Reviewed, UniProtKB/Swiss-Prot Q14119 (VEZF1_HUMAN)

Names and origin

Protein names

Recommended name:
Vascular endothelial zinc finger 1

Alternative name(s):
Zinc finger protein 161
Putative transcription factor DB1

Gene names

Name:	VEZF1
Synonyms:	DB1, ZNF161

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	516 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3. Ref.1
Subunit structure	Interacts with ARHGAP22 By similarity.
Subcellular location	Nucleus Ref.1.
Tissue specificity	Ubiquitously expressed. Highest levels in skeletal muscle and kidney. Ref.1
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 6 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
PTM	Acetylation
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular defense response Ref.1 Traceable author statement. Source: ProtInc cellular transcription Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription from RNA polymerase II promoter Ref.1 Traceable author statement. Source: ProtInc
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW specific RNA polymerase II transcription factor activity Ref.1 Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 516	516	Vascular endothelial zinc finger 1		PRO_0000047435
Regions
	Repeat	389 – 395	7	1
	Repeat	440 – 446	7	2
	Repeat	452 – 458	7	3
	Repeat	474 – 480	7	4
	Zinc finger	74 – 96	23	C2H2-type 1
	Zinc finger	174 – 196	23	C2H2-type 2
	Zinc finger	202 – 224	23	C2H2-type 3
	Zinc finger	232 – 255	24	C2H2-type 4
	Zinc finger	261 – 283	23	C2H2-type 5
	Zinc finger	287 – 308	22	C2H2-type 6
	Region	389 – 480	92	4 X 7 AA repeats of P-[LV]-T-[IL]-T-[ST]-P
	Compositional bias	335 – 349	15	Poly-Gln
Amino acid modifications
	Modified residue	357	1	N6-acetyllysine Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q14119-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 699A813C993C9677	FASTA	516	56,363
	10 20 30 40 50 60 MEANWTAFLF QAHEASHHQQ QAAQNSLLPL LSSAVEPPDQ KPLLPIPITQ KPQGAPETLK 70 80 90 100 110 120 DAIGIKKEKP KTSFVCTYCS KAFRDSYHLR RHESCHTGIK LVSRPKKTPT TVVPLISTIA 130 140 150 160 170 180 GDSSRTSLVS TIAGILSTVT TSSSGTNPSS SASTTAMPVT QSVKKPSKPV KKNHACEMCG 190 200 210 220 230 240 KAFRDVYHLN RHKLSHSDEK PFECPICNQR FKRKDRMTYH VRSHEGGITK PYTCSVCGKG 250 260 270 280 290 300 FSRPDHLSCH VKHVHSTERP FKCQTCTAAF ATKDRLRTHM VRHEGKVSCN ICGKLLSAAY 310 320 330 340 350 360 ITSHLKTHGQ SQSINCNTCK QGISKTCMSE ETSNQKQQQQ QQQQQQQQQH VTSWPGKQVE 370 380 390 400 410 420 TLRLWEEAVK ARKKEAANLC QTSTAATTPV TLTTPFSITS SVSSETMSNP VTVAAAMSMR 430 440 450 460 470 480 SPVNVSSAVN ITSPMNIGHP VTITSPLSMT SPLTLTTPVN LPTPVTAPVN IAHPVTITSP 490 500 510 MNLPTPMTLA APLNIAMRPV ESMPFLPQAL PTSPPW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter." Koyano-Nakagawa N., Nishida J., Baldwin D., Arai K., Yokota T. Mol. Cell. Biol. 14:5099-5107(1994) [PubMed: 8035792] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Lymphoma.
[2]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-357, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D28118 mRNA. Translation: BAA05663.1.
IPI	IPI00028912.
PIR	A53772.
RefSeq	NP_009077.2.
UniGene	Hs.463569
3D structure databases
SMR	Q14119. Positions 72-285, 172-288.
ModBase	Search...
Protein-protein interaction databases
STRING	Q14119.
PTM databases
PhosphoSite	Q14119.
Proteomic databases
PRIDE	Q14119.
Genome annotation databases
Ensembl	ENST00000258963; ENSP00000258963; ENSG00000136451; Homo sapiens. [Genome view]
GeneID	7716.
KEGG	hsa:7716.
UCSC	uc002ivf.1. human.
Organism-specific databases
CTD	7716.
GeneCards	GC17M053403.
H-InvDB	HIX0014022.
HGNC	HGNC:12949. VEZF1.
MIM	606747. gene.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG08984.
HOGENOM	HBG717200.
HOVERGEN	HBG058083.
InParanoid	Q14119.
Gene expression databases
ArrayExpress	Q14119.
Bgee	Q14119.
CleanEx	HS_VEZF1.
Genevestigator	Q14119.
GermOnline	ENSG00000136451. Homo sapiens.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.
SMART	SM00355. ZnF_C2H2. 6 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 5 hits. PS50157. ZINC_FINGER_C2H2_2. 5 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	29906.
SOURCE	Search...

Entry information

Entry name

VEZF1_HUMAN

Accession

Primary (citable) accession number: Q14119

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	March 2, 2010
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.