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Protein

Cyclin-dependent kinase 13

Gene

CDK13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.4 Publications

Catalytic activityi

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.1 Publication
ATP + a protein = ADP + a phosphoprotein.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei734ATPPROSITE-ProRule annotation1
Active sitei837Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi711 – 719ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cyclin binding Source: MGI
  • cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  • poly(A) RNA binding Source: UniProtKB
  • protein kinase activity Source: ProtInc
  • RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB

GO - Biological processi

  • alternative mRNA splicing, via spliceosome Source: UniProtKB
  • hemopoiesis Source: UniProtKB
  • multicellular organism development Source: ProtInc
  • phosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB
  • positive regulation of cell proliferation Source: ProtInc
  • regulation of mitotic nuclear division Source: ProtInc
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Host-virus interaction, mRNA processing, mRNA splicing

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS00857-MONOMER.
ReactomeiR-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-HSA-6798695. Neutrophil degranulation.
SignaLinkiQ14004.
SIGNORiQ14004.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 13 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
CDC2-related protein kinase 5
Cell division cycle 2-like protein kinase 5
Cell division protein kinase 13
Short name:
hCDK13
Cholinesterase-related cell division controller
Gene namesi
Name:CDK13
Synonyms:CDC2L, CDC2L5, CHED, KIAA1791
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:1733. CDK13.

Subcellular locationi

GO - Cellular componenti

  • cyclin K-CDK13 complex Source: MGI
  • cytoplasm Source: HPA
  • extracellular space Source: UniProtKB
  • Golgi apparatus Source: HPA
  • nuclear cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
  • nuclear speck Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8621.
OpenTargetsiENSG00000065883.
PharmGKBiPA26264.

Chemistry databases

ChEMBLiCHEMBL1795192.
GuidetoPHARMACOLOGYi1966.

Polymorphism and mutation databases

BioMutaiCDK13.
DMDMi66774048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857111 – 1512Cyclin-dependent kinase 13Add BLAST1512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei315PhosphoserineCombined sources1
Modified residuei317PhosphoserineCombined sources1
Modified residuei325PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1
Modified residuei342PhosphoserineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei395PhosphoserineCombined sources1
Modified residuei397PhosphoserineCombined sources1
Modified residuei400PhosphoserineCombined sources1
Modified residuei437PhosphoserineCombined sources1
Modified residuei439PhosphoserineCombined sources1
Modified residuei525PhosphoserineCombined sources1
Modified residuei556N6-acetyllysineCombined sources1
Modified residuei588PhosphothreonineCombined sources1
Modified residuei871PhosphothreonineCombined sources1
Modified residuei1048PhosphoserineCombined sources1
Modified residuei1058PhosphothreonineBy similarity1
Modified residuei1246PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ14004.
MaxQBiQ14004.
PaxDbiQ14004.
PeptideAtlasiQ14004.
PRIDEiQ14004.

PTM databases

iPTMnetiQ14004.
PhosphoSitePlusiQ14004.

Miscellaneous databases

PMAP-CutDBQ14004.

Expressioni

Tissue specificityi

Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.

Gene expression databases

BgeeiENSG00000065883.
CleanExiHS_CDC2L5.
ExpressionAtlasiQ14004. baseline and differential.
GenevisibleiQ14004. HS.

Organism-specific databases

HPAiHPA059241.

Interactioni

Subunit structurei

Interacts with CCNL1 and CCNL2 (By similarity). Interacts with CCNK. Interacts with C1QBP. Interacts with HIV-1 Tat.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
C1QBPQ070216EBI-6375898,EBI-347528
CCNKO759096EBI-968626,EBI-739806

GO - Molecular functioni

  • cyclin binding Source: MGI

Protein-protein interaction databases

BioGridi114176. 57 interactors.
IntActiQ14004. 15 interactors.
MINTiMINT-1197921.
STRINGi9606.ENSP00000181839.

Chemistry databases

BindingDBiQ14004.

Structurei

Secondary structure

11512
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi702 – 704Combined sources3
Beta strandi705 – 713Combined sources9
Beta strandi715 – 724Combined sources10
Turni725 – 727Combined sources3
Beta strandi730 – 736Combined sources7
Beta strandi739 – 741Combined sources3
Helixi747 – 758Combined sources12
Beta strandi767 – 772Combined sources6
Beta strandi787 – 792Combined sources6
Beta strandi795 – 797Combined sources3
Helixi798 – 804Combined sources7
Helixi811 – 830Combined sources20
Helixi840 – 842Combined sources3
Beta strandi843 – 845Combined sources3
Beta strandi851 – 853Combined sources3
Helixi856 – 858Combined sources3
Beta strandi864 – 866Combined sources3
Helixi877 – 879Combined sources3
Helixi882 – 885Combined sources4
Helixi894 – 908Combined sources15
Beta strandi909 – 911Combined sources3
Helixi919 – 930Combined sources12
Turni935 – 937Combined sources3
Helixi939 – 943Combined sources5
Turni945 – 950Combined sources6
Helixi960 – 963Combined sources4
Turni964 – 966Combined sources3
Helixi969 – 978Combined sources10
Turni983 – 985Combined sources3
Helixi989 – 994Combined sources6
Turni996 – 1000Combined sources5
Helixi1003 – 1005Combined sources3
Helixi1019 – 1024Combined sources6
Helixi1026 – 1030Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EFQX-ray2.00A/C694-1039[»]
ProteinModelPortaliQ14004.
SMRiQ14004.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini705 – 998Protein kinasePROSITE-ProRule annotationAdd BLAST294

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0600. Eukaryota.
ENOG410XPIR. LUCA.
GeneTreeiENSGT00860000133755.
HOVERGENiHBG050851.
InParanoidiQ14004.
KOiK08819.
OMAiNVAPVKT.
OrthoDBiEOG091G08Z8.
PhylomeDBiQ14004.
TreeFamiTF101060.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q14004-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ
60 70 80 90 100
PPPPPPPLLF LAAPGTAAAA AAAAAASSSC FSPGPPLEVK RLARGKRRAG
110 120 130 140 150
GRQKRRRGPR AGQEAEKRRV FSLPQPQQDG GGGASSGGGV TPLVEYEDVS
160 170 180 190 200
SQSEQGLLLG GASAATAATA AGGTGGSGGS PASSSGTQRR GEGSERRPRR
210 220 230 240 250
DRRSSSGRSK ERHREHRRRD GQRGGSEASK SRSRHSHSGE ERAEVAKSGS
260 270 280 290 300
SSSSGGRRKS ASATSSSSSS RKDRDSKAHR SRTKSSKEPP SAYKEPPKAY
310 320 330 340 350
REDKTEPKAY RRRRSLSPLG GRDDSPVSHR ASQSLRSRKS PSPAGGGSSP
360 370 380 390 400
YSRRLPRSPS PYSRRRSPSY SRHSSYERGG DVSPSPYSSS SWRRSRSPYS
410 420 430 440 450
PVLRRSGKSR SRSPYSSRHS RSRSRHRLSR SRSRHSSISP STLTLKSSLA
460 470 480 490 500
AELNKNKKAR AAEAARAAEA AKAAEATKAA EAAAKAAKAS NTSTPTKGNT
510 520 530 540 550
ETSASASQTN HVKDVKKIKI EHAPSPSSGG TLKNDKAKTK PPLQVTKVEN
560 570 580 590 600
NLIVDKATKK AVIVGKESKS AATKEESVSL KEKTKPLTPS IGAKEKEQHV
610 620 630 640 650
ALVTSTLPPL PLPPMLPEDK EADSLRGNIS VKAVKKEVEK KLRCLLADLP
660 670 680 690 700
LPPELPGGDD LSKSPEEKKT ATQLHSKRRP KICGPRYGET KEKDIDWGKR
710 720 730 740 750
CVDKFDIIGI IGEGTYGQVY KARDKDTGEM VALKKVRLDN EKEGFPITAI
760 770 780 790 800
REIKILRQLT HQSIINMKEI VTDKEDALDF KKDKGAFYLV FEYMDHDLMG
810 820 830 840 850
LLESGLVHFN ENHIKSFMRQ LMEGLDYCHK KNFLHRDIKC SNILLNNRGQ
860 870 880 890 900
IKLADFGLAR LYSSEESRPY TNKVITLWYR PPELLLGEER YTPAIDVWSC
910 920 930 940 950
GCILGELFTK KPIFQANQEL AQLELISRIC GSPCPAVWPD VIKLPYFNTM
960 970 980 990 1000
KPKKQYRRKL REEFVFIPAA ALDLFDYMLA LDPSKRCTAE QALQCEFLRD
1010 1020 1030 1040 1050
VEPSKMPPPD LPLWQDCHEL WSKKRRRQKQ MGMTDDVSTI KAPRKDLSLG
1060 1070 1080 1090 1100
LDDSRTNTPQ GVLPSSQLKS QGSSNVAPVK TGPGQHLNHS ELAILLNLLQ
1110 1120 1130 1140 1150
SKTSVNMADF VQVLNIKVNS ETQQQLNKIN LPAGILATGE KQTDPSTPQQ
1160 1170 1180 1190 1200
ESSKPLGGIQ PSSQTIQPKV ETDAAQAAVQ SAFAVLLTQL IKAQQSKQKD
1210 1220 1230 1240 1250
VLLEERENGS GHEASLQLRP PPEPSTPVSG QDDLIQHQDM RILELTPEPD
1260 1270 1280 1290 1300
RPRILPPDQR PPEPPEPPPV TEEDLDYRTE NQHVPTTSSS LTDPHAGVKA
1310 1320 1330 1340 1350
ALLQLLAQHQ PQDDPKREGG IDYQAGDTYV STSDYKDNFG SSSFSSAPYV
1360 1370 1380 1390 1400
SNDGLGSSSA PPLERRSFIG NSDIQSLDNY STASSHSGGP PQPSAFSESF
1410 1420 1430 1440 1450
PSSVAGYGDI YLNAGPMLFS GDKDHRFEYS HGPIAVLANS SDPSTGPEST
1460 1470 1480 1490 1500
HPLPAKMHNY NYGGNLQENP SGPSLMHGQT WTSPAQGPGY SQGYRGHIST
1510
STGRGRGRGL PY
Length:1,512
Mass (Da):164,923
Last modified:May 10, 2005 - v2
Checksum:i3CA54A3585A2943D
GO
Isoform 2 (identifier: Q14004-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1079-1138: Missing.

Show »
Length:1,452
Mass (Da):158,435
Checksum:i8A8B712D8621EEA3
GO

Sequence cautioni

The sequence AAA58424 differs from that shown. Reason: Frameshift at position 1006.Curated
The sequence AAS07490 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21K → R in CAC10400 (PubMed:11162436).Curated1
Sequence conflicti21K → R in CAC10401 (PubMed:11162436).Curated1
Sequence conflicti671A → T in CAC10400 (PubMed:11162436).Curated1
Sequence conflicti671A → T in CAC10401 (PubMed:11162436).Curated1
Sequence conflicti671A → T in AAA58424 (PubMed:1731328).Curated1
Sequence conflicti810N → Y in AAA58424 (PubMed:1731328).Curated1
Sequence conflicti862 – 866YSSEE → FSVFF in BAB47420 (Ref. 5) Curated5
Sequence conflicti1180Q → R in BAD96773 (Ref. 5) Curated1
Sequence conflicti1356G → E in BAD96773 (Ref. 5) Curated1

RNA editingi

Edited at position 103.1 Publication
Edited at about 88%.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_066526103Q → R in RNA edited version. 1
Natural variantiVAR_053926340S → F.Corresponds to variant rs13622dbSNPEnsembl.1
Natural variantiVAR_022381356P → A.1 PublicationCorresponds to variant rs17537669dbSNPEnsembl.1
Natural variantiVAR_022382403L → F.1 PublicationCorresponds to variant rs3735137dbSNPEnsembl.1
Natural variantiVAR_022383410R → Q.1 PublicationCorresponds to variant rs17496261dbSNPEnsembl.1
Natural variantiVAR_041965494T → A.1 PublicationCorresponds to variant rs34624759dbSNPEnsembl.1
Natural variantiVAR_022384500T → A.2 PublicationsCorresponds to variant rs3735135dbSNPEnsembl.1
Natural variantiVAR_022385624S → G.1 PublicationCorresponds to variant rs17496275dbSNPEnsembl.1
Natural variantiVAR_041966670T → R.1 PublicationCorresponds to variant rs34775357dbSNPEnsembl.1
Natural variantiVAR_022386700R → L.2 PublicationsCorresponds to variant rs1057000dbSNPEnsembl.1
Natural variantiVAR_0223871062V → M.1 PublicationCorresponds to variant rs17496712dbSNPEnsembl.1
Natural variantiVAR_0419671170V → M.2 PublicationsCorresponds to variant rs3204309dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0135791079 – 1138Missing in isoform 2. 2 PublicationsAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297709 mRNA. Translation: CAC10400.1.
AJ297710 mRNA. Translation: CAC10401.1.
AY679523 Genomic DNA. Translation: AAT74623.1.
AC072061 Genomic DNA. Translation: AAS07490.1. Sequence problems.
AC072061 Genomic DNA. Translation: AAS07491.1.
AC006023 Genomic DNA. Translation: AAD54514.1.
M80629 mRNA. Translation: AAA58424.1. Frameshift.
AK223053 mRNA. Translation: BAD96773.1.
AB058694 mRNA. Translation: BAB47420.1.
CCDSiCCDS5461.1. [Q14004-1]
CCDS5462.1. [Q14004-2]
PIRiA38197.
RefSeqiNP_003709.3. NM_003718.4. [Q14004-1]
NP_112557.2. NM_031267.3. [Q14004-2]
UniGeneiHs.233552.

Genome annotation databases

EnsembliENST00000181839; ENSP00000181839; ENSG00000065883. [Q14004-1]
ENST00000340829; ENSP00000340557; ENSG00000065883. [Q14004-2]
GeneIDi8621.
KEGGihsa:8621.
UCSCiuc003thh.5. human. [Q14004-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism, RNA editing

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ297709 mRNA. Translation: CAC10400.1.
AJ297710 mRNA. Translation: CAC10401.1.
AY679523 Genomic DNA. Translation: AAT74623.1.
AC072061 Genomic DNA. Translation: AAS07490.1. Sequence problems.
AC072061 Genomic DNA. Translation: AAS07491.1.
AC006023 Genomic DNA. Translation: AAD54514.1.
M80629 mRNA. Translation: AAA58424.1. Frameshift.
AK223053 mRNA. Translation: BAD96773.1.
AB058694 mRNA. Translation: BAB47420.1.
CCDSiCCDS5461.1. [Q14004-1]
CCDS5462.1. [Q14004-2]
PIRiA38197.
RefSeqiNP_003709.3. NM_003718.4. [Q14004-1]
NP_112557.2. NM_031267.3. [Q14004-2]
UniGeneiHs.233552.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5EFQX-ray2.00A/C694-1039[»]
ProteinModelPortaliQ14004.
SMRiQ14004.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114176. 57 interactors.
IntActiQ14004. 15 interactors.
MINTiMINT-1197921.
STRINGi9606.ENSP00000181839.

Chemistry databases

BindingDBiQ14004.
ChEMBLiCHEMBL1795192.
GuidetoPHARMACOLOGYi1966.

PTM databases

iPTMnetiQ14004.
PhosphoSitePlusiQ14004.

Polymorphism and mutation databases

BioMutaiCDK13.
DMDMi66774048.

Proteomic databases

EPDiQ14004.
MaxQBiQ14004.
PaxDbiQ14004.
PeptideAtlasiQ14004.
PRIDEiQ14004.

Protocols and materials databases

DNASUi8621.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000181839; ENSP00000181839; ENSG00000065883. [Q14004-1]
ENST00000340829; ENSP00000340557; ENSG00000065883. [Q14004-2]
GeneIDi8621.
KEGGihsa:8621.
UCSCiuc003thh.5. human. [Q14004-1]

Organism-specific databases

CTDi8621.
DisGeNETi8621.
GeneCardsiCDK13.
HGNCiHGNC:1733. CDK13.
HPAiHPA059241.
MIMi603309. gene.
neXtProtiNX_Q14004.
OpenTargetsiENSG00000065883.
PharmGKBiPA26264.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0600. Eukaryota.
ENOG410XPIR. LUCA.
GeneTreeiENSGT00860000133755.
HOVERGENiHBG050851.
InParanoidiQ14004.
KOiK08819.
OMAiNVAPVKT.
OrthoDBiEOG091G08Z8.
PhylomeDBiQ14004.
TreeFamiTF101060.

Enzyme and pathway databases

BioCyciZFISH:HS00857-MONOMER.
ReactomeiR-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-HSA-6798695. Neutrophil degranulation.
SignaLinkiQ14004.
SIGNORiQ14004.

Miscellaneous databases

ChiTaRSiCDK13. human.
GeneWikiiCDC2L5.
GenomeRNAii8621.
PMAP-CutDBQ14004.
PROiQ14004.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000065883.
CleanExiHS_CDC2L5.
ExpressionAtlasiQ14004. baseline and differential.
GenevisibleiQ14004. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDK13_HUMAN
AccessioniPrimary (citable) accession number: Q14004
Secondary accession number(s): Q53G78
, Q6DKQ9, Q75MH4, Q75MH5, Q96JN4, Q9H4A0, Q9H4A1, Q9UDR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2005
Last modified: November 30, 2016
This is version 170 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.