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Protein
Submitted name:

CYP2B protein

Gene

CYP2B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
CYP2B proteinImported
Submitted name:
Cytochrome P450 2B7 short isoformImported
Gene namesi
Name:CYP2BImported
Synonyms:CYP2B7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Chemistry

DrugBankiDB00856. Chlorphenesin.
DB00366. Doxylamine.
DB00472. Fluoxetine.
DB01149. Nefazodone.
DB01104. Sertraline.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 377355Sequence analysisPRO_5007699176Add
BLAST

Proteomic databases

PeptideAtlasiQ14097.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

HOVERGENiHBG015789.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14097-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSVLLFLA LLTGLLLLLV QRHPNSHGTL PPGPRPLPLL GNLLQMDRRG
60 70 80 90 100
LLKSFLRFRE KYGDVFTVHL GPRPVVMLCG VEAIREALVD NAEAFSGRGK
110 120 130 140 150
IVIMDPVYQG YGMLFANGNR WKVLRRFSVT TMRDFGMGKR SVEERIQDEA
160 170 180 190 200
QCLIEELRKS KGALVDPTFL FHSITANIIC SIIFGKRFHY QDQEFLKTLN
210 220 230 240 250
LFCQSFLLIS SISSQLFELF SGFLKYFPGA HRQVYKNLQE INAYIGHSVE
260 270 280 290 300
KHRETLDPSA PRDLIDTYLL HMEKEKSNPH SEFSHQNLII NTLSLFFAGT
310 320 330 340 350
ETTSTTLRYG FLLMLKYPHV AERVYKEIEQ VVGPHRPPAL DDRAKMPYTE
360 370
AVIREIQRFA DLLPMGVPHI VTQHTSF
Length:377
Mass (Da):43,148
Last modified:November 1, 1996 - v1
Checksum:i2869CA952D4DF004
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29873 mRNA. Translation: AAA52143.1.
DQ198367 mRNA. Translation: ABB05543.1.
UniGeneiHs.529117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29873 mRNA. Translation: AAA52143.1.
DQ198367 mRNA. Translation: ABB05543.1.
UniGeneiHs.529117.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

DrugBankiDB00856. Chlorphenesin.
DB00366. Doxylamine.
DB00472. Fluoxetine.
DB01149. Nefazodone.
DB01104. Sertraline.

Proteomic databases

PeptideAtlasiQ14097.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

H-InvDBHIX0027523.

Phylogenomic databases

HOVERGENiHBG015789.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver."
    Yamano S., Nhamburo P.T., Aoyama T., Meyer U.A., Inaba T., Kalow W., Gelboin H.V., McBride O.W., Gonzalez F.J.
    Biochemistry 28:7340-7348(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Identification and functional characterization of a CYP2B7 variant from African-Americans."
    Court M.H., Alrohaimi A.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ14097_HUMAN
AccessioniPrimary (citable) accession number: Q14097
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.