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Q13YU3

- MASZ_BURXL

UniProt

Q13YU3 - MASZ_BURXL

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Protein
Malate synthase G
Gene
glcB, Bxeno_A2208, Bxe_A2223
Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei275 – 2751Acetyl-CoA By similarity
Binding sitei312 – 3121Acetyl-CoA By similarity
Active sitei340 – 3401Proton acceptor By similarity
Binding sitei340 – 3401Glyoxylate By similarity
Metal bindingi429 – 4291Magnesium By similarity
Binding sitei429 – 4291Glyoxylate By similarity
Metal bindingi457 – 4571Magnesium By similarity
Binding sitei538 – 5381Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei633 – 6331Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciBXEN266265:GJII-2309-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:Bxeno_A2208
ORF Names:Bxe_A2223
OrganismiBurkholderia xenovorans (strain LB400)
Taxonomic identifieri266265 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000001817: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 724724Malate synthase GUniRule annotation
PRO_1000056900Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei619 – 6191Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi266265.Bxe_A2223.

Structurei

3D structure databases

ProteinModelPortaliQ13YU3.
SMRiQ13YU3. Positions 10-722.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1262Acetyl-CoA binding By similarity
Regioni454 – 4574Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
HOGENOMiHOG000220740.
KOiK01638.
OMAiARTENVD.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Q13YU3-1 [UniParc]FASTAAdd to Basket

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MTQMNPRGGL QVAANLDQFV ETEALPGTGL DSAAFWSGFD ALVHELAPKN    50
RALLAERDRL QTELDNWHRA NPGPVRDLRA YRAFLEGIGY IVPVPASVKA 100
TTDHVDTEIA EQAGPQLVVP LSNQRYALNA ANARWGSLYD ALYGTDAIPE 150
ANGAEKQKAF NPVRGAAVIA YARRFLDQAA PLANGSHADA TRYGVEGGKL 200
VVTLKNGTSE LKTPAQFIGY QGEESAPSAV LLKHNGLHFE IQIDANDSIG 250
KTDSAHVKDV VVEAAVSTII DCEDSVAAVD ADDKVQLYRN WLGLMNGDLT 300
EEVTKNGKTF TRRLNADRVY TAANGTAPVV LHGRSLLFIR NVGHLMTNPA 350
VLTKDGHEIP EGILDAVITS LCALHDRKHK LNSRTGSIYI VKPKMHGPAE 400
VAFASELFAR VEDLLKLPRN TIKMGIMDEE RRTSVNLLAC INEARERVAF 450
INTGFLDRTG DEMHTAMEAG PMLRKGDMKS SAWIAAYERS NVLVGLSAGL 500
RGRSQIGKGM WAMPDLMHAM LEQKIAHPKA GANTAWVPSP TAATLHALHY 550
HQVDVQAVQQ ELERTDYAKV RDELLDGLLT IPVVAEAKWS DDEIRSEIDN 600
NAQGILGYVV RWIDQGVGCS KVPDIHNVGL MEDRATLRIS SQHIANWLYH 650
GVVKRELVEE TFRRMARVVD EQNAGDPLYK PMAPGFDTIA FKAAQALVFE 700
GRQQPSGYTE PLLHKFRLEV KKEA 724
Length:724
Mass (Da):79,450
Last modified:August 22, 2006 - v1
Checksum:i342CB47D2034DB90
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000270 Genomic DNA. Translation: ABE30746.1.
RefSeqiWP_011488362.1. NC_007951.1.
YP_558798.1. NC_007951.1.

Genome annotation databases

EnsemblBacteriaiABE30746; ABE30746; Bxe_A2223.
GeneIDi4003121.
KEGGibxe:Bxe_A2223.
PATRICi19329978. VBIBurXen52548_2309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000270 Genomic DNA. Translation: ABE30746.1 .
RefSeqi WP_011488362.1. NC_007951.1.
YP_558798.1. NC_007951.1.

3D structure databases

ProteinModelPortali Q13YU3.
SMRi Q13YU3. Positions 10-722.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266265.Bxe_A2223.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABE30746 ; ABE30746 ; Bxe_A2223 .
GeneIDi 4003121.
KEGGi bxe:Bxe_A2223.
PATRICi 19329978. VBIBurXen52548_2309.

Phylogenomic databases

eggNOGi COG2225.
HOGENOMi HOG000220740.
KOi K01638.
OMAi ARTENVD.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci BXEN266265:GJII-2309-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LB400.

Entry informationi

Entry nameiMASZ_BURXL
AccessioniPrimary (citable) accession number: Q13YU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 22, 2006
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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