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Q14116

- IL18_HUMAN

UniProt

Q14116 - IL18_HUMAN

Protein

Interleukin-18

Gene

IL18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

    GO - Molecular functioni

    1. cytokine activity Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: UniProtKB
    2. cell-cell signaling Source: ProtInc
    3. cellular response to organic cyclic compound Source: UniProtKB
    4. chemokine biosynthetic process Source: UniProtKB
    5. granulocyte macrophage colony-stimulating factor biosynthetic process Source: UniProtKB
    6. immune response Source: ProtInc
    7. inflammatory response Source: UniProtKB
    8. interferon-gamma biosynthetic process Source: UniProtKB
    9. interleukin-13 biosynthetic process Source: UniProtKB
    10. interleukin-2 biosynthetic process Source: UniProtKB
    11. lipopolysaccharide-mediated signaling pathway Source: UniProtKB
    12. MAPK cascade Source: UniProtKB
    13. natural killer cell activation Source: Ensembl
    14. positive regulation of activated T cell proliferation Source: UniProtKB
    15. positive regulation of gene expression Source: Ensembl
    16. positive regulation of granulocyte macrophage colony-stimulating factor production Source: BHF-UCL
    17. positive regulation of inflammatory response Source: BHF-UCL
    18. positive regulation of interferon-gamma production Source: BHF-UCL
    19. positive regulation of interleukin-17 production Source: BHF-UCL
    20. positive regulation of natural killer cell proliferation Source: BHF-UCL
    21. positive regulation of NF-kappaB import into nucleus Source: Ensembl
    22. positive regulation of NK T cell proliferation Source: BHF-UCL
    23. positive regulation of tissue remodeling Source: BHF-UCL
    24. regulation of cell adhesion Source: UniProtKB
    25. sleep Source: UniProtKB
    26. T-helper 1 type immune response Source: UniProtKB
    27. type 2 immune response Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine

    Enzyme and pathway databases

    ReactomeiREACT_23950. Interleukin-1 processing.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-18
    Short name:
    IL-18
    Alternative name(s):
    Iboctadekin
    Interferon gamma-inducing factor
    Short name:
    IFN-gamma-inducing factor
    Interleukin-1 gamma
    Short name:
    IL-1 gamma
    Gene namesi
    Name:IL18
    Synonyms:IGIF, IL1F4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:5986. IL18.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. extracellular region Source: UniProtKB
    3. extracellular space Source: UniProtKB-KW
    4. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29802.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 3636By similarityPRO_0000015343Add
    BLAST
    Chaini37 – 193157Interleukin-18PRO_0000015344Add
    BLAST

    Post-translational modificationi

    The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.1 Publication

    Proteomic databases

    MaxQBiQ14116.
    PaxDbiQ14116.
    PRIDEiQ14116.

    2D gel databases

    OGPiQ14116.

    PTM databases

    PhosphoSiteiQ14116.

    Miscellaneous databases

    PMAP-CutDBQ14116.

    Expressioni

    Gene expression databases

    ArrayExpressiQ14116.
    BgeeiQ14116.
    CleanExiHS_IL18.
    GenevestigatoriQ14116.

    Organism-specific databases

    HPAiCAB007772.
    CAB027385.
    HPA003980.

    Interactioni

    Protein-protein interaction databases

    BioGridi109819. 5 interactions.
    DIPiDIP-3785N.
    IntActiQ14116. 1 interaction.
    STRINGi9606.ENSP00000280357.

    Structurei

    Secondary structure

    1
    193
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi42 – 498
    Beta strandi55 – 584
    Beta strandi64 – 674
    Helixi71 – 766
    Turni77 – 815
    Beta strandi83 – 919
    Turni92 – 943
    Beta strandi95 – 11117
    Helixi113 – 1153
    Beta strandi118 – 1214
    Beta strandi126 – 1316
    Beta strandi137 – 1426
    Beta strandi145 – 15612
    Beta strandi159 – 1668
    Beta strandi169 – 1768
    Turni178 – 1803
    Helixi183 – 1853
    Beta strandi187 – 1915

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1J0SNMR-A37-193[»]
    2VXTX-ray1.49I37-193[»]
    3F62X-ray2.00B37-193[»]
    4EEEX-ray2.71B/D37-193[»]
    4EKXX-ray1.75B/D37-193[»]
    4HJJX-ray2.10A37-192[»]
    ProteinModelPortaliQ14116.
    SMRiQ14116. Positions 37-193.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ14116.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-1 family.Curated

    Phylogenomic databases

    eggNOGiNOG77229.
    HOGENOMiHOG000048723.
    HOVERGENiHBG000388.
    InParanoidiQ14116.
    KOiK05482.
    OMAiVPGHDDK.
    OrthoDBiEOG7SR4NN.
    PhylomeDBiQ14116.
    TreeFamiTF336297.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR015529. IL-18.
    IPR000975. IL-1_fam.
    [Graphical view]
    PANTHERiPTHR11326. PTHR11326. 1 hit.
    PfamiPF00340. IL1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015162. Interleukin_18. 1 hit.
    PRINTSiPR01933. INTRLEUKIN18.
    SUPFAMiSSF50353. SSF50353. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q14116-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAEPVEDNC INFVAMKFID NTLYFIAEDD ENLESDYFGK LESKLSVIRN    50
    LNDQVLFIDQ GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI 100
    SVKCEKISTL SCENKIISFK EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ 150
    FESSSYEGYF LACEKERDLF KLILKKEDEL GDRSIMFTVQ NED 193
    Length:193
    Mass (Da):22,326
    Last modified:November 1, 1996 - v1
    Checksum:i323C62C203788D55
    GO
    Isoform 2 (identifier: Q14116-2) [UniParc]FASTAAdd to Basket

    Also known as: Delta3pro-IL-18

    The sequence of this isoform differs from the canonical sequence as follows:
         27-30: Missing.

    Note: Expressed in ovarian carcinoma but undetectable in normal ovarian epithelial cells. Resistant to proteolytic activation by caspase-1 and -4.

    Show »
    Length:189
    Mass (Da):21,896
    Checksum:iA8BA275CF713A4B6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661F → L in AAC27787. 1 PublicationCurated
    Sequence conflicti86 – 861S → R in AAC27787. 1 PublicationCurated
    Sequence conflicti191 – 1911N → S in AAC27787. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei27 – 304Missing in isoform 2. 1 PublicationVSP_044934

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49950 mRNA. Translation: BAA08706.1.
    AY266351 mRNA. Translation: AAP92112.1.
    AF077611 mRNA. Translation: AAC27787.1.
    AY044641 mRNA. Translation: AAK95950.1.
    CR541973 mRNA. Translation: CAG46771.1.
    CR542001 mRNA. Translation: CAG46798.1.
    AP002007 Genomic DNA. No translation available.
    AP002884 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW67184.1.
    BC007007 mRNA. Translation: AAH07007.1.
    BC007461 mRNA. Translation: AAH07461.1.
    U90434 mRNA. Translation: AAB50010.1.
    CCDSiCCDS44731.1. [Q14116-1]
    CCDS58180.1. [Q14116-2]
    RefSeqiNP_001230140.1. NM_001243211.1. [Q14116-2]
    NP_001553.1. NM_001562.3. [Q14116-1]
    UniGeneiHs.83077.

    Genome annotation databases

    EnsembliENST00000280357; ENSP00000280357; ENSG00000150782. [Q14116-1]
    ENST00000524595; ENSP00000434561; ENSG00000150782. [Q14116-2]
    ENST00000528832; ENSP00000434161; ENSG00000150782. [Q14116-1]
    GeneIDi3606.
    KEGGihsa:3606.
    UCSCiuc001pna.2. human. [Q14116-1]
    uc009yym.2. human.

    Polymorphism databases

    DMDMi3219817.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Interleukin-1 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49950 mRNA. Translation: BAA08706.1 .
    AY266351 mRNA. Translation: AAP92112.1 .
    AF077611 mRNA. Translation: AAC27787.1 .
    AY044641 mRNA. Translation: AAK95950.1 .
    CR541973 mRNA. Translation: CAG46771.1 .
    CR542001 mRNA. Translation: CAG46798.1 .
    AP002007 Genomic DNA. No translation available.
    AP002884 Genomic DNA. No translation available.
    CH471065 Genomic DNA. Translation: EAW67184.1 .
    BC007007 mRNA. Translation: AAH07007.1 .
    BC007461 mRNA. Translation: AAH07461.1 .
    U90434 mRNA. Translation: AAB50010.1 .
    CCDSi CCDS44731.1. [Q14116-1 ]
    CCDS58180.1. [Q14116-2 ]
    RefSeqi NP_001230140.1. NM_001243211.1. [Q14116-2 ]
    NP_001553.1. NM_001562.3. [Q14116-1 ]
    UniGenei Hs.83077.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1J0S NMR - A 37-193 [» ]
    2VXT X-ray 1.49 I 37-193 [» ]
    3F62 X-ray 2.00 B 37-193 [» ]
    4EEE X-ray 2.71 B/D 37-193 [» ]
    4EKX X-ray 1.75 B/D 37-193 [» ]
    4HJJ X-ray 2.10 A 37-192 [» ]
    ProteinModelPortali Q14116.
    SMRi Q14116. Positions 37-193.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109819. 5 interactions.
    DIPi DIP-3785N.
    IntActi Q14116. 1 interaction.
    STRINGi 9606.ENSP00000280357.

    PTM databases

    PhosphoSitei Q14116.

    Polymorphism databases

    DMDMi 3219817.

    2D gel databases

    OGPi Q14116.

    Proteomic databases

    MaxQBi Q14116.
    PaxDbi Q14116.
    PRIDEi Q14116.

    Protocols and materials databases

    DNASUi 3606.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000280357 ; ENSP00000280357 ; ENSG00000150782 . [Q14116-1 ]
    ENST00000524595 ; ENSP00000434561 ; ENSG00000150782 . [Q14116-2 ]
    ENST00000528832 ; ENSP00000434161 ; ENSG00000150782 . [Q14116-1 ]
    GeneIDi 3606.
    KEGGi hsa:3606.
    UCSCi uc001pna.2. human. [Q14116-1 ]
    uc009yym.2. human.

    Organism-specific databases

    CTDi 3606.
    GeneCardsi GC11M112013.
    HGNCi HGNC:5986. IL18.
    HPAi CAB007772.
    CAB027385.
    HPA003980.
    MIMi 600953. gene.
    neXtProti NX_Q14116.
    PharmGKBi PA29802.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG77229.
    HOGENOMi HOG000048723.
    HOVERGENi HBG000388.
    InParanoidi Q14116.
    KOi K05482.
    OMAi VPGHDDK.
    OrthoDBi EOG7SR4NN.
    PhylomeDBi Q14116.
    TreeFami TF336297.

    Enzyme and pathway databases

    Reactomei REACT_23950. Interleukin-1 processing.

    Miscellaneous databases

    EvolutionaryTracei Q14116.
    GeneWikii Interleukin_18.
    GenomeRNAii 3606.
    NextBioi 14093.
    PMAP-CutDB Q14116.
    PROi Q14116.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q14116.
    Bgeei Q14116.
    CleanExi HS_IL18.
    Genevestigatori Q14116.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR015529. IL-18.
    IPR000975. IL-1_fam.
    [Graphical view ]
    PANTHERi PTHR11326. PTHR11326. 1 hit.
    Pfami PF00340. IL1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015162. Interleukin_18. 1 hit.
    PRINTSi PR01933. INTRLEUKIN18.
    SUPFAMi SSF50353. SSF50353. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein."
      Ushio S., Namba M., Okura T., Hattori K., Nukada Y., Akita K., Tanabe F., Konishi K., Micallef M., Fujii M., Torigoe K., Tanimoto T., Fukuda S., Ikeda M., Okamura H., Kurimoto M.
      J. Immunol. 156:4274-4279(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    2. "A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing."
      Gaggero A., De Ambrosis A., Mezzanzanica D., Piazza T., Rubartelli A., Figini M., Canevari S., Ferrini S.
      Oncogene 23:7552-7560(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PROTEOLYTIC PROCESSING, ALTERNATIVE SPLICING.
    3. "Cloning and sequencing of the cDNA for precursor hIL-18."
      Yong D., Guixin D., Lihua H., Haitao W.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Cloning of human interleukin 18 cDNA."
      Liu J., Peng X., Yuan J., Qiang B.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Urinary bladder.
    9. Conti B., Kim S.J., Tinti C., Chun H.S., Joh T.H.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-193 (ISOFORM 1).
      Tissue: Peripheral blood.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIL18_HUMAN
    AccessioniPrimary (citable) accession number: Q14116
    Secondary accession number(s): O75599, Q6FGY3, Q6WWJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3