Q14116 (IL18_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-18
Short name=IL-18

Alternative name(s):
Iboctadekin
Interferon gamma-inducing factor
Short name=IFN-gamma-inducing factor
Interleukin-1 gamma
Short name=IL-1 gamma

Gene names

Name:	IL18
Synonyms:	IGIF, IL1F4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
Subcellular location	Secreted.
Sequence similarities	Belongs to the IL-1 family.

Ontologies

Keywords
Cellular component	Secreted
Molecular function	Cytokine
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	T-helper 1 type immune response Inferred from direct assay. Source: UniProtKB angiogenesis Inferred from direct assay. Source: UniProtKB cell-cell signaling Traceable author statement. Source: ProtInc chemokine biosynthetic process Traceable author statement. Source: UniProtKB granulocyte macrophage colony-stimulating factor biosynthetic process Traceable author statement. Source: UniProtKB interferon-gamma biosynthetic process Traceable author statement. Source: UniProtKB interleukin-13 biosynthetic process Traceable author statement. Source: UniProtKB interleukin-2 biosynthetic process Traceable author statement. Source: UniProtKB positive regulation of NK T cell proliferation Inferred from direct assay. Source: BHF-UCL positive regulation of activated T cell proliferation Inferred from direct assay. Source: UniProtKB positive regulation of granulocyte macrophage colony-stimulating factor production Inferred from direct assay. Source: BHF-UCL positive regulation of inflammatory response Inferred by curator. Source: BHF-UCL positive regulation of interferon-gamma production Inferred from direct assay. Source: BHF-UCL positive regulation of interleukin-17 production Inferred from direct assay. Source: BHF-UCL positive regulation of natural killer cell proliferation Inferred from direct assay. Source: BHF-UCL positive regulation of tissue remodeling Inferred by curator. Source: BHF-UCL regulation of cell adhesion Inferred from direct assay. Source: UniProtKB sleep Inferred from sequence or structural similarity. Source: UniProtKB type 2 immune response Traceable author statement. Source: UniProtKB
Cellular component	cytosol Traceable author statement. Source: Reactome extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Propeptide

1 – 36

36

By similarity

PRO_0000015343

Chain

37 – 193

157

Interleukin-18

PRO_0000015344

Experimental info

Sequence conflict

66

1

F → L in AAC27787. Ref.2

Sequence conflict

86

1

S → R in AAC27787. Ref.2

Sequence conflict

191

1

N → S in AAC27787. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

193

Helix Strand Turn

Details...

Beta strand

40 – 49

10

Beta strand

55 – 58

4

Beta strand

64 – 67

4

Turn

74 – 77

4

Beta strand

84 – 88

5

Beta strand

96 – 98

3

Beta strand

100 – 102

3

Beta strand

104 – 106

3

Beta strand

108 – 112

5

Beta strand

114 – 120

7

Beta strand

129 – 132

4

Beta strand

137 – 141

5

Beta strand

145 – 147

3

Beta strand

149 – 155

7

Beta strand

160 – 166

7

Beta strand

169 – 175

7

Helix

183 – 185

3

Beta strand

187 – 191

5

Sequences

	Sequence		Length	Mass (Da)
	Q14116 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 323C62C203788D55	FASTA	193	22,326
	10 20 30 40 50 60 MAAEPVEDNC INFVAMKFID NTLYFIAEDD ENLESDYFGK LESKLSVIRN LNDQVLFIDQ 70 80 90 100 110 120 GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI SVKCEKISTL SCENKIISFK 130 140 150 160 170 180 EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ FESSSYEGYF LACEKERDLF KLILKKEDEL 190 GDRSIMFTVQ NED

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein." Ushio S., Namba M., Okura T., Hattori K., Nukada Y., Akita K., Tanabe F., Konishi K., Micallef M., Fujii M., Torigoe K., Tanimoto T., Fukuda S., Ikeda M., Okamura H., Kurimoto M. J. Immunol. 156:4274-4279(1996) [PubMed: 8666798] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Cloning and sequencing of the cDNA for precursor hIL-18." Yong D., Guixin D., Lihua H., Haitao W. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning of human interleukin 18 cDNA." Liu J., Peng X., Yuan J., Qiang B. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Urinary bladder.
[6]	Conti B., Kim S.J., Tinti C., Chun H.S., Joh T.H. Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-193. Tissue: Peripheral blood.
+	Additional computationally mapped references.

Web resources

Wikipedia

Interleukin-1 entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D49950 mRNA. Translation: BAA08706.1.
AF077611 mRNA. Translation: AAC27787.1.
AY044641 mRNA. Translation: AAK95950.1.
CR541973 mRNA. Translation: CAG46771.1.
CR542001 mRNA. Translation: CAG46798.1.
BC007007 mRNA. Translation: AAH07007.1.
BC007461 mRNA. Translation: AAH07461.1.
U90434 mRNA. Translation: AAB50010.1.

IPI

IPI00290198.

RefSeq

NP_001230140.1. NM_001243211.1.
NP_001553.1. NM_001562.3.

UniGene

Hs.83077.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1J0S	NMR	-	A	37-193	[»]
2VXT	X-ray	1.49	I	37-193	[»]
3F62	X-ray	2.00	B	37-193	[»]

ProteinModelPortal

Q14116.

SMR

Q14116. Positions 37-193.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-3785N.

IntAct

Q14116. 1 interaction.

STRING

Q14116.

PTM databases

PhosphoSite

Q14116.

Polymorphism databases

DMDM

3219817.

2D gel databases

OGP

Q14116.

Proteomic databases

PRIDE

Q14116.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000280357; ENSP00000280357; ENSG00000150782.

GeneID

3606.

KEGG

hsa:3606.

UCSC

uc001pnb.1. human.

Organism-specific databases

CTD

3606.

GeneCards

GC11M112013.

H-InvDB

HIX0010123.

HGNC

HGNC:5986. IL18.

HPA

CAB007772.
CAB027385.
HPA003980.

MIM

600953. gene.

neXtProt

NX_Q14116.

PharmGKB

PA29802.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG19678.

HOGENOM

HBG283751.

HOVERGEN

HBG000388.

InParanoid

Q14116.

OMA

IFFQRSV.

OrthoDB

EOG4B8JFJ.

Enzyme and pathway databases

Pathway_Interaction_DB

anthraxpathway. Cellular roles of Anthrax toxin.
il12_stat4pathway. IL12 signaling mediated by STAT4.
il12_2pathway. IL12-mediated signaling events.
il23pathway. IL23-mediated signaling events.
il27pathway. IL27-mediated signaling events.

Reactome

REACT_6900. Immune System.

Gene expression databases

ArrayExpress

Q14116.

Bgee

Q14116.

CleanEx

HS_IL18.

Genevestigator

Q14116.

GermOnline

ENSG00000150782. Homo sapiens.

Family and domain databases

InterPro

IPR008996. Cytokine_IL1-like.
IPR000975. Interleukin_1.
IPR015529. Interleukin_18.
[Graphical view]

KO

K05482.

PANTHER

PTHR11326. Interleukin_18. 1 hit.

Pfam

PF00340. IL1. 1 hit.
[Graphical view]

PIRSF

PIRSF015162. Interleukin_18. 1 hit.

PRINTS

PR01933. INTRLEUKIN18.

SMART

SM00125. IL1. 1 hit.
[Graphical view]

SUPFAM

SSF50353. Cytok_IL1_like. 1 hit.

ProtoNet

Search...

Other

NextBio

14093.

PMAP-CutDB

Q14116.

SOURCE

Search...

Entry information

Entry name

IL18_HUMAN

Accession

Primary (citable) accession number: Q14116
Secondary accession number(s): O75599, Q6FGY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.