Reviewed, UniProtKB/Swiss-Prot Q14106 (TOB2_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein Tob2
Alternative name(s):
    Transducer of erbB-2 2
    Protein Tob4

Gene names

Name:	TOB2
Synonyms:	KIAA1663, TOB4, TROB2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.
Subunit structure	Associates with CAF1.
Subcellular location	Cytoplasm.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the BTG family.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	female gamete generation Ref.1 Traceable author statement. Source: ProtInc negative regulation of cell proliferation Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 344	344	Protein Tob2		PRO_0000143815
Experimental info
	Sequence conflict	34 – 35	2	RL → QA in BAA10971. Ref.1
	Sequence conflict	214	1	P → H in BAA10971. Ref.1
	Sequence conflict	278 – 317	40	QGSGT…FLEKT → RAAAPQARLEAVGLAPATAA ALTWPRYLEVVPTASSWRRH in BAA10971. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q14106-1 [UniParc]. Last modified January 24, 2001. Version 2. Checksum: ACE4CD8939641BD5	FASTA	344	36,632
	10 20 30 40 50 60 MQLEIKVALN FIISYLYNKL PRRRADLFGE ELERLLKKKY EGHWYPEKPL KGSGFRCVHI 70 80 90 100 110 120 GEMVDPVVEL AAKRSGLAVE DVRANVPEEL SVWIDPFEVS YQIGEKGAVK VLYLDDSEGC 130 140 150 160 170 180 GAPELDKEIK SSFNPDAQVF VPIGSQDSSL SNSPSPSFGQ SPSPTFIPRS AQPITFTTAS 190 200 210 220 230 240 FAATKFGSTK MKKGGGAASG GGVASSGAGG QQPPQQPRMA RSPTNSLLKH KSLSLSMHSL 250 260 270 280 290 300 NFITANPAPQ SQLSPNAKEF VYNGGGSPSL FFDAADGQGS GTPGPFGGSG AGTCNSSSFD 310 320 330 340 MAQVFGGGAN SLFLEKTPFV EGLSYNLNTM QYPSQQFQPV VLAN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases." Ikematsu N., Yoshida Y., Kawamura-Tsuzuku J., Ohsugi M., Onda M., Hirai M., Fujimoto J., Yamamoto T. Oncogene 18:7432-7441(1999) [PubMed: 10602502] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping." Hirosawa M., Nagase T., Murahashi Y., Kikuno R., Ohara O. DNA Res. 8:1-9(2001) [PubMed: 11258795] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) [PubMed: 15461802] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed: 10591208] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D64109 mRNA. Translation: BAA10971.1. AB035207 mRNA. Translation: BAA87042.1. AB051450 mRNA. Translation: BAB33333.1. Different initiation. CR456594 mRNA. Translation: CAG30480.1. CR541684 mRNA. Translation: CAG46485.1. AL008582 Genomic DNA. Translation: CAB62938.1. BC038957 mRNA. Translation: AAH38957.1.
IPI	IPI00028889.
RefSeq	NP_057356.1.
UniGene	Hs.474978
3D structure databases
SMR	Q14106. Positions 1-115.
ModBase	Search...
Protein-protein interaction databases
STRING	Q14106.
Proteomic databases
PRIDE	Q14106.
Genome annotation databases
Ensembl	ENST00000327492; ENSP00000331305; ENSG00000183864; Homo sapiens. [Genome view] ENST00000434408; ENSP00000388549; ENSG00000183864; Homo sapiens. [Genome view]
GeneID	10766.
KEGG	hsa:10766.
UCSC	uc003azz.1. human.
Organism-specific databases
CTD	10766.
GeneCards	GC22M040153.
H-InvDB	HIX0016518.
HGNC	HGNC:11980. TOB2.
MIM	607396. gene.
PharmGKB	PA36664.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q14106.
HOVERGEN	Q14106.
OMA	QPFQPVV.
Gene expression databases
ArrayExpress	Q14106.
Bgee	Q14106.
CleanEx	HS_TOB2.
Genevestigator	Q14106.
GermOnline	ENSG00000183864. Homo sapiens.
Family and domain databases
InterPro	IPR002087. Anti_prolifrtn. IPR009818. Ataxin-2_C. IPR015676. TOB. IPR015678. TOB2. [Graphical view]
PANTHER	PTHR17537. TOB. 1 hit. PTHR17537:SF3. TOB2. 1 hit.
Pfam	PF07742. BTG. 1 hit. PF07145. PAM2. 2 hits. [Graphical view]
PRINTS	PR00310. ANTIPRLFBTG1.
SMART	SM00099. btg1. 1 hit. [Graphical view]
PROSITE	PS00960. BTG_1. 1 hit. PS01203. BTG_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	40881.
SOURCE	Search...

Entry information

Entry name

TOB2_HUMAN

Accession

Primary (citable) accession number: Q14106
Secondary accession number(s): Q6FHR7, Q9BY97, Q9UBI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 24, 2001
Last modified:	November 3, 2009
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.