Q14108 (SCRB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lysosome membrane protein 2

Alternative name(s):
85 kDa lysosomal membrane sialoglycoprotein
Short name=LGP85
CD36 antigen-like 2
Lysosome membrane protein II
Short name=LIMP II
Scavenger receptor class B member 2
CD_antigen=CD36

Gene names

Name:	SCARB2
Synonyms:	CD36L2, LIMPII

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. Ref.11
Subunit structure	Interacts with GBA (via the coiled-coil domain). Ref.11
Subcellular location	Lysosome membrane; Multi-pass membrane protein Ref.11 Ref.12.
Involvement in disease	Epilepsy, progressive myoclonic 4, with or without renal failure (EPM4) [MIM:254900]: An autosomal recessive progressive myoclonic epilepsy associated with renal failure in some cases. Cognitive function is preserved. Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13 Ref.14 Ref.16 Ref.18 Ref.19 Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease. Ref.18
Sequence similarities	Belongs to the CD36 family.
Mass spectrometry	Molecular mass is 54158.97 Da from positions 2 - 478. Determined by MALDI. Ref.9

Ontologies

Keywords
Cellular component	Lysosome Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Epilepsy
Domain	Coiled coil Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from electronic annotation. Source: InterPro protein targeting to lysosome Inferred from mutant phenotype Ref.11. Source: BHF-UCL
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc lysosomal lumen Inferred from sequence or structural similarity Ref.11. Source: BHF-UCL lysosomal membrane Inferred from sequence or structural similarity Ref.11. Source: BHF-UCL
Molecular_function	receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Gba	P17439	1	EBI-1564650,EBI-1564504	From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q14108-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q14108-2)

The sequence of this isoform differs from the canonical sequence as follows:
     93-235: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 478	477	Lysosome membrane protein 2		PRO_0000144155
Regions
	Topological domain	2 – 4	3	Cytoplasmic Potential
	Transmembrane	5 – 27	23	Helical; Potential
	Topological domain	28 – 433	406	Lumenal Potential
	Transmembrane	434 – 459	26	Helical; Potential
	Topological domain	460 – 478	19	Cytoplasmic Potential
	Coiled coil	150 – 167	18	Ref.11
Amino acid modifications
	Glycosylation	45	1	N-linked (GlcNAc...) Ref.15
	Glycosylation	68	1	N-linked (GlcNAc...) Ref.15
	Glycosylation	105	1	N-linked (GlcNAc...) Ref.15
	Glycosylation	206	1	N-linked (GlcNAc...) Ref.15
	Glycosylation	224	1	N-linked (GlcNAc...) Potential
	Glycosylation	249	1	N-linked (GlcNAc...) Ref.10 Ref.15
	Glycosylation	304	1	N-linked (GlcNAc...) Ref.15
	Glycosylation	325	1	N-linked (GlcNAc...) Ref.15
	Glycosylation	412	1	N-linked (GlcNAc...) Ref.10
	Glycosylation	430	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	93 – 235	143	Missing in isoform 2.		VSP_044826
	Natural variant	363	1	H → N in EPM4; no renal failure. Ref.19		VAR_066744
	Natural variant	471	1	E → G May act as a modifier of Gaucher disease. Ref.18		VAR_066745
Experimental info
	Mutagenesis	475	1	L → A, G, D or V: Prevents the targeting of the protein to lysosomes. Ref.8
	Mutagenesis	475	1	L → I: Some loss in the efficiency of targeting of the protein to lysosomes. Ref.8
	Mutagenesis	476	1	I → A or V: Does not prevent the targeting of the protein to lysosomes completely. Ref.8
	Mutagenesis	476	1	I → D, E or G: Prevents the targeting of the protein to lysosomes. Ref.8
	Mutagenesis	476	1	I → L: Normal targeting of the protein to lysosomes. Ref.8
	Mutagenesis	477	1	R → A, E, G, K or Q: Normal targeting of the protein to lysosomes. Ref.8
	Mutagenesis	478	1	T → G, I, S or V: Normal targeting of the protein to lysosomes. Ref.8
	Sequence conflict	351	1	S → P in BAG59150. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: FDCF27F3BA337B2C	FASTA	478	54,290
	10 20 30 40 50 60 MGRCCFYTAG TLSLLLLVTS VTLLVARVFQ KAVDQSIEKK IVLRNGTEAF DSWEKPPLPV 70 80 90 100 110 120 YTQFYFFNVT NPEEILRGET PRVEEVGPYT YRELRNKANI QFGDNGTTIS AVSNKAYVFE 130 140 150 160 170 180 RDQSVGDPKI DLIRTLNIPV LTVIEWSQVH FLREIIEAML KAYQQKLFVT HTVDELLWGY 190 200 210 220 230 240 KDEILSLIHV FRPDISPYFG LFYEKNGTND GDYVFLTGED SYLNFTKIVE WNGKTSLDWW 250 260 270 280 290 300 ITDKCNMING TDGDSFHPLI TKDEVLYVFP SDFCRSVYIT FSDYESVQGL PAFRYKVPAE 310 320 330 340 350 360 ILANTSDNAG FCIPEGNCLG SGVLNVSICK NGAPIIMSFP HFYQADERFV SAIEGMHPNQ 370 380 390 400 410 420 EDHETFVDIN PLTGIILKAA KRFQINIYVK KLDDFVETGD IRTMVFPVMY LNESVHIDKE 430 440 450 460 470 TASRLKSMIN TTLIITNIPY IIMALGVFFG LVFTWLACKG QGSMDEGTAD ERAPLIRT
	Isoform 2 [UniParc]. Checksum: 41D643B2B222B187	FASTA	335	37,767
	10 20 30 40 50 60 MGRCCFYTAG TLSLLLLVTS VTLLVARVFQ KAVDQSIEKK IVLRNGTEAF DSWEKPPLPV 70 80 90 100 110 120 YTQFYFFNVT NPEEILRGET PRVEEVGPYT YRSLDWWITD KCNMINGTDG DSFHPLITKD 130 140 150 160 170 180 EVLYVFPSDF CRSVYITFSD YESVQGLPAF RYKVPAEILA NTSDNAGFCI PEGNCLGSGV 190 200 210 220 230 240 LNVSICKNGA PIIMSFPHFY QADERFVSAI EGMHPNQEDH ETFVDINPLT GIILKAAKRF 250 260 270 280 290 300 QINIYVKKLD DFVETGDIRT MVFPVMYLNE SVHIDKETAS RLKSMINTTL IITNIPYIIM 310 320 330 ALGVFFGLVF TWLACKGQGS MDEGTADERA PLIRT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and sequencing of a cDNA clone encoding the 85 kDa human lysosomal sialoglycoprotein (hLGP85) in human metastatic pancreas islet tumor cells." Fujita H., Takata Y., Kono A., Tanaka Y., Takahashi T., Himeno M., Kato K. Biochem. Biophys. Res. Commun. 184:604-611(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The CD36, CLA-1 (CD36L1), and LIMPII (CD36L2) gene family: cellular distribution, chromosomal location, and genetic evolution." Calvo D., Dopazo J., Vega M.A. Genomics 25:100-106(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Cerebellum and Thalamus.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Eye.
[8]	"The residues Leu(Ile)475-Ile(Leu, Val, Ala)476, contained in the extended carboxyl cytoplasmic tail, are critical for targeting of the resident lysosomal membrane protein LIMP II to lysosomes." Sandoval I.V., Arredondo J.J., Alcalde J., Gonzalez Noriega A., Vandekerckhove J., Jimenez M.A., Rico M. J. Biol. Chem. 269:6622-6631(1994) [PubMed] [Europe PMC] [Abstract] Cited for: MUTAGENESIS OF LEU-475; ILE-476; ARG-477 AND THR-478.
[9]	"Cluster analysis of an extensive human breast cancer cell line protein expression map database." Harris R.A., Yang A., Stein R.C., Lucy K., Brusten L., Herath A., Parekh R., Waterfield M.D., O'Hare M.J., Neville M.A., Page M.J., Zvelebil M.J. Proteomics 2:212-223(2002) [PubMed] [Europe PMC] [Abstract] Cited for: MASS SPECTROMETRY. Tissue: Mammary cancer.
[10]	"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry." Zhang H., Li X.-J., Martin D.B., Aebersold R. Nat. Biotechnol. 21:660-666(2003) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION AT ASN-249 AND ASN-412.
[11]	"LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of beta-glucocerebrosidase." Reczek D., Schwake M., Schroder J., Hughes H., Blanz J., Jin X., Brondyk W., Van Patten S., Edmunds T., Saftig P. Cell 131:770-783(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, COILED-COIL DOMAIN, INTERACTION WITH GBA.
[12]	"Integral and associated lysosomal membrane proteins." Schroeder B., Wrocklage C., Pan C., Jaeger R., Koesters B., Schaefer H., Elsaesser H.-P., Mann M., Hasilik A. Traffic 8:1676-1686(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Tissue: Placenta.
[13]	"Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis." Berkovic S.F., Dibbens L.M., Oshlack A., Silver J.D., Katerelos M., Vears D.F., Luellmann-Rauch R., Blanz J., Zhang K.W., Stankovich J., Kalnins R.M., Dowling J.P., Andermann E., Andermann F., Faldini E., D'Hooge R., Vadlamudi L., Macdonell R.A. , Hodgson B.L., Bayly M.A., Savige J., Mulley J.C., Smyth G.K., Power D.A., Saftig P., Bahlo M. Am. J. Hum. Genet. 82:673-684(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN EPM4.
[14]	"A nonsense mutation in the LIMP-2 gene associated with progressive myoclonic epilepsy and nephrotic syndrome." Balreira A., Gaspar P., Caiola D., Chaves J., Beirao I., Lima J.L., Azevedo J.E., Miranda M.C. Hum. Mol. Genet. 17:2238-2243(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN EPM4.
[15]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-45; ASN-68; ASN-105; ASN-206; ASN-249; ASN-304 AND ASN-325, MASS SPECTROMETRY. Tissue: Liver.
[16]	"Mutation of SCARB2 in a patient with progressive myoclonus epilepsy and demyelinating peripheral neuropathy." Dibbens L.M., Karakis I., Bayly M.A., Costello D.J., Cole A.J., Berkovic S.F. Arch. Neurol. 68:812-813(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN EPM4.
[17]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[18]	"A mutation in SCARB2 is a modifier in Gaucher disease." Velayati A., DePaolo J., Gupta N., Choi J.H., Moaven N., Westbroek W., Goker-Alpan O., Goldin E., Stubblefield B.K., Kolodny E., Tayebi N., Sidransky E. Hum. Mutat. 32:1232-1238(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN GAUCHER DISEASE AS MODIFIER GENE, VARIANT GLY-471.
[19]	"Biochemical and molecular findings in a patient with myoclonic epilepsy due to a mistarget of the beta-glucosidase enzyme." Dardis A., Filocamo M., Grossi S., Ciana G., Franceschetti S., Dominissini S., Rubboli G., Di Rocco M., Bembi B. Mol. Genet. Metab. 97:309-311(2009) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT EPM4 ASN-363.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D12676 mRNA. Translation: BAA02177.1. BT006939 mRNA. Translation: AAP35585.1. AK296519 mRNA. Translation: BAG59150.1. AK313016 mRNA. Translation: BAG35851.1. AC034139 Genomic DNA. No translation available. AC110795 Genomic DNA. No translation available. CH471057 Genomic DNA. Translation: EAX05779.1. BC021892 mRNA. Translation: AAH21892.1.
IPI	IPI00217766. IPI00909338.
PIR	A56525.
RefSeq	NP_001191184.1. NM_001204255.1. NP_005497.1. NM_005506.3.
UniGene	Hs.349656. Hs.714206.
3D structure databases
ProteinModelPortal	Q14108.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q14108. 5 interactions.
MINT	MINT-4054592.
STRING	9606.ENSP00000264896.
PTM databases
PhosphoSite	Q14108.
Polymorphism databases
DMDM	2498525.
Proteomic databases
PaxDb	Q14108.
PeptideAtlas	Q14108.
PRIDE	Q14108.
Protocols and materials databases
DNASU	950.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264896; ENSP00000264896; ENSG00000138760. ENST00000452464; ENSP00000399154; ENSG00000138760.
GeneID	950.
KEGG	hsa:950.
UCSC	uc003hju.2. human.
Organism-specific databases
CTD	950.
GeneCards	GC04M077079.
HGNC	HGNC:1665. SCARB2.
HPA	CAB015415. HPA018014.
MIM	254900. phenotype. 602257. gene.
neXtProt	NX_Q14108.
Orphanet	163696. Action myoclonus - renal failure syndrome. 77259. Gaucher disease type 1. 308. Unverricht-Lundborg disease.
PharmGKB	PA35038.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG257244.
HOGENOM	HOG000252951.
HOVERGEN	HBG106707.
InParanoid	Q14108.
KO	K12384.
OMA	LNESVHI.
OrthoDB	EOG4CJVHB.
PhylomeDB	Q14108.
Gene expression databases
ArrayExpress	Q14108.
Bgee	Q14108.
CleanEx	HS_SCARB2.
Genevestigator	Q14108.
GermOnline	ENSG00000138760. Homo sapiens.
Family and domain databases
InterPro	IPR002159. CD36. IPR005429. LimpII. [Graphical view]
PANTHER	PTHR11923. PTHR11923. 1 hit.
Pfam	PF01130. CD36. 1 hit. [Graphical view]
PRINTS	PR01609. CD36FAMILY. PR01611. LIMPII.
ProtoNet	Search...
Other
ChiTaRS	SCARB2. human.
GenomeRNAi	950.
NextBio	3952.
SOURCE	Search...

Entry information

Entry name

SCRB2_HUMAN

Accession

Primary (citable) accession number: Q14108
Secondary accession number(s): B4DKD8, E7EM68, Q53Y63

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 126 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.