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Protein

Cylicin-2

Gene

CYLC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Possible architectural role during spermatogenesis. May be involved in spermatid differentiation.

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Cylicin-2
Alternative name(s):
Cylicin II
Multiple-band polypeptide II
Gene namesi
Name:CYLC2
Synonyms:CYL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:2583. CYLC2.

Subcellular locationi

GO - Cellular componenti

  • cytoskeletal calyx Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27083.

Polymorphism and mutation databases

BioMutaiCYLC2.
DMDMi2498278.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Cylicin-2PRO_0000079755Add
BLAST

Proteomic databases

PaxDbiQ14093.
PeptideAtlasiQ14093.
PRIDEiQ14093.

PTM databases

iPTMnetiQ14093.
PhosphoSiteiQ14093.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiENSG00000155833.
CleanExiHS_CYLC2.
ExpressionAtlasiQ14093. baseline and differential.
GenevisibleiQ14093. HS.

Interactioni

Protein-protein interaction databases

BioGridi107919. 2 interactions.
IntActiQ14093. 13 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ14093.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati157 – 184281Add
BLAST
Repeati185 – 212282Add
BLAST
Repeati213 – 240283Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 34732331 X 3 AA repeats of K-K-XAdd
BLAST
Regioni157 – 240843 X approximate tandem repeatsAdd
BLAST

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J18N. Eukaryota.
ENOG4111C35. LUCA.
GeneTreeiENSGT00730000111075.
HOGENOMiHOG000112131.
InParanoidiQ14093.
OMAiPRXSELS.
OrthoDBiEOG091G0PH9.
PhylomeDBiQ14093.
TreeFamiTF337809.

Family and domain databases

InterProiIPR026189. CYLC.
IPR029354. Cylicin_N.
[Graphical view]
PANTHERiPTHR16742. PTHR16742. 1 hit.
PfamiPF15241. Cylicin_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14093-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPRFQRVN FGPYDNYIPV SELSKKSWNQ QHFALLFPKP QRPGTKRRSK
60 70 80 90 100
PSQIRDNTVS IIDEEQLRGD RRQPLWMYRS LMRISERPSV YLAARRQPLK
110 120 130 140 150
PTRTVEVDSK AAEIGKKGED KTTQKDTTDS ESELKQGKKD SKKGKDIEKG
160 170 180 190 200
KEEKLDAKKD SKKGKKDAEK GKDSATESED EKGGAKKDNK KDKKDSNKGK
210 220 230 240 250
DSATESEGEK GGTEKDSKKG KKDSKKGKDS AIELQAVKAD EKKDEDGKKD
260 270 280 290 300
ANKGDESKDA KKDAKEIKKG KKDKKKPSST DSDSKDDVKK ESKKDATKDA
310 320 330 340
KKVAKKDTEK ESADSKKDAK KNAKKDAKKD AKKNAKKDEK KDAKKKGK
Length:348
Mass (Da):39,079
Last modified:November 1, 1997 - v1
Checksum:iD86766599C1809E7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti146 – 1461D → Y.
Corresponds to variant rs13293961 [ dbSNP | Ensembl ].
VAR_050938
Natural varianti184 – 1841G → D.
Corresponds to variant rs10990424 [ dbSNP | Ensembl ].
VAR_050939
Natural varianti190 – 1901K → E.
Corresponds to variant rs2298050 [ dbSNP | Ensembl ].
VAR_020100
Natural varianti208 – 2081G → D.
Corresponds to variant rs2298051 [ dbSNP | Ensembl ].
VAR_020101
Natural varianti319 – 3191A → E.
Corresponds to variant rs3763636 [ dbSNP | Ensembl ].
VAR_020102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46788 mRNA. Translation: CAA86752.1.
AK313349 mRNA. Translation: BAG36151.1.
AL449304 Genomic DNA. No translation available.
BC114547 mRNA. Translation: AAI14548.1.
CCDSiCCDS35085.1.
PIRiI37271.
RefSeqiNP_001331.1. NM_001340.4.
UniGeneiHs.3232.

Genome annotation databases

EnsembliENST00000374798; ENSP00000420256; ENSG00000155833.
ENST00000487798; ENSP00000417674; ENSG00000155833.
ENST00000612124; ENSP00000478399; ENSG00000155833.
GeneIDi1539.
KEGGihsa:1539.
UCSCiuc004bbs.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46788 mRNA. Translation: CAA86752.1.
AK313349 mRNA. Translation: BAG36151.1.
AL449304 Genomic DNA. No translation available.
BC114547 mRNA. Translation: AAI14548.1.
CCDSiCCDS35085.1.
PIRiI37271.
RefSeqiNP_001331.1. NM_001340.4.
UniGeneiHs.3232.

3D structure databases

ProteinModelPortaliQ14093.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107919. 2 interactions.
IntActiQ14093. 13 interactions.

PTM databases

iPTMnetiQ14093.
PhosphoSiteiQ14093.

Polymorphism and mutation databases

BioMutaiCYLC2.
DMDMi2498278.

Proteomic databases

PaxDbiQ14093.
PeptideAtlasiQ14093.
PRIDEiQ14093.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374798; ENSP00000420256; ENSG00000155833.
ENST00000487798; ENSP00000417674; ENSG00000155833.
ENST00000612124; ENSP00000478399; ENSG00000155833.
GeneIDi1539.
KEGGihsa:1539.
UCSCiuc004bbs.2. human.

Organism-specific databases

CTDi1539.
GeneCardsiCYLC2.
HGNCiHGNC:2583. CYLC2.
MIMi604035. gene.
neXtProtiNX_Q14093.
PharmGKBiPA27083.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J18N. Eukaryota.
ENOG4111C35. LUCA.
GeneTreeiENSGT00730000111075.
HOGENOMiHOG000112131.
InParanoidiQ14093.
OMAiPRXSELS.
OrthoDBiEOG091G0PH9.
PhylomeDBiQ14093.
TreeFamiTF337809.

Miscellaneous databases

ChiTaRSiCYLC2. human.
GenomeRNAii1539.
PROiQ14093.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155833.
CleanExiHS_CYLC2.
ExpressionAtlasiQ14093. baseline and differential.
GenevisibleiQ14093. HS.

Family and domain databases

InterProiIPR026189. CYLC.
IPR029354. Cylicin_N.
[Graphical view]
PANTHERiPTHR16742. PTHR16742. 1 hit.
PfamiPF15241. Cylicin_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYLC2_HUMAN
AccessioniPrimary (citable) accession number: Q14093
Secondary accession number(s): B2R8F4, Q5VVJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.