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Q14116 (IL18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-18

Short name=IL-18
Alternative name(s):
Iboctadekin
Interferon gamma-inducing factor
Short name=IFN-gamma-inducing factor
Interleukin-1 gamma
Short name=IL-1 gamma
Gene names
Name:IL18
Synonyms:IGIF, IL1F4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

Subcellular location

Secreted.

Post-translational modification

The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.

Sequence similarities

Belongs to the IL-1 family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   Molecular functionCytokine
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from mutant phenotype PubMed 21147091. Source: UniProtKB

T-helper 1 type immune response

Inferred from direct assay PubMed 8766574. Source: UniProtKB

angiogenesis

Inferred from direct assay PubMed 11466388. Source: UniProtKB

cell-cell signaling

Traceable author statement PubMed 9792649. Source: ProtInc

cellular response to organic cyclic compound

Inferred from direct assay PubMed 21147091. Source: UniProtKB

chemokine biosynthetic process

Traceable author statement PubMed 11598150. Source: UniProtKB

granulocyte macrophage colony-stimulating factor biosynthetic process

Traceable author statement PubMed 10653850. Source: UniProtKB

inflammatory response

Inferred from direct assay PubMed 21147091. Source: UniProtKB

interferon-gamma biosynthetic process

Traceable author statement PubMed 10227975. Source: UniProtKB

interleukin-13 biosynthetic process

Traceable author statement PubMed 10227975. Source: UniProtKB

interleukin-2 biosynthetic process

Traceable author statement PubMed 10653850. Source: UniProtKB

lipopolysaccharide-mediated signaling pathway

Inferred from direct assay PubMed 21147091. Source: UniProtKB

natural killer cell activation

Inferred from electronic annotation. Source: Ensembl

positive regulation of NF-kappaB import into nucleus

Inferred from electronic annotation. Source: Ensembl

positive regulation of NK T cell proliferation

Inferred from direct assay PubMed 19088061. Source: BHF-UCL

positive regulation of activated T cell proliferation

Inferred from direct assay PubMed 10000000PubMed 8766574. Source: UniProtKB

positive regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

positive regulation of granulocyte macrophage colony-stimulating factor production

Inferred from direct assay PubMed 20027291. Source: BHF-UCL

positive regulation of inflammatory response

Inferred by curator PubMed 16482511. Source: BHF-UCL

positive regulation of interferon-gamma production

Inferred from direct assay PubMed 19088061PubMed 20027291. Source: BHF-UCL

positive regulation of interleukin-17 production

Inferred from direct assay PubMed 16482511. Source: BHF-UCL

positive regulation of natural killer cell proliferation

Inferred from direct assay PubMed 19088061. Source: BHF-UCL

positive regulation of tissue remodeling

Inferred by curator PubMed 16482511. Source: BHF-UCL

regulation of cell adhesion

Inferred from direct assay PubMed 11477102. Source: UniProtKB

sleep

Inferred from sequence or structural similarity PubMed 11506998. Source: UniProtKB

type 2 immune response

Traceable author statement PubMed 11905033. Source: UniProtKB

   Cellular_componentcytosol

Traceable author statement. Source: Reactome

extracellular region

Traceable author statement PubMed 11598150. Source: UniProtKB

extracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncytokine activity

Traceable author statement PubMed 11598150. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q14116-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q14116-2)

Also known as: Delta3pro-IL-18;

The sequence of this isoform differs from the canonical sequence as follows:
     27-30: Missing.
Note: Expressed in ovarian carcinoma but undetectable in normal ovarian epithelial cells. Resistant to proteolytic activation by caspase-1 and -4.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 3636 By similarity
PRO_0000015343
Chain37 – 193157Interleukin-18
PRO_0000015344

Natural variations

Alternative sequence27 – 304Missing in isoform 2.
VSP_044934

Experimental info

Sequence conflict661F → L in AAC27787. Ref.3
Sequence conflict861S → R in AAC27787. Ref.3
Sequence conflict1911N → S in AAC27787. Ref.3

Secondary structure

.................................. 193
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 323C62C203788D55

FASTA19322,326
        10         20         30         40         50         60 
MAAEPVEDNC INFVAMKFID NTLYFIAEDD ENLESDYFGK LESKLSVIRN LNDQVLFIDQ 

        70         80         90        100        110        120 
GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI SVKCEKISTL SCENKIISFK 

       130        140        150        160        170        180 
EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLF KLILKKEDEL 

       190 
GDRSIMFTVQ NED 

« Hide

Isoform 2 (Delta3pro-IL-18) [UniParc].

Checksum: A8BA275CF713A4B6
Show »

FASTA18921,896

References

« Hide 'large scale' references
[1]"Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein."
Ushio S., Namba M., Okura T., Hattori K., Nukada Y., Akita K., Tanabe F., Konishi K., Micallef M., Fujii M., Torigoe K., Tanimoto T., Fukuda S., Ikeda M., Okamura H., Kurimoto M.
J. Immunol. 156:4274-4279(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Liver.
[2]"A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing."
Gaggero A., De Ambrosis A., Mezzanzanica D., Piazza T., Rubartelli A., Figini M., Canevari S., Ferrini S.
Oncogene 23:7552-7560(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PROTEOLYTIC PROCESSING, ALTERNATIVE SPLICING.
[3]"Cloning and sequencing of the cDNA for precursor hIL-18."
Yong D., Guixin D., Lihua H., Haitao W.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"Cloning of human interleukin 18 cDNA."
Liu J., Peng X., Yuan J., Qiang B.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Urinary bladder.
[9]Conti B., Kim S.J., Tinti C., Chun H.S., Joh T.H.
Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-193 (ISOFORM 1).
Tissue: Peripheral blood.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-1 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D49950 mRNA. Translation: BAA08706.1.
AY266351 mRNA. Translation: AAP92112.1.
AF077611 mRNA. Translation: AAC27787.1.
AY044641 mRNA. Translation: AAK95950.1.
CR541973 mRNA. Translation: CAG46771.1.
CR542001 mRNA. Translation: CAG46798.1.
AP002007 Genomic DNA. No translation available.
AP002884 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67184.1.
BC007007 mRNA. Translation: AAH07007.1.
BC007461 mRNA. Translation: AAH07461.1.
U90434 mRNA. Translation: AAB50010.1.
RefSeqNP_001230140.1. NM_001243211.1.
NP_001553.1. NM_001562.3.
UniGeneHs.83077.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1J0SNMR-A37-193[»]
2VXTX-ray1.49I37-193[»]
3F62X-ray2.00B37-193[»]
4EEEX-ray2.71B/D37-193[»]
4EKXX-ray1.75B/D37-193[»]
4HJJX-ray2.10A37-192[»]
ProteinModelPortalQ14116.
SMRQ14116. Positions 37-193.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109819. 5 interactions.
DIPDIP-3785N.
IntActQ14116. 1 interaction.
STRING9606.ENSP00000280357.

PTM databases

PhosphoSiteQ14116.

Polymorphism databases

DMDM3219817.

2D gel databases

OGPQ14116.

Proteomic databases

PaxDbQ14116.
PRIDEQ14116.

Protocols and materials databases

DNASU3606.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000280357; ENSP00000280357; ENSG00000150782. [Q14116-1]
ENST00000524595; ENSP00000434561; ENSG00000150782. [Q14116-2]
ENST00000528832; ENSP00000434161; ENSG00000150782. [Q14116-1]
GeneID3606.
KEGGhsa:3606.
UCSCuc001pna.2. human. [Q14116-1]
uc009yym.2. human.

Organism-specific databases

CTD3606.
GeneCardsGC11M112013.
HGNCHGNC:5986. IL18.
HPACAB007772.
CAB027385.
HPA003980.
MIM600953. gene.
neXtProtNX_Q14116.
PharmGKBPA29802.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG77229.
HOGENOMHOG000048723.
HOVERGENHBG000388.
InParanoidQ14116.
KOK05482.
OMAVPGHDDK.
OrthoDBEOG7SR4NN.
TreeFamTF336297.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressQ14116.
BgeeQ14116.
CleanExHS_IL18.
GenevestigatorQ14116.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR000975. IL-1.
IPR015529. IL-18.
[Graphical view]
PANTHERPTHR11326. PTHR11326. 1 hit.
PfamPF00340. IL1. 1 hit.
[Graphical view]
PIRSFPIRSF015162. Interleukin_18. 1 hit.
PRINTSPR01933. INTRLEUKIN18.
SMARTSM00125. IL1. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ14116.
GeneWikiInterleukin_18.
GenomeRNAi3606.
NextBio14093.
PMAP-CutDBQ14116.
PROQ14116.
SOURCESearch...

Entry information

Entry nameIL18_HUMAN
AccessionPrimary (citable) accession number: Q14116
Secondary accession number(s): O75599, Q6FGY3, Q6WWJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM