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Protein

Ras-related protein Rab-33A

Gene

RAB33A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi43 – 50GTPBy similarity8
Nucleotide bindingi91 – 95GTPBy similarity5
Nucleotide bindingi151 – 154GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • antigen processing and presentation Source: UniProtKB
  • membrane organization Source: Reactome
  • regulation of autophagosome assembly Source: GO_Central

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8854214. TBC/RABGAPs.
R-HSA-8873719. RAB geranylgeranylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-33A
Alternative name(s):
Small GTP-binding protein S10
Gene namesi
Name:RAB33A
Synonyms:RABS10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:9773. RAB33A.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9363.
OpenTargetsiENSG00000134594.
PharmGKBiPA34124.

Polymorphism and mutation databases

BioMutaiRAB33A.
DMDMi2500071.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212371 – 237Ras-related protein Rab-33AAdd BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi235S-geranylgeranyl cysteineBy similarity1
Modified residuei237Cysteine methyl esterBy similarity1
Lipidationi237S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ14088.
MaxQBiQ14088.
PaxDbiQ14088.
PeptideAtlasiQ14088.
PRIDEiQ14088.

PTM databases

iPTMnetiQ14088.
PhosphoSitePlusiQ14088.

Expressioni

Tissue specificityi

Expressed only in lymphoid cell lines.

Gene expression databases

BgeeiENSG00000134594.
CleanExiHS_RAB33A.
GenevisibleiQ14088. HS.

Organism-specific databases

HPAiHPA059737.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi114764. 8 interactors.
IntActiQ14088. 13 interactors.
MINTiMINT-1455156.
STRINGi9606.ENSP00000257017.

Structurei

3D structure databases

ProteinModelPortaliQ14088.
SMRiQ14088.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0084. Eukaryota.
ENOG410XQN5. LUCA.
GeneTreeiENSGT00880000137857.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ14088.
KOiK07919.
OMAiWIEECNG.
OrthoDBiEOG091G0FVM.
PhylomeDBiQ14088.
TreeFamiTF300097.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q14088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQPILGHGS LQPASAAGLA SLELDSSLDQ YVQIRIFKII VIGDSNVGKT
60 70 80 90 100
CLTFRFCGGT FPDKTEATIG VDFREKTVEI EGEKIKVQVW DTAGQERFRK
110 120 130 140 150
SMVEHYYRNV HAVVFVYDVT KMTSFTNLKM WIQECNGHAV PPLVPKVLVG
160 170 180 190 200
NKCDLREQIQ VPSNLALKFA DAHNMLLFET SAKDPKESQN VESIFMCLAC
210 220 230
RLKAQKSLLY RDAERQQGKV QKLEFPQEAN SKTSCPC
Length:237
Mass (Da):26,593
Last modified:May 1, 1997 - v2
Checksum:i2EE23B8237225F4A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_006849102M → T. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14889 mRNA. Translation: BAA03606.1.
AF498959 mRNA. Translation: AAM21107.1.
BT007038 mRNA. Translation: AAP35687.1.
AL139234 Genomic DNA. No translation available.
BC001157 mRNA. Translation: AAH01157.1.
BC009996 mRNA. Translation: AAH09996.1.
CCDSiCCDS14621.1.
PIRiS35058.
RefSeqiNP_004785.1. NM_004794.2.
UniGeneiHs.654356.

Genome annotation databases

EnsembliENST00000257017; ENSP00000257017; ENSG00000134594.
GeneIDi9363.
KEGGihsa:9363.
UCSCiuc004evl.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRB33A_HUMAN
AccessioniPrimary (citable) accession number: Q14088
Secondary accession number(s): Q5JUZ6, Q92465
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 7, 2017
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families