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Q14126 (DSG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Desmoglein-2
Alternative name(s):
Cadherin family member 5
HDGC
Gene names
Name:DSG2
Synonyms:CDHF5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1118 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Subcellular location

Cell membrane; Single-pass type I membrane protein. Cell junctiondesmosome.

Tissue specificity

All of the tissues tested and carcinomas.

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Involvement in disease

Arrhythmogenic right ventricular dysplasia, familial, 10 (ARVD10) [MIM:610193]: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.17 Ref.19 Ref.20 Ref.21

Cardiomyopathy, dilated 1BB (CMD1BB) [MIM:612877]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.18

Sequence similarities

Contains 4 cadherin domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell junction
Cell membrane
Membrane
   Coding sequence diversityPolymorphism
   DiseaseCardiomyopathy
Disease mutation
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
Metal-binding
   PTMCleavage on pair of basic residues
Glycoprotein
Phosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Traceable author statement. Source: Reactome

bundle of His cell to Purkinje myocyte communication

Inferred from mutant phenotype PubMed 22781308. Source: BHF-UCL

cell adhesion

Inferred from direct assay PubMed 17559062. Source: UniProtKB

cellular component disassembly involved in execution phase of apoptosis

Traceable author statement. Source: Reactome

homophilic cell adhesion

Inferred from electronic annotation. Source: InterPro

maternal process involved in female pregnancy

Inferred from electronic annotation. Source: Ensembl

regulation of heart rate by cardiac conduction

Inferred from mutant phenotype PubMed 22781308. Source: BHF-UCL

response to progesterone

Inferred from electronic annotation. Source: Ensembl

ventricular cardiac muscle cell action potential

Inferred from mutant phenotype PubMed 22781308. Source: BHF-UCL

   Cellular_componentapical plasma membrane

Inferred from electronic annotation. Source: Ensembl

cell-cell junction

Traceable author statement Ref.1. Source: ProtInc

desmosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular vesicular exosome

Inferred from direct assay PubMed 19199708. Source: UniProt

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

lateral plasma membrane

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay PubMed 20859650. Source: UniProt

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Propeptide24 – 4926 Potential
PRO_0000003845
Chain50 – 11181069Desmoglein-2
PRO_0000003846

Regions

Topological domain50 – 609560Extracellular Potential
Transmembrane610 – 63425Helical; Potential
Topological domain635 – 1118484Cytoplasmic Potential
Domain50 – 160111Cadherin 1
Domain161 – 273113Cadherin 2
Domain274 – 388115Cadherin 3
Domain389 – 503115Cadherin 4
Repeat881 – 91232Desmoglein repeat 1
Repeat913 – 94230Desmoglein repeat 2
Repeat943 – 96826Desmoglein repeat 3
Repeat969 – 99224Desmoglein repeat 4
Repeat993 – 102129Desmoglein repeat 5
Repeat1022 – 105130Desmoglein repeat 6

Amino acid modifications

Modified residue6801Phosphoserine Ref.6 Ref.7 Ref.8 Ref.12 Ref.13 Ref.15
Modified residue7031Phosphoserine Ref.15
Modified residue11181Phosphoserine Ref.13
Glycosylation1121N-linked (GlcNAc...) Ref.4 Ref.9
Glycosylation1821N-linked (GlcNAc...) Ref.5 Ref.9 Ref.11
Glycosylation3091N-linked (GlcNAc...) Potential
Glycosylation4621N-linked (GlcNAc...) (complex) Ref.10 Ref.11
Glycosylation5141N-linked (GlcNAc...) Potential

Natural variations

Natural variant461R → Q in ARVD10. Ref.17 Ref.19
VAR_029365
Natural variant491R → H in ARVD10. Ref.17 Ref.19 Ref.20 Ref.21
VAR_029366
Natural variant561V → M Associated with CMD1BB and ARVD10 although it may not be sufficient by itself to result in cardiomyopathy. Ref.18 Ref.19
Corresponds to variant rs121913013 [ dbSNP | Ensembl ].
VAR_062387
Natural variant891Y → C.
Corresponds to variant rs2230232 [ dbSNP | Ensembl ].
VAR_048508
Natural variant1581V → G. Ref.18
Corresponds to variant rs191143292 [ dbSNP | Ensembl ].
VAR_062388
Natural variant2931I → V. Ref.18 Ref.20
Corresponds to variant rs2230234 [ dbSNP | Ensembl ].
VAR_048509
Natural variant3351T → A in ARVD10. Ref.19
Corresponds to variant rs191564916 [ dbSNP | Ensembl ].
VAR_065686
Natural variant5071C → Y in ARVD10. Ref.17 Ref.19
VAR_029367
Natural variant5151V → I.
Corresponds to variant rs2230235 [ dbSNP | Ensembl ].
VAR_048510
Natural variant7131E → K. Ref.18 Ref.20
Corresponds to variant rs79241126 [ dbSNP | Ensembl ].
VAR_062389
Natural variant7731R → K. Ref.18 Ref.20
Corresponds to variant rs2278792 [ dbSNP | Ensembl ].
VAR_048511
Natural variant8121G → C in ARVD10. Ref.17 Ref.19
VAR_029368
Natural variant8631M → L.
Corresponds to variant rs16962093 [ dbSNP | Ensembl ].
VAR_048512
Natural variant9031T → I.
Corresponds to variant rs34065672 [ dbSNP | Ensembl ].
VAR_048513
Natural variant9201V → G. Ref.18 Ref.20
Corresponds to variant rs142841727 [ dbSNP | Ensembl ].
VAR_062390

Experimental info

Sequence conflict4 – 107SPGRAYA → TRDRVR in CAA81226. Ref.1
Sequence conflict5931C → V in CAA81226. Ref.1
Sequence conflict6431G → A in CAA81226. Ref.1

Secondary structure

.................... 1118
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q14126 [UniParc].

Last modified May 29, 2007. Version 2.
Checksum: E1481AA1686DB80A

FASTA1,118122,294
        10         20         30         40         50         60 
MARSPGRAYA LLLLLICFNV GSGLHLQVLS TRNENKLLPK HPHLVRQKRA WITAPVALRE 

        70         80         90        100        110        120 
GEDLSKKNPI AKIHSDLAEE RGLKITYKYT GKGITEPPFG IFVFNKDTGE LNVTSILDRE 

       130        140        150        160        170        180 
ETPFFLLTGY ALDARGNNVE KPLELRIKVL DINDNEPVFT QDVFVGSVEE LSAAHTLVMK 

       190        200        210        220        230        240 
INATDADEPN TLNSKISYRI VSLEPAYPPV FYLNKDTGEI YTTSVTLDRE EHSSYTLTVE 

       250        260        270        280        290        300 
ARDGNGEVTD KPVKQAQVQI RILDVNDNIP VVENKVLEGM VEENQVNVEV TRIKVFDADE 

       310        320        330        340        350        360 
IGSDNWLANF TFASGNEGGY FHIETDAQTN EGIVTLIKEV DYEEMKNLDF SVIVANKAAF 

       370        380        390        400        410        420 
HKSIRSKYKP TPIPIKVKVK NVKEGIHFKS SVISIYVSES MDRSSKGQII GNFQAFDEDT 

       430        440        450        460        470        480 
GLPAHARYVK LEDRDNWISV DSVTSEIKLA KLPDFESRYV QNGTYTVKIV AISEDYPRKT 

       490        500        510        520        530        540 
ITGTVLINVE DINDNCPTLI EPVQTICHDA EYVNVTAEDL DGHPNSGPFS FSVIDKPPGM 

       550        560        570        580        590        600 
AEKWKIARQE STSVLLQQSE KKLGRSEIQF LISDNQGFSC PEKQVLTLTV CECLHGSGCR 

       610        620        630        640        650        660 
EAQHDSYVGL GPAAIALMIL AFLLLLLVPL LLLMCHCGKG AKGFTPIPGT IEMLHPWNNE 

       670        680        690        700        710        720 
GAPPEDKVVP SFLPVDQGGS LVGRNGVGGM AKEATMKGSS SASIVKGQHE MSEMDGRWEE 

       730        740        750        760        770        780 
HRSLLSGRAT QFTGATGAIM TTETTKTARA TGASRDMAGA QAAAVALNEE FLRNYFTDKA 

       790        800        810        820        830        840 
ASYTEEDENH TAKDCLLVYS QEETESLNAS IGCCSFIEGE LDDRFLDDLG LKFKTLAEVC 

       850        860        870        880        890        900 
LGQKIDINKE IEQRQKPATE TSMNTASHSL CEQTMVNSEN TYSSGSSFPV PKSLQEANAE 

       910        920        930        940        950        960 
KVTQEIVTER SVSSRQAQKV ATPLPDPMAS RNVIATETSY VTGSTMPPTT VILGPSQPQS 

       970        980        990       1000       1010       1020 
LIVTERVYAP ASTLVDQPYA NEGTVVVTER VIQPHGGGSN PLEGTQHLQD VPYVMVRERE 

      1030       1040       1050       1060       1070       1080 
SFLAPSSGVQ PTLAMPNIAV GQNVTVTERV LAPASTLQSS YQIPTENSMT ARNTTVSGAG 

      1090       1100       1110 
VPGPLPDFGL EESGHSNSTI TTSSTRVTKH STVQHSYS 

« Hide

References

« Hide 'large scale' references
[1]"Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins."
Schaefer S., Koch P.J., Franke W.W.
Exp. Cell Res. 211:391-399(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Colon carcinoma.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Complete amino acid sequence of the epidermal desmoglein precursor polypeptide and identification of a second type of desmoglein gene."
Koch P.J., Goldschmidt M.D., Walsh M.J., Zimbelmann R., Franke W.W.
Eur. J. Cell Biol. 55:200-208(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 778-1118.
[4]"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H., Li X.-J., Martin D.B., Aebersold R.
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-112.
[5]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-182.
Tissue: Plasma.
[6]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-112 AND ASN-182.
Tissue: Liver.
[10]"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H.
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-462.
[11]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-182 AND ASN-462.
Tissue: Leukemic T-cell.
[12]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[13]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680 AND SER-1118, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[14]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[15]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680 AND SER-703, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]"Solution structure of the first cadherin domain from human desmoglein-2."
RIKEN structural genomics initiative (RSGI)
Submitted (OCT-2007) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 47-162.
[17]"DSG2 mutations contribute to arrhythmogenic right ventricular dysplasia/cardiomyopathy."
Awad M.M., Dalal D., Cho E., Amat-Alarcon N., James C., Tichnell C., Tucker A., Russell S.D., Bluemke D.A., Dietz H.C., Calkins H., Judge D.P.
Am. J. Hum. Genet. 79:136-142(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ARVD10 GLN-46; HIS-49; TYR-507 AND CYS-812.
[18]"A missense variant in desmoglein-2 predisposes to dilated cardiomyopathy."
Posch M.G., Posch M.J., Geier C., Erdmann B., Mueller W., Richter A., Ruppert V., Pankuweit S., Maisch B., Perrot A., Buttgereit J., Dietz R., Haverkamp W., Ozcelik C.
Mol. Genet. Metab. 95:74-80(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS MET-56; GLY-158; VAL-293; LYS-713; LYS-773 AND GLY-920, INVOLVEMENT IN SUSCEPTIBILITY TO CMD1BB.
[19]"Comprehensive desmosome mutation analysis in North Americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy."
den Haan A.D., Tan B.Y., Zikusoka M.N., Llado L.I., Jain R., Daly A., Tichnell C., James C., Amat-Alarcon N., Abraham T., Russell S.D., Bluemke D.A., Calkins H., Dalal D., Judge D.P.
Circ. Cardiovasc. Genet. 2:428-435(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ARVD10 GLN-46; HIS-49; ALA-335; TYR-507 AND CYS-812, VARIANT MET-56.
[20]"Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia."
Barahona-Dussault C., Benito B., Campuzano O., Iglesias A., Leung T.L., Robb L., Talajic M., Brugada R.
Clin. Genet. 77:37-48(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ARVD10 HIS-49, VARIANTS VAL-293; LYS-713; LYS-773 AND GLY-920.
[21]"Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations."
Gehmlich K., Syrris P., Peskett E., Evans A., Ehler E., Asimaki A., Anastasakis A., Tsatsopoulou A., Vouliotis A.I., Stefanadis C., Saffitz J.E., Protonotarios N., McKenna W.J.
Cardiovasc. Res. 90:77-87(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ARVD10 HIS-49.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z26317 mRNA. Translation: CAA81226.1.
BC099655 mRNA. Translation: AAH99655.1.
BC099656 mRNA. Translation: AAH99656.1.
BC099657 mRNA. Translation: AAH99657.1.
CCDSCCDS42423.1.
PIRS38673.
RefSeqNP_001934.2. NM_001943.3.
UniGeneHs.412597.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YQGNMR-A47-162[»]
ProteinModelPortalQ14126.
SMRQ14126. Positions 47-593.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108163. 14 interactions.
DIPDIP-46250N.
IntActQ14126. 4 interactions.
MINTMINT-4990532.
STRING9606.ENSP00000261590.

PTM databases

PhosphoSiteQ14126.

Polymorphism databases

DMDM148876773.

Proteomic databases

MaxQBQ14126.
PaxDbQ14126.
PRIDEQ14126.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261590; ENSP00000261590; ENSG00000046604.
GeneID1829.
KEGGhsa:1829.
UCSCuc002kwu.4. human.

Organism-specific databases

CTD1829.
GeneCardsGC18P029101.
GeneReviewsDSG2.
H-InvDBHIX0039840.
HGNCHGNC:3049. DSG2.
HPACAB025122.
HPA004896.
MIM125671. gene.
610193. phenotype.
612877. phenotype.
neXtProtNX_Q14126.
Orphanet293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
154. Familial isolated dilated cardiomyopathy.
PharmGKBPA27502.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG293589.
HOGENOMHOG000236266.
HOVERGENHBG005532.
InParanoidQ14126.
KOK07597.
OMAVMVRERE.
OrthoDBEOG7HQN78.
PhylomeDBQ14126.
TreeFamTF331809.

Enzyme and pathway databases

ReactomeREACT_578. Apoptosis.

Gene expression databases

ArrayExpressQ14126.
BgeeQ14126.
CleanExHS_DSG2.
GenevestigatorQ14126.

Family and domain databases

Gene3D2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERPTHR24025. PTHR24025. 1 hit.
PfamPF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTSM00112. CA. 4 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 5 hits.
PROSITEPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSDSG2. human.
EvolutionaryTraceQ14126.
GeneWikiDesmoglein_2.
GenomeRNAi1829.
NextBio7465.
PMAP-CutDBQ14126.
PROQ14126.
SOURCESearch...

Entry information

Entry nameDSG2_HUMAN
AccessionPrimary (citable) accession number: Q14126
Secondary accession number(s): Q4KKU6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 29, 2007
Last modified: July 9, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM