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Q14108 (SCRB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 135. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosome membrane protein 2
Alternative name(s):
85 kDa lysosomal membrane sialoglycoprotein
Short name=LGP85
CD36 antigen-like 2
Lysosome membrane protein II
Short name=LIMP II
Scavenger receptor class B member 2
CD_antigen=CD36
Gene names
Name:SCARB2
Synonyms:CD36L2, LIMP2, LIMPII
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. Ref.11

Subunit structure

Interacts with GBA. Ref.11 Ref.19

Subcellular location

Lysosome membrane; Multi-pass membrane protein Ref.8 Ref.11 Ref.12.

Involvement in disease

Epilepsy, progressive myoclonic 4, with or without renal failure (EPM4) [MIM:254900]: An autosomal recessive progressive myoclonic epilepsy associated with renal failure in some cases. Cognitive function is preserved. Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13 Ref.14 Ref.16 Ref.18 Ref.20

Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease. Ref.18

Sequence similarities

Belongs to the CD36 family.

Mass spectrometry

Molecular mass is 54158.97 Da from positions 2 - 478. Determined by MALDI. Ref.9

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PLCG1P191742EBI-1564650,EBI-79387

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q14108-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q14108-2)

The sequence of this isoform differs from the canonical sequence as follows:
     93-235: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 478477Lysosome membrane protein 2
PRO_0000144155

Regions

Topological domain2 – 43Cytoplasmic Potential
Transmembrane5 – 2723Helical; Potential
Topological domain28 – 433406Lumenal Potential
Transmembrane434 – 45926Helical; Potential
Topological domain460 – 47819Cytoplasmic Potential
Region155 – 19137Important for interaction with GBA

Amino acid modifications

Glycosylation451N-linked (GlcNAc...) Ref.15 Ref.19
Glycosylation681N-linked (GlcNAc...) Ref.15 Ref.19
Glycosylation1051N-linked (GlcNAc...) Ref.15
Glycosylation2061N-linked (GlcNAc...) Ref.15 Ref.19
Glycosylation2241N-linked (GlcNAc...) Ref.19
Glycosylation2491N-linked (GlcNAc...) Ref.10 Ref.15 Ref.19
Glycosylation3041N-linked (GlcNAc...) Ref.15 Ref.19
Glycosylation3251N-linked (GlcNAc...) Ref.15 Ref.19
Glycosylation4121N-linked (GlcNAc...) Ref.10 Ref.19
Glycosylation4301N-linked (GlcNAc...) Potential
Disulfide bond274 ↔ 329 Ref.19
Disulfide bond312 ↔ 318 Ref.19

Natural variations

Alternative sequence93 – 235143Missing in isoform 2.
VSP_044826
Natural variant3631H → N in EPM4; no renal failure. Ref.20
VAR_066744
Natural variant4711E → G May act as a modifier of Gaucher disease. Ref.18
VAR_066745

Experimental info

Mutagenesis4751L → A, G, D or V: Prevents the targeting of the protein to lysosomes. Ref.8
Mutagenesis4751L → I: Some loss in the efficiency of targeting of the protein to lysosomes. Ref.8
Mutagenesis4761I → A or V: Does not prevent the targeting of the protein to lysosomes completely. Ref.8
Mutagenesis4761I → D, E or G: Prevents the targeting of the protein to lysosomes. Ref.8
Mutagenesis4761I → L: Normal targeting of the protein to lysosomes. Ref.8
Mutagenesis4771R → A, E, G, K or Q: Normal targeting of the protein to lysosomes. Ref.8
Mutagenesis4781T → G, I, S or V: Normal targeting of the protein to lysosomes. Ref.8
Sequence conflict3511S → P in BAG59150. Ref.4

Secondary structure

.................................................................................. 478
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: FDCF27F3BA337B2C

FASTA47854,290
        10         20         30         40         50         60 
MGRCCFYTAG TLSLLLLVTS VTLLVARVFQ KAVDQSIEKK IVLRNGTEAF DSWEKPPLPV 

        70         80         90        100        110        120 
YTQFYFFNVT NPEEILRGET PRVEEVGPYT YRELRNKANI QFGDNGTTIS AVSNKAYVFE 

       130        140        150        160        170        180 
RDQSVGDPKI DLIRTLNIPV LTVIEWSQVH FLREIIEAML KAYQQKLFVT HTVDELLWGY 

       190        200        210        220        230        240 
KDEILSLIHV FRPDISPYFG LFYEKNGTND GDYVFLTGED SYLNFTKIVE WNGKTSLDWW 

       250        260        270        280        290        300 
ITDKCNMING TDGDSFHPLI TKDEVLYVFP SDFCRSVYIT FSDYESVQGL PAFRYKVPAE 

       310        320        330        340        350        360 
ILANTSDNAG FCIPEGNCLG SGVLNVSICK NGAPIIMSFP HFYQADERFV SAIEGMHPNQ 

       370        380        390        400        410        420 
EDHETFVDIN PLTGIILKAA KRFQINIYVK KLDDFVETGD IRTMVFPVMY LNESVHIDKE 

       430        440        450        460        470 
TASRLKSMIN TTLIITNIPY IIMALGVFFG LVFTWLACKG QGSMDEGTAD ERAPLIRT 

« Hide

Isoform 2 [UniParc].

Checksum: 41D643B2B222B187
Show »

FASTA33537,767

References

« Hide 'large scale' references
[1]"Isolation and sequencing of a cDNA clone encoding the 85 kDa human lysosomal sialoglycoprotein (hLGP85) in human metastatic pancreas islet tumor cells."
Fujita H., Takata Y., Kono A., Tanaka Y., Takahashi T., Himeno M., Kato K.
Biochem. Biophys. Res. Commun. 184:604-611(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution."
Calvo D., Dopazo J., Vega M.A.
Genomics 25:100-106(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Cerebellum and Thalamus.
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Eye.
[8]"The residues Leu(Ile)475-Ile(Leu, Val, Ala)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes."
Sandoval I.V., Arredondo J.J., Alcalde J., Gonzalez Noriega A., Vandekerckhove J., Jimenez M.A., Rico M.
J. Biol. Chem. 269:6622-6631(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: MUTAGENESIS OF LEU-475; ILE-476; ARG-477 AND THR-478, SUBCELLULAR LOCATION.
[9]"Cluster analysis of an extensive human breast cancer cell line protein expression map database."
Harris R.A., Yang A., Stein R.C., Lucy K., Brusten L., Herath A., Parekh R., Waterfield M.D., O'Hare M.J., Neville M.A., Page M.J., Zvelebil M.J.
Proteomics 2:212-223(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: MASS SPECTROMETRY.
Tissue: Mammary cancer.
[10]"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H., Li X.-J., Martin D.B., Aebersold R.
Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-249 AND ASN-412.
[11]"LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase."
Reczek D., Schwake M., Schroder J., Hughes H., Blanz J., Jin X., Brondyk W., Van Patten S., Edmunds T., Saftig P.
Cell 131:770-783(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, REGION, INTERACTION WITH GBA.
[12]"Integral and associated lysosomal membrane proteins."
Schroeder B., Wrocklage C., Pan C., Jaeger R., Koesters B., Schaefer H., Elsaesser H.-P., Mann M., Hasilik A.
Traffic 8:1676-1686(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Placenta.
[13]"Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis."
Berkovic S.F., Dibbens L.M., Oshlack A., Silver J.D., Katerelos M., Vears D.F., Luellmann-Rauch R., Blanz J., Zhang K.W., Stankovich J., Kalnins R.M., Dowling J.P., Andermann E., Andermann F., Faldini E., D'Hooge R., Vadlamudi L., Macdonell R.A. expand/collapse author list , Hodgson B.L., Bayly M.A., Savige J., Mulley J.C., Smyth G.K., Power D.A., Saftig P., Bahlo M.
Am. J. Hum. Genet. 82:673-684(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN EPM4.
[14]"A nonsense mutation in the LIMP-2 gene associated with progressive myoclonic epilepsy and nephrotic syndrome."
Balreira A., Gaspar P., Caiola D., Chaves J., Beirao I., Lima J.L., Azevedo J.E., Miranda M.C.
Hum. Mol. Genet. 17:2238-2243(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN EPM4.
[15]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-45; ASN-68; ASN-105; ASN-206; ASN-249; ASN-304 AND ASN-325.
Tissue: Liver.
[16]"Mutation of SCARB2 in a patient with progressive myoclonus epilepsy and demyelinating peripheral neuropathy."
Dibbens L.M., Karakis I., Bayly M.A., Costello D.J., Cole A.J., Berkovic S.F.
Arch. Neurol. 68:812-813(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN EPM4.
[17]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[18]"A mutation in SCARB2 is a modifier in Gaucher disease."
Velayati A., DePaolo J., Gupta N., Choi J.H., Moaven N., Westbroek W., Goker-Alpan O., Goldin E., Stubblefield B.K., Kolodny E., Tayebi N., Sidransky E.
Hum. Mutat. 32:1232-1238(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN GAUCHER DISEASE AS MODIFIER GENE, VARIANT GLY-471.
[19]"Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36."
Neculai D., Schwake M., Ravichandran M., Zunke F., Collins R.F., Peters J., Neculai M., Plumb J., Loppnau P., Pizarro J.C., Seitova A., Trimble W.S., Saftig P., Grinstein S., Dhe-Paganon S.
Nature 504:172-176(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 35-430, DISULFIDE BOND, GLYCOSYLATION AT ASN-45; ASN-68; ASN-206; ASN-224; ASN-249; ASN-304; ASN-325 AND ASN-412, INTERACTION WITH GBA.
[20]"Biochemical and molecular findings in a patient with myoclonic epilepsy due to a mistarget of the beta-glucosidase enzyme."
Dardis A., Filocamo M., Grossi S., Ciana G., Franceschetti S., Dominissini S., Rubboli G., Di Rocco M., Bembi B.
Mol. Genet. Metab. 97:309-311(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT EPM4 ASN-363.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D12676 mRNA. Translation: BAA02177.1.
BT006939 mRNA. Translation: AAP35585.1.
AK296519 mRNA. Translation: BAG59150.1.
AK313016 mRNA. Translation: BAG35851.1.
AC034139 Genomic DNA. No translation available.
AC110795 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX05779.1.
BC021892 mRNA. Translation: AAH21892.1.
PIRA56525.
RefSeqNP_001191184.1. NM_001204255.1.
NP_005497.1. NM_005506.3.
UniGeneHs.349656.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4F7BX-ray3.00A/B/C/D/E/F35-430[»]
ProteinModelPortalQ14108.
SMRQ14108. Positions 36-428.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107388. 11 interactions.
IntActQ14108. 9 interactions.
MINTMINT-4054592.
STRING9606.ENSP00000264896.

PTM databases

PhosphoSiteQ14108.

Polymorphism databases

DMDM2498525.

Proteomic databases

PaxDbQ14108.
PeptideAtlasQ14108.
PRIDEQ14108.

Protocols and materials databases

DNASU950.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000264896; ENSP00000264896; ENSG00000138760. [Q14108-1]
ENST00000452464; ENSP00000399154; ENSG00000138760. [Q14108-2]
GeneID950.
KEGGhsa:950.
UCSCuc003hju.2. human. [Q14108-1]

Organism-specific databases

CTD950.
GeneCardsGC04M077079.
HGNCHGNC:1665. SCARB2.
HPACAB015415.
HPA018014.
MIM254900. phenotype.
602257. gene.
neXtProtNX_Q14108.
Orphanet163696. Action myoclonus - renal failure syndrome.
77259. Gaucher disease type 1.
308. Unverricht-Lundborg disease.
PharmGKBPA35038.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG257244.
HOGENOMHOG000252951.
HOVERGENHBG106707.
InParanoidQ14108.
KOK12384.
OMALNESVHI.
OrthoDBEOG79SDWX.
PhylomeDBQ14108.
TreeFamTF317925.

Gene expression databases

ArrayExpressQ14108.
BgeeQ14108.
CleanExHS_SCARB2.
GenevestigatorQ14108.

Family and domain databases

InterProIPR002159. CD36.
IPR005429. LimpII.
[Graphical view]
PANTHERPTHR11923. PTHR11923. 1 hit.
PfamPF01130. CD36. 1 hit.
[Graphical view]
PRINTSPR01609. CD36FAMILY.
PR01611. LIMPII.
ProtoNetSearch...

Other

ChiTaRSSCARB2. human.
GeneWikiSCARB2.
GenomeRNAi950.
NextBio3952.
PROQ14108.
SOURCESearch...

Entry information

Entry nameSCRB2_HUMAN
AccessionPrimary (citable) accession number: Q14108
Secondary accession number(s): B4DKD8, E7EM68, Q53Y63
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM