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Unreviewed, UniProtKB/TrEMBL Q14007 (Q14007_HUMAN)

Last modified January 19, 2010. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    C-has/bas p21 protein EMBL AAA35687.1
OrganismHomo sapiens (Human) EMBL AAA35687.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length37 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level.

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Ontologies

Keywords
   LigandGTP-binding RuleBase RU003312V0 Spearmint SPM015592
Nucleotide-binding
Gene Ontology (GO)
   Biological processRas protein signal transduction

Inferred from electronic annotation. Source: Compara

actin cytoskeleton organization

Inferred from electronic annotation. Source: Compara

apoptosis

Inferred from electronic annotation. Source: Compara

cell aging

Inferred from electronic annotation. Source: Compara

cytokine-mediated signaling pathway

Inferred from electronic annotation. Source: Compara

endocytosis

Inferred from electronic annotation. Source: Compara

negative regulation of neuron apoptosis

Inferred from electronic annotation. Source: Compara

positive regulation of DNA replication

Inferred from electronic annotation. Source: Compara

positive regulation of MAP kinase activity

Inferred from electronic annotation. Source: Compara

positive regulation of NF-kappaB transcription factor activity

Inferred from electronic annotation. Source: Compara

positive regulation of Rac protein signal transduction

Inferred from electronic annotation. Source: Compara

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Compara

positive regulation of nitric-oxide synthase activity

Inferred from electronic annotation. Source: Compara

protein heterooligomerization

Inferred from electronic annotation. Source: Compara

regulation of long-term neuronal synaptic plasticity

Inferred from electronic annotation. Source: Compara

regulation of synaptic transmission, GABAergic

Inferred from electronic annotation. Source: Compara

response to glucocorticoid stimulus

Inferred from electronic annotation. Source: Compara

response to mineralocorticoid stimulus

Inferred from electronic annotation. Source: Compara

striated muscle cell differentiation

Inferred from electronic annotation. Source: Compara

visual learning

Inferred from electronic annotation. Source: Compara

   Cellular componentmembrane fraction

Inferred from electronic annotation. Source: Compara

membrane raft

Inferred from electronic annotation. Source: Compara

plasma membrane

Inferred from electronic annotation. Source: Compara

   Molecular functionGDP binding

Inferred from electronic annotation. Source: Compara

GMP binding

Inferred from electronic annotation. Source: Compara

GTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: InterPro

LRR domain binding

Inferred from electronic annotation. Source: Compara

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue371 EMBL AAA35687.1

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Sequences

Sequence LengthMass (Da)Tools
Q14007-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: AAA68422D73D686A

FASTA374,095
        10         20         30 
MTEYKLVVVG ADGVGKSALT IQLIQNHFVD EYDPTIE

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References

[1]"Spontaneous activation of a human proto-oncogene."
Santos E., Reddy E.P., Pulciani S., Feldmann R.J., Barbacid M.
Proc. Natl. Acad. Sci. U.S.A. 80:4679-4683(1983) [PubMed: 6308640] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"PCR detection of an insertion/deletion polymorphism in intron 1 of the HRAS1 locus."
Tanci P., Genuardi M., Santini S.A., Neri G.
Nucleic Acids Res. 20:1157-1157(1992) [PubMed: 1549493] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		K00654 Genomic DNA. Translation: AAA35687.1.
IPIIPI00791238.
UniGeneHs.37003

3D structure databases

HSSPHSSP built from PDB template 1PLL based on UniProtKB P01112.
SMRQ14007. Positions 1-37.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ14007.

Proteomic databases

PRIDEQ14007.

Genome annotation databases

EnsemblENST00000256078; ENSP00000256078; ENSG00000133703; Homo sapiens. [Genome view]
ENST00000311175; ENSP00000312305; ENSG00000174775; Homo sapiens. [Genome view]
ENST00000311189; ENSP00000309845; ENSG00000174775; Homo sapiens. [Genome view]
ENST00000311936; ENSP00000308495; ENSG00000133703; Homo sapiens. [Genome view]
ENST00000369535; ENSP00000358548; ENSG00000213281; Homo sapiens. [Genome view]
ENST00000388730; ENSP00000373382; ENSG00000174775; Homo sapiens. [Genome view]
ENST00000395977; ENSP00000379301; ENSG00000133703; Homo sapiens. [Genome view]
ENST00000397594; ENSP00000380722; ENSG00000174775; Homo sapiens. [Genome view]
ENST00000397596; ENSP00000380723; ENSG00000174775; Homo sapiens. [Genome view]
ENST00000406761; ENSP00000385392; ENSG00000133703; Homo sapiens. [Genome view]
ENST00000417302; ENSP00000388246; ENSG00000174775; Homo sapiens. [Genome view]
ENST00000451590; ENSP00000407586; ENSG00000174775; Homo sapiens. [Genome view]

Organism-specific databases

HGNCHGNC:5173. HRAS.
HGNC:6407. KRAS.
HGNC:7989. NRAS.

Phylogenomic databases

HOVERGENQ14007.

Gene expression databases

ArrayExpressQ14007.
BgeeQ14007.

Family and domain databases

InterProIPR013753. Ras.
IPR001806. Ras_GTPase.
IPR015592. Ras_Ras_related.
IPR020849. Ras_small_GTPase.
[Graphical view]
PANTHERPTHR11708:SF125. Ras_Ras_related. 1 hit.
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
PROSITEPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameQ14007_HUMAN
AccessionPrimary (citable) accession number: Q14007
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: January 19, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
Names and origin · Protein attributes · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information