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Unreviewed, UniProtKB/TrEMBL Q14015 (Q14015_HUMAN)

Last modified January 19, 2010. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    PR371 c-K-ras oncogene EMBL AAA35690.1
OrganismHomo sapiens (Human) EMBL AAA35690.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length150 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level.

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Ontologies

Keywords
   LigandGTP-binding RuleBase RU003312V0 Spearmint SPM003577
Nucleotide-binding
Gene Ontology (GO)
   Biological processactin cytoskeleton organization

Inferred from electronic annotation. Source: Compara

cell aging

Inferred from electronic annotation. Source: Compara

cytokine-mediated signaling pathway

Inferred from electronic annotation. Source: Compara

endocytosis

Inferred from electronic annotation. Source: Compara

negative regulation of neuron apoptosis

Inferred from electronic annotation. Source: Compara

positive regulation of MAP kinase activity

Inferred from electronic annotation. Source: Compara

positive regulation of NF-kappaB transcription factor activity

Inferred from electronic annotation. Source: Compara

positive regulation of Rac protein signal transduction

Inferred from electronic annotation. Source: Compara

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Compara

positive regulation of nitric-oxide synthase activity

Inferred from electronic annotation. Source: Compara

regulation of long-term neuronal synaptic plasticity

Inferred from electronic annotation. Source: Compara

regulation of synaptic transmission, GABAergic

Inferred from electronic annotation. Source: Compara

response to glucocorticoid stimulus

Inferred from electronic annotation. Source: Compara

response to mineralocorticoid stimulus

Inferred from electronic annotation. Source: Compara

small GTPase mediated signal transduction

Inferred from electronic annotation. Source: InterPro

striated muscle cell differentiation

Inferred from electronic annotation. Source: Compara

visual learning

Inferred from electronic annotation. Source: Compara

   Cellular componentintracellular

Inferred from electronic annotation. Source: InterPro

membrane fraction

Inferred from electronic annotation. Source: Compara

membrane raft

Inferred from electronic annotation. Source: Compara

   Molecular functionGDP binding

Inferred from electronic annotation. Source: Compara

GMP binding

Inferred from electronic annotation. Source: Compara

GTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: InterPro

LRR domain binding

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue1501 EMBL AAA35690.1

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Sequences

Sequence LengthMass (Da)Tools
Q14015-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 5F5862DE1353B889

FASTA15016,991
        10         20         30         40         50         60 
MTEYKLVVVG ACGVGKSALT IQLIDNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG 

        70         80         90        100        110        120 
QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI KRVKDSEDVP MVLVGNKCDL 

       130        140        150 
PSRTVDTKQA QDLARSYGIP FIQTSAKTRQ

« Hide

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References

[1]"Structure and mechanisms of activation of c-K-ras oncogenes in human lung cancer."
Yamamoto F., Nakano H., Neville C., Perucho M.
Prog. Med. Virol. 32:101-114(1985) [PubMed: 3895297] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M35505 mRNA. Translation: AAA35690.1.
IPIIPI00423570.
PIRI80324.
UniGeneHs.505033

3D structure databases

HSSPHSSP built from PDB template 1PLL based on UniProtKB P01112.
SMRQ14015. Positions 1-150.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ14015.

Genome annotation databases

EnsemblENST00000256078; ENSP00000256078; ENSG00000133703; Homo sapiens. [Genome view]
ENST00000311936; ENSP00000308495; ENSG00000133703; Homo sapiens. [Genome view]
ENST00000395977; ENSP00000379301; ENSG00000133703; Homo sapiens. [Genome view]

Organism-specific databases

HGNCHGNC:6407. KRAS.

Phylogenomic databases

HOVERGENQ14015.

Gene expression databases

ArrayExpressQ14015.
BgeeQ14015.

Family and domain databases

InterProIPR003577. GTPase_Ras.
IPR013753. Ras.
IPR001806. Ras_GTPase.
IPR015592. Ras_Ras_related.
IPR020849. Ras_small_GTPase.
IPR005225. Small_GTP_bd.
[Graphical view]
PANTHERPTHR11708:SF125. Ras_Ras_related. 1 hit.
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00173. RAS. 1 hit.
[Graphical view]
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameQ14015_HUMAN
AccessionPrimary (citable) accession number: Q14015
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: January 19, 2010
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
Names and origin · Protein attributes · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information