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Q14123

- PDE1C_HUMAN

UniProt

Q14123 - PDE1C_HUMAN

Protein

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

Gene

PDE1C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP.

    Catalytic activityi

    Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Enzyme regulationi

    Type I PDE are activated by the binding of calmodulin in the presence of Ca2+.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei228 – 2281Proton donorBy similarity
    Metal bindingi232 – 2321Divalent metal cation 1By similarity
    Metal bindingi268 – 2681Divalent metal cation 1By similarity
    Metal bindingi269 – 2691Divalent metal cation 1By similarity
    Metal bindingi269 – 2691Divalent metal cation 2By similarity
    Metal bindingi376 – 3761Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. calmodulin-dependent cyclic-nucleotide phosphodiesterase activity Source: ProtInc
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. activation of phospholipase C activity Source: Reactome
    2. epidermal growth factor receptor signaling pathway Source: Reactome
    3. fibroblast growth factor receptor signaling pathway Source: Reactome
    4. innate immune response Source: Reactome
    5. metabolic process Source: GOC
    6. neurotrophin TRK receptor signaling pathway Source: Reactome
    7. signal transduction Source: Reactome

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Calmodulin-binding, cAMP, cGMP, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_15408. Cam-PDE 1 activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC:3.1.4.17)
    Short name:
    Cam-PDE 1C
    Alternative name(s):
    hCam-3
    Gene namesi
    Name:PDE1C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:8776. PDE1C.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33124.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 709709Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CPRO_0000198792Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ14123.
    PaxDbiQ14123.
    PRIDEiQ14123.

    PTM databases

    PhosphoSiteiQ14123.

    Expressioni

    Tissue specificityi

    Expressed in several tissues, including brain and heart.

    Gene expression databases

    ArrayExpressiQ14123.
    BgeeiQ14123.
    CleanExiHS_PDE1C.
    GenevestigatoriQ14123.

    Organism-specific databases

    HPAiHPA021751.
    HPA052375.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000379485.

    Structurei

    Secondary structure

    1
    709
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni164 – 1674
    Helixi173 – 1797
    Helixi184 – 19512
    Helixi198 – 2014
    Helixi206 – 21813
    Beta strandi223 – 2253
    Helixi230 – 24415
    Helixi247 – 2493
    Turni250 – 2523
    Helixi255 – 26713
    Turni268 – 2714
    Helixi277 – 2826
    Helixi286 – 2905
    Turni291 – 2933
    Helixi296 – 30712
    Helixi308 – 3136
    Helixi323 – 33816
    Helixi342 – 3443
    Helixi345 – 35410
    Helixi365 – 37612
    Helixi379 – 3813
    Helixi384 – 40724
    Turni418 – 4203
    Helixi423 – 43311
    Helixi435 – 44511
    Turni446 – 4505
    Helixi451 – 4599

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LXSmodel-A163-460[»]
    ProteinModelPortaliQ14123.
    SMRiQ14123. Positions 151-450.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni202 – 521320CatalyticBy similarityAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG139098.
    HOGENOMiHOG000231888.
    HOVERGENiHBG056120.
    KOiK13755.
    OrthoDBiEOG7X9G6J.
    PhylomeDBiQ14123.
    TreeFamiTF314638.

    Family and domain databases

    Gene3Di1.10.1300.10. 2 hits.
    InterProiIPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    IPR013706. PDEase_N.
    [Graphical view]
    PfamiPF00233. PDEase_I. 1 hit.
    PF08499. PDEase_I_N. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00471. HDc. 1 hit.
    [Graphical view]
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Note: Additional isoforms seem to exist.

    Isoform PDE1C2 (identifier: Q14123-1) [UniParc]FASTAAdd to Basket

    Also known as: HCam-3A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESPTKEIEE FESNSLKYLQ PEQIEKIWLR LRGLRKYKKT SQRLRSLVKQ    50
    LERGEASVVD LKKNLEYAAT VLESVYIDET RRLLDTEDEL SDIQSDAVPS 100
    EVRDWLASTF TRQMGMMLRR SDEKPRFKSI VHAVQAGIFV ERMYRRTSNM 150
    VGLSYPPAVI EALKDVDKWS FDVFSLNEAS GDHALKFIFY ELLTRYDLIS 200
    RFKIPISALV SFVEALEVGY SKHKNPYHNL MHAADVTQTV HYLLYKTGVA 250
    NWLTELEIFA IIFSAAIHDY EHTGTTNNFH IQTRSDPAIL YNDRSVLENH 300
    HLSAAYRLLQ DDEEMNILIN LSKDDWREFR TLVIEMVMAT DMSCHFQQIK 350
    AMKTALQQPE AIEKPKALSL MLHTADISHP AKAWDLHHRW TMSLLEEFFR 400
    QGDREAELGL PFSPLCDRKS TMVAQSQVGF IDFIVEPTFT VLTDMTEKIV 450
    SPLIDETSQT GGTGQRRSSL NSISSSDAKR SGVKTSGSEG SAPINNSVIS 500
    VDYKSFKATW TEVVHINRER WRAKVPKEEK AKKEAEEKAR LAAEEQQKEM 550
    EAKSQAEEGA SGKAEKKTSG ETKNQVNGTR ANKSDNPRGK NSKAEKSSGE 600
    QQQNGDFKDG KNKTDKKDHS NIGNDSKKTD GTKQRSHGSP APSTSSTCRL 650
    TLPVIKPPLR HFKRPAYASS SYAPSVSKKT DEHPARYKML DQRIKMKKIQ 700
    NISHNWNRK 709
    Length:709
    Mass (Da):80,760
    Last modified:November 1, 1997 - v1
    Checksum:i77133D4DDBE5F7C0
    GO
    Isoform PDE1C1 (identifier: Q14123-2) [UniParc]FASTAAdd to Basket

    Also known as: HCam-3B

    The sequence of this isoform differs from the canonical sequence as follows:
         631-634: GTKQ → DSQE
         635-709: Missing.

    Show »
    Length:634
    Mass (Da):72,208
    Checksum:i73F9A72EDCEAF6F7
    GO
    Isoform 3 (identifier: Q14123-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-38: MESPTKEIEE...LRLRGLRKYK → MTDAGNRKEG...PQLDSSEVLV

    Note: No experimental confirmation available.Curated

    Show »
    Length:769
    Mass (Da):86,896
    Checksum:i47B4A412522129DA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421Q → F in BAC03734. (PubMed:14702039)Curated
    Sequence conflicti126 – 1261R → L in BAC03734. (PubMed:14702039)Curated
    Isoform 3 (identifier: Q14123-3)
    Sequence conflicti4 – 41A → V in BAC03734. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3838MESPT…LRKYK → MTDAGNRKEGFKKCRSATFS IDGYSFTIVANEAGDKNARP LARFSRSKSQNCLWNSLIDG LTGNVKEKPRPTIVHDPRPP EEILADELPQLDSSEVLV in isoform 3. 1 PublicationVSP_044468Add
    BLAST
    Alternative sequencei631 – 6344GTKQ → DSQE in isoform PDE1C1. 1 PublicationVSP_004552
    Alternative sequencei635 – 70975Missing in isoform PDE1C1. 1 PublicationVSP_004553Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40371 mRNA. Translation: AAC50437.1.
    U40372 mRNA. Translation: AAA96961.1.
    AK056170 mRNA. Translation: BAG51638.1.
    AK091734 mRNA. Translation: BAC03734.1.
    AC004931 Genomic DNA. No translation available.
    AC005589 Genomic DNA. No translation available.
    AC006377 Genomic DNA. No translation available.
    AC007033 Genomic DNA. No translation available.
    AC007093 Genomic DNA. No translation available.
    AC018637 Genomic DNA. No translation available.
    CCDSiCCDS5437.1. [Q14123-2]
    CCDS55099.1. [Q14123-1]
    CCDS55100.1. [Q14123-3]
    RefSeqiNP_001177985.1. NM_001191056.2. [Q14123-2]
    NP_001177986.1. NM_001191057.2. [Q14123-1]
    NP_001177987.2. NM_001191058.2.
    NP_001177988.1. NM_001191059.2. [Q14123-1]
    NP_005011.1. NM_005020.3. [Q14123-2]
    UniGeneiHs.728862.

    Genome annotation databases

    EnsembliENST00000321453; ENSP00000318105; ENSG00000154678. [Q14123-1]
    ENST00000396182; ENSP00000379485; ENSG00000154678. [Q14123-2]
    ENST00000396184; ENSP00000379487; ENSG00000154678. [Q14123-2]
    ENST00000396191; ENSP00000379494; ENSG00000154678. [Q14123-1]
    GeneIDi5137.
    KEGGihsa:5137.
    UCSCiuc003tcm.2. human. [Q14123-1]
    uc003tco.2. human. [Q14123-3]
    uc003tcr.3. human. [Q14123-2]

    Polymorphism databases

    DMDMi2499445.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40371 mRNA. Translation: AAC50437.1 .
    U40372 mRNA. Translation: AAA96961.1 .
    AK056170 mRNA. Translation: BAG51638.1 .
    AK091734 mRNA. Translation: BAC03734.1 .
    AC004931 Genomic DNA. No translation available.
    AC005589 Genomic DNA. No translation available.
    AC006377 Genomic DNA. No translation available.
    AC007033 Genomic DNA. No translation available.
    AC007093 Genomic DNA. No translation available.
    AC018637 Genomic DNA. No translation available.
    CCDSi CCDS5437.1. [Q14123-2 ]
    CCDS55099.1. [Q14123-1 ]
    CCDS55100.1. [Q14123-3 ]
    RefSeqi NP_001177985.1. NM_001191056.2. [Q14123-2 ]
    NP_001177986.1. NM_001191057.2. [Q14123-1 ]
    NP_001177987.2. NM_001191058.2.
    NP_001177988.1. NM_001191059.2. [Q14123-1 ]
    NP_005011.1. NM_005020.3. [Q14123-2 ]
    UniGenei Hs.728862.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LXS model - A 163-460 [» ]
    ProteinModelPortali Q14123.
    SMRi Q14123. Positions 151-450.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000379485.

    Chemistry

    BindingDBi Q14123.
    ChEMBLi CHEMBL2095150.
    GuidetoPHARMACOLOGYi 1296.

    PTM databases

    PhosphoSitei Q14123.

    Polymorphism databases

    DMDMi 2499445.

    Proteomic databases

    MaxQBi Q14123.
    PaxDbi Q14123.
    PRIDEi Q14123.

    Protocols and materials databases

    DNASUi 5137.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000321453 ; ENSP00000318105 ; ENSG00000154678 . [Q14123-1 ]
    ENST00000396182 ; ENSP00000379485 ; ENSG00000154678 . [Q14123-2 ]
    ENST00000396184 ; ENSP00000379487 ; ENSG00000154678 . [Q14123-2 ]
    ENST00000396191 ; ENSP00000379494 ; ENSG00000154678 . [Q14123-1 ]
    GeneIDi 5137.
    KEGGi hsa:5137.
    UCSCi uc003tcm.2. human. [Q14123-1 ]
    uc003tco.2. human. [Q14123-3 ]
    uc003tcr.3. human. [Q14123-2 ]

    Organism-specific databases

    CTDi 5137.
    GeneCardsi GC07M031759.
    HGNCi HGNC:8776. PDE1C.
    HPAi HPA021751.
    HPA052375.
    MIMi 602987. gene.
    neXtProti NX_Q14123.
    PharmGKBi PA33124.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG139098.
    HOGENOMi HOG000231888.
    HOVERGENi HBG056120.
    KOi K13755.
    OrthoDBi EOG7X9G6J.
    PhylomeDBi Q14123.
    TreeFami TF314638.

    Enzyme and pathway databases

    Reactomei REACT_15408. Cam-PDE 1 activation.

    Miscellaneous databases

    ChiTaRSi PDE1C. human.
    GeneWikii PDE1C.
    GenomeRNAii 5137.
    NextBioi 19808.
    PROi Q14123.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14123.
    Bgeei Q14123.
    CleanExi HS_PDE1C.
    Genevestigatori Q14123.

    Family and domain databases

    Gene3Di 1.10.1300.10. 2 hits.
    InterProi IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    IPR013706. PDEase_N.
    [Graphical view ]
    Pfami PF00233. PDEase_I. 1 hit.
    PF08499. PDEase_I_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00471. HDc. 1 hit.
    [Graphical view ]
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases."
      Loughney K., Martins T.J., Harris E.A.S., Sadhu K., Hicks J.B., Sonnenburg W.K., Beavo J.A., Ferguson K.
      J. Biol. Chem. 271:796-806(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS PDE1C1 AND PDE1C2).
      Tissue: Heart.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS PDE1C2 AND 3).
      Tissue: Heart.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPDE1C_HUMAN
    AccessioniPrimary (citable) accession number: Q14123
    Secondary accession number(s): B3KPC6
    , E9PE92, Q14124, Q8NB10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3