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Q13YI8

- PHNX_BURXL

UniProt

Q13YI8 - PHNX_BURXL

Protein

Phosphonoacetaldehyde hydrolase

Gene

phnX

Organism
Burkholderia xenovorans (strain LB400)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (22 Aug 2006)
      Previous versions | rss
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    Functioni

    Involved in phosphonate degradation.UniRule annotation

    Catalytic activityi

    Phosphonoacetaldehyde + H2O = acetaldehyde + phosphate.UniRule annotation

    Cofactori

    Binds 1 Mg2+ ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei10 – 101NucleophileUniRule annotation
    Metal bindingi10 – 101MagnesiumUniRule annotation
    Metal bindingi12 – 121Magnesium; via carbonyl oxygenUniRule annotation
    Active sitei51 – 511Schiff-base intermediate with substrateUniRule annotation
    Metal bindingi184 – 1841MagnesiumUniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphonoacetaldehyde hydrolase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. organic phosphonate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium, Metal-binding, Schiff base

    Enzyme and pathway databases

    BioCyciBXEN266265:GJII-2415-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphonoacetaldehyde hydrolaseUniRule annotation (EC:3.11.1.1UniRule annotation)
    Short name:
    PhosphonataseUniRule annotation
    Alternative name(s):
    Phosphonoacetaldehyde phosphonohydrolaseUniRule annotation
    Gene namesi
    Name:phnXUniRule annotation
    Ordered Locus Names:Bxeno_A2313
    ORF Names:Bxe_A2117
    OrganismiBurkholderia xenovorans (strain LB400)
    Taxonomic identifieri266265 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000001817: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267Phosphonoacetaldehyde hydrolasePRO_0000284587Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi266265.Bxe_A2117.

    Structurei

    3D structure databases

    ProteinModelPortaliQ13YI8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HAD-like hydrolase superfamily. PhnX family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0637.
    HOGENOMiHOG000217971.
    KOiK05306.
    OMAiDERNVER.
    OrthoDBiEOG6ZH2FH.

    Family and domain databases

    Gene3Di1.10.150.240. 1 hit.
    3.40.50.1000. 2 hits.
    HAMAPiMF_01375. PhnX.
    InterProiIPR023214. HAD-like_dom.
    IPR023198. PGP_dom2.
    IPR006323. Phosphonoacetald_hydro.
    [Graphical view]
    PfamiPF13419. HAD_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01422. phosphonatase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q13YI8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKHVKAVIFD WAGTVVDYGS LAPMGAFVET FGQFGVPITI DEARGPMGMA    50
    KRPHIAALMA LPRVAQAWTD KYGHAPDDAD IDAVYDVFVP KNIAVAASYS 100
    SVIPGVADVA SALRGDDIRI GTTTGYTREI MAEIVPGAAA QGFSPDSIVC 150
    TGDTAEGRPS PYMIYRTLPE LGVWRAKEAI KVDDTEVGIE EGINGGTWTV 200
    GVSVSGNAFG MAEGDVKALA PDEFAWRRNA AIQKLQAAGA HYVIDSVADL 250
    MPVVYDIEAR LARGERP 267
    Length:267
    Mass (Da):28,358
    Last modified:August 22, 2006 - v1
    Checksum:iAB50CDAD236F0F83
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000270 Genomic DNA. Translation: ABE30851.1.
    RefSeqiWP_011488465.1. NC_007951.1.
    YP_558903.1. NC_007951.1.

    Genome annotation databases

    EnsemblBacteriaiABE30851; ABE30851; Bxe_A2117.
    GeneIDi4005089.
    KEGGibxe:Bxe_A2117.
    PATRICi19330202. VBIBurXen52548_2421.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000270 Genomic DNA. Translation: ABE30851.1 .
    RefSeqi WP_011488465.1. NC_007951.1.
    YP_558903.1. NC_007951.1.

    3D structure databases

    ProteinModelPortali Q13YI8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266265.Bxe_A2117.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE30851 ; ABE30851 ; Bxe_A2117 .
    GeneIDi 4005089.
    KEGGi bxe:Bxe_A2117.
    PATRICi 19330202. VBIBurXen52548_2421.

    Phylogenomic databases

    eggNOGi COG0637.
    HOGENOMi HOG000217971.
    KOi K05306.
    OMAi DERNVER.
    OrthoDBi EOG6ZH2FH.

    Enzyme and pathway databases

    BioCyci BXEN266265:GJII-2415-MONOMER.

    Family and domain databases

    Gene3Di 1.10.150.240. 1 hit.
    3.40.50.1000. 2 hits.
    HAMAPi MF_01375. PhnX.
    InterProi IPR023214. HAD-like_dom.
    IPR023198. PGP_dom2.
    IPR006323. Phosphonoacetald_hydro.
    [Graphical view ]
    Pfami PF13419. HAD_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01422. phosphonatase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LB400.

    Entry informationi

    Entry nameiPHNX_BURXL
    AccessioniPrimary (citable) accession number: Q13YI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 17, 2007
    Last sequence update: August 22, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3