266.
    HOVERGENiHBG005532.
    InParanoidiQ14126.
    KOiK07597.
    OMAiVMVRERE.
    OrthoDBiEOG7HQN78.
    PhylomeDBiQ14126.
    TreeFamiTF331809.

    Family and domain databases

    Gene3Di2.60.40.60. 4 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    IPR009123. Desmoglein.
    IPR009122. Desmosomal_cadherin.
    [Graphical view]
    PANTHERiPTHR24025. PTHR24025. 1 hit.
    PfamiPF00028. Cadherin. 3 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    PR01818. DESMOCADHERN.
    PR01819. DESMOGLEIN.
    SMARTiSM00112. CA. 4 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 5 hits.
    PROSITEiPS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q14126-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARSPGRAYA LLLLLICFNV GSGLHLQVLS TRNENKLLPK HPHLVRQKRA     50
    WITAPVALRE GEDLSKKNPI AKIHSDLAEE RGLKITYKYT GKGITEPPFG 100
    IFVFNKDTGE LNVTSILDRE ETPFFLLTGY ALDARGNNVE KPLELRIKVL 150
    DINDNEPVFT QDVFVGSVEE LSAAHTLVMK INATDADEPN TLNSKISYRI 200
    VSLEPAYPPV FYLNKDTGEI YTTSVTLDRE EHSSYTLTVE ARDGNGEVTD 250
    KPVKQAQVQI RILDVNDNIP VVENKVLEGM VEENQVNVEV TRIKVFDADE 300
    IGSDNWLANF TFASGNEGGY FHIETDAQTN EGIVTLIKEV DYEEMKNLDF 350
    SVIVANKAAF HKSIRSKYKP TPIPIKVKVK NVKEGIHFKS SVISIYVSES 400
    MDRSSKGQII GNFQAFDEDT GLPAHARYVK LEDRDNWISV DSVTSEIKLA 450
    KLPDFESRYV QNGTYTVKIV AISEDYPRKT ITGTVLINVE DINDNCPTLI 500
    EPVQTICHDA EYVNVTAEDL DGHPNSGPFS FSVIDKPPGM AEKWKIARQE 550
    STSVLLQQSE KKLGRSEIQF LISDNQGFSC PEKQVLTLTV CECLHGSGCR 600
    EAQHDSYVGL GPAAIALMIL AFLLLLLVPL LLLMCHCGKG AKGFTPIPGT 650
    IEMLHPWNNE GAPPEDKVVP SFLPVDQGGS LVGRNGVGGM AKEATMKGSS 700
    SASIVKGQHE MSEMDGRWEE HRSLLSGRAT QFTGATGAIM TTETTKTARA 750
    TGASRDMAGA QAAAVALNEE FLRNYFTDKA ASYTEEDENH TAKDCLLVYS 800
    QEETESLNAS IGCCSFIEGE LDDRFLDDLG LKFKTLAEVC LGQKIDINKE 850
    IEQRQKPATE TSMNTASHSL CEQTMVNSEN TYSSGSSFPV PKSLQEANAE 900
    KVTQEIVTER SVSSRQAQKV ATPLPDPMAS RNVIATETSY VTGSTMPPTT 950
    VILGPSQPQS LIVTERVYAP ASTLVDQPYA NEGTVVVTER VIQPHGGGSN 1000
    PLEGTQHLQD VPYVMVRERE SFLAPSSGVQ PTLAMPNIAV GQNVTVTERV 1050
    LAPASTLQSS YQIPTENSMT ARNTTVSGAG VPGPLPDFGL EESGHSNSTI 1100
    TTSSTRVTKH STVQHSYS 1118
    Length:1,118
    Mass (Da):122,294
    Last modified:May 29, 2007 - v2
    Checksum:iE1481AA1686DB80A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 107SPGRAYA → TRDRVR in CAA81226. (PubMed:8143788)Curated
    Sequence conflicti593 – 5931C → V in CAA81226. (PubMed:8143788)Curated
    Sequence conflicti643 – 6431G → A in CAA81226. (PubMed:8143788)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti46 – 461R → Q in ARVD10. 2 Publications
    VAR_029365
    Natural varianti49 – 491R → H in ARVD10. 4 Publications
    VAR_029366
    Natural varianti56 – 561V → M Associated with CMD1BB and ARVD10 although it may not be sufficient by itself to result in cardiomyopathy. 2 Publications
    Corresponds to variant rs121913013 [ dbSNP | Ensembl ].
    VAR_062387
    Natural varianti89 – 891Y → C.
    Corresponds to variant rs2230232 [ dbSNP | Ensembl ].
    VAR_048508
    Natural varianti158 – 1581V → G.1 Publication
    Corresponds to variant rs191143292 [ dbSNP | Ensembl ].
    VAR_062388
    Natural varianti293 – 2931I → V.2 Publications
    Corresponds to variant rs2230234 [ dbSNP | Ensembl ].
    VAR_048509
    Natural varianti335 – 3351T → A in ARVD10. 1 Publication
    Corresponds to variant rs191564916 [ dbSNP | Ensembl ].
    VAR_065686
    Natural varianti507 – 5071C → Y in ARVD10. 2 Publications
    VAR_029367
    Natural varianti515 – 5151V → I.
    Corresponds to variant rs2230235 [ dbSNP | Ensembl ].
    VAR_048510
    Natural varianti713 – 7131E → K.2 Publications
    Corresponds to variant rs79241126 [ dbSNP | Ensembl ].
    VAR_062389
    Natural varianti773 – 7731R → K.2 Publications
    Corresponds to variant rs2278792 [ dbSNP | Ensembl ].
    VAR_048511
    Natural varianti812 – 8121G → C in ARVD10. 2 Publications
    VAR_029368
    Natural varianti863 – 8631M → L.
    Corresponds to variant rs16962093 [ dbSNP | Ensembl ].
    VAR_048512
    Natural varianti903 – 9031T → I.
    Corresponds to variant rs34065672 [ dbSNP | Ensembl ].
    VAR_048513
    Natural varianti920 – 9201V → G.2 Publications
    Corresponds to variant rs142841727 [ dbSNP | Ensembl ].
    VAR_062390

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z26317 mRNA. Translation: CAA81226.1.
    BC099655 mRNA. Translation: AAH99655.1.
    BC099656 mRNA. Translation: AAH99656.1.
    BC099657 mRNA. Translation: AAH99657.1.
    CCDSiCCDS42423.1.
    PIRiS38673.
    RefSeqiNP_001934.2. NM_001943.3.
    UniGeneiHs.412597.

    Genome annotation databases

    EnsembliENST00000261590; ENSP00000261590; ENSG00000046604.
    GeneIDi1829.
    KEGGihsa:1829.
    UCSCiuc002kwu.4. human.

    Polymorphism databases

    DMDMi148876773.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z26317 mRNA. Translation: CAA81226.1 .
    BC099655 mRNA. Translation: AAH99655.1 .
    BC099656 mRNA. Translation: AAH99656.1 .
    BC099657 mRNA. Translation: AAH99657.1 .
    CCDSi CCDS42423.1.
    PIRi S38673.
    RefSeqi NP_001934.2. NM_001943.3.
    UniGenei Hs.412597.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YQG NMR - A 47-162 [» ]
    ProteinModelPortali Q14126.
    SMRi Q14126. Positions 47-593.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108163. 14 interactions.
    DIPi DIP-46250N.
    IntActi Q14126. 4 interactions.
    MINTi MINT-4990532.
    STRINGi 9606.ENSP00000261590.

    PTM databases

    PhosphoSitei Q14126.

    Polymorphism databases

    DMDMi 148876773.

    Proteomic databases

    MaxQBi Q14126.
    PaxDbi Q14126.
    PRIDEi Q14126.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261590 ; ENSP00000261590 ; ENSG00000046604 .
    GeneIDi 1829.
    KEGGi hsa:1829.
    UCSCi uc002kwu.4. human.

    Organism-specific databases

    CTDi 1829.
    GeneCardsi GC18P029101.
    GeneReviewsi DSG2.
    H-InvDB HIX0039840.
    HGNCi HGNC:3049. DSG2.
    HPAi CAB025122.
    HPA004896.
    MIMi 125671. gene.
    610193. phenotype.
    612877. phenotype.
    neXtProti NX_Q14126.
    Orphaneti 293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
    293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
    293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
    154. Familial isolated dilated cardiomyopathy.
    PharmGKBi PA27502.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293589.
    HOGENOMi HOG000236266.
    HOVERGENi HBG005532.
    InParanoidi Q14126.
    KOi K07597.
    OMAi VMVRERE.
    OrthoDBi EOG7HQN78.
    PhylomeDBi Q14126.
    TreeFami TF331809.

    Enzyme and pathway databases

    Reactomei REACT_13579. Apoptotic cleavage of cell adhesion proteins.

    Miscellaneous databases

    ChiTaRSi DSG2. human.
    EvolutionaryTracei Q14126.
    GeneWikii Desmoglein_2.
    GenomeRNAii 1829.
    NextBioi 7465.
    PMAP-CutDB Q14126.
    PROi Q14126.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14126.
    Bgeei Q14126.
    CleanExi HS_DSG2.
    Genevestigatori Q14126.

    Family and domain databases

    Gene3Di 2.60.40.60. 4 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    IPR009123. Desmoglein.
    IPR009122. Desmosomal_cadherin.
    [Graphical view ]
    PANTHERi PTHR24025. PTHR24025. 1 hit.
    Pfami PF00028. Cadherin. 3 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    PR01818. DESMOCADHERN.
    PR01819. DESMOGLEIN.
    SMARTi SM00112. CA. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 5 hits.
    PROSITEi PS00232. CADHERIN_1. 3 hits.
    PS50268. CADHERIN_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins."
      Schaefer S., Koch P.J., Franke W.W.
      Exp. Cell Res. 211:391-399(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Colon carcinoma.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete amino acid sequence of the epidermal desmoglein precursor polypeptide and identification of a second type of desmoglein gene."
      Koch P.J., Goldschmidt M.D., Walsh M.J., Zimbelmann R., Franke W.W.
      Eur. J. Cell Biol. 55:200-208(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 778-1118.
    4. "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H., Li X.-J., Martin D.B., Aebersold R.
      Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-112.
    5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-182.
      Tissue: Plasma.
    6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112 AND ASN-182.
      Tissue: Liver.
    10. Cited for: GLYCOSYLATION AT ASN-462.
    11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-182 AND ASN-462.
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680 AND SER-1118, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680 AND SER-703, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "Solution structure of the first cadherin domain from human desmoglein-2."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 47-162.
    17. "DSG2 mutations contribute to arrhythmogenic right ventricular dysplasia/cardiomyopathy."
      Awad M.M., Dalal D., Cho E., Amat-Alarcon N., James C., Tichnell C., Tucker A., Russell S.D., Bluemke D.A., Dietz H.C., Calkins H., Judge D.P.
      Am. J. Hum. Genet. 79:136-142(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ARVD10 GLN-46; HIS-49; TYR-507 AND CYS-812.
    18. Cited for: VARIANTS MET-56; GLY-158; VAL-293; LYS-713; LYS-773 AND GLY-920, INVOLVEMENT IN SUSCEPTIBILITY TO CMD1BB.
    19. "Comprehensive desmosome mutation analysis in North Americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy."
      den Haan A.D., Tan B.Y., Zikusoka M.N., Llado L.I., Jain R., Daly A., Tichnell C., James C., Amat-Alarcon N., Abraham T., Russell S.D., Bluemke D.A., Calkins H., Dalal D., Judge D.P.
      Circ. Cardiovasc. Genet. 2:428-435(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ARVD10 GLN-46; HIS-49; ALA-335; TYR-507 AND CYS-812, VARIANT MET-56.
    20. "Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia."
      Barahona-Dussault C., Benito B., Campuzano O., Iglesias A., Leung T.L., Robb L., Talajic M., Brugada R.
      Clin. Genet. 77:37-48(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ARVD10 HIS-49, VARIANTS VAL-293; LYS-713; LYS-773 AND GLY-920.
    21. "Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations."
      Gehmlich K., Syrris P., Peskett E., Evans A., Ehler E., Asimaki A., Anastasakis A., Tsatsopoulou A., Vouliotis A.I., Stefanadis C., Saffitz J.E., Protonotarios N., McKenna W.J.
      Cardiovasc. Res. 90:77-87(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ARVD10 HIS-49.

    Entry informationi

    Entry nameiDSG2_HUMAN
    AccessioniPrimary (citable) accession number: Q14126
    Secondary accession number(s): Q4KKU6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 140 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3