Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-33A

Gene

RAB33A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi43 – 508GTPBy similarity
Nucleotide bindingi91 – 955GTPBy similarity
Nucleotide bindingi151 – 1544GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • antigen processing and presentation Source: UniProtKB
  • intracellular protein transport Source: GO_Central
  • metabolic process Source: GOC
  • Rab protein signal transduction Source: GO_Central
  • regulation of autophagosome assembly Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-33A
Alternative name(s):
Small GTP-binding protein S10
Gene namesi
Name:RAB33A
Synonyms:RABS10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:9773. RAB33A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34124.

Polymorphism and mutation databases

BioMutaiRAB33A.
DMDMi2500071.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Ras-related protein Rab-33APRO_0000121237Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi235 – 2351S-geranylgeranyl cysteineBy similarity
Modified residuei237 – 2371Cysteine methyl esterBy similarity
Lipidationi237 – 2371S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiQ14088.
PaxDbiQ14088.
PRIDEiQ14088.

PTM databases

PhosphoSiteiQ14088.

Expressioni

Tissue specificityi

Expressed only in lymphoid cell lines.

Gene expression databases

BgeeiQ14088.
CleanExiHS_RAB33A.
GenevisibleiQ14088. HS.

Organism-specific databases

HPAiHPA059737.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ARL6IP1Q150413EBI-744685,EBI-714543
CCDC136Q96JN2-23EBI-744685,EBI-10171416
Hoxa1P090223EBI-744685,EBI-3957603From a different organism.
RABAC1Q9UI143EBI-744685,EBI-712367
SIAH1Q8IUQ43EBI-744685,EBI-747107

Protein-protein interaction databases

BioGridi114764. 9 interactions.
IntActiQ14088. 7 interactions.
MINTiMINT-1455156.
STRINGi9606.ENSP00000257017.

Structurei

3D structure databases

ProteinModelPortaliQ14088.
SMRiQ14088. Positions 35-199.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00800000124063.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ14088.
KOiK07919.
OMAiTWIEECN.
OrthoDBiEOG78PVB5.
PhylomeDBiQ14088.
TreeFamiTF300097.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q14088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQPILGHGS LQPASAAGLA SLELDSSLDQ YVQIRIFKII VIGDSNVGKT
60 70 80 90 100
CLTFRFCGGT FPDKTEATIG VDFREKTVEI EGEKIKVQVW DTAGQERFRK
110 120 130 140 150
SMVEHYYRNV HAVVFVYDVT KMTSFTNLKM WIQECNGHAV PPLVPKVLVG
160 170 180 190 200
NKCDLREQIQ VPSNLALKFA DAHNMLLFET SAKDPKESQN VESIFMCLAC
210 220 230
RLKAQKSLLY RDAERQQGKV QKLEFPQEAN SKTSCPC
Length:237
Mass (Da):26,593
Last modified:May 1, 1997 - v2
Checksum:i2EE23B8237225F4A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021M → T.
VAR_006849

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14889 mRNA. Translation: BAA03606.1.
AF498959 mRNA. Translation: AAM21107.1.
BT007038 mRNA. Translation: AAP35687.1.
AL139234 Genomic DNA. Translation: CAI42781.1.
BC001157 mRNA. Translation: AAH01157.1.
BC009996 mRNA. Translation: AAH09996.1.
CCDSiCCDS14621.1.
PIRiS35058.
RefSeqiNP_004785.1. NM_004794.2.
UniGeneiHs.654356.

Genome annotation databases

EnsembliENST00000257017; ENSP00000257017; ENSG00000134594.
GeneIDi9363.
KEGGihsa:9363.
UCSCiuc004evl.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14889 mRNA. Translation: BAA03606.1.
AF498959 mRNA. Translation: AAM21107.1.
BT007038 mRNA. Translation: AAP35687.1.
AL139234 Genomic DNA. Translation: CAI42781.1.
BC001157 mRNA. Translation: AAH01157.1.
BC009996 mRNA. Translation: AAH09996.1.
CCDSiCCDS14621.1.
PIRiS35058.
RefSeqiNP_004785.1. NM_004794.2.
UniGeneiHs.654356.

3D structure databases

ProteinModelPortaliQ14088.
SMRiQ14088. Positions 35-199.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114764. 9 interactions.
IntActiQ14088. 7 interactions.
MINTiMINT-1455156.
STRINGi9606.ENSP00000257017.

PTM databases

PhosphoSiteiQ14088.

Polymorphism and mutation databases

BioMutaiRAB33A.
DMDMi2500071.

Proteomic databases

MaxQBiQ14088.
PaxDbiQ14088.
PRIDEiQ14088.

Protocols and materials databases

DNASUi9363.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257017; ENSP00000257017; ENSG00000134594.
GeneIDi9363.
KEGGihsa:9363.
UCSCiuc004evl.3. human.

Organism-specific databases

CTDi9363.
GeneCardsiGC0XP129305.
HGNCiHGNC:9773. RAB33A.
HPAiHPA059737.
MIMi300333. gene.
neXtProtiNX_Q14088.
PharmGKBiPA34124.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00800000124063.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ14088.
KOiK07919.
OMAiTWIEECN.
OrthoDBiEOG78PVB5.
PhylomeDBiQ14088.
TreeFamiTF300097.

Miscellaneous databases

GeneWikiiRAB33A.
GenomeRNAii9363.
NextBioi35063.
PROiQ14088.
SOURCEiSearch...

Gene expression databases

BgeeiQ14088.
CleanExiHS_RAB33A.
GenevisibleiQ14088. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a cDNA encoding a novel small GTP-binding protein."
    Koda T., Kakinuma M.
    FEBS Lett. 328:21-24(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRB33A_HUMAN
AccessioniPrimary (citable) accession number: Q14088
Secondary accession number(s): Q5JUZ6, Q92465
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: July 22, 2015
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.