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Protein

Interleukin-18

Gene

IL18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

GO - Biological processi

  • activation of protein kinase B activity Source: BHF-UCL
  • angiogenesis Source: UniProtKB
  • cell-cell signaling Source: ProtInc
  • cellular response to organic cyclic compound Source: UniProtKB
  • chemokine biosynthetic process Source: UniProtKB
  • cholesterol homeostasis Source: BHF-UCL
  • granulocyte macrophage colony-stimulating factor biosynthetic process Source: UniProtKB
  • immune response Source: ProtInc
  • inflammatory response Source: UniProtKB
  • interferon-gamma biosynthetic process Source: UniProtKB
  • interleukin-13 biosynthetic process Source: UniProtKB
  • interleukin-18-mediated signaling pathway Source: BHF-UCL
  • interleukin-2 biosynthetic process Source: UniProtKB
  • lipopolysaccharide-mediated signaling pathway Source: UniProtKB
  • MAPK cascade Source: UniProtKB
  • natural killer cell activation Source: Ensembl
  • negative regulation of myoblast differentiation Source: Ensembl
  • positive regulation of activated T cell proliferation Source: UniProtKB
  • positive regulation of granulocyte macrophage colony-stimulating factor production Source: BHF-UCL
  • positive regulation of inflammatory response Source: BHF-UCL
  • positive regulation of interferon-gamma production Source: BHF-UCL
  • positive regulation of interleukin-17 production Source: BHF-UCL
  • positive regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  • positive regulation of natural killer cell proliferation Source: BHF-UCL
  • positive regulation of NF-kappaB import into nucleus Source: Ensembl
  • positive regulation of NK T cell proliferation Source: BHF-UCL
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
  • positive regulation of protein kinase B signaling Source: BHF-UCL
  • positive regulation of smooth muscle cell proliferation Source: BHF-UCL
  • positive regulation of T-helper 2 cell differentiation Source: BHF-UCL
  • positive regulation of tissue remodeling Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: CACAO
  • regulation of cell adhesion Source: UniProtKB
  • sleep Source: UniProtKB
  • T-helper 1 type immune response Source: UniProtKB
  • triglyceride homeostasis Source: BHF-UCL
  • type 2 immune response Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150782-MONOMER.
ReactomeiR-HSA-448706. Interleukin-1 processing.
R-HSA-449147. Signaling by Interleukins.
SIGNORiQ14116.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18
Short name:
IL-18
Alternative name(s):
Iboctadekin
Interferon gamma-inducing factor
Short name:
IFN-gamma-inducing factor
Interleukin-1 gamma
Short name:
IL-1 gamma
Gene namesi
Name:IL18
Synonyms:IGIF, IL1F4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:5986. IL18.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3606.
OpenTargetsiENSG00000150782.
PharmGKBiPA29802.

Polymorphism and mutation databases

BioMutaiIL18.
DMDMi3219817.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000153431 – 36By similarityAdd BLAST36
ChainiPRO_000001534437 – 193Interleukin-18Add BLAST157

Post-translational modificationi

The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.1 Publication

Proteomic databases

EPDiQ14116.
MaxQBiQ14116.
PaxDbiQ14116.
PeptideAtlasiQ14116.
PRIDEiQ14116.

2D gel databases

OGPiQ14116.

PTM databases

iPTMnetiQ14116.
PhosphoSitePlusiQ14116.

Miscellaneous databases

PMAP-CutDBQ14116.

Expressioni

Gene expression databases

BgeeiENSG00000150782.
CleanExiHS_IL18.
ExpressionAtlasiQ14116. baseline and differential.
GenevisibleiQ14116. HS.

Organism-specific databases

HPAiCAB007772.
CAB027385.
HPA003980.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IL18R1Q134782EBI-3910835,EBI-9817499

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

Protein-protein interaction databases

BioGridi109819. 11 interactors.
DIPiDIP-3785N.
IntActiQ14116. 3 interactors.
STRINGi9606.ENSP00000280357.

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi42 – 49Combined sources8
Beta strandi55 – 58Combined sources4
Beta strandi64 – 67Combined sources4
Helixi71 – 76Combined sources6
Turni77 – 81Combined sources5
Beta strandi83 – 91Combined sources9
Turni92 – 94Combined sources3
Beta strandi95 – 111Combined sources17
Helixi113 – 115Combined sources3
Beta strandi118 – 121Combined sources4
Beta strandi126 – 131Combined sources6
Beta strandi137 – 142Combined sources6
Beta strandi145 – 156Combined sources12
Beta strandi159 – 166Combined sources8
Beta strandi169 – 176Combined sources8
Turni178 – 180Combined sources3
Helixi183 – 185Combined sources3
Beta strandi187 – 191Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J0SNMR-A37-193[»]
2VXTX-ray1.49I37-193[»]
3F62X-ray2.00B37-193[»]
3WO2X-ray2.33A/B/C/D37-193[»]
3WO3X-ray3.10A/C/E/G/I/K37-193[»]
3WO4X-ray3.10A37-193[»]
4EEEX-ray2.71B/D37-193[»]
4EKXX-ray1.75B/D37-193[»]
4HJJX-ray2.10A37-192[»]
4R6UX-ray2.80B/D37-193[»]
4XFSX-ray1.91A/B37-193[»]
4XFTX-ray2.00A/B37-193[»]
4XFUX-ray2.85A/B37-193[»]
ProteinModelPortaliQ14116.
SMRiQ14116.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14116.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410J3U9. Eukaryota.
ENOG410ZGS8. LUCA.
GeneTreeiENSGT00390000001053.
HOGENOMiHOG000048723.
HOVERGENiHBG000388.
InParanoidiQ14116.
KOiK05482.
OMAiVPGHDDK.
OrthoDBiEOG091G0NGF.
PhylomeDBiQ14116.
TreeFamiTF336297.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR015529. IL-18.
IPR000975. IL-1_fam.
[Graphical view]
PANTHERiPTHR11326. PTHR11326. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PIRSFiPIRSF015162. Interleukin_18. 1 hit.
PRINTSiPR01933. INTRLEUKIN18.
SUPFAMiSSF50353. SSF50353. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14116-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAEPVEDNC INFVAMKFID NTLYFIAEDD ENLESDYFGK LESKLSVIRN
60 70 80 90 100
LNDQVLFIDQ GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI
110 120 130 140 150
SVKCEKISTL SCENKIISFK EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ
160 170 180 190
FESSSYEGYF LACEKERDLF KLILKKEDEL GDRSIMFTVQ NED
Length:193
Mass (Da):22,326
Last modified:November 1, 1996 - v1
Checksum:i323C62C203788D55
GO
Isoform 2 (identifier: Q14116-2) [UniParc]FASTAAdd to basket
Also known as: Delta3pro-IL-18

The sequence of this isoform differs from the canonical sequence as follows:
     27-30: Missing.

Note: Expressed in ovarian carcinoma but undetectable in normal ovarian epithelial cells. Resistant to proteolytic activation by caspase-1 and -4.
Show »
Length:189
Mass (Da):21,896
Checksum:iA8BA275CF713A4B6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66F → L in AAC27787 (Ref. 3) Curated1
Sequence conflicti86S → R in AAC27787 (Ref. 3) Curated1
Sequence conflicti191N → S in AAC27787 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04493427 – 30Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49950 mRNA. Translation: BAA08706.1.
AY266351 mRNA. Translation: AAP92112.1.
AF077611 mRNA. Translation: AAC27787.1.
AY044641 mRNA. Translation: AAK95950.1.
CR541973 mRNA. Translation: CAG46771.1.
CR542001 mRNA. Translation: CAG46798.1.
AP002007 Genomic DNA. No translation available.
AP002884 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67184.1.
BC007007 mRNA. Translation: AAH07007.1.
BC007461 mRNA. Translation: AAH07461.1.
U90434 mRNA. Translation: AAB50010.1.
CCDSiCCDS44731.1. [Q14116-1]
CCDS58180.1. [Q14116-2]
RefSeqiNP_001230140.1. NM_001243211.1. [Q14116-2]
NP_001553.1. NM_001562.3. [Q14116-1]
XP_011541107.1. XM_011542805.1. [Q14116-2]
XP_011541108.1. XM_011542806.2. [Q14116-1]
UniGeneiHs.83077.

Genome annotation databases

EnsembliENST00000280357; ENSP00000280357; ENSG00000150782. [Q14116-1]
ENST00000524595; ENSP00000434561; ENSG00000150782. [Q14116-2]
ENST00000528832; ENSP00000434161; ENSG00000150782. [Q14116-1]
GeneIDi3606.
KEGGihsa:3606.
UCSCiuc001pnb.2. human. [Q14116-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49950 mRNA. Translation: BAA08706.1.
AY266351 mRNA. Translation: AAP92112.1.
AF077611 mRNA. Translation: AAC27787.1.
AY044641 mRNA. Translation: AAK95950.1.
CR541973 mRNA. Translation: CAG46771.1.
CR542001 mRNA. Translation: CAG46798.1.
AP002007 Genomic DNA. No translation available.
AP002884 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67184.1.
BC007007 mRNA. Translation: AAH07007.1.
BC007461 mRNA. Translation: AAH07461.1.
U90434 mRNA. Translation: AAB50010.1.
CCDSiCCDS44731.1. [Q14116-1]
CCDS58180.1. [Q14116-2]
RefSeqiNP_001230140.1. NM_001243211.1. [Q14116-2]
NP_001553.1. NM_001562.3. [Q14116-1]
XP_011541107.1. XM_011542805.1. [Q14116-2]
XP_011541108.1. XM_011542806.2. [Q14116-1]
UniGeneiHs.83077.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J0SNMR-A37-193[»]
2VXTX-ray1.49I37-193[»]
3F62X-ray2.00B37-193[»]
3WO2X-ray2.33A/B/C/D37-193[»]
3WO3X-ray3.10A/C/E/G/I/K37-193[»]
3WO4X-ray3.10A37-193[»]
4EEEX-ray2.71B/D37-193[»]
4EKXX-ray1.75B/D37-193[»]
4HJJX-ray2.10A37-192[»]
4R6UX-ray2.80B/D37-193[»]
4XFSX-ray1.91A/B37-193[»]
4XFTX-ray2.00A/B37-193[»]
4XFUX-ray2.85A/B37-193[»]
ProteinModelPortaliQ14116.
SMRiQ14116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109819. 11 interactors.
DIPiDIP-3785N.
IntActiQ14116. 3 interactors.
STRINGi9606.ENSP00000280357.

PTM databases

iPTMnetiQ14116.
PhosphoSitePlusiQ14116.

Polymorphism and mutation databases

BioMutaiIL18.
DMDMi3219817.

2D gel databases

OGPiQ14116.

Proteomic databases

EPDiQ14116.
MaxQBiQ14116.
PaxDbiQ14116.
PeptideAtlasiQ14116.
PRIDEiQ14116.

Protocols and materials databases

DNASUi3606.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280357; ENSP00000280357; ENSG00000150782. [Q14116-1]
ENST00000524595; ENSP00000434561; ENSG00000150782. [Q14116-2]
ENST00000528832; ENSP00000434161; ENSG00000150782. [Q14116-1]
GeneIDi3606.
KEGGihsa:3606.
UCSCiuc001pnb.2. human. [Q14116-1]

Organism-specific databases

CTDi3606.
DisGeNETi3606.
GeneCardsiIL18.
HGNCiHGNC:5986. IL18.
HPAiCAB007772.
CAB027385.
HPA003980.
MIMi600953. gene.
neXtProtiNX_Q14116.
OpenTargetsiENSG00000150782.
PharmGKBiPA29802.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3U9. Eukaryota.
ENOG410ZGS8. LUCA.
GeneTreeiENSGT00390000001053.
HOGENOMiHOG000048723.
HOVERGENiHBG000388.
InParanoidiQ14116.
KOiK05482.
OMAiVPGHDDK.
OrthoDBiEOG091G0NGF.
PhylomeDBiQ14116.
TreeFamiTF336297.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000150782-MONOMER.
ReactomeiR-HSA-448706. Interleukin-1 processing.
R-HSA-449147. Signaling by Interleukins.
SIGNORiQ14116.

Miscellaneous databases

EvolutionaryTraceiQ14116.
GeneWikiiInterleukin_18.
GenomeRNAii3606.
PMAP-CutDBQ14116.
PROiQ14116.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150782.
CleanExiHS_IL18.
ExpressionAtlasiQ14116. baseline and differential.
GenevisibleiQ14116. HS.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR015529. IL-18.
IPR000975. IL-1_fam.
[Graphical view]
PANTHERiPTHR11326. PTHR11326. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PIRSFiPIRSF015162. Interleukin_18. 1 hit.
PRINTSiPR01933. INTRLEUKIN18.
SUPFAMiSSF50353. SSF50353. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIL18_HUMAN
AccessioniPrimary (citable) accession number: Q14116
Secondary accession number(s): O75599, Q6FGY3, Q6WWJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.