Q14112 (NID2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nidogen-2
Short name=NID-2

Alternative name(s):
Osteonidogen

Gene names

Name:

NID2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1375 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.
Subunit structure	Interacts with LAMA2 By similarity. Interacts with COL13A1. Ref.6
Subcellular location	Secreted › extracellular space › extracellular matrix › basement membrane.
Tissue specificity	Heart, placenta and bone. Less in pancreas, kidney and skeletal muscle.
Post-translational modification	Highly N- and O-glycosylated. Ref.7
Sequence similarities	Contains 5 EGF-like domains. Contains 5 LDL-receptor class B repeats. Contains 1 NIDO domain. Contains 1 nidogen G2 beta-barrel domain. Contains 2 thyroglobulin type-1 domains.
Sequence caution	The sequence BAA13087.1 differs from that shown. Reason: Frameshift at positions 54, 68, 150 and 172. The sequence BAA24112.1 differs from that shown. Reason: Frameshift at positions 54, 68, 150 and 172.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Basement membrane Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	EGF-like domain Repeat Signal
Ligand	Calcium
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	basement membrane Traceable author statement. Source: ProtInc
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro collagen binding Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14112-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14112-2)

The sequence of this isoform differs from the canonical sequence as follows:
     7-59: Missing.
     844-892: LITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYAGDGHQCTD → Y

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30
	Chain	31 – 1375	1345	Nidogen-2		PRO_0000007671
Regions
	Domain	108 – 273	166	NIDO
	Domain	484 – 524	41	EGF-like 1
	Domain	528 – 758	231	Nidogen G2 beta-barrel
	Domain	759 – 800	42	EGF-like 2
	Domain	801 – 843	43	EGF-like 3; calcium-binding Potential
	Domain	848 – 891	44	EGF-like 4
	Domain	892 – 930	39	EGF-like 5; calcium-binding Potential
	Domain	937 – 1005	69	Thyroglobulin type-1 1
	Domain	1016 – 1084	69	Thyroglobulin type-1 2
	Repeat	1154 – 1197	44	LDL-receptor class B 1
	Repeat	1198 – 1240	43	LDL-receptor class B 2
	Repeat	1241 – 1285	45	LDL-receptor class B 3
	Repeat	1286 – 1327	42	LDL-receptor class B 4
	Repeat	1329 – 1373	45	LDL-receptor class B 5
Amino acid modifications
	Glycosylation	417	1	N-linked (GlcNAc...) Probable
	Glycosylation	658	1	N-linked (GlcNAc...) Probable
	Glycosylation	693	1	N-linked (GlcNAc...) Probable
	Glycosylation	703	1	N-linked (GlcNAc...) Probable
	Glycosylation	1124	1	N-linked (GlcNAc...) Ref.7
	Disulfide bond	763 ↔ 776		By similarity
	Disulfide bond	770 ↔ 786		By similarity
	Disulfide bond	788 ↔ 799		By similarity
	Disulfide bond	805 ↔ 818		By similarity
	Disulfide bond	812 ↔ 827		By similarity
	Disulfide bond	829 ↔ 842		By similarity
	Disulfide bond	852 ↔ 867		By similarity
	Disulfide bond	859 ↔ 877		By similarity
	Disulfide bond	879 ↔ 890		By similarity
	Disulfide bond	896 ↔ 907		By similarity
	Disulfide bond	901 ↔ 916		By similarity
	Disulfide bond	918 ↔ 929		By similarity
	Disulfide bond	940 ↔ 963		By similarity
	Disulfide bond	974 ↔ 981		By similarity
	Disulfide bond	983 ↔ 1005		By similarity
	Disulfide bond	1019 ↔ 1043		By similarity
	Disulfide bond	1054 ↔ 1061		By similarity
	Disulfide bond	1063 ↔ 1084		By similarity
Natural variations
	Alternative sequence	7 – 59	53	Missing in isoform 2.		VSP_038779
	Alternative sequence	844 – 892	49	LITPP…HQCTD → Y in isoform 2.		VSP_038780
	Natural variant	22	1	P → Q. Ref.1 Ref.2 Ref.3 Ref.4 Corresponds to variant rs3920038 [ dbSNP | Ensembl ].		VAR_062850
	Natural variant	313	1	D → G. Corresponds to variant rs17124969 [ dbSNP | Ensembl ].		VAR_055767
	Natural variant	354	1	P → H. Corresponds to variant rs35657569 [ dbSNP | Ensembl ].		VAR_055768
	Natural variant	453	1	G → D. Ref.1 Corresponds to variant rs2101919 [ dbSNP | Ensembl ].		VAR_062851
	Natural variant	529	1	P → S. Corresponds to variant rs17831525 [ dbSNP | Ensembl ].		VAR_055769
	Natural variant	656	1	S → P. Ref.1 Ref.2 Ref.3 Ref.4 Corresponds to variant rs3742536 [ dbSNP | Ensembl ].		VAR_062852
	Natural variant	726	1	V → M. Corresponds to variant rs35147930 [ dbSNP | Ensembl ].		VAR_055770
	Natural variant	760	1	G → V. Ref.1 Ref.2 Ref.3 Ref.4 Corresponds to variant rs2273430 [ dbSNP | Ensembl ].		VAR_062853
	Natural variant	775	1	R → Q. Corresponds to variant rs10134590 [ dbSNP | Ensembl ].		VAR_055771
	Natural variant	830	1	R → Q. Corresponds to variant rs7144523 [ dbSNP | Ensembl ].		VAR_055772
	Natural variant	866	1	R → Q. Corresponds to variant rs28507587 [ dbSNP | Ensembl ].		VAR_055773
	Natural variant	1238	1	P → S in a breast cancer sample; somatic mutation. Ref.8		VAR_035836
Experimental info
	Sequence conflict	44	1	G → W in BAA13087. Ref.2
	Sequence conflict	44	1	G → W in BAA24112. Ref.3
	Sequence conflict	700	1	I → T in BAG62181. Ref.4
	Sequence conflict	1242	1	N → D in BAF84341. Ref.4
	Sequence conflict	1245	1	W → R in BAF84341. Ref.4
	Sequence conflict	1249	1	N → D in BAF84341. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 2, 2010. Version 3. Checksum: 198D1F4E286A53E2	FASTA	1,375	151,254
	10 20 30 40 50 60 MEGDRVAGRP VLSSLPVLLL LPLLMLRAAA LHPDELFPHG ESWGDQLLQE GDDESSAVVK 70 80 90 100 110 120 LANPLHFYEA RFSNLYVGTN GIISTQDFPR ETQYVDYDFP TDFPAIAPFL ADIDTSHGRG 130 140 150 160 170 180 RVLYREDTSP AVLGLAARYV RAGFPRSARF TPTHAFLATW EQVGAYEEVK RGALPSGELN 190 200 210 220 230 240 TFQAVLASDG SDSYALFLYP ANGLQFLGTR PKESYNVQLQ LPARVGFCRG EADDLKSEGP 250 260 270 280 290 300 YFSLTSTEQS VKNLYQLSNL GIPGVWAFHI GSTSPLDNVR PAAVGDLSAA HSSVPLGRSF 310 320 330 340 350 360 SHATALESDY NEDNLDYYDV NEEEAEYLPG EPEEALNGHS SIDVSFQSKV DTKPLEESST 370 380 390 400 410 420 LDPHTKEGTS LGEVGGPDLK GQVEPWDERE TRSPAPPEVD RDSLAPSWET PPPYPENGSI 430 440 450 460 470 480 QPYPDGGPVP SEMDVPPAHP EEEIVLRSYP ASGHTTPLSR GTYEVGLEDN IGSNTEVFTY 490 500 510 520 530 540 NAANKETCEH NHRQCSRHAF CTDYATGFCC HCQSKFYGNG KHCLPEGAPH RVNGKVSGHL 550 560 570 580 590 600 HVGHTPVHFT DVDLHAYIVG NDGRAYTAIS HIPQPAAQAL LPLTPIGGLF GWLFALEKPG 610 620 630 640 650 660 SENGFSLAGA AFTHDMEVTF YPGEETVRIT QTAEGLDPEN YLSIKTNIQG QVPYVSANFT 670 680 690 700 710 720 AHISPYKELY HYSDSTVTST SSRDYSLTFG AINQTWSYRI HQNITYQVCR HAPRHPSFPT 730 740 750 760 770 780 TQQLNVDRVF ALYNDEERVL RFAVTNQIGP VKEDSDPTPG NPCYDGSHMC DTTARCHPGT 790 800 810 820 830 840 GVDYTCECAS GYQGDGRNCV DENECATGFH RCGPNSVCIN LPGSYRCECR SGYEFADDRH 850 860 870 880 890 900 TCILITPPAN PCEDGSHTCA PAGQARCVHH GGSTFSCACL PGYAGDGHQC TDVDECSENR 910 920 930 940 950 960 CHPAATCYNT PGSFSCRCQP GYYGDGFQCI PDSTSSLTPC EQQQRHAQAQ YAYPGARFHI 970 980 990 1000 1010 1020 PQCDEQGNFL PLQCHGSTGF CWCVDPDGHE VPGTQTPPGS TPPHCGPSPE PTQRPPTICE 1030 1040 1050 1060 1070 1080 RWRENLLEHY GGTPRDDQYV PQCDDLGHFI PLQCHGKSDF CWCVDKDGRE VQGTRSQPGT 1090 1100 1110 1120 1130 1140 TPACIPTVAP PMVRPTPRPD VTPPSVGTFL LYTQGQQIGY LPLNGTRLQK DAAKTLLSLH 1150 1160 1170 1180 1190 1200 GSIIVGIDYD CRERMVYWTD VAGRTISRAG LELGAEPETI VNSGLISPEG LAIDHIRRTM 1210 1220 1230 1240 1250 1260 YWTDSVLDKI ESALLDGSER KVLFYTDLVN PRAIAVDPIR GNLYWTDWNR EAPKIETSSL 1270 1280 1290 1300 1310 1320 DGENRRILIN TDIGLPNGLT FDPFSKLLCW ADAGTKKLEC TLPDGTGRRV IQNNLKYPFS 1330 1340 1350 1360 1370 IVSYADHFYH TDWRRDGVVS VNKHSGQFTD EYLPEQRSHL YGITAVYPYC PTGRK
	Isoform 2 [UniParc]. Checksum: C6E3D787DB40235B	FASTA	1,274	140,866
	10 20 30 40 50 60 MEGDRVKLAN PLHFYEARFS NLYVGTNGII STQDFPRETQ YVDYDFPTDF PAIAPFLADI 70 80 90 100 110 120 DTSHGRGRVL YREDTSPAVL GLAARYVRAG FPRSARFTPT HAFLATWEQV GAYEEVKRGA 130 140 150 160 170 180 LPSGELNTFQ AVLASDGSDS YALFLYPANG LQFLGTRPKE SYNVQLQLPA RVGFCRGEAD 190 200 210 220 230 240 DLKSEGPYFS LTSTEQSVKN LYQLSNLGIP GVWAFHIGST SPLDNVRPAA VGDLSAAHSS 250 260 270 280 290 300 VPLGRSFSHA TALESDYNED NLDYYDVNEE EAEYLPGEPE EALNGHSSID VSFQSKVDTK 310 320 330 340 350 360 PLEESSTLDP HTKEGTSLGE VGGPDLKGQV EPWDERETRS PAPPEVDRDS LAPSWETPPP 370 380 390 400 410 420 YPENGSIQPY PDGGPVPSEM DVPPAHPEEE IVLRSYPASG HTTPLSRGTY EVGLEDNIGS 430 440 450 460 470 480 NTEVFTYNAA NKETCEHNHR QCSRHAFCTD YATGFCCHCQ SKFYGNGKHC LPEGAPHRVN 490 500 510 520 530 540 GKVSGHLHVG HTPVHFTDVD LHAYIVGNDG RAYTAISHIP QPAAQALLPL TPIGGLFGWL 550 560 570 580 590 600 FALEKPGSEN GFSLAGAAFT HDMEVTFYPG EETVRITQTA EGLDPENYLS IKTNIQGQVP 610 620 630 640 650 660 YVSANFTAHI SPYKELYHYS DSTVTSTSSR DYSLTFGAIN QTWSYRIHQN ITYQVCRHAP 670 680 690 700 710 720 RHPSFPTTQQ LNVDRVFALY NDEERVLRFA VTNQIGPVKE DSDPTPGNPC YDGSHMCDTT 730 740 750 760 770 780 ARCHPGTGVD YTCECASGYQ GDGRNCVDEN ECATGFHRCG PNSVCINLPG SYRCECRSGY 790 800 810 820 830 840 EFADDRHTCI YVDECSENRC HPAATCYNTP GSFSCRCQPG YYGDGFQCIP DSTSSLTPCE 850 860 870 880 890 900 QQQRHAQAQY AYPGARFHIP QCDEQGNFLP LQCHGSTGFC WCVDPDGHEV PGTQTPPGST 910 920 930 940 950 960 PPHCGPSPEP TQRPPTICER WRENLLEHYG GTPRDDQYVP QCDDLGHFIP LQCHGKSDFC 970 980 990 1000 1010 1020 WCVDKDGREV QGTRSQPGTT PACIPTVAPP MVRPTPRPDV TPPSVGTFLL YTQGQQIGYL 1030 1040 1050 1060 1070 1080 PLNGTRLQKD AAKTLLSLHG SIIVGIDYDC RERMVYWTDV AGRTISRAGL ELGAEPETIV 1090 1100 1110 1120 1130 1140 NSGLISPEGL AIDHIRRTMY WTDSVLDKIE SALLDGSERK VLFYTDLVNP RAIAVDPIRG 1150 1160 1170 1180 1190 1200 NLYWTDWNRE APKIETSSLD GENRRILINT DIGLPNGLTF DPFSKLLCWA DAGTKKLECT 1210 1220 1230 1240 1250 1260 LPDGTGRRVI QNNLKYPFSI VSYADHFYHT DWRRDGVVSV NKHSGQFTDE YLPEQRSHLY 1270 GITAVYPYCP TGRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nidogen-2: a new basement membrane protein with diverse binding properties." Kohfeldt E., Sasaki T., Goehring W., Timpl R. J. Mol. Biol. 282:99-109(1998) [PubMed: 9733643] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF N-TERMINUS, VARIANTS GLN-22; ASP-453; PRO-656 AND VAL-760.
[2]	"The cloning and characterization of a cDNA for the novel bone matrix protein: osteonidogen." Ohno I., Hashimoto J., Takaoka K., Ochi T., Okubo K., Matsubara K. Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS GLN-22; PRO-656 AND VAL-760. Tissue: Cancellous bone.
[3]	"Human osteonidogen gene: intron-exon junctions and chromosomal localization." Ohno I., Okubo K., Matsubara K. Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1), VARIANTS GLN-22; PRO-656 AND VAL-760.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS GLN-22; PRO-656; VAL-760 AND VAL-760. Tissue: Placenta.
[5]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin." Tu H., Sasaki T., Snellman A., Gohring W., Pirila P., Timpl R., Pihlajaniemi T. J. Biol. Chem. 277:23092-23099(2002) [PubMed: 11956183] [Abstract] Cited for: INTERACTION WITH COL13A1.
[7]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1124, MASS SPECTROMETRY. Tissue: Liver.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-1238.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ223500 mRNA. Translation: CAA11418.1. D86425 mRNA. Translation: BAA13087.1. Frameshift. AB009799 Genomic DNA. Translation: BAA24112.1. Frameshift. AK300462 mRNA. Translation: BAG62181.1. AK291652 mRNA. Translation: BAF84341.1.
IPI	IPI00028908. IPI00955436.
PIR	G00043.
RefSeq	NP_031387.3. NM_007361.3.
UniGene	Hs.369840.
3D structure databases
ProteinModelPortal	Q14112.
SMR	Q14112. Positions 487-752, 759-930, 983-1373.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1183597.
STRING	Q14112.
PTM databases
PhosphoSite	Q14112.
Polymorphism databases
DMDM	290457669.
Proteomic databases
PRIDE	Q14112.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000216286; ENSP00000216286; ENSG00000087303.
GeneID	22795.
KEGG	hsa:22795.
UCSC	uc001wzo.1. human.
Organism-specific databases
CTD	22795.
GeneCards	GC14M052471.
H-InvDB	HIX0026668.
HGNC	HGNC:13389. NID2.
MIM	605399. gene.
neXtProt	NX_Q14112.
PharmGKB	PA31626.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG11227.
GeneTree	ENSGT00580000081234.
HOGENOM	HBG715409.
HOVERGEN	HBG006498.
InParanoid	Q14112.
OMA	QDFPRET.
OrthoDB	EOG4VMFDH.
PhylomeDB	Q14112.
Gene expression databases
ArrayExpress	Q14112.
Bgee	Q14112.
CleanEx	HS_NID2.
Genevestigator	Q14112.
GermOnline	ENSG00000087303. Homo sapiens.
Family and domain databases
InterPro	IPR011042. 6-blade_b-propeller_TolB-like. IPR006210. EGF-like. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_reg_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR000742. EGF_3. IPR018097. EGF_Ca-bd_CS. IPR024731. EGF_dom_MSP1-like. IPR006605. G2_nidogen/fibulin_G2F. IPR009017. Green_fluorescent_prot-like. IPR000033. LDLR_classB_rpt. IPR003886. Nidogen_extracell_dom. IPR000716. Thyroglobulin_1. [Graphical view]
Gene3D	G3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 1 hit. G3DSA:4.10.800.10. Thyroglobulin_1. 2 hits.
KO	K06826.
Pfam	PF12947. EGF_3. 1 hit. PF07645. EGF_CA. 1 hit. PF07474. G2F. 1 hit. PF00058. Ldl_recept_b. 2 hits. PF06119. NIDO. 1 hit. PF00086. Thyroglobulin_1. 2 hits. [Graphical view]
SMART	SM00181. EGF. 3 hits. SM00179. EGF_CA. 2 hits. SM00682. G2F. 1 hit. SM00135. LY. 5 hits. SM00539. NIDO. 1 hit. SM00211. TY. 2 hits. [Graphical view]
SUPFAM	SSF54511. GFP_like. 1 hit. SSF57610. Thyroglobulin_1. 2 hits.
PROSITE	PS00010. ASX_HYDROXYL. 3 hits. PS01186. EGF_2. 4 hits. PS50026. EGF_3. 4 hits. PS01187. EGF_CA. 2 hits. PS51120. LDLRB. 4 hits. PS51220. NIDO. 1 hit. PS50993. NIDOGEN_G2. 1 hit. PS00484. THYROGLOBULIN_1_1. 2 hits. PS51162. THYROGLOBULIN_1_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	43128.
SOURCE	Search...

Entry information

Entry name

NID2_HUMAN

Accession

Primary (citable) accession number: Q14112
Secondary accession number(s): A8K6I7, B4DU19, O43710

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	March 2, 2010
Last modified:	January 25, 2012
This is version 116 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.