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Q14123 (PDE1C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Short name=Cam-PDE 1C
EC=3.1.4.17
Alternative name(s):
hCam-3
Gene names
Name:PDE1C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length709 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.

Catalytic activity

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Enzyme regulation

Type I PDE are activated by the binding of calmodulin in the presence of Ca2+.

Subunit structure

Homodimer By similarity.

Tissue specificity

Expressed in several tissues, including brain and heart.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform PDE1C2 (identifier: Q14123-1)

Also known as: HCam-3A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform PDE1C1 (identifier: Q14123-2)

Also known as: HCam-3B;

The sequence of this isoform differs from the canonical sequence as follows:
     631-634: GTKQ → DSQE
     635-709: Missing.
Isoform 3 (identifier: Q14123-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MESPTKEIEE...LRLRGLRKYK → MTDAGNRKEG...PQLDSSEVLV
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 709709Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
PRO_0000198792

Regions

Region202 – 521320Catalytic By similarity

Sites

Active site2281Proton donor By similarity
Metal binding2321Divalent metal cation 1 By similarity
Metal binding2681Divalent metal cation 1 By similarity
Metal binding2691Divalent metal cation 1 By similarity
Metal binding2691Divalent metal cation 2 By similarity
Metal binding3761Divalent metal cation 1 By similarity

Amino acid modifications

Modified residue11N-acetylmethionine Ref.4

Natural variations

Alternative sequence1 – 3838MESPT…LRKYK → MTDAGNRKEGFKKCRSATFS IDGYSFTIVANEAGDKNARP LARFSRSKSQNCLWNSLIDG LTGNVKEKPRPTIVHDPRPP EEILADELPQLDSSEVLV in isoform 3.
VSP_044468
Alternative sequence631 – 6344GTKQ → DSQE in isoform PDE1C1.
VSP_004552
Alternative sequence635 – 70975Missing in isoform PDE1C1.
VSP_004553

Experimental info

Sequence conflict421Q → F in BAC03734. Ref.2
Sequence conflict1261R → L in BAC03734. Ref.2
Isoform 3:
Sequence conflict41A → V in BAC03734. Ref.2

Secondary structure

................................................ 709
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform PDE1C2 (HCam-3A) [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 77133D4DDBE5F7C0

FASTA70980,760
        10         20         30         40         50         60 
MESPTKEIEE FESNSLKYLQ PEQIEKIWLR LRGLRKYKKT SQRLRSLVKQ LERGEASVVD 

        70         80         90        100        110        120 
LKKNLEYAAT VLESVYIDET RRLLDTEDEL SDIQSDAVPS EVRDWLASTF TRQMGMMLRR 

       130        140        150        160        170        180 
SDEKPRFKSI VHAVQAGIFV ERMYRRTSNM VGLSYPPAVI EALKDVDKWS FDVFSLNEAS 

       190        200        210        220        230        240 
GDHALKFIFY ELLTRYDLIS RFKIPISALV SFVEALEVGY SKHKNPYHNL MHAADVTQTV 

       250        260        270        280        290        300 
HYLLYKTGVA NWLTELEIFA IIFSAAIHDY EHTGTTNNFH IQTRSDPAIL YNDRSVLENH 

       310        320        330        340        350        360 
HLSAAYRLLQ DDEEMNILIN LSKDDWREFR TLVIEMVMAT DMSCHFQQIK AMKTALQQPE 

       370        380        390        400        410        420 
AIEKPKALSL MLHTADISHP AKAWDLHHRW TMSLLEEFFR QGDREAELGL PFSPLCDRKS 

       430        440        450        460        470        480 
TMVAQSQVGF IDFIVEPTFT VLTDMTEKIV SPLIDETSQT GGTGQRRSSL NSISSSDAKR 

       490        500        510        520        530        540 
SGVKTSGSEG SAPINNSVIS VDYKSFKATW TEVVHINRER WRAKVPKEEK AKKEAEEKAR 

       550        560        570        580        590        600 
LAAEEQQKEM EAKSQAEEGA SGKAEKKTSG ETKNQVNGTR ANKSDNPRGK NSKAEKSSGE 

       610        620        630        640        650        660 
QQQNGDFKDG KNKTDKKDHS NIGNDSKKTD GTKQRSHGSP APSTSSTCRL TLPVIKPPLR 

       670        680        690        700 
HFKRPAYASS SYAPSVSKKT DEHPARYKML DQRIKMKKIQ NISHNWNRK 

« Hide

Isoform PDE1C1 (HCam-3B) [UniParc].

Checksum: 73F9A72EDCEAF6F7
Show »

FASTA63472,208
Isoform 3 [UniParc].

Checksum: 47B4A412522129DA
Show »

FASTA76986,896

References

« Hide 'large scale' references
[1]"Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases."
Loughney K., Martins T.J., Harris E.A.S., Sadhu K., Hicks J.B., Sonnenburg W.K., Beavo J.A., Ferguson K.
J. Biol. Chem. 271:796-806(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PDE1C1 AND PDE1C2).
Tissue: Heart.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS PDE1C2 AND 3).
Tissue: Heart.
[3]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U40371 mRNA. Translation: AAC50437.1.
U40372 mRNA. Translation: AAA96961.1.
AK056170 mRNA. Translation: BAG51638.1.
AK091734 mRNA. Translation: BAC03734.1.
AC004931 Genomic DNA. No translation available.
AC005589 Genomic DNA. No translation available.
AC006377 Genomic DNA. No translation available.
AC007033 Genomic DNA. No translation available.
AC007093 Genomic DNA. No translation available.
AC018637 Genomic DNA. No translation available.
CCDSCCDS5437.1. [Q14123-2]
CCDS55099.1. [Q14123-1]
RefSeqNP_001177985.1. NM_001191056.2. [Q14123-2]
NP_001177986.1. NM_001191057.2. [Q14123-1]
NP_001177987.2. NM_001191058.2.
NP_001177988.1. NM_001191059.2. [Q14123-1]
NP_005011.1. NM_005020.3. [Q14123-2]
UniGeneHs.728862.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1LXSmodel-A163-460[»]
ProteinModelPortalQ14123.
SMRQ14123. Positions 151-450.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000379485.

Chemistry

BindingDBQ14123.
ChEMBLCHEMBL2095150.
GuidetoPHARMACOLOGY1296.

PTM databases

PhosphoSiteQ14123.

Polymorphism databases

DMDM2499445.

Proteomic databases

MaxQBQ14123.
PaxDbQ14123.
PRIDEQ14123.

Protocols and materials databases

DNASU5137.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000321453; ENSP00000318105; ENSG00000154678. [Q14123-1]
ENST00000396182; ENSP00000379485; ENSG00000154678. [Q14123-2]
ENST00000396184; ENSP00000379487; ENSG00000154678. [Q14123-2]
ENST00000396191; ENSP00000379494; ENSG00000154678. [Q14123-1]
GeneID5137.
KEGGhsa:5137.
UCSCuc003tcm.2. human. [Q14123-1]
uc003tco.2. human. [Q14123-3]
uc003tcr.3. human. [Q14123-2]

Organism-specific databases

CTD5137.
GeneCardsGC07M031759.
HGNCHGNC:8776. PDE1C.
HPAHPA021751.
HPA052375.
MIM602987. gene.
neXtProtNX_Q14123.
PharmGKBPA33124.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG139098.
HOGENOMHOG000231888.
HOVERGENHBG056120.
KOK13755.
OrthoDBEOG7X9G6J.
PhylomeDBQ14123.
TreeFamTF314638.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressQ14123.
BgeeQ14123.
CleanExHS_PDE1C.
GenevestigatorQ14123.

Family and domain databases

Gene3D1.10.1300.10. 2 hits.
InterProIPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
IPR013706. PDEase_N.
[Graphical view]
PfamPF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00471. HDc. 1 hit.
[Graphical view]
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPDE1C. human.
GeneWikiPDE1C.
GenomeRNAi5137.
NextBio19808.
PROQ14123.
SOURCESearch...

Entry information

Entry namePDE1C_HUMAN
AccessionPrimary (citable) accession number: Q14123
Secondary accession number(s): B3KPC6 expand/collapse secondary AC list , E9PE92, Q14124, Q8NB10
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM