Reviewed, UniProtKB/Swiss-Prot Q14002 (CEAM7_HUMAN)

Names and origin

Protein names

Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 7
Alternative name(s):
    Carcinoembryonic antigen CGM2

Gene names

Name:	CEACAM7
Synonyms:	CGM2

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor Potential.
Tissue specificity	Strongly down-regulated in colonic adenocarcinomas.
Sequence similarities	Belongs to the immunoglobulin superfamily. CEA family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Ref.1 Traceable author statement. Source: ProtInc plasma membrane Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2a (identifier: Q14002-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2b (identifier: Q14002-2)

The sequence of this isoform differs from the canonical sequence as follows:
     143-235: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 35	35	Ref.9
	Chain	36 – 242	207	Carcinoembryonic antigen-related cell adhesion molecule 7		PRO_0000014570
	Propeptide	243 – 265	23	Removed in mature form Potential		PRO_0000014571
Regions
	Domain	36 – 142	107	Ig-like V-type
	Domain	146 – 233	88	Ig-like C2-type
Amino acid modifications
	Lipidation	242	1	GPI-anchor amidated serine Potential
	Glycosylation	57	1	N-linked (GlcNAc...) Potential
	Glycosylation	85	1	N-linked (GlcNAc...) Potential
	Glycosylation	105	1	N-linked (GlcNAc...) Potential
	Glycosylation	112	1	N-linked (GlcNAc...) Potential
	Glycosylation	174	1	N-linked (GlcNAc...) Potential
	Glycosylation	183	1	N-linked (GlcNAc...) Potential
	Glycosylation	198	1	N-linked (GlcNAc...) Potential
	Disulfide bond	168 ↔ 216		Probable
Natural variations
	Alternative sequence	143 – 235	93	Missing in isoform 2b.		VSP_002488
	Natural variant	120	1	F → I: dbSNP rs8102488. Ref.3 Ref.4 Ref.6		VAR_024494
	Natural variant	236	1	Y → H: dbSNP rs16975478.		VAR_059384
	Natural variant	263	1	A → V: dbSNP rs7259532.		VAR_049848
Experimental info
	Sequence conflict	40	1	V → G in AAB62924. Ref.3
	Sequence conflict	40	1	V → G in AAB62925. Ref.3
	Sequence conflict	71	1	E → Q in AAB62924. Ref.3
	Sequence conflict	71	1	E → Q in AAB62925. Ref.3
	Sequence conflict	235	1	R → C in AAB62924. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2a [UniParc]. Last modified November 1, 1996. Version 1. Checksum: B6B836F66BD10D3B	FASTA	265	29,379
	10 20 30 40 50 60 MGSPSACPYR VCIPWQGLLL TASLLTFWNL PNSAQTNIDV VPFNVAEGKE VLLVVHNESQ 70 80 90 100 110 120 NLYGYNWYKG ERVHANYRII GYVKNISQEN APGPAHNGRE TIYPNGTLLI QNVTHNDAGF 130 140 150 160 170 180 YTLHVIKENL VNEEVTRQFY VFSEPPKPSI TSNNFNPVEN KDIVVLTCQP ETQNTTYLWW 190 200 210 220 230 240 VNNQSLLVSP RLLLSTDNRT LVLLSATKND IGPYECEIQN PVGASRSDPV TLNVRYESVQ 250 260 ASSPDLSAGT AVSIMIGVLA GMALI
	Isoform 2b. Checksum: DE939FA24349681D	FASTA	172	19,031
	10 20 30 40 50 60 MGSPSACPYR VCIPWQGLLL TASLLTFWNL PNSAQTNIDV VPFNVAEGKE VLLVVHNESQ 70 80 90 100 110 120 NLYGYNWYKG ERVHANYRII GYVKNISQEN APGPAHNGRE TIYPNGTLLI QNVTHNDAGF 130 140 150 160 170 YTLHVIKENL VNEEVTRQFY VFYESVQASS PDLSAGTAVS IMIGVLAGMA LI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"CGM2, a member of the carcinoembryonic antigen gene family is down-regulated in colorectal carcinomas." Thompson J., Zimmermann W., Nollau P., Neumaier M., Weber-Arden J., Schrewe H., Craig I., Willcocks T. J. Biol. Chem. 269:32924-32931(1994) [PubMed: 7806520] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2A).
[2]	"Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis." Thompson J., Seitz M., Chastre E., Ditter M., Aldrian C., Gespach C., Zimmermann W. Cancer Res. 57:1776-1784(1997) [PubMed: 9135022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2A). Tissue: Colon mucosa.
[3]	"Two isoforms of CEA gene family member 2 (CGM2) mRNA are co-expressed in small and large intestine mucosa epithelium and in colorectal tumor cells." Zhou G.Q. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2A AND 2B), VARIANT ILE-120.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2A), VARIANT ILE-120. Tissue: Colon and Oesophagus.
[5]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2A), VARIANT ILE-120.
[7]	"Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons." Thompson J.A., Mauch E.-M., Chen F.-S., Hinoda Y., Schrewe H., Berling B., Barnert S., von Kleist S., Shively J.E., Zimmermann W. Biochem. Biophys. Res. Commun. 158:996-1004(1989) [PubMed: 2537643] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-142. Tissue: Liver.
[8]	"Identification of three new genes and estimation of the size of the carcinoembryonic antigen family." Khan W.N., Fraengsmyr L., Teglund S., Israelsson A., Bremer K., Hammarstroem S. Genomics 14:384-390(1992) [PubMed: 1427854] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 35-142.
[9]	"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Zhang Z., Henzel W.J. Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract] Cited for: PROTEIN SEQUENCE OF 36-50.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L31792 mRNA. Translation: AAA66186.1. X98311 mRNA. Translation: CAA66955.1. AF006622 mRNA. Translation: AAB62924.1. AF006623 mRNA. Translation: AAB62925.1. AK292213 mRNA. Translation: BAF84902.1. AK313108 mRNA. Translation: BAG35930.1. AC005797 Genomic DNA. Translation: AAC62825.1. AC005797 Genomic DNA. Translation: AAC62826.1. BC121132 mRNA. Translation: AAI21133.1. M22434 Genomic DNA. Translation: AAA51966.1.
IPI	IPI00028270. IPI00216610.
PIR	A55811.
RefSeq	NP_008821.1.
UniGene	Hs.74466
3D structure databases
SMR	Q14002. Positions 34-144, 36-237, 146-239.
ModBase	Search...
Protein-protein interaction databases
STRING	Q14002.
PTM databases
PhosphoSite	Q14002.
Proteomic databases
PRIDE	Q14002.
Genome annotation databases
Ensembl	ENST00000006724; ENSP00000006724; ENSG00000007306; Homo sapiens. [Genome view] ENST00000401731; ENSP00000385932; ENSG00000007306; Homo sapiens. [Genome view]
GeneID	1087.
KEGG	hsa:1087.
UCSC	uc002ori.1. human. uc010ehy.1. human.
Organism-specific databases
CTD	1087.
GeneCards	GC19M046869.
H-InvDB	HIX0039944.
HGNC	HGNC:1819. CEACAM7.
PharmGKB	PA26363.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG283340.
HOVERGEN	Q14002.
InParanoid	Q14002.
OMA	VTHNDAG.
OrthoDB	EOG9CNT9N.
PhylomeDB	Q14002.
Gene expression databases
ArrayExpress	Q14002.
Bgee	Q14002.
CleanEx	HS_CEACAM7.
Genevestigator	Q14002.
GermOnline	ENSG00000007306. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013098. Ig_I-set. IPR003599. Ig_sub. IPR013106. Ig_V-set. [Graphical view]
Pfam	PF07679. I-set. 1 hit. PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 2 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	4522.

Entry information

Entry name

CEAM7_HUMAN

Accession

Primary (citable) accession number: Q14002
Secondary accession number(s): A8K848 , O15148, O15149, Q0VAC1, Q13983, Q9UPJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	January 19, 2010
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.