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Q14116

- IL18_HUMAN

UniProt

Q14116 - IL18_HUMAN

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Protein

Interleukin-18

Gene

IL18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

GO - Molecular functioni

  1. cytokine activity Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: UniProtKB
  2. cell-cell signaling Source: ProtInc
  3. cellular response to organic cyclic compound Source: UniProtKB
  4. chemokine biosynthetic process Source: UniProtKB
  5. granulocyte macrophage colony-stimulating factor biosynthetic process Source: UniProtKB
  6. immune response Source: ProtInc
  7. inflammatory response Source: UniProtKB
  8. interferon-gamma biosynthetic process Source: UniProtKB
  9. interleukin-13 biosynthetic process Source: UniProtKB
  10. interleukin-2 biosynthetic process Source: UniProtKB
  11. lipopolysaccharide-mediated signaling pathway Source: UniProtKB
  12. MAPK cascade Source: UniProtKB
  13. natural killer cell activation Source: Ensembl
  14. positive regulation of activated T cell proliferation Source: UniProtKB
  15. positive regulation of gene expression Source: Ensembl
  16. positive regulation of granulocyte macrophage colony-stimulating factor production Source: BHF-UCL
  17. positive regulation of inflammatory response Source: BHF-UCL
  18. positive regulation of interferon-gamma production Source: BHF-UCL
  19. positive regulation of interleukin-17 production Source: BHF-UCL
  20. positive regulation of natural killer cell proliferation Source: BHF-UCL
  21. positive regulation of NF-kappaB import into nucleus Source: Ensembl
  22. positive regulation of NK T cell proliferation Source: BHF-UCL
  23. positive regulation of tissue remodeling Source: BHF-UCL
  24. regulation of cell adhesion Source: UniProtKB
  25. sleep Source: UniProtKB
  26. T-helper 1 type immune response Source: UniProtKB
  27. type 2 immune response Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiREACT_23950. Interleukin-1 processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18
Short name:
IL-18
Alternative name(s):
Iboctadekin
Interferon gamma-inducing factor
Short name:
IFN-gamma-inducing factor
Interleukin-1 gamma
Short name:
IL-1 gamma
Gene namesi
Name:IL18
Synonyms:IGIF, IL1F4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:5986. IL18.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. extracellular region Source: UniProtKB
  3. extracellular space Source: UniProtKB-KW
  4. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 3636By similarityPRO_0000015343Add
BLAST
Chaini37 – 193157Interleukin-18PRO_0000015344Add
BLAST

Post-translational modificationi

The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.1 Publication

Proteomic databases

MaxQBiQ14116.
PaxDbiQ14116.
PRIDEiQ14116.

2D gel databases

OGPiQ14116.

PTM databases

PhosphoSiteiQ14116.

Miscellaneous databases

PMAP-CutDBQ14116.

Expressioni

Gene expression databases

BgeeiQ14116.
CleanExiHS_IL18.
ExpressionAtlasiQ14116. baseline and differential.
GenevestigatoriQ14116.

Organism-specific databases

HPAiCAB007772.
CAB027385.
HPA003980.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IL18R1Q134782EBI-3910835,EBI-9817499

Protein-protein interaction databases

BioGridi109819. 5 interactions.
DIPiDIP-3785N.
IntActiQ14116. 2 interactions.
STRINGi9606.ENSP00000280357.

Structurei

Secondary structure

1
193
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi42 – 498Combined sources
Beta strandi55 – 584Combined sources
Beta strandi64 – 674Combined sources
Helixi71 – 766Combined sources
Turni77 – 815Combined sources
Beta strandi83 – 919Combined sources
Turni92 – 943Combined sources
Beta strandi95 – 11117Combined sources
Helixi113 – 1153Combined sources
Beta strandi118 – 1214Combined sources
Beta strandi126 – 1316Combined sources
Beta strandi137 – 1426Combined sources
Beta strandi145 – 15612Combined sources
Beta strandi159 – 1668Combined sources
Beta strandi169 – 1768Combined sources
Turni178 – 1803Combined sources
Helixi183 – 1853Combined sources
Beta strandi187 – 1915Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J0SNMR-A37-193[»]
2VXTX-ray1.49I37-193[»]
3F62X-ray2.00B37-193[»]
4EEEX-ray2.71B/D37-193[»]
4EKXX-ray1.75B/D37-193[»]
4HJJX-ray2.10A37-192[»]
ProteinModelPortaliQ14116.
SMRiQ14116. Positions 37-193.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ14116.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiNOG77229.
GeneTreeiENSGT00390000001053.
HOGENOMiHOG000048723.
HOVERGENiHBG000388.
InParanoidiQ14116.
KOiK05482.
OMAiVPGHDDK.
OrthoDBiEOG7SR4NN.
PhylomeDBiQ14116.
TreeFamiTF336297.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR015529. IL-18.
IPR000975. IL-1_fam.
[Graphical view]
PANTHERiPTHR11326. PTHR11326. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PIRSFiPIRSF015162. Interleukin_18. 1 hit.
PRINTSiPR01933. INTRLEUKIN18.
SUPFAMiSSF50353. SSF50353. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q14116-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAEPVEDNC INFVAMKFID NTLYFIAEDD ENLESDYFGK LESKLSVIRN
60 70 80 90 100
LNDQVLFIDQ GNRPLFEDMT DSDCRDNAPR TIFIISMYKD SQPRGMAVTI
110 120 130 140 150
SVKCEKISTL SCENKIISFK EMNPPDNIKD TKSDIIFFQR SVPGHDNKMQ
160 170 180 190
FESSSYEGYF LACEKERDLF KLILKKEDEL GDRSIMFTVQ NED
Length:193
Mass (Da):22,326
Last modified:November 1, 1996 - v1
Checksum:i323C62C203788D55
GO
Isoform 2 (identifier: Q14116-2) [UniParc]FASTAAdd to Basket

Also known as: Delta3pro-IL-18

The sequence of this isoform differs from the canonical sequence as follows:
     27-30: Missing.

Note: Expressed in ovarian carcinoma but undetectable in normal ovarian epithelial cells. Resistant to proteolytic activation by caspase-1 and -4.

Show »
Length:189
Mass (Da):21,896
Checksum:iA8BA275CF713A4B6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661F → L in AAC27787. 1 PublicationCurated
Sequence conflicti86 – 861S → R in AAC27787. 1 PublicationCurated
Sequence conflicti191 – 1911N → S in AAC27787. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei27 – 304Missing in isoform 2. 1 PublicationVSP_044934

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49950 mRNA. Translation: BAA08706.1.
AY266351 mRNA. Translation: AAP92112.1.
AF077611 mRNA. Translation: AAC27787.1.
AY044641 mRNA. Translation: AAK95950.1.
CR541973 mRNA. Translation: CAG46771.1.
CR542001 mRNA. Translation: CAG46798.1.
AP002007 Genomic DNA. No translation available.
AP002884 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67184.1.
BC007007 mRNA. Translation: AAH07007.1.
BC007461 mRNA. Translation: AAH07461.1.
U90434 mRNA. Translation: AAB50010.1.
CCDSiCCDS44731.1. [Q14116-1]
CCDS58180.1. [Q14116-2]
RefSeqiNP_001230140.1. NM_001243211.1. [Q14116-2]
NP_001553.1. NM_001562.3. [Q14116-1]
UniGeneiHs.83077.

Genome annotation databases

EnsembliENST00000280357; ENSP00000280357; ENSG00000150782. [Q14116-1]
ENST00000524595; ENSP00000434561; ENSG00000150782. [Q14116-2]
ENST00000528832; ENSP00000434161; ENSG00000150782. [Q14116-1]
GeneIDi3606.
KEGGihsa:3606.
UCSCiuc001pna.2. human. [Q14116-1]
uc009yym.2. human.

Polymorphism databases

DMDMi3219817.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Wikipedia

Interleukin-1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49950 mRNA. Translation: BAA08706.1 .
AY266351 mRNA. Translation: AAP92112.1 .
AF077611 mRNA. Translation: AAC27787.1 .
AY044641 mRNA. Translation: AAK95950.1 .
CR541973 mRNA. Translation: CAG46771.1 .
CR542001 mRNA. Translation: CAG46798.1 .
AP002007 Genomic DNA. No translation available.
AP002884 Genomic DNA. No translation available.
CH471065 Genomic DNA. Translation: EAW67184.1 .
BC007007 mRNA. Translation: AAH07007.1 .
BC007461 mRNA. Translation: AAH07461.1 .
U90434 mRNA. Translation: AAB50010.1 .
CCDSi CCDS44731.1. [Q14116-1 ]
CCDS58180.1. [Q14116-2 ]
RefSeqi NP_001230140.1. NM_001243211.1. [Q14116-2 ]
NP_001553.1. NM_001562.3. [Q14116-1 ]
UniGenei Hs.83077.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1J0S NMR - A 37-193 [» ]
2VXT X-ray 1.49 I 37-193 [» ]
3F62 X-ray 2.00 B 37-193 [» ]
4EEE X-ray 2.71 B/D 37-193 [» ]
4EKX X-ray 1.75 B/D 37-193 [» ]
4HJJ X-ray 2.10 A 37-192 [» ]
ProteinModelPortali Q14116.
SMRi Q14116. Positions 37-193.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109819. 5 interactions.
DIPi DIP-3785N.
IntActi Q14116. 2 interactions.
STRINGi 9606.ENSP00000280357.

PTM databases

PhosphoSitei Q14116.

Polymorphism databases

DMDMi 3219817.

2D gel databases

OGPi Q14116.

Proteomic databases

MaxQBi Q14116.
PaxDbi Q14116.
PRIDEi Q14116.

Protocols and materials databases

DNASUi 3606.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000280357 ; ENSP00000280357 ; ENSG00000150782 . [Q14116-1 ]
ENST00000524595 ; ENSP00000434561 ; ENSG00000150782 . [Q14116-2 ]
ENST00000528832 ; ENSP00000434161 ; ENSG00000150782 . [Q14116-1 ]
GeneIDi 3606.
KEGGi hsa:3606.
UCSCi uc001pna.2. human. [Q14116-1 ]
uc009yym.2. human.

Organism-specific databases

CTDi 3606.
GeneCardsi GC11M112013.
HGNCi HGNC:5986. IL18.
HPAi CAB007772.
CAB027385.
HPA003980.
MIMi 600953. gene.
neXtProti NX_Q14116.
PharmGKBi PA29802.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG77229.
GeneTreei ENSGT00390000001053.
HOGENOMi HOG000048723.
HOVERGENi HBG000388.
InParanoidi Q14116.
KOi K05482.
OMAi VPGHDDK.
OrthoDBi EOG7SR4NN.
PhylomeDBi Q14116.
TreeFami TF336297.

Enzyme and pathway databases

Reactomei REACT_23950. Interleukin-1 processing.

Miscellaneous databases

EvolutionaryTracei Q14116.
GeneWikii Interleukin_18.
GenomeRNAii 3606.
NextBioi 14093.
PMAP-CutDB Q14116.
PROi Q14116.
SOURCEi Search...

Gene expression databases

Bgeei Q14116.
CleanExi HS_IL18.
ExpressionAtlasi Q14116. baseline and differential.
Genevestigatori Q14116.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR015529. IL-18.
IPR000975. IL-1_fam.
[Graphical view ]
PANTHERi PTHR11326. PTHR11326. 1 hit.
Pfami PF00340. IL1. 1 hit.
[Graphical view ]
PIRSFi PIRSF015162. Interleukin_18. 1 hit.
PRINTSi PR01933. INTRLEUKIN18.
SUPFAMi SSF50353. SSF50353. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein."
    Ushio S., Namba M., Okura T., Hattori K., Nukada Y., Akita K., Tanabe F., Konishi K., Micallef M., Fujii M., Torigoe K., Tanimoto T., Fukuda S., Ikeda M., Okamura H., Kurimoto M.
    J. Immunol. 156:4274-4279(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "A novel isoform of pro-interleukin-18 expressed in ovarian tumors is resistant to caspase-1 and -4 processing."
    Gaggero A., De Ambrosis A., Mezzanzanica D., Piazza T., Rubartelli A., Figini M., Canevari S., Ferrini S.
    Oncogene 23:7552-7560(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), PROTEOLYTIC PROCESSING, ALTERNATIVE SPLICING.
  3. "Cloning and sequencing of the cDNA for precursor hIL-18."
    Yong D., Guixin D., Lihua H., Haitao W.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Cloning of human interleukin 18 cDNA."
    Liu J., Peng X., Yuan J., Qiang B.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Urinary bladder.
  9. Conti B., Kim S.J., Tinti C., Chun H.S., Joh T.H.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-193 (ISOFORM 1).
    Tissue: Peripheral blood.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIL18_HUMAN
AccessioniPrimary (citable) accession number: Q14116
Secondary accession number(s): O75599, Q6FGY3, Q6WWJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3