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Protein

Vascular endothelial zinc finger 1

Gene

VEZF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri74 – 9623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri174 – 19623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri202 – 22423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25524C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30822C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: Ensembl
  • cellular defense response Source: ProtInc
  • endothelial cell development Source: Ensembl
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Vascular endothelial zinc finger 1
Alternative name(s):
Putative transcription factor DB1
Zinc finger protein 161
Gene namesi
Name:VEZF1
Synonyms:DB1, ZNF161
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:12949. VEZF1.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162408823.

Polymorphism and mutation databases

BioMutaiVEZF1.
DMDMi317373301.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Vascular endothelial zinc finger 1PRO_0000047435Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei362 – 3621N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ14119.
MaxQBiQ14119.
PaxDbiQ14119.
PRIDEiQ14119.

PTM databases

iPTMnetiQ14119.
PhosphoSiteiQ14119.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highest levels in skeletal muscle and kidney.1 Publication

Gene expression databases

BgeeiQ14119.
CleanExiHS_VEZF1.
ExpressionAtlasiQ14119. baseline and differential.
GenevisibleiQ14119. HS.

Organism-specific databases

HPAiHPA027520.
HPA048315.

Interactioni

Subunit structurei

Interacts with ARHGAP22.By similarity

Protein-protein interaction databases

BioGridi113509. 5 interactions.
STRINGi9606.ENSP00000462337.

Structurei

3D structure databases

ProteinModelPortaliQ14119.
SMRiQ14119. Positions 64-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati394 – 40071
Repeati445 – 45172
Repeati457 – 46373
Repeati479 – 48574

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni394 – 485924 X 7 AA repeats of P-[LV]-T-[IL]-T-[ST]-PAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi340 – 35415Poly-GlnAdd
BLAST

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri74 – 9623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri174 – 19623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri202 – 22423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25524C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri287 – 30822C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063522.
HOGENOMiHOG000294183.
HOVERGENiHBG058083.
InParanoidiQ14119.
OMAiIAMRPVD.
PhylomeDBiQ14119.
TreeFamiTF331686.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14119-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEANWTAFLF QAHEASHHQQ QAAQNSLLPL LSSAVEPPDQ KPLLPIPITQ
60 70 80 90 100
KPQGAPETLK DAIGIKKEKP KTSFVCTYCS KAFRDSYHLR RHESCHTGIK
110 120 130 140 150
LVSRPKKTPT TVVPLISTIA GDSSRTSLVS TIAGILSTVT TSSSGTNPSS
160 170 180 190 200
SASTTAMPVT QSVKKPSKPV KKNHACEMCG KAFRDVYHLN RHKLSHSDEK
210 220 230 240 250
PFECPICNQR FKRKDRMTYH VRSHEGGITK PYTCSVCGKG FSRPDHLSCH
260 270 280 290 300
VKHVHSTERP FKCQTCTAAF ATKDRLRTHM VRHEGKVSCN ICGKLLSAAY
310 320 330 340 350
ITSHLKTHGQ SQSINCNTCK QGISKTCMSE ETSNQKQQQQ QQQQQQQQQQ
360 370 380 390 400
QQQQHVTSWP GKQVETLRLW EEAVKARKKE AANLCQTSTA ATTPVTLTTP
410 420 430 440 450
FSITSSVSSG TMSNPVTVAA AMSMRSPVNV SSAVNITSPM NIGHPVTITS
460 470 480 490 500
PLSMTSPLTL TTPVNLPTPV TAPVNIAHPV TITSPMNLPT PMTLAAPLNI
510 520
AMRPVESMPF LPQALPTSPP W
Length:521
Mass (Da):56,931
Last modified:January 11, 2011 - v2
Checksum:iB16095D95094E385
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti350 – 3545Missing in BAA05663 (PubMed:8035792).Curated
Sequence conflicti410 – 4101G → E in BAA05663 (PubMed:8035792).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28118 mRNA. Translation: BAA05663.1.
AC015813 Genomic DNA. No translation available.
CCDSiCCDS32687.1.
PIRiA53772.
RefSeqiNP_009077.2. NM_007146.2.
UniGeneiHs.463569.

Genome annotation databases

EnsembliENST00000581208; ENSP00000462337; ENSG00000136451.
GeneIDi7716.
KEGGihsa:7716.
UCSCiuc002ivf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28118 mRNA. Translation: BAA05663.1.
AC015813 Genomic DNA. No translation available.
CCDSiCCDS32687.1.
PIRiA53772.
RefSeqiNP_009077.2. NM_007146.2.
UniGeneiHs.463569.

3D structure databases

ProteinModelPortaliQ14119.
SMRiQ14119. Positions 64-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113509. 5 interactions.
STRINGi9606.ENSP00000462337.

PTM databases

iPTMnetiQ14119.
PhosphoSiteiQ14119.

Polymorphism and mutation databases

BioMutaiVEZF1.
DMDMi317373301.

Proteomic databases

EPDiQ14119.
MaxQBiQ14119.
PaxDbiQ14119.
PRIDEiQ14119.

Protocols and materials databases

DNASUi7716.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000581208; ENSP00000462337; ENSG00000136451.
GeneIDi7716.
KEGGihsa:7716.
UCSCiuc002ivf.2. human.

Organism-specific databases

CTDi7716.
GeneCardsiVEZF1.
HGNCiHGNC:12949. VEZF1.
HPAiHPA027520.
HPA048315.
MIMi606747. gene.
neXtProtiNX_Q14119.
PharmGKBiPA162408823.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063522.
HOGENOMiHOG000294183.
HOVERGENiHBG058083.
InParanoidiQ14119.
OMAiIAMRPVD.
PhylomeDBiQ14119.
TreeFamiTF331686.

Miscellaneous databases

ChiTaRSiVEZF1. human.
GenomeRNAii7716.
NextBioi29906.
PROiQ14119.
SOURCEiSearch...

Gene expression databases

BgeeiQ14119.
CleanExiHS_VEZF1.
ExpressionAtlasiQ14119. baseline and differential.
GenevisibleiQ14119. HS.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter."
    Koyano-Nakagawa N., Nishida J., Baldwin D., Arai K., Yokota T.
    Mol. Cell. Biol. 14:5099-5107(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Lymphoma.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-362, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiVEZF1_HUMAN
AccessioniPrimary (citable) accession number: Q14119
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 11, 2011
Last modified: April 13, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.