Reviewed, UniProtKB/Swiss-Prot Q14011 (CIRBP_HUMAN)

Names and origin

Protein names

Recommended name:
    Cold-inducible RNA-binding protein
Alternative name(s):
    Glycine-rich RNA-binding protein CIRP
    A18 hnRNP

Gene names

Name:	CIRBP
Synonyms:	A18HNRNP, CIRP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Seems to play an essential role in cold-induced suppression of cell proliferation.
Subcellular location	Nucleus › nucleoplasm By similarity.
Tissue specificity	Ubiquitous.
Induction	By cold stress an in response to DNA damage induced by UV irradiation or UV mimetic agents.
Sequence similarities	Contains 1 RRM (RNA recognition motif) domain.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Nucleus
Ligand	RNA-binding
Technical term	3D-structure
Gene Ontology (GO)
Biological process	response to cold Traceable author statement. Source: ProtInc
Cellular component	nucleoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Traceable author statement. Source: ProtInc nucleotide binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LXN	Q9BS40	1	EBI-538850,EBI-1044504

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 172

172

Cold-inducible RNA-binding protein

PRO_0000081503

Regions

Domain

6 – 84

79

RRM

Compositional bias

92 – 158

67

Gly-rich

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

172

Helix Strand Turn

Details...

Beta strand

6 – 12

7

Helix

19 – 29

11

Beta strand

34 – 37

4

Beta strand

41 – 43

3

Beta strand

48 – 53

6

Helix

57 – 67

11

Beta strand

78 – 83

6

Sequences

	Sequence		Length	Mass (Da)
	Q14011-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 003FABF28F5405D0	FASTA	172	18,648
	10 20 30 40 50 60 MASDEGKLFV GGLSFDTNEQ SLEQVFSKYG QISEVVVVKD RETQRSRGFG FVTFENIDDA 70 80 90 100 110 120 KDAMMAMNGK SVDGRQIRVD QAGKSSDNRS RGYRGGSAGG RGFFRGGRGR GRGFSRGGGD 130 140 150 160 170 RGYGGNRFES RSGGYGGSRD YYSSRSQSGG YSDRSSGGSY RDSYDSYATH NE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene." Nishiyama H., Higashitsuji H., Yokoi H., Itoh K., Danno S., Matsuda T., Fujita J. Gene 204:115-120(1997) [PubMed: 9434172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein." Sheikh M.S., Carrier F., Papathanasiou M.A., Hollander M.C., Zhan Q., Yu K., Fornace A.J. Jr. J. Biol. Chem. 272:26720-26726(1997) [PubMed: 9334257] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Placenta.
[5]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[6]	"Solution structure of RRM domain in A18 HNRNP." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 1-90.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

D78134 mRNA. Translation: BAA11212.1.
AF021336 mRNA. Translation: AAC51787.1.
AC004258 Genomic DNA. Translation: AAC04895.1.
BC000403 mRNA. Translation: AAH00403.1.
BC000901 mRNA. Translation: AAH00901.1.

IPI

IPI00180954.

RefSeq

NP_001271.1.

UniGene

Hs.634522
Hs.664127

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1X5S	NMR	-	A	1-89	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q14011. 5 interactions.

PTM databases

PhosphoSite

Q14011.

2-D gel databases

REPRODUCTION-2DPAGE

IPI00180954.

Proteomic databases

PRIDE

Q14011.

Genome annotation databases

Ensembl

ENSG00000099622. Homo sapiens. [Contig view]

GeneID

1153.

KEGG

hsa:1153.

Organism-specific databases

GeneCards

GC19P001220.

H-InvDB

HIX0014577.

HGNC

HGNC:1982. CIRBP.

MIM

602649. gene.

PharmGKB

PA26519.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q14011.

HOVERGEN

Q14011.

OMA

Q14011. YGQIAEV.

Gene expression databases

ArrayExpress

Q14011.

Bgee

Q14011.

CleanEx

HS_CIRBP.

GermOnline

ENSG00000099622. Homo sapiens.

Family and domain databases

InterPro

IPR012677. a_b_plait_nuc_bd.
IPR000504. RRM_RNP1.
[Graphical view]

Gene3D

G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit.

Pfam

PF00076. RRM_1. 1 hit.
[Graphical view]

SMART

SM00360. RRM. 1 hit.
[Graphical view]

PROSITE

PS50102. RRM. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

4788.

SOURCE

Search...

Entry information

Entry name

CIRBP_HUMAN

Accession

Primary (citable) accession number: Q14011

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)