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Protein

Cytoskeleton-associated protein 5

Gene

CKAP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles.2 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • centrosome organization Source: HGNC
  • establishment or maintenance of microtubule cytoskeleton polarity Source: HGNC
  • G2/M transition of mitotic cell cycle Source: Reactome
  • mitotic cell cycle Source: Reactome
  • mitotic nuclear division Source: UniProtKB-KW
  • organelle organization Source: Reactome
  • RNA transport Source: HGNC
  • small GTPase mediated signal transduction Source: Reactome
  • spindle organization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoskeleton-associated protein 5
Alternative name(s):
Colonic and hepatic tumor overexpressed gene protein
Short name:
Ch-TOG
Gene namesi
Name:CKAP5
Synonyms:KIAA0097
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28959. CKAP5.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytosol Source: Reactome
  • membrane Source: UniProtKB
  • protein complex Source: MGI
  • spindle pole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672107.

Polymorphism and mutation databases

BioMutaiCKAP5.
DMDMi212276513.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20322032Cytoskeleton-associated protein 5PRO_0000089663Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481N6-acetyllysineCombined sources
Modified residuei816 – 8161PhosphoserineCombined sources
Modified residuei1861 – 18611PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14008.
MaxQBiQ14008.
PaxDbiQ14008.
PRIDEiQ14008.

PTM databases

iPTMnetiQ14008.
PhosphoSiteiQ14008.
SwissPalmiQ14008.

Expressioni

Tissue specificityi

Overexpressed in hepatomas and colonic tumors. Also expressed in skeletal muscle, brain, heart, placenta, lung, liver, kidney and pancreas.

Gene expression databases

BgeeiQ14008.
CleanExiHS_CKAP5.
ExpressionAtlasiQ14008. baseline and differential.
GenevisibleiQ14008. HS.

Organism-specific databases

HPAiHPA039377.
HPA040375.

Interactioni

Subunit structurei

Interacts with TACC1 (PubMed:11903063). Interacts with SLAIN2 (PubMed:21646404). Interacts with HNRNPA2B1 (PubMed:15703215).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163333EBI-310585,EBI-389883
SLAIN2Q9P2704EBI-310585,EBI-3959887
TACC1O754104EBI-310585,EBI-624237
TACC1O75410-13EBI-310585,EBI-624252
TACC1O75410-62EBI-310585,EBI-624278
TACC3Q9Y6A57EBI-310585,EBI-2554984

Protein-protein interaction databases

BioGridi115137. 93 interactions.
IntActiQ14008. 61 interactions.
MINTiMINT-5002817.
STRINGi9606.ENSP00000432768.

Structurei

Secondary structure

1
2032
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi858 – 8603Combined sources
Helixi863 – 8697Combined sources
Helixi874 – 89118Combined sources
Beta strandi892 – 8943Combined sources
Helixi901 – 9066Combined sources
Turni907 – 9104Combined sources
Helixi914 – 93118Combined sources
Helixi932 – 9387Combined sources
Turni939 – 9424Combined sources
Helixi943 – 9486Combined sources
Helixi949 – 9513Combined sources
Helixi955 – 97218Combined sources
Helixi975 – 9784Combined sources
Beta strandi979 – 9813Combined sources
Helixi982 – 9876Combined sources
Helixi992 – 100514Combined sources
Helixi1006 – 10083Combined sources
Helixi1016 – 10194Combined sources
Helixi1020 – 10278Combined sources
Helixi1032 – 104918Combined sources
Helixi1051 – 10566Combined sources
Helixi1057 – 10604Combined sources
Helixi1063 – 107614Combined sources
Helixi1077 – 10793Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4QMIX-ray1.90A/B846-1081[»]
4QMJX-ray2.50A846-1081[»]
ProteinModelPortaliQ14008.
SMRiQ14008. Positions 852-1080.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati159 – 19739HEAT 1Add
BLAST
Repeati356 – 39439HEAT 2Add
BLAST
Repeati434 – 47239HEAT 3Add
BLAST
Repeati750 – 78839HEAT 4Add
BLAST
Repeati855 – 89339HEAT 5Add
BLAST
Repeati936 – 97439HEAT 6Add
BLAST
Repeati1013 – 105139HEAT 7Add
BLAST
Repeati1284 – 132239HEAT 8Add
BLAST
Repeati1324 – 135734HEAT 9Add
BLAST
Repeati1361 – 139939HEAT 10Add
BLAST

Sequence similaritiesi

Belongs to the TOG/XMAP215 family.Curated
Contains 10 HEAT repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1820. Eukaryota.
ENOG410XPTW. LUCA.
GeneTreeiENSGT00390000014757.
HOVERGENiHBG050955.
InParanoidiQ14008.
KOiK16803.
OMAiITEFGFQ.
OrthoDBiEOG751NDM.
PhylomeDBiQ14008.
TreeFamiTF105639.

Family and domain databases

Gene3Di1.25.10.10. 6 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024395. CLASP_N_dom.
IPR021133. HEAT_type_2.
[Graphical view]
PfamiPF12348. CLASP_N. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 10 hits.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14008-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDDSEWLKL PVDQKCEHKL WKARLSGYEE ALKIFQKIKD EKSPEWSKFL
60 70 80 90 100
GLIKKFVTDS NAVVQLKGLE AALVYVENAH VAGKTTGEVV SGVVSKVFNQ
110 120 130 140 150
PKAKAKELGI EICLMYIEIE KGEAVQEELL KGLDNKNPKI IVACIETLRK
160 170 180 190 200
ALSEFGSKII LLKPIIKVLP KLFESREKAV RDEAKLIAVE IYRWIRDALR
210 220 230 240 250
PPLQNINSVQ LKELEEEWVK LPTSAPRPTR FLRSQQELEA KLEQQQSAGG
260 270 280 290 300
DAEGGGDDGD EVPQIDAYEL LEAVEILSKL PKDFYDKIEA KKWQERKEAL
310 320 330 340 350
ESVEVLIKNP KLEAGDYADL VKALKKVVGK DTNVMLVALA AKCLTGLAVG
360 370 380 390 400
LRKKFGQYAG HVVPTILEKF KEKKPQVVQA LQEAIDAIFL TTTLQNISED
410 420 430 440 450
VLAVMDNKNP TIKQQTSLFI ARSFRHCTAS TLPKSLLKPF CAALLKHIND
460 470 480 490 500
SAPEVRDAAF EALGTALKVV GEKAVNPFLA DVDKLKLDKI KECSEKVELI
510 520 530 540 550
HGKKAGLAAD KKEFKPLPGR TAASGAAGDK DTKDISAPKP GPLKKAPAAK
560 570 580 590 600
AGGPPKKGKP AAPGGAGNTG TKNKKGLETK EIVEPELSIE VCEEKASAVL
610 620 630 640 650
PPTCIQLLDS SNWKERLACM EEFQKAVELM DRTEMPCQAL VRMLAKKPGW
660 670 680 690 700
KETNFQVMQM KLHIVALIAQ KGNFSKTSAQ VVLDGLVDKI GDVKCGNNAK
710 720 730 740 750
EAMTAIAEAC MLPWTAEQVV SMAFSQKNPK NQSETLNWLS NAIKEFGFSG
760 770 780 790 800
LNVKAFISNV KTALAATNPA VRTAAITLLG VMYLYVGPSL RMFFEDEKPA
810 820 830 840 850
LLSQIDAEFE KMQGQSPPAP TRGISKHSTS GTDEGEDGDE PDDGSNDVVD
860 870 880 890 900
LLPRTEISDK ITSELVSKIG DKNWKIRKEG LDEVAGIIND AKFIQPNIGE
910 920 930 940 950
LPTALKGRLN DSNKILVQQT LNILQQLAVA MGPNIKQHVK NLGIPIITVL
960 970 980 990 1000
GDSKNNVRAA ALATVNAWAE QTGMKEWLEG EDLSEELKKE NPFLRQELLG
1010 1020 1030 1040 1050
WLAEKLPTLR STPTDLILCV PHLYSCLEDR NGDVRKKAQD ALPFFMMHLG
1060 1070 1080 1090 1100
YEKMAKATGK LKPTSKDQVL AMLEKAKVNM PAKPAPPTKA TSKPMGGSAP
1110 1120 1130 1140 1150
AKFQPASAPA EDCISSSTEP KPDPKKAKAP GLSSKAKSAQ GKKMPSKTSL
1160 1170 1180 1190 1200
KEDEDKSGPI FIVVPNGKEQ RMKDEKGLKV LKWNFTTPRD EYIEQLKTQM
1210 1220 1230 1240 1250
SSCVAKWLQD EMFHSDFQHH NKALAVMVDH LESEKEGVIG CLDLILKWLT
1260 1270 1280 1290 1300
LRFFDTNTSV LMKALEYLKL LFTLLSEEEY HLTENEASSF IPYLVVKVGE
1310 1320 1330 1340 1350
PKDVIRKDVR AILNRMCLVY PASKMFPFIM EGTKSKNSKQ RAECLEELGC
1360 1370 1380 1390 1400
LVESYGMNVC QPTPGKALKE IAVHIGDRDN AVRNAALNTI VTVYNVHGDQ
1410 1420 1430 1440 1450
VFKLIGNLSE KDMSMLEERI KRSAKRPSAA PIKQVEEKPQ RAQNISSNAN
1460 1470 1480 1490 1500
MLRKGPAEDM SSKLNQARSM SGHPEAAQMV RREFQLDLDE IENDNGTVRC
1510 1520 1530 1540 1550
EMPELVQHKL DDIFEPVLIP EPKIRAVSPH FDDMHSNTAS TINFIISQVA
1560 1570 1580 1590 1600
SGDINTSIQA LTQIDEVLRQ EDKAEAMSGH IDQFLIATFM QLRLIYNTHM
1610 1620 1630 1640 1650
ADEKLEKDEI IKLYSCIIGN MISLFQIESL AREASTGVLK DLMHGLITLM
1660 1670 1680 1690 1700
LDSRIEDLEE GQQVIRSVNL LVVKVLEKSD QTNILSALLV LLQDSLLATA
1710 1720 1730 1740 1750
SSPKFSELVM KCLWRMVRLL PDTINSINLD RILLDIHIFM KVFPKEKLKQ
1760 1770 1780 1790 1800
CKSEFPIRTL KTLLHTLCKL KGPKILDHLT MIDNKNESEL EAHLCRMMKH
1810 1820 1830 1840 1850
SMDQTGSKSD KETEKGASRI DEKSSKAKVN DFLAEIFKKI GSKENTKEGL
1860 1870 1880 1890 1900
AELYEYKKKY SDADIEPFLK NSSQFFQSYV ERGLRVIEME REGKGRISTS
1910 1920 1930 1940 1950
TGISPQMEVT CVPTPTSTVS SIGNTNGEEV GPSVYLERLK ILRQRCGLDN
1960 1970 1980 1990 2000
TKQDDRPPLT SLLSKPAVPT VASSTDMLHS KLSQLRESRE QHQHSDLDSN
2010 2020 2030
QTHSSGTVTS SSSTANIDDL KKRLERIKSS RK
Length:2,032
Mass (Da):225,495
Last modified:November 4, 2008 - v3
Checksum:iB2BBFB1CF2ED688B
GO
Isoform 2 (identifier: Q14008-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1564-1623: Missing.

Show »
Length:1,972
Mass (Da):218,525
Checksum:i17596E610D1B7FC9
GO
Isoform 3 (identifier: Q14008-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1774-1774: K → KSCMCLPQ

Note: No experimental confirmation available.
Show »
Length:2,039
Mass (Da):226,258
Checksum:i94281848BC2A3952
GO

Sequence cautioni

The sequence AAH17856.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH70136.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI11044.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI20871.1 differs from that shown. Reason: Frameshift at position 18. Curated
The sequence BAA07892.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti476 – 4761N → K in CAA63212 (PubMed:8536682).Curated
Sequence conflicti476 – 4761N → K in BAA07892 (PubMed:7788527).Curated
Sequence conflicti1814 – 18141E → A in CAA63212 (PubMed:8536682).Curated
Sequence conflicti1822 – 18221E → A in CAA63212 (PubMed:8536682).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti785 – 7851Y → C.
Corresponds to variant rs11038988 [ dbSNP | Ensembl ].
VAR_045627

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1564 – 162360Missing in isoform 2. 1 PublicationVSP_035668Add
BLAST
Alternative sequencei1774 – 17741K → KSCMCLPQ in isoform 3. 1 PublicationVSP_036400

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92474 mRNA. Translation: CAA63212.1.
D43948 mRNA. Translation: BAA07892.2. Different initiation.
AC115088 Genomic DNA. No translation available.
BC017856 mRNA. Translation: AAH17856.1. Sequence problems.
BC070136 mRNA. Translation: AAH70136.1. Sequence problems.
BC111043 mRNA. Translation: AAI11044.1. Sequence problems.
BC120869 mRNA. Translation: AAI20870.1.
BC120870 mRNA. Translation: AAI20871.1. Frameshift.
CCDSiCCDS31477.1. [Q14008-1]
CCDS7924.1. [Q14008-2]
PIRiS68176.
RefSeqiNP_001008938.1. NM_001008938.3. [Q14008-1]
NP_055571.2. NM_014756.3. [Q14008-2]
UniGeneiHs.201253.
Hs.737795.

Genome annotation databases

EnsembliENST00000312055; ENSP00000310227; ENSG00000175216. [Q14008-2]
ENST00000354558; ENSP00000346566; ENSG00000175216. [Q14008-2]
ENST00000529230; ENSP00000432768; ENSG00000175216. [Q14008-1]
GeneIDi9793.
KEGGihsa:9793.
UCSCiuc001ndi.3. human. [Q14008-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92474 mRNA. Translation: CAA63212.1.
D43948 mRNA. Translation: BAA07892.2. Different initiation.
AC115088 Genomic DNA. No translation available.
BC017856 mRNA. Translation: AAH17856.1. Sequence problems.
BC070136 mRNA. Translation: AAH70136.1. Sequence problems.
BC111043 mRNA. Translation: AAI11044.1. Sequence problems.
BC120869 mRNA. Translation: AAI20870.1.
BC120870 mRNA. Translation: AAI20871.1. Frameshift.
CCDSiCCDS31477.1. [Q14008-1]
CCDS7924.1. [Q14008-2]
PIRiS68176.
RefSeqiNP_001008938.1. NM_001008938.3. [Q14008-1]
NP_055571.2. NM_014756.3. [Q14008-2]
UniGeneiHs.201253.
Hs.737795.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4QMIX-ray1.90A/B846-1081[»]
4QMJX-ray2.50A846-1081[»]
ProteinModelPortaliQ14008.
SMRiQ14008. Positions 852-1080.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115137. 93 interactions.
IntActiQ14008. 61 interactions.
MINTiMINT-5002817.
STRINGi9606.ENSP00000432768.

PTM databases

iPTMnetiQ14008.
PhosphoSiteiQ14008.
SwissPalmiQ14008.

Polymorphism and mutation databases

BioMutaiCKAP5.
DMDMi212276513.

Proteomic databases

EPDiQ14008.
MaxQBiQ14008.
PaxDbiQ14008.
PRIDEiQ14008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312055; ENSP00000310227; ENSG00000175216. [Q14008-2]
ENST00000354558; ENSP00000346566; ENSG00000175216. [Q14008-2]
ENST00000529230; ENSP00000432768; ENSG00000175216. [Q14008-1]
GeneIDi9793.
KEGGihsa:9793.
UCSCiuc001ndi.3. human. [Q14008-1]

Organism-specific databases

CTDi9793.
GeneCardsiCKAP5.
H-InvDBHIX0022364.
HGNCiHGNC:28959. CKAP5.
HPAiHPA039377.
HPA040375.
MIMi611142. gene.
neXtProtiNX_Q14008.
PharmGKBiPA142672107.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1820. Eukaryota.
ENOG410XPTW. LUCA.
GeneTreeiENSGT00390000014757.
HOVERGENiHBG050955.
InParanoidiQ14008.
KOiK16803.
OMAiITEFGFQ.
OrthoDBiEOG751NDM.
PhylomeDBiQ14008.
TreeFamiTF105639.

Enzyme and pathway databases

ReactomeiR-HSA-2467813. Separation of Sister Chromatids.
R-HSA-2500257. Resolution of Sister Chromatid Cohesion.
R-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-5663220. RHO GTPases Activate Formins.
R-HSA-68877. Mitotic Prometaphase.

Miscellaneous databases

ChiTaRSiCKAP5. human.
GeneWikiiCKAP5.
GenomeRNAii9793.
NextBioi36878.
PROiQ14008.
SOURCEiSearch...

Gene expression databases

BgeeiQ14008.
CleanExiHS_CKAP5.
ExpressionAtlasiQ14008. baseline and differential.
GenevisibleiQ14008. HS.

Family and domain databases

Gene3Di1.25.10.10. 6 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024395. CLASP_N_dom.
IPR021133. HEAT_type_2.
[Graphical view]
PfamiPF12348. CLASP_N. 3 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 10 hits.
PROSITEiPS50077. HEAT_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors."
    Charrasse S., Mazel M., Taviaux S., Berta P., Chow T., Larroque C.
    Eur. J. Biochem. 234:406-413(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Brain tumor.
  2. "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1."
    Nagase T., Miyajima N., Tanaka A., Sazuka T., Seki N., Sato S., Tabata S., Ishikawa K., Kawarabayasi Y., Kotani H., Nomura N.
    DNA Res. 2:37-43(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Uterus.
  5. "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells."
    Lauffart B., Howell S.J., Tasch J.E., Cowell J.K., Still I.H.
    Biochem. J. 363:195-200(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TACC1.
  6. "The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells."
    Gergely F., Draviam V.M., Raff J.W.
    Genes Dev. 17:336-341(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2."
    Kosturko L.D., Maggipinto M.J., D'Sa C., Carson J.H., Barbarese E.
    Mol. Biol. Cell 16:1938-1947(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HNRNPA2B1.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-816, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-48, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase."
    van der Vaart B., Manatschal C., Grigoriev I., Olieric V., Gouveia S.M., Bjelic S., Demmers J., Vorobjev I., Hoogenraad C.C., Steinmetz M.O., Akhmanova A.
    J. Cell Biol. 193:1083-1099(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH SLAIN2, SUBCELLULAR LOCATION.
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1861, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCKAP5_HUMAN
AccessioniPrimary (citable) accession number: Q14008
Secondary accession number(s): Q05D70
, Q0VAX7, Q0VAX8, Q14668, Q2TA89, Q6NSH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 4, 2008
Last modified: April 13, 2016
This is version 157 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.