Q14119 (VEZF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vascular endothelial zinc finger 1

Alternative name(s):
Putative transcription factor DB1
Zinc finger protein 161

Gene names

Name:	VEZF1
Synonyms:	DB1, ZNF161

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	521 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3. Ref.1
Subunit structure	Interacts with ARHGAP22 By similarity.
Subcellular location	Nucleus Ref.1.
Tissue specificity	Ubiquitously expressed. Highest levels in skeletal muscle and kidney. Ref.1
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 6 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular defense response Traceable author statement. Source: ProtInc regulation of transcription from RNA polymerase II promoter Traceable author statement. Source: ProtInc transcription from RNA polymerase II promoter Traceable author statement. Source: ProtInc
Cellular component	nucleus Inferred from direct assay. Source: HPA
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 521	521	Vascular endothelial zinc finger 1		PRO_0000047435
Regions
	Repeat	394 – 400	7	1
	Repeat	445 – 451	7	2
	Repeat	457 – 463	7	3
	Repeat	479 – 485	7	4
	Zinc finger	74 – 96	23	C2H2-type 1
	Zinc finger	174 – 196	23	C2H2-type 2
	Zinc finger	202 – 224	23	C2H2-type 3
	Zinc finger	232 – 255	24	C2H2-type 4
	Zinc finger	261 – 283	23	C2H2-type 5
	Zinc finger	287 – 308	22	C2H2-type 6
	Region	394 – 485	92	4 X 7 AA repeats of P-[LV]-T-[IL]-T-[ST]-P
	Compositional bias	340 – 354	15	Poly-Gln
Amino acid modifications
	Modified residue	362	1	N6-acetyllysine Ref.3
Experimental info
	Sequence conflict	350 – 354	5	Missing in BAA05663. Ref.1
	Sequence conflict	410	1	G → E in BAA05663. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q14119 [UniParc]. Last modified January 11, 2011. Version 2. Checksum: B16095D95094E385	FASTA	521	56,931
	10 20 30 40 50 60 MEANWTAFLF QAHEASHHQQ QAAQNSLLPL LSSAVEPPDQ KPLLPIPITQ KPQGAPETLK 70 80 90 100 110 120 DAIGIKKEKP KTSFVCTYCS KAFRDSYHLR RHESCHTGIK LVSRPKKTPT TVVPLISTIA 130 140 150 160 170 180 GDSSRTSLVS TIAGILSTVT TSSSGTNPSS SASTTAMPVT QSVKKPSKPV KKNHACEMCG 190 200 210 220 230 240 KAFRDVYHLN RHKLSHSDEK PFECPICNQR FKRKDRMTYH VRSHEGGITK PYTCSVCGKG 250 260 270 280 290 300 FSRPDHLSCH VKHVHSTERP FKCQTCTAAF ATKDRLRTHM VRHEGKVSCN ICGKLLSAAY 310 320 330 340 350 360 ITSHLKTHGQ SQSINCNTCK QGISKTCMSE ETSNQKQQQQ QQQQQQQQQQ QQQQHVTSWP 370 380 390 400 410 420 GKQVETLRLW EEAVKARKKE AANLCQTSTA ATTPVTLTTP FSITSSVSSG TMSNPVTVAA 430 440 450 460 470 480 AMSMRSPVNV SSAVNITSPM NIGHPVTITS PLSMTSPLTL TTPVNLPTPV TAPVNIAHPV 490 500 510 520 TITSPMNLPT PMTLAAPLNI AMRPVESMPF LPQALPTSPP W

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter." Koyano-Nakagawa N., Nishida J., Baldwin D., Arai K., Yokota T. Mol. Cell. Biol. 14:5099-5107(1994) [PubMed: 8035792] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Lymphoma.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-362, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D28118 mRNA. Translation: BAA05663.1. AC015813 Genomic DNA. No translation available.
IPI	IPI00028912.
PIR	A53772.
RefSeq	NP_009077.2. NM_007146.2.
UniGene	Hs.463569.
3D structure databases
ProteinModelPortal	Q14119.
SMR	Q14119. Positions 69-334.
ModBase	Search...
Protein-protein interaction databases
STRING	Q14119.
PTM databases
PhosphoSite	Q14119.
Polymorphism databases
DMDM	6137305.
Proteomic databases
PRIDE	Q14119.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000258963; ENSP00000258963; ENSG00000136451.
GeneID	7716.
KEGG	hsa:7716.
UCSC	uc002ivf.1. human.
Organism-specific databases
CTD	7716.
GeneCards	GC17M056048.
H-InvDB	HIX0202446.
HGNC	HGNC:12949. VEZF1.
HPA	HPA027520.
MIM	606747. gene.
neXtProt	NX_Q14119.
PharmGKB	PA162408823.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08984.
GeneTree	ENSGT00530000063522.
HOGENOM	HBG717200.
HOVERGEN	HBG058083.
InParanoid	Q14119.
OMA	KLVSRPK.
OrthoDB	EOG4MKNGC.
PhylomeDB	Q14119.
Gene expression databases
ArrayExpress	Q14119.
Bgee	Q14119.
CleanEx	HS_VEZF1.
Genevestigator	Q14119.
GermOnline	ENSG00000136451. Homo sapiens.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 5 hits.
Pfam	PF00096. zf-C2H2. 5 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 6 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 5 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	29906.
SOURCE	Search...

Entry information

Entry name

VEZF1_HUMAN

Accession

Primary (citable) accession number: Q14119

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	January 11, 2011
Last modified:	January 25, 2012
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.