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Protein

Carcinoembryonic antigen-related cell adhesion molecule 7

Gene

CEACAM7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000007306-MONOMER.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 7
Alternative name(s):
Carcinoembryonic antigen CGM2
Gene namesi
Name:CEACAM7
Synonyms:CGM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1819. CEACAM7.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • integral component of membrane Source: ProtInc
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1087.
PharmGKBiPA26363.

Polymorphism and mutation databases

BioMutaiCEACAM7.
DMDMi5921734.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 351 PublicationAdd BLAST35
ChainiPRO_000001457036 – 242Carcinoembryonic antigen-related cell adhesion molecule 7Add BLAST207
PropeptideiPRO_0000014571243 – 265Removed in mature formSequence analysisAdd BLAST23

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1
Glycosylationi105N-linked (GlcNAc...)Sequence analysis1
Glycosylationi112N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi168 ↔ 216Curated
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Glycosylationi183N-linked (GlcNAc...)Sequence analysis1
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Lipidationi242GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ14002.
PeptideAtlasiQ14002.
PRIDEiQ14002.

PTM databases

iPTMnetiQ14002.
PhosphoSitePlusiQ14002.

Expressioni

Tissue specificityi

Strongly down-regulated in colonic adenocarcinomas.

Gene expression databases

BgeeiENSG00000007306.
CleanExiHS_CEACAM7.
ExpressionAtlasiQ14002. baseline and differential.
GenevisibleiQ14002. HS.

Organism-specific databases

HPAiHPA069621.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi107513. 2 interactors.
IntActiQ14002. 2 interactors.
STRINGi9606.ENSP00000006724.

Structurei

Secondary structure

1265
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 46Combined sources10
Beta strandi51 – 56Combined sources6
Beta strandi62 – 71Combined sources10
Helixi75 – 77Combined sources3
Beta strandi78 – 83Combined sources6
Turni84 – 87Combined sources4
Beta strandi100 – 102Combined sources3
Beta strandi108 – 110Combined sources3
Helixi115 – 117Combined sources3
Beta strandi119 – 127Combined sources9
Beta strandi133 – 142Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Y89X-ray1.47A/B/C/D34-142[»]
ProteinModelPortaliQ14002.
SMRiQ14002.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 142Ig-like V-typeAdd BLAST107
Domaini146 – 233Ig-like C2-typeAdd BLAST88

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
HOVERGENiHBG007922.
InParanoidiQ14002.
KOiK06499.
OrthoDBiEOG091G0AMM.
PhylomeDBiQ14002.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2a (identifier: Q14002-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSPSACPYR VCIPWQGLLL TASLLTFWNL PNSAQTNIDV VPFNVAEGKE
60 70 80 90 100
VLLVVHNESQ NLYGYNWYKG ERVHANYRII GYVKNISQEN APGPAHNGRE
110 120 130 140 150
TIYPNGTLLI QNVTHNDAGF YTLHVIKENL VNEEVTRQFY VFSEPPKPSI
160 170 180 190 200
TSNNFNPVEN KDIVVLTCQP ETQNTTYLWW VNNQSLLVSP RLLLSTDNRT
210 220 230 240 250
LVLLSATKND IGPYECEIQN PVGASRSDPV TLNVRYESVQ ASSPDLSAGT
260
AVSIMIGVLA GMALI
Length:265
Mass (Da):29,379
Last modified:November 1, 1996 - v1
Checksum:iB6B836F66BD10D3B
GO
Isoform 2b (identifier: Q14002-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-235: Missing.

Show »
Length:172
Mass (Da):19,031
Checksum:iDE939FA24349681D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40V → G in AAB62924 (Ref. 3) Curated1
Sequence conflicti40V → G in AAB62925 (Ref. 3) Curated1
Sequence conflicti71E → Q in AAB62924 (Ref. 3) Curated1
Sequence conflicti71E → Q in AAB62925 (Ref. 3) Curated1
Sequence conflicti235R → C in AAB62924 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024494120F → I.3 PublicationsCorresponds to variant rs8102488dbSNPEnsembl.1
Natural variantiVAR_059384236Y → H.Corresponds to variant rs16975478dbSNPEnsembl.1
Natural variantiVAR_049848263A → V.Corresponds to variant rs7259532dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002488143 – 235Missing in isoform 2b. CuratedAdd BLAST93

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31792 mRNA. Translation: AAA66186.1.
X98311 mRNA. Translation: CAA66955.1.
AF006622 mRNA. Translation: AAB62924.1.
AF006623 mRNA. Translation: AAB62925.1.
AK292213 mRNA. Translation: BAF84902.1.
AK313108 mRNA. Translation: BAG35930.1.
AC005797 Genomic DNA. Translation: AAC62825.1.
AC005797 Genomic DNA. Translation: AAC62826.1.
BC121132 mRNA. Translation: AAI21133.1.
M22434 Genomic DNA. Translation: AAA51966.1.
CCDSiCCDS12583.1. [Q14002-1]
PIRiA55811.
RefSeqiNP_001278414.1. NM_001291485.1.
NP_008821.2. NM_006890.4.
UniGeneiHs.74466.

Genome annotation databases

EnsembliENST00000006724; ENSP00000006724; ENSG00000007306.
ENST00000401731; ENSP00000385932; ENSG00000007306.
GeneIDi1087.
KEGGihsa:1087.
UCSCiuc002ori.2. human. [Q14002-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31792 mRNA. Translation: AAA66186.1.
X98311 mRNA. Translation: CAA66955.1.
AF006622 mRNA. Translation: AAB62924.1.
AF006623 mRNA. Translation: AAB62925.1.
AK292213 mRNA. Translation: BAF84902.1.
AK313108 mRNA. Translation: BAG35930.1.
AC005797 Genomic DNA. Translation: AAC62825.1.
AC005797 Genomic DNA. Translation: AAC62826.1.
BC121132 mRNA. Translation: AAI21133.1.
M22434 Genomic DNA. Translation: AAA51966.1.
CCDSiCCDS12583.1. [Q14002-1]
PIRiA55811.
RefSeqiNP_001278414.1. NM_001291485.1.
NP_008821.2. NM_006890.4.
UniGeneiHs.74466.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Y89X-ray1.47A/B/C/D34-142[»]
ProteinModelPortaliQ14002.
SMRiQ14002.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107513. 2 interactors.
IntActiQ14002. 2 interactors.
STRINGi9606.ENSP00000006724.

Protein family/group databases

MEROPSiI43.001.

PTM databases

iPTMnetiQ14002.
PhosphoSitePlusiQ14002.

Polymorphism and mutation databases

BioMutaiCEACAM7.
DMDMi5921734.

Proteomic databases

PaxDbiQ14002.
PeptideAtlasiQ14002.
PRIDEiQ14002.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000006724; ENSP00000006724; ENSG00000007306.
ENST00000401731; ENSP00000385932; ENSG00000007306.
GeneIDi1087.
KEGGihsa:1087.
UCSCiuc002ori.2. human. [Q14002-1]

Organism-specific databases

CTDi1087.
DisGeNETi1087.
GeneCardsiCEACAM7.
HGNCiHGNC:1819. CEACAM7.
HPAiHPA069621.
neXtProtiNX_Q14002.
PharmGKBiPA26363.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
HOVERGENiHBG007922.
InParanoidiQ14002.
KOiK06499.
OrthoDBiEOG091G0AMM.
PhylomeDBiQ14002.
TreeFamiTF336859.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000007306-MONOMER.

Miscellaneous databases

ChiTaRSiCEACAM7. human.
GeneWikiiCEACAM7.
GenomeRNAii1087.
PROiQ14002.

Gene expression databases

BgeeiENSG00000007306.
CleanExiHS_CEACAM7.
ExpressionAtlasiQ14002. baseline and differential.
GenevisibleiQ14002. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEAM7_HUMAN
AccessioniPrimary (citable) accession number: Q14002
Secondary accession number(s): A8K848
, O15148, O15149, Q0VAC1, Q13983, Q9UPJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.