##gff-version 3
Q14116	UniProtKB	Propeptide	1	36	.	.	.	ID=PRO_0000015343;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9334240;Dbxref=PMID:9334240	
Q14116	UniProtKB	Chain	37	193	.	.	.	ID=PRO_0000015344;Note=Interleukin-18	
Q14116	UniProtKB	Site	36	37	.	.	.	Note=Cleavage%3B by CASP1%2C CASP4 and CASP5;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:25261253,ECO:0000269|PubMed:37993712,ECO:0000269|PubMed:37993714,ECO:0000269|PubMed:9334240;Dbxref=PMID:25261253,PMID:37993712,PMID:37993714,PMID:9334240	
Q14116	UniProtKB	Site	71	72	.	.	.	Note=Cleavage%3B by CASP3;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:37993714,ECO:0000269|PubMed:9334240;Dbxref=PMID:37993714,PMID:9334240	
Q14116	UniProtKB	Alternative sequence	27	30	.	.	.	ID=VSP_044934;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15326478;Dbxref=PMID:15326478	
Q14116	UniProtKB	Mutagenesis	12	12	.	.	.	Note=Strongly decreased processing by CASP4 or CASP5%3B when associated with A-28. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37993714;Dbxref=PMID:37993714	
Q14116	UniProtKB	Mutagenesis	28	28	.	.	.	Note=Strongly decreased processing by CASP4 or CASP5%3B when associated with A-12. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37993714;Dbxref=PMID:37993714	
Q14116	UniProtKB	Mutagenesis	33	35	.	.	.	Note=Abolished processing by CASP1%2C CASP4 or CASP5 and maturation. LES->AAA;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:37993712,ECO:0000269|PubMed:37993714;Dbxref=PMID:37993712,PMID:37993714	
Q14116	UniProtKB	Mutagenesis	36	36	.	.	.	Note=Abolished processing by CASP1 or CASP4 or CASP5 and maturation. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37993714;Dbxref=PMID:37993714	
Q14116	UniProtKB	Mutagenesis	37	38	.	.	.	Note=Does not strongly affect cleavage by CASP4. YF->AA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37993714;Dbxref=PMID:37993714	
Q14116	UniProtKB	Mutagenesis	38	38	.	.	.	Note=Abolished ability to bind the IL18R1 receptor without affecting its processing by CASP4. F->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37993714;Dbxref=PMID:37993714	
Q14116	UniProtKB	Mutagenesis	40	40	.	.	.	Note=Reduces binding to IL18R1 and the ability to induce IFNG production. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293	
Q14116	UniProtKB	Mutagenesis	41	41	.	.	.	Note=Impairs binding to IL18R1 and the ability to induce IFNG production. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293	
Q14116	UniProtKB	Mutagenesis	44	44	.	.	.	Note=Reduces binding to IL18R1 and the ability to induce IFNG production. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293	
Q14116	UniProtKB	Mutagenesis	47	48	.	.	.	Note=Decreased binding to CASP4. VI->NN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37993712;Dbxref=PMID:37993712	
Q14116	UniProtKB	Mutagenesis	49	49	.	.	.	Note=Reduces binding to IL18R1 and the ability to induce IFNG production. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293	
Q14116	UniProtKB	Mutagenesis	53	53	.	.	.	Note=Reduces binding to IL18R1 and the ability to induce IFNG production. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293	
Q14116	UniProtKB	Mutagenesis	69	69	.	.	.	Note=Impairs binding to IL18R1 and the ability to induce IFNG production. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293	
Q14116	UniProtKB	Mutagenesis	70	77	.	.	.	Note=Abolished ability to bind the IL18R1 receptor without affecting its processing by CASP4. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37993714;Dbxref=PMID:37993714	
Q14116	UniProtKB	Mutagenesis	71	71	.	.	.	Note=Impairs binding to IL18R1 and the ability to induce IFNG production. Abolished cleavage by CASP3. D->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14528293,ECO:0000269|PubMed:37993714;Dbxref=PMID:14528293,PMID:37993714	
Q14116	UniProtKB	Mutagenesis	94	94	.	.	.	Note=Impairs binding to IL18R1 and the ability to induce IFNG production. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293	
Q14116	UniProtKB	Mutagenesis	96	96	.	.	.	Note=Impairs binding to IL18R1 and the ability to induce IFNG production. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293	
Q14116	UniProtKB	Mutagenesis	115	115	.	.	.	Note=Reduces binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP resulting in impaired IFNG production. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293	
Q14116	UniProtKB	Mutagenesis	120	120	.	.	.	Note=Reduces binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP resulting in impaired IFNG production. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293	
Q14116	UniProtKB	Mutagenesis	134	134	.	.	.	Note=Reduces binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP resulting in impaired IFNG production. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293	
Q14116	UniProtKB	Mutagenesis	140	140	.	.	.	Note=Reduces binding to IL18R1 and the ability to induce IFNG production. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293	
Q14116	UniProtKB	Mutagenesis	144	144	.	.	.	Note=Abolishes binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP. G->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25500532;Dbxref=PMID:25500532	
Q14116	UniProtKB	Mutagenesis	145	145	.	.	.	Note=Abolishes binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25500532;Dbxref=PMID:25500532	
Q14116	UniProtKB	Mutagenesis	146	146	.	.	.	Note=Reduces binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25500532;Dbxref=PMID:25500532	
Q14116	UniProtKB	Mutagenesis	148	148	.	.	.	Note=Abolishes binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP. K->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25500532;Dbxref=PMID:25500532	
Q14116	UniProtKB	Mutagenesis	168	168	.	.	.	Note=Reduces binding to IL18R1 and the ability to induce IFNG production. D->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14528293;Dbxref=PMID:14528293	
Q14116	UniProtKB	Mutagenesis	183	183	.	.	.	Note=Reduces binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP. R->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25500532;Dbxref=PMID:25500532	
Q14116	UniProtKB	Mutagenesis	186	186	.	.	.	Note=Reduces binding of the preformed binary complex of IL18 and IL18R1 to IL18RAP. M->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25500532;Dbxref=PMID:25500532	
Q14116	UniProtKB	Mutagenesis	192	193	.	.	.	Note=Decreased binding to Casp4/Casp11. ED->KK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:37993712;Dbxref=PMID:37993712	
Q14116	UniProtKB	Sequence conflict	66	66	.	.	.	Note=F->L;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q14116	UniProtKB	Sequence conflict	86	86	.	.	.	Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q14116	UniProtKB	Sequence conflict	191	191	.	.	.	Note=N->S;Ontology_term=ECO:0000305;evidence=ECO:0000305	
Q14116	UniProtKB	Beta strand	42	49	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT	
Q14116	UniProtKB	Beta strand	55	58	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT	
Q14116	UniProtKB	Beta strand	64	67	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT	
Q14116	UniProtKB	Helix	71	76	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT	
Q14116	UniProtKB	Turn	77	81	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT	
Q14116	UniProtKB	Beta strand	83	91	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT	
Q14116	UniProtKB	Turn	92	94	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT	
Q14116	UniProtKB	Beta strand	95	111	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT	
Q14116	UniProtKB	Helix	113	115	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT	
Q14116	UniProtKB	Beta strand	118	121	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT	
Q14116	UniProtKB	Beta strand	126	131	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT	
Q14116	UniProtKB	Beta strand	137	142	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT	
Q14116	UniProtKB	Beta strand	145	156	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT	
Q14116	UniProtKB	Beta strand	159	166	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT	
Q14116	UniProtKB	Beta strand	169	176	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT	
Q14116	UniProtKB	Turn	178	180	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4HJJ	
Q14116	UniProtKB	Helix	183	185	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT	
Q14116	UniProtKB	Beta strand	187	191	.	.	.	Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2VXT