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Protein

Carcinoembryonic antigen-related cell adhesion molecule 7

Gene

CEACAM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 7
Alternative name(s):
Carcinoembryonic antigen CGM2
Gene namesi
Name:CEACAM7
Synonyms:CGM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1819. CEACAM7.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • integral component of membrane Source: ProtInc
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26363.

Polymorphism and mutation databases

BioMutaiCEACAM7.
DMDMi5921734.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 35351 PublicationAdd
BLAST
Chaini36 – 242207Carcinoembryonic antigen-related cell adhesion molecule 7PRO_0000014570Add
BLAST
Propeptidei243 – 26523Removed in mature formSequence analysisPRO_0000014571Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence analysis
Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence analysis
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence analysis
Disulfide bondi168 ↔ 216Curated
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence analysis
Glycosylationi183 – 1831N-linked (GlcNAc...)Sequence analysis
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence analysis
Lipidationi242 – 2421GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ14002.
PeptideAtlasiQ14002.
PRIDEiQ14002.

PTM databases

iPTMnetiQ14002.
PhosphoSiteiQ14002.

Expressioni

Tissue specificityi

Strongly down-regulated in colonic adenocarcinomas.

Gene expression databases

BgeeiQ14002.
CleanExiHS_CEACAM7.
ExpressionAtlasiQ14002. baseline and differential.
GenevisibleiQ14002. HS.

Organism-specific databases

HPAiHPA069621.

Interactioni

Protein-protein interaction databases

BioGridi107513. 2 interactions.
IntActiQ14002. 2 interactions.
STRINGi9606.ENSP00000006724.

Structurei

Secondary structure

1
265
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi37 – 4610Combined sources
Beta strandi51 – 566Combined sources
Beta strandi62 – 7110Combined sources
Helixi75 – 773Combined sources
Beta strandi78 – 836Combined sources
Turni84 – 874Combined sources
Beta strandi100 – 1023Combined sources
Beta strandi108 – 1103Combined sources
Helixi115 – 1173Combined sources
Beta strandi119 – 1279Combined sources
Beta strandi133 – 14210Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Y89X-ray1.47A/B/C/D34-142[»]
ProteinModelPortaliQ14002.
SMRiQ14002. Positions 34-234.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 142107Ig-like V-typeAdd
BLAST
Domaini146 – 23388Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
HOVERGENiHBG007922.
InParanoidiQ14002.
KOiK06499.
OrthoDBiEOG74BJS7.
PhylomeDBiQ14002.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2a (identifier: Q14002-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSPSACPYR VCIPWQGLLL TASLLTFWNL PNSAQTNIDV VPFNVAEGKE
60 70 80 90 100
VLLVVHNESQ NLYGYNWYKG ERVHANYRII GYVKNISQEN APGPAHNGRE
110 120 130 140 150
TIYPNGTLLI QNVTHNDAGF YTLHVIKENL VNEEVTRQFY VFSEPPKPSI
160 170 180 190 200
TSNNFNPVEN KDIVVLTCQP ETQNTTYLWW VNNQSLLVSP RLLLSTDNRT
210 220 230 240 250
LVLLSATKND IGPYECEIQN PVGASRSDPV TLNVRYESVQ ASSPDLSAGT
260
AVSIMIGVLA GMALI
Length:265
Mass (Da):29,379
Last modified:November 1, 1996 - v1
Checksum:iB6B836F66BD10D3B
GO
Isoform 2b (identifier: Q14002-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-235: Missing.

Show »
Length:172
Mass (Da):19,031
Checksum:iDE939FA24349681D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401V → G in AAB62924 (Ref. 3) Curated
Sequence conflicti40 – 401V → G in AAB62925 (Ref. 3) Curated
Sequence conflicti71 – 711E → Q in AAB62924 (Ref. 3) Curated
Sequence conflicti71 – 711E → Q in AAB62925 (Ref. 3) Curated
Sequence conflicti235 – 2351R → C in AAB62924 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201F → I.3 Publications
Corresponds to variant rs8102488 [ dbSNP | Ensembl ].
VAR_024494
Natural varianti236 – 2361Y → H.
Corresponds to variant rs16975478 [ dbSNP | Ensembl ].
VAR_059384
Natural varianti263 – 2631A → V.
Corresponds to variant rs7259532 [ dbSNP | Ensembl ].
VAR_049848

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei143 – 23593Missing in isoform 2b. CuratedVSP_002488Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31792 mRNA. Translation: AAA66186.1.
X98311 mRNA. Translation: CAA66955.1.
AF006622 mRNA. Translation: AAB62924.1.
AF006623 mRNA. Translation: AAB62925.1.
AK292213 mRNA. Translation: BAF84902.1.
AK313108 mRNA. Translation: BAG35930.1.
AC005797 Genomic DNA. Translation: AAC62825.1.
AC005797 Genomic DNA. Translation: AAC62826.1.
BC121132 mRNA. Translation: AAI21133.1.
M22434 Genomic DNA. Translation: AAA51966.1.
CCDSiCCDS12583.1. [Q14002-1]
PIRiA55811.
RefSeqiNP_001278414.1. NM_001291485.1.
NP_008821.2. NM_006890.4.
UniGeneiHs.74466.

Genome annotation databases

EnsembliENST00000006724; ENSP00000006724; ENSG00000007306.
ENST00000401731; ENSP00000385932; ENSG00000007306.
GeneIDi1087.
KEGGihsa:1087.
UCSCiuc002ori.2. human. [Q14002-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31792 mRNA. Translation: AAA66186.1.
X98311 mRNA. Translation: CAA66955.1.
AF006622 mRNA. Translation: AAB62924.1.
AF006623 mRNA. Translation: AAB62925.1.
AK292213 mRNA. Translation: BAF84902.1.
AK313108 mRNA. Translation: BAG35930.1.
AC005797 Genomic DNA. Translation: AAC62825.1.
AC005797 Genomic DNA. Translation: AAC62826.1.
BC121132 mRNA. Translation: AAI21133.1.
M22434 Genomic DNA. Translation: AAA51966.1.
CCDSiCCDS12583.1. [Q14002-1]
PIRiA55811.
RefSeqiNP_001278414.1. NM_001291485.1.
NP_008821.2. NM_006890.4.
UniGeneiHs.74466.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Y89X-ray1.47A/B/C/D34-142[»]
ProteinModelPortaliQ14002.
SMRiQ14002. Positions 34-234.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107513. 2 interactions.
IntActiQ14002. 2 interactions.
STRINGi9606.ENSP00000006724.

Protein family/group databases

MEROPSiI43.001.

PTM databases

iPTMnetiQ14002.
PhosphoSiteiQ14002.

Polymorphism and mutation databases

BioMutaiCEACAM7.
DMDMi5921734.

Proteomic databases

PaxDbiQ14002.
PeptideAtlasiQ14002.
PRIDEiQ14002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000006724; ENSP00000006724; ENSG00000007306.
ENST00000401731; ENSP00000385932; ENSG00000007306.
GeneIDi1087.
KEGGihsa:1087.
UCSCiuc002ori.2. human. [Q14002-1]

Organism-specific databases

CTDi1087.
GeneCardsiCEACAM7.
HGNCiHGNC:1819. CEACAM7.
HPAiHPA069621.
neXtProtiNX_Q14002.
PharmGKBiPA26363.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
HOVERGENiHBG007922.
InParanoidiQ14002.
KOiK06499.
OrthoDBiEOG74BJS7.
PhylomeDBiQ14002.
TreeFamiTF336859.

Miscellaneous databases

ChiTaRSiCEACAM7. human.
GeneWikiiCEACAM7.
GenomeRNAii1087.
PROiQ14002.

Gene expression databases

BgeeiQ14002.
CleanExiHS_CEACAM7.
ExpressionAtlasiQ14002. baseline and differential.
GenevisibleiQ14002. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "CGM2, a member of the carcinoembryonic antigen gene family is down-regulated in colorectal carcinomas."
    Thompson J., Zimmermann W., Nollau P., Neumaier M., Weber-Arden J., Schrewe H., Craig I., Willcocks T.
    J. Biol. Chem. 269:32924-32931(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2A).
  2. "Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis."
    Thompson J., Seitz M., Chastre E., Ditter M., Aldrian C., Gespach C., Zimmermann W.
    Cancer Res. 57:1776-1784(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2A).
    Tissue: Colon mucosa.
  3. "Two isoforms of CEA gene family member 2 (CGM2) mRNA are co-expressed in small and large intestine mucosa epithelium and in colorectal tumor cells."
    Zhou G.Q.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2A AND 2B), VARIANT ILE-120.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2A), VARIANT ILE-120.
    Tissue: Colon and Esophagus.
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2A), VARIANT ILE-120.
  7. "Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons."
    Thompson J.A., Mauch E.-M., Chen F.-S., Hinoda Y., Schrewe H., Berling B., Barnert S., von Kleist S., Shively J.E., Zimmermann W.
    Biochem. Biophys. Res. Commun. 158:996-1004(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-142.
    Tissue: Liver.
  8. "Identification of three new genes and estimation of the size of the carcinoembryonic antigen family."
    Khan W.N., Fraengsmyr L., Teglund S., Israelsson A., Bremer K., Hammarstroem S.
    Genomics 14:384-390(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 35-142.
  9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 36-50.

Entry informationi

Entry nameiCEAM7_HUMAN
AccessioniPrimary (citable) accession number: Q14002
Secondary accession number(s): A8K848
, O15148, O15149, Q0VAC1, Q13983, Q9UPJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.