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Protein

Protein Tob2

Gene

TOB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.

GO - Molecular functioni

GO - Biological processi

  • female gamete generation Source: ProtInc
  • negative regulation of cell proliferation Source: ProtInc
  • negative regulation of osteoclast differentiation Source: Ensembl
  • positive regulation of ossification Source: Ensembl
  • regulation of gene expression Source: GO_Central
  • signaling Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32054-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Tob2
Alternative name(s):
Protein Tob4
Transducer of erbB-2 2
Gene namesi
Name:TOB2
Synonyms:KIAA1663, TOB4, TROB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:11980. TOB2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10766.
OpenTargetsiENSG00000183864.
PharmGKBiPA36664.

Polymorphism and mutation databases

BioMutaiTOB2.
DMDMi12643431.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438151 – 344Protein Tob2Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei254PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ14106.
MaxQBiQ14106.
PaxDbiQ14106.
PeptideAtlasiQ14106.
PRIDEiQ14106.

PTM databases

iPTMnetiQ14106.
PhosphoSitePlusiQ14106.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000183864.
CleanExiHS_TOB2.
ExpressionAtlasiQ14106. baseline and differential.
GenevisibleiQ14106. HS.

Organism-specific databases

HPAiHPA054112.

Interactioni

Subunit structurei

Associates with CAF1.

Binary interactionsi

WithEntry#Exp.IntActNotes
BHLHE40O145033EBI-2562000,EBI-711810
CEP76Q8TAP63EBI-2562000,EBI-742887
CNOT7Q9UIV15EBI-2562000,EBI-2105113
CNOT8Q9UFF93EBI-2562000,EBI-742299
PABPC1P119404EBI-2562000,EBI-81531

Protein-protein interaction databases

BioGridi115985. 14 interactors.
DIPiDIP-41990N.
IntActiQ14106. 11 interactors.
MINTiMINT-203035.
STRINGi9606.ENSP00000331305.

Structurei

3D structure databases

ProteinModelPortaliQ14106.
SMRiQ14106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000253939.
HOVERGENiHBG006617.
InParanoidiQ14106.
KOiK14443.
OMAiMQYPSQS.
OrthoDBiEOG091G0LEQ.
PhylomeDBiQ14106.
TreeFamiTF105274.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
IPR009818. Ataxin-2_C.
IPR015676. Tob1/2.
IPR015678. Tob2.
[Graphical view]
PANTHERiPTHR17537. PTHR17537. 1 hit.
PTHR17537:SF3. PTHR17537:SF3. 1 hit.
PfamiPF07742. BTG. 1 hit.
PF07145. PAM2. 2 hits.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14106-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQLEIKVALN FIISYLYNKL PRRRADLFGE ELERLLKKKY EGHWYPEKPL
60 70 80 90 100
KGSGFRCVHI GEMVDPVVEL AAKRSGLAVE DVRANVPEEL SVWIDPFEVS
110 120 130 140 150
YQIGEKGAVK VLYLDDSEGC GAPELDKEIK SSFNPDAQVF VPIGSQDSSL
160 170 180 190 200
SNSPSPSFGQ SPSPTFIPRS AQPITFTTAS FAATKFGSTK MKKGGGAASG
210 220 230 240 250
GGVASSGAGG QQPPQQPRMA RSPTNSLLKH KSLSLSMHSL NFITANPAPQ
260 270 280 290 300
SQLSPNAKEF VYNGGGSPSL FFDAADGQGS GTPGPFGGSG AGTCNSSSFD
310 320 330 340
MAQVFGGGAN SLFLEKTPFV EGLSYNLNTM QYPSQQFQPV VLAN
Length:344
Mass (Da):36,632
Last modified:January 24, 2001 - v2
Checksum:iACE4CD8939641BD5
GO
Isoform 2 (identifier: Q14106-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     245-344: ANPAPQSQLS...QQFQPVVLAN → DYNHDQ

Note: No experimental confirmation available.
Show »
Length:250
Mass (Da):27,192
Checksum:i70F83F6D4DF29526
GO

Sequence cautioni

The sequence BAB33333 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34 – 35RL → QA in BAA10971 (PubMed:10602502).Curated2
Sequence conflicti214P → H in BAA10971 (PubMed:10602502).Curated1
Sequence conflicti278 – 317QGSGT…FLEKT → RAAAPQARLEAVGLAPATAA ALTWPRYLEVVPTASSWRRH in BAA10971 (PubMed:10602502).CuratedAdd BLAST40

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055557245 – 344ANPAP…VVLAN → DYNHDQ in isoform 2. 1 PublicationAdd BLAST100

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D64109 mRNA. Translation: BAA10971.1.
AB035207 mRNA. Translation: BAA87042.1.
AB051450 mRNA. Translation: BAB33333.1. Different initiation.
CR456594 mRNA. Translation: CAG30480.1.
CR541684 mRNA. Translation: CAG46485.1.
AL008582 Genomic DNA. Translation: CAB62938.1.
BC028919 mRNA. Translation: AAH28919.1.
BC038957 mRNA. Translation: AAH38957.1.
CCDSiCCDS14015.1. [Q14106-1]
RefSeqiNP_057356.1. NM_016272.3. [Q14106-1]
XP_005261372.1. XM_005261315.2. [Q14106-1]
XP_006724168.1. XM_006724105.3. [Q14106-1]
XP_016884028.1. XM_017028539.1. [Q14106-1]
UniGeneiHs.474978.

Genome annotation databases

EnsembliENST00000327492; ENSP00000331305; ENSG00000183864. [Q14106-1]
GeneIDi10766.
KEGGihsa:10766.
UCSCiuc003azz.2. human. [Q14106-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D64109 mRNA. Translation: BAA10971.1.
AB035207 mRNA. Translation: BAA87042.1.
AB051450 mRNA. Translation: BAB33333.1. Different initiation.
CR456594 mRNA. Translation: CAG30480.1.
CR541684 mRNA. Translation: CAG46485.1.
AL008582 Genomic DNA. Translation: CAB62938.1.
BC028919 mRNA. Translation: AAH28919.1.
BC038957 mRNA. Translation: AAH38957.1.
CCDSiCCDS14015.1. [Q14106-1]
RefSeqiNP_057356.1. NM_016272.3. [Q14106-1]
XP_005261372.1. XM_005261315.2. [Q14106-1]
XP_006724168.1. XM_006724105.3. [Q14106-1]
XP_016884028.1. XM_017028539.1. [Q14106-1]
UniGeneiHs.474978.

3D structure databases

ProteinModelPortaliQ14106.
SMRiQ14106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115985. 14 interactors.
DIPiDIP-41990N.
IntActiQ14106. 11 interactors.
MINTiMINT-203035.
STRINGi9606.ENSP00000331305.

PTM databases

iPTMnetiQ14106.
PhosphoSitePlusiQ14106.

Polymorphism and mutation databases

BioMutaiTOB2.
DMDMi12643431.

Proteomic databases

EPDiQ14106.
MaxQBiQ14106.
PaxDbiQ14106.
PeptideAtlasiQ14106.
PRIDEiQ14106.

Protocols and materials databases

DNASUi10766.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327492; ENSP00000331305; ENSG00000183864. [Q14106-1]
GeneIDi10766.
KEGGihsa:10766.
UCSCiuc003azz.2. human. [Q14106-1]

Organism-specific databases

CTDi10766.
DisGeNETi10766.
GeneCardsiTOB2.
HGNCiHGNC:11980. TOB2.
HPAiHPA054112.
MIMi607396. gene.
neXtProtiNX_Q14106.
OpenTargetsiENSG00000183864.
PharmGKBiPA36664.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4006. Eukaryota.
ENOG410ZZC0. LUCA.
GeneTreeiENSGT00550000074461.
HOGENOMiHOG000253939.
HOVERGENiHBG006617.
InParanoidiQ14106.
KOiK14443.
OMAiMQYPSQS.
OrthoDBiEOG091G0LEQ.
PhylomeDBiQ14106.
TreeFamiTF105274.

Enzyme and pathway databases

BioCyciZFISH:G66-32054-MONOMER.

Miscellaneous databases

ChiTaRSiTOB2. human.
GeneWikiiTOB2.
GenomeRNAii10766.
PROiQ14106.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183864.
CleanExiHS_TOB2.
ExpressionAtlasiQ14106. baseline and differential.
GenevisibleiQ14106. HS.

Family and domain databases

InterProiIPR002087. Anti_prolifrtn.
IPR009818. Ataxin-2_C.
IPR015676. Tob1/2.
IPR015678. Tob2.
[Graphical view]
PANTHERiPTHR17537. PTHR17537. 1 hit.
PTHR17537:SF3. PTHR17537:SF3. 1 hit.
PfamiPF07742. BTG. 1 hit.
PF07145. PAM2. 2 hits.
[Graphical view]
PRINTSiPR00310. ANTIPRLFBTG1.
SMARTiSM00099. btg1. 1 hit.
[Graphical view]
SUPFAMiSSF160696. SSF160696. 1 hit.
PROSITEiPS00960. BTG_1. 1 hit.
PS01203. BTG_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOB2_HUMAN
AccessioniPrimary (citable) accession number: Q14106
Secondary accession number(s): Q6FHR7
, Q6PIT9, Q9BY97, Q9UBI0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 24, 2001
Last modified: November 30, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.