Q14097 (Q14097_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
CYP2B protein EMBL AAA52143.1

Submitted name:
Cytochrome P450 2B7 short isoform EMBL ABB05543.1
Submitted name:
Uncharacterized protein Ensembl ENSP00000441190

Gene names

Name:	CYP2B EMBL AAA52143.1 HGNC 2614
Synonyms:	CYP2B7 EMBL ABB05543.1

Organism

Homo sapiens (Human) EMBL AAA52143.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the cytochrome P450 family. RuleBase RU000461

Ontologies

Keywords
Ligand	Heme RuleBase RU000461 Iron Metal-binding
Molecular function	Monooxygenase RuleBase RU003700 Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q14097 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 2869CA952D4DF004	FASTA	377	43,148
	10 20 30 40 50 60 MELSVLLFLA LLTGLLLLLV QRHPNSHGTL PPGPRPLPLL GNLLQMDRRG LLKSFLRFRE 70 80 90 100 110 120 KYGDVFTVHL GPRPVVMLCG VEAIREALVD NAEAFSGRGK IVIMDPVYQG YGMLFANGNR 130 140 150 160 170 180 WKVLRRFSVT TMRDFGMGKR SVEERIQDEA QCLIEELRKS KGALVDPTFL FHSITANIIC 190 200 210 220 230 240 SIIFGKRFHY QDQEFLKTLN LFCQSFLLIS SISSQLFELF SGFLKYFPGA HRQVYKNLQE 250 260 270 280 290 300 INAYIGHSVE KHRETLDPSA PRDLIDTYLL HMEKEKSNPH SEFSHQNLII NTLSLFFAGT 310 320 330 340 350 360 ETTSTTLRYG FLLMLKYPHV AERVYKEIEQ VVGPHRPPAL DDRAKMPYTE AVIREIQRFA 370 DLLPMGVPHI VTQHTSF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver." Yamano S., Nhamburo P.T., Aoyama T., Meyer U.A., Inaba T., Kalow W., Gelboin H.V., McBride O.W., Gonzalez F.J. Biochemistry 28:7340-7348(1989) [PubMed: 2573390] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Identification and functional characterization of a CYP2B7 variant from African-Americans." Court M.H., Alrohaimi A. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC008537 Genomic DNA. No translation available. AC092071 Genomic DNA. No translation available. M29873 mRNA. Translation: AAA52143.1. DQ198367 mRNA. Translation: ABB05543.1.
IPI	IPI00066215.
UniGene	Hs.529117.
3D structure databases
HSSP	HSSP built from PDB template 1PO5 based on UniProtKB P00178.
ProteinModelPortal	Q14097.
SMR	Q14097. Positions 42-377.
ModBase	Search...
Protein-protein interaction databases
STRING	Q14097.
Proteomic databases
PRIDE	Q14097.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000541697; ENSP00000441190; ENSG00000256612.
NMPDR	fig|9606.3.peg.16493.
Organism-specific databases
H-InvDB	HIX0027523.
Phylogenomic databases
eggNOG	prNOG10968.
HOVERGEN	HBG015789.
PhylomeDB	Q14097.
Gene expression databases
ArrayExpress	Q14097.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR002401. Cyt_P450_E_grp-I. IPR008068. Cyt_P450_E_grp-I_CYP2B-like. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01685. EP450ICYP2B. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q14097_HUMAN

Accession

Primary (citable) accession number: Q14097

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	December 14, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.